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Pigmented Purpuric Lichenoid Dermatosis

Gougerot and Blum Syndrome


Presentation

  • Patient presented with annular petechial patches with red-yellow background.[healio.com]
  • J Appl Hematol 2014;5:71-2 Sir, A 10-year-old boy presented with asymptomatic reddish-brown eruption on lower extremities present since last 4 years with slow progression.[jahjournal.org]
  • Superficial, and deep perivascular lymphocytic infiltrate is present. Perineural and periappendageal infiltrate is exceedingly rare and only case has been reported.[histopathology-india.net]
  • Histopathological properties of Majocchi disease are same of the other capillaritis, but perivascular lymphocytic infiltration may be present.[e-ijd.org]
  • Pigmentary purpuric eruptions may present with one of several clinical patterns. There may be overlapping characteristics among pigmented purpuric dermatosis and between their signs and those of other purpuric eruptions.[wikinow.co]
Physician
  • Gougerot, Henri, French physician, 1881-1955. Gougerot and Blum disease - an eruption of lichenoid papules on the legs.[medical-dictionary.thefreedictionary.com]
  • Her primary care physician had performed a lab workup looking for common bleeding disorders, which was negative.[healio.com]
  • It is not intended nor implied to be a substitute for professional medical advice and shall not create a physician - patient relationship. If you have a specific question or concern about a skin lesion or disease, please consult a dermatologist.[aocd.org]
  • Coauthor(s) Jennifer Michelle Heyl, MD Resident Physician, Department of Dermatology, Wayne State University School of Medicine Disclosure: Nothing to disclose.[emedicine.medscape.com]
Fever
  • Synonym: Brazilian haemorrhagic fever, Brazilian purpuric fever. (05 Mar 2000) purpuric 1. Of or pertaining to purpura. 2. Pertaining to or designating, a nitrogenous acid contained in uric acid.[kmle.co.kr]
  • ., sepsis) may present with fever and a petechial or purpuric rash.[diki.pl]
  • Some less common examples of dermatosis include: transient acantholytic dermatosis (Grover’s disease): chronic, itchy blistering triggered by heat or sweating acute febrile neutrophilic dermatosis (Sweet’s syndrome): red, swollen rash with fever and papules[healthline.com]
  • Clinical signs (rapid onset of multiple disseminated ulcerated plaques, papules and tumors without prior patches and plaques, mucosal involvement) and symptoms (reduced performance state, fever, weight loss) and histological features (striking pagetoid[wjgnet.com]
Sepsis
  • […] skin eruption, characterised clinically by induration and thickening of the skin with accentuation of skin markings, and microscopically by a band-like lymphocytic infiltration of the papillary dermis. (05 Mar 2000) Brazilian purpuric fever Fulminating sepsis[kmle.co.kr]
  • ., sepsis) may present with fever and a petechial or purpuric rash.[diki.pl]
Weakness
  • Weakness or disturbance of the cutaneous blood vessels leading to RBC extravasation and capillary fragility has been implicated.[sydneyskinandvein.com.au]
  • First is that they are hypothesised to be due to weakness or disturbance in cutaneous blood vessels, fragility of capillaries and extravasation of red blood cells.[jahjournal.org]
Fulminant Sepsis
  • sepsis, usually beginning with conjunctivitis, characterised by purpuric skin lesions, a high fatality rate; thought to be due to Haemophilus aegyptius.[kmle.co.kr]
Purpura
  • […] pig·men·ted pur·pu·ric li·chen·oid der·ma·to·sis an eruption composed of lichenoid papules variously pigmented from the hemosiderin of the associated purpura; found on the legs, usually in men over 40 years of age.[medical-dictionary.thefreedictionary.com]
  • ., predominant in women, of rapid onset and characterized by plaquelike lesions, usually multiple, on the … Medical dictionary chronic pigmented purpura — any of a group of benign dermatoses of unknown etiology, not associated with underlying systemic[translate.academic.ru]
  • Of or pertaining to purpura. 2. Pertaining to or designating, a nitrogenous acid contained in uric acid. It is not known in the pure state, but forms well-known purple-red compounds (as murexide), whence its name.[kmle.co.kr]
  • To date, there is no effective treatment for pigmented purpura. Causes of Pigmented Purpura The cause (etiology) of pigmented purpura is generally unknown.[healthcommunities.com]
Eruptions
  • Leichen, lichen, a lichen-like eruption eidos, resemblance (05 Mar 2000) lichenoid eczema Thickening of skin with accentuated skin lines in eczema.[kmle.co.kr]
  • — Classification and external resources Examples of drug eruptions.[translate.academic.ru]
  • […] pig·men·ted pur·pu·ric li·chen·oid der·ma·to·sis an eruption composed of lichenoid papules variously pigmented from the hemosiderin of the associated purpura; found on the legs, usually in men over 40 years of age.[medical-dictionary.thefreedictionary.com]
  • . - Pigmented purpuric dermatosis - Pigmented purpuric eruption - Pigmented purpuric lichenoid dermatosis of Gougerot and Blum - Gougerot's trisymptomatic disease - Gougerot-Blum capillaritis - Pigmented purpuric lichenoid dermatitis of Gougerot and Blum[snomedbrowser.com]
  • […] skin conditions characterized by purpuric skin eruptions.[wikinow.co]
Papule
  • Synonym(s): Gougerot trilogy Gougerot-Carteaud syndrome - discrete and confluent gray-brown papules of the anterior and posterior midchest. Synonym(s): confluent and reticulate papillomatosis[medical-dictionary.thefreedictionary.com]
  • Lichen planus is the prototype of all lichenoid eruptions. (12 Dec 1998) lichenoid keratosis A solitary benign papule or plaque, with microscopic features resembling lichen planus, occurring on sun-exposed or unexposed skin.[kmle.co.kr]
  • These papules form plaques (superficial, solid lesions on the skin) The skin papules are occasionally itchy, but are usually not painful The onset of the patches takes place slowly, beginning from the lower legs.[dovemed.com]
  • Terms you may hear to describe dermatosis of the skin include: rash: a wide variety of skin conditions that are red and raised lesion: an area of skin that is abnormal macule: a change in color or consistency of the skin papule: a bump on the skin smaller[healthline.com]
  • Clinically,. lichen aureus is characterized by an erythematous brownish, coppery or golden macules and/or papules. Linear or segmental presentations have also been described.[histopathology-india.net]
Skin Lesion
  • Dermatoscopy and videodermatoscopy can be used for differential diagnosis, prognostic evaluation, and monitoring response to treatment of various disorders including inflammatory diseases, parasitoses, viral and fungal infections, nonpigmented skin lesions[books.google.de]
  • lesions that are usually symmetrical and generalized.[1]:224 See also Lichen planus List of … Wikipedia Drug eruption — Classification and external resources Examples of drug eruptions.[translate.academic.ru]
  • lesions, a high fatality rate; thought to be due to Haemophilus aegyptius.[kmle.co.kr]
  • […] is not helpful in the treatment of this skin condition Despite therapy, the skin lesions persist for a long period of time, resulting in a chronic skin disorder.[dovemed.com]
  • lesion List of cutaneous conditions References [ edit ] External links [ edit ][en.wikipedia.org]
Keratosis
  • Lichen planus is the prototype of all lichenoid eruptions. (12 Dec 1998) lichenoid keratosis A solitary benign papule or plaque, with microscopic features resembling lichen planus, occurring on sun-exposed or unexposed skin.[kmle.co.kr]
  • L82.0 Inflamed seborrheic keratosis L82.1 Other seborrheic keratosis L83 Acanthosis nigricans L84 Corns and callosities L85 Other epidermal thickening L85.0 Acquired ichthyosis L85.1 Acquired keratosis [keratoderma] palmaris et plantaris Reimbursement[icd10data.com]
  • […] scarring impetigo : a skin infection caused by bacteria melanoma : the most serious form of skin cancer basal cell carcinoma: the most common form of skin cancer that strikes in the top layer of the epidermis moles: dark growths on the skin actinic keratosis[healthline.com]
  • […] lichenoides chronica Bahadoran et al [ 53 ] Ichthyosis Eisman et al [ 54 ], Kütting et al [ 55 ], Badawy et al [ 56 ] Follicular hyperkeratosis Klemke et al [ 57 ] Porokeratosis Mibelli Breneman et al [ 58 ] Seborrhoeic keratosis Bazza et al [ 59 ] Bowen[wjgnet.com]

Workup

  • Her primary care physician had performed a lab workup looking for common bleeding disorders, which was negative.[healio.com]
  • In addition, we integrate our own atypical cases of mycosis fungoides to exemplarily delineate the diagnostic workup of such ambiguous cases.[wjgnet.com]

Treatment

  • Dermatoscopy and videodermatoscopy can be used for differential diagnosis, prognostic evaluation, and monitoring response to treatment of various disorders including inflammatory diseases, parasitoses, viral and fungal infections, nonpigmented skin lesions[books.google.de]
  • These include treatment with narrowband UVB and psoralen plus UVA, griseofulvin and treatment with ascorbic acid and rutoside.[ic.steadyhealth.com]
  • They may also recur after suitable treatment and over time the condition becomes chronic.[dovemed.com]
  • Although treatment with oral steroids can be effective in clearing the lesions, these are not generally used, as the risks of treatment far outweigh any potential benefits. Antihistamines may offer relief from pruritus but at the cost of sedation.[patient.info]

Prognosis

  • The mainline of treatment is the use of steroidal creams and lotions The prognosis of Gougerot-Blum Disease is generally good, though it may be present for several years.[dovemed.com]
  • Prognosis Many lesions persist or extend with time. Most eventually resolve spontaneously.[emedicine.medscape.com]
  • Cutaneous vasculitis update: diagnostic criteria, classification, epidemiology, etiology, pathogenesis, evaluation and prognosis. Am J Dermatopathol. 2005;27:504-528. Marks, JG, Miller JJ. Lookingbill and Marks’ Principles of Dermatology, 4th ed.[clinicaladvisor.com]
  • Generally, the treatment and prognosis are similar. The pigmented purpuric dermatoses include [ 2 ] : Schamberg's disease (progressive pigmentary dermatosis). Eczematoid-like purpura of Doucas and Kapetanakis.[patient.info]

Etiology

  • ., predominant in women, of rapid onset and characterized by plaquelike lesions, usually multiple, on the … Medical dictionary chronic pigmented purpura — any of a group of benign dermatoses of unknown etiology, not associated with underlying systemic[translate.academic.ru]
  • When the etiology remains obscure therapy has to be empirical.[clinicalgate.com]
  • Pathophysiology The etiology is unknown.[emedicine.medscape.com]
  • Causes of Pigmented Purpura The cause (etiology) of pigmented purpura is generally unknown. There may be tiny blood vessel (capillary) fragility that allows red blood cells to escape into the skin.[healthcommunities.com]
  • Pigmented purpuric dermatosis (PPD) is a chronic disorder of unknown etiology. It is quite common, and no therapy is significantly effective. Calcium dobesilate (Cd) has been tried successfully in many vascular disorders.[pubfacts.com]

Epidemiology

  • Keywords Herpes simplex antigen bacteria bacterial infection diagnosis epidemiology histopathology infection pregnancy prevention skin therapy treatment viral infection virus Authors and affiliations Sungnack Lee 1 Dongsik Bang 2 Eun-So Lee 1 Seonghyang[link.springer.com]
  • Extravasation of red blood cells with marked hemosiderin deposition in macrophages is also found, and a rare granulomatous variant of chronic pigmented dermatosis has been reported. [3] Epidemiology Frequency United States Pigmented purpuric dermatoses[emedicine.medscape.com]
  • Aim: To study the epidemiology, etiological, host and environmental factors, clinical manifestations, its variations, and the type prevalent in this part of the world.[idoj.in]
  • Cutaneous vasculitis update: diagnostic criteria, classification, epidemiology, etiology, pathogenesis, evaluation and prognosis. Am J Dermatopathol. 2005;27:504-528. Marks, JG, Miller JJ. Lookingbill and Marks’ Principles of Dermatology, 4th ed.[clinicaladvisor.com]
  • Epidemiology The conditions are uncommon. Generally they affect males more than females, except in Majocchi's disease. There is no racial difference in incidence. Schamberg's disease occurs at any age.[patient.info]
Sex distribution
Age distribution

Pathophysiology

  • Possible pathophysiological factors that can be addressed therapeutically are a cell-mediated immune response, increased venous pressure, increased vascular permeability or vascular fragility due to subtle defects in the extracellular matrix.[clinicalgate.com]
  • Pathophysiology The etiology is unknown.[emedicine.medscape.com]
  • Pathophysiology The aetiology is unknown but important contributory factors include venous hypertension, exercise and gravitational dependency [ 2 ].[patient.info]
  • Pathophysiology: The etiology is unknown. Venous hypertension, exercise, and gravitational dependency are important cofactors that appear to influence disease presentation.[answers.google.com]

Prevention

  • The goal of medicamentous treatment is reduction of morbidity and prevention of potential complications. If the condition is closely related to venous stasis, it can improve if one uses compressive hosiery.[ic.steadyhealth.com]
  • Keywords Herpes simplex antigen bacteria bacterial infection diagnosis epidemiology histopathology infection pregnancy prevention skin therapy treatment viral infection virus Authors and affiliations Sungnack Lee 1 Dongsik Bang 2 Eun-So Lee 1 Seonghyang[link.springer.com]
  • […] cosmetic issues and the affected individuals may face a lot of emotional stress Please find comprehensive information on Gougerot-Blum Disease regarding definition, distribution, risk factors, causes, signs & symptoms, diagnosis, complications, treatment, prevention[dovemed.com]
  • Phototherapy can be effective at clearing capillaritis but do not prevent it recurring. If the lower leg is affected, consider wearing graduated compression elastic hose. This is helpful to reduce exercise-induced capillaritis.[dermnetnz.org]

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