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Pick Disease of The Brain

Lobar Cerebral Atrophy


Presentation

  • It is caused by the absence of an enzyme, acid sphingomyelinase, which helps in the metabolism of sphingomyelin that is present in all body cells; thus accumulation of this substance.[startstemcells.com]
  • Cerebral atrophy is the morphological presentation of brain parenchymal volume loss that is frequently seen on cross sectional imaging.[radiopaedia.org]
  • When dementia and depression are present together, intellectual deterioration may be exaggerated. Depression, whether present alone or in combination with dementia, can be reversed with proper treatment.[alzcare.org]
  • Histiocytes are cells that are part of the reticuloendothelial system and are responsible for phagocytosis and antigen presentation.[embryo.asu.edu]
  • Clinical presentation depends on the particular pattern of cortical involvement, and is discussed in the frontotemporal lobar degeneration (FTLD) article.[radiopaedia.org]
Aggressive Behavior
  • However, pharmacological intervention with psychotherapy depressants is often needed to control aggressive behaviors.[news-medical.net]
Compulsive Disorder
  • Repetitive Compulsive Behaviors People living with FTD might develop Obsessive Compulsive Disorder (OCD), an anxiety disorder that is characterized by unwanted and repetitive thoughts, feelings, and behaviors that drive them ‘to do something’ (compulsions[pineseducation.org]
Personality Change
  • Behavior and personality changes are the most significant early symptoms in Pick’s disease.[healthline.com]
  • Patients with Pick’s disease may have personality changes so severe that their loved ones do not recognize them as the people they formerly were.[alzheimers.net]
  • In the absence of temporal or frontal lobar atrophy on CTs, all the Pick patients and none of the AD patients had three of five clinical features: presenile onset (before age 66), an initial personality change, hyperorality, disinhibition, and roaming[neurology.org]
  • Most often, behavioral and personality changes occur first, so usually the first type of treatment is psychiatric instead of neurological. The causes of early onset-dementias fall into three categories: random, genetic, and lifestyle.[goinggentleintothatgoodnight.com]
  • changes can help doctors distinguish Pick's disease from Alzheimer's disease (AD).[dementia.org]
Irritability
  • You may: Act aggressively toward others Be uninterested in everyday activities Be very aware of everything you do all the time Feel irritable or agitated Have drastic and quick mood swings Have trouble feeling warmth, sympathy, or concern for others Have[webmd.com]
  • There are medications that can reduce agitation, irritability and/or depression. These treatments should be used to help improve quality of life.[alz.org]
  • […] hygiene repetitive or obsessional behaviours, such as humming, hand-rubbing and foot-tapping, or complex routines such as walking exactly the same route repetitively seeming more selfish inability to empathise with others, seeming cold and uncaring irritability[psychologized.org]
  • Personality changes - perhaps becoming irritable, suspicious or fearful. Loss of initiative - showing less interest in starting something or going somewhere. As the patient ages, late-stage dementia symptoms tend to worsen.[medicalnewstoday.com]
  • […] coordination in the arms, legs, head, face and upper body Progressive decline in thinking and reasoning skills, including memory, concentration, judgment and the ability to plan and organize Mood disturbances, including depression, anxiety, anger, and irritability[goinggentleintothatgoodnight.com]
Amnesia
  • An amnesia score (Berliner Amnesietest-Kurzform) and the d2 test were highly pathological.[jnnp.bmj.com]

Treatment

  • Purpose of Treatment Pick’s disease is known to be incurable. Treatment is geared towards minimizing the symptoms.[startstemcells.com]
  • There are no known treatments that effectively slow the progression of Pick’s disease. Your doctor can prescribe treatments to help ease some of your symptoms.[healthline.com]
  • To make a referral please call us on 0800 090 1356 Current Bed Availability Find a treatment location Find a treatment location for Pick's Disease[priorygroup.com]
  • Symptoms and treatment of Pick’s disease Pick’s disease is a condition closely related to ‘ fronto-temporal lobar degeneration’ (FTLD) and is one of the rarer types of dementia.[clinical-partners.co.uk]
  • There is no treatment for frontotemporal dementia and treatment is directed toward minimizing symptoms. Frontotemporal dementia progresses steadily and often rapidly and is fatal.[medicinenet.com]

Prognosis

  • Prognosis The prognosis of FTD is poor. Life expectancy ranges anywhere from from two to 20 years after diagnosis, depending on the speed of progression and the presence of other diseases.[verywell.com]
  • Pick’s Disease Treatment and Prognosis Like Alzheimer’s disease, Pick’s disease is currently untreatable.[alzheimers.net]
  • What is the prognosis (the outlook) for frontotemporal dementia? The outcome for people with frontotemporal dementia is poor.[medicinenet.com]
  • Prognosis and treatment of Pick's Disease As yet, there is no cure for Pick's disease and neither can the progression be slowed down with any medication treatment.[depression-guide.com]
  • -- www.ninds.nih.gov/Disorders/All-Disorders/Niemann-Pick-Disease-Information-Page National Niemann-Pick Disease Foundation -- nnpdf.org National Organization for Rare Disorders -- rarediseases.org/rare-diseases/niemann-pick-disease-type-c Outlook (Prognosis[mountsinai.org]

Pathophysiology

  • Forecast Stem cell therapy is a promising solution for Pick disease affecting the frontotemporal lobes of the brain since it shares some similarities with the Niemann-Pick disease in the pathophysiology process — both involve a genetic abnormality.[startstemcells.com]
  • This study establishes the integrity of brain tissue in Niemann-Pick disease type B and suggests that the lysocompound Sphingosylphosphorylcholine could play a role in the pathophysiology of brain dysfunction in the neuronopathic type A.[link.springer.com]

Prevention

  • Collaborative Meta-Analysis of Randomised Trials of Antiplatelet Therapy for Prevention of Death, Myocardial Infarction, and Stroke in High Risk Patients. ‎[books.google.es]
  • Preventing or delaying dementia Recent research suggests that healthy lifestyle habits and mental stimulation may prevent dementia altogether or at least delay its onset.[helpguide.org]
  • This prevents normal blood flow, depriving brain cells of oxygen. Injury - post-traumatic dementia is directly related to brain cell death caused by injury.[medicalnewstoday.com]
  • "Discovering new genes and gene mutations could provide another key to unlocking the doors to new treatments and prevention strategies for dementia."[sciencedaily.com]
  • There is no known prevention. Semantic dementia; Dementia - semantic; Frontotemporal dementia; FTD; Arnold Pick disease; Pick disease; 3R tauopathy Bang J, Spina S, Miller BL. Frontotemporal dementia. Lancet. 2015;386(10004):1672-1682.[medlineplus.gov]

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