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Pineal Gland Cyst
Cyst of the Pineal Gland

Images

WIKIDATA, CC BY-SA 3.0
WIKIDATA, CC BY-SA 3.0
WIKIDATA, CC BY-SA 3.0

Presentation

The mean patient age at presentation was 28.7 years (range 15 to 46 years); 18 were female and six male. [thejns.org]

Uncommon clinical presentations in three cases were related to increased cyst size caused by hemorrhage, sudden death, and postural syncope and loss of consciousness. [ncbi.nlm.nih.gov]

Vignette: A 34 year old female presents with headaches. Image Findings: A T2-weighted axial MR scan shows a mass in the pineal region. The mass is ovoid with smooth edges and is isodense to CSF. [radrounds.com]

In the present study, septation was observed in 18 PCs (32.14%). [wjgnet.com]

Entire Body System

  • Asymptomatic

    Asymptomatic cysts of the pineal gland are found frequently by radiological examination of the brain or at postmortem examination. Symptomatic cysts are rare, and may require surgical intervention. [ncbi.nlm.nih.gov]

    Abstract Pineal cysts are usually asymptomatic; however, they may rarely cause symptoms such as chronic headache, paroxysmal headache with gaze paresis, postural syncope, loss of consciousness, and sudden death. [doi.org]

    In contrast to patients with pineal neoplasms, pineal cysts are usually asymptomatic. They infrequently obstruct the aqueduct to cause hydrocephalus or compress the tectum to produce the neuro-ophthalmologic signs of dorsal midbrain dysfunction. [n.neurology.org]

  • Fatigue

    CONCLUSIONS: Pineal cysts can present with vague and unusual symptoms such as weakness, fatigue, depression, loss of appetite and weight loss that must be kept in the differential diagnosis. [n.neurology.org]

    I have a pineal cyst like most of you, with a lot of the same symptoms (fatigue, vision problems, trouble sleeping, pressure headaches, problems with my short term memory, irritability). [steadyhealth.com]

    We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition. Last updated: March 12, 2020 [patientslikeme.com]

    Walking up the stairs I was easily fatigued. [pinealglandcystsurgery.com]

    […] smaller cysts (less than 5.0 mm) were usually asymptomatic, but for larger cysts (greater than 5.0 mm), symptoms could include headache, unexpected seizures, visual disturbances, memory loss, cognitive decline, muscle fasciculations, nausea, weakness, fatigue [youtube.com]

  • Weakness

    CONCLUSIONS: Pineal cysts can present with vague and unusual symptoms such as weakness, fatigue, depression, loss of appetite and weight loss that must be kept in the differential diagnosis. [n.neurology.org]

    Customer: She said it could be just a weak muscle neuromd2012 : very good. [justanswer.com]

    […] believed that smaller cysts (less than 5.0 mm) were usually asymptomatic, but for larger cysts (greater than 5.0 mm), symptoms could include headache, unexpected seizures, visual disturbances, memory loss, cognitive decline, muscle fasciculations, nausea, weakness [youtube.com]

    I was having all kinds of weird neurological symptoms last fall...strong pressure in my head, dizziness, weakness, headaches, etc. MRI showed nothing but a 6mm pineal cyst. [healthboards.com]

    It is something to worry about when you have a bunch of symptoms such as blurred vision, double vision, eyes not focusing, spots in the eye that flicker, weakness in your legs, blacking out, dizziness, sick at your stomach, ringing in the ears, sezuires [change.org]

  • Swelling

    Anna Example of the ice bag that I use on top of my head to help with swelling. The wedge that you must sleep on 3 weeks after surgery to prevent brain bleeding. [annaelizmon.wordpress.com]

    Symptoms The symptoms of a pilonidal cyst include: Pain, redness, and swelling at the bottom of the spine Pus or blood draining out of it Bad smell from the pus Tenderness to the touch Fever They can vary in size. [webmd.com]

    This question featured in : What causes bartholin gland to swell Symptoms of pineal gland cyst Disclaimer : The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. [practo.com]

  • Surgical Procedure

    Other surgical procedures include complete cyst and cyst wall excision along with the pilonidal sinus tracts, the use of fibrin glue, and taking (core out) only diseased tissue and the cyst out with punch biopsies. [webmd.com]

    In cases where there is any doubt as to the actual diagnosis and in patients who are symptomatic a surgical procedure may be recommended. [nervous-system-diseases.com]

    The first surgical procedure on a PC was published by Pussep et al. in 1914 in a boy with hemorrhagic apoplexy of the gland [3]. The pathogenesis of the PC remains unknown despite that numerous hypotheses have been formulated over the years. [cnjournal.biomedcentral.com]

    […] resection in favor of cerebrospinal fluid (CSF) diversion followed by empiric radiotherapy. [15] If the patient did not respond to radiation, a surgical procedure to remove radioresistant tumor was performed. [emedicine.medscape.com]

Gastrointestinal

  • Nausea

    Pineal cysts manifest in childhood or early adulthood through clinical symptoms such as headaches, nausea, vomiting, visual disorders or disturbances of equilibrium. [www2.medizin.uni-greifswald.de]

    If narrowing of the cerebral aqueduct occurs, many neurological symptoms may exist, including headaches, vertigo, nausea, muscle fasciculations, eye sensitivity, and ataxia. [youtube.com]

    Nausea. Oh man, the nausea. I do have a very sensitive stomach but it would have been good to have a heads up that Dr. Shaianian actually expects extreme nausea after surgery. [annaelizmon.wordpress.com]

    If narrowing of the aqueduct of sylvius occurs, many neurological symptoms may exist, including headaches, vertigo, nausea, eye sensitivity, and ataxia. [medhelp.org]

    Pineal cyst apoplexy is a very rare entity with previously reported symptoms of severe frontal or occipital headache, gaze paresis and visual field defects, nausea or vomiting, syncope, ataxia, hearing loss and sudden death. [ncbi.nlm.nih.gov]

  • Vomiting

    Pineal cysts manifest in childhood or early adulthood through clinical symptoms such as headaches, nausea, vomiting, visual disorders or disturbances of equilibrium. [www2.medizin.uni-greifswald.de]

    Pineal cyst apoplexy is a very rare entity with previously reported symptoms of severe frontal or occipital headache, gaze paresis and visual field defects, nausea or vomiting, syncope, ataxia, hearing loss and sudden death. [ncbi.nlm.nih.gov]

    Presenting features in 20 symptomatic cases included: headache in 19; nausea and/or vomiting in seven; papilledema in five; visual disturbances in five (diplopia in three, “blurred vision” in two, and unilateral partial oculomotor nerve palsy in one); [thejns.org]

    Presenting features in 20 symptomatic cases included: headache in 19; nausea and/or vomiting in seven; papilledema in five; visual disturbances in five (diplopia in three, 'blurred vision' in two, and unilateral partial oculomotor nerve palsy in one); [mayoclinic.pure.elsevier.com]

Ears

  • Tinnitus

    Robb09 Member Location: Canada Tinnitus Since: 3/2015 Cause of Tinnitus: buzzing shaver/laptop fan whine/pellet gun/music/caff/wax/ eardrum red How are you doing nowadays @Matty ? Hope all is well. [tinnitustalk.com]

    […] mm) were usually asymptomatic, but for larger cysts (greater than 5.0 mm), symptoms could include headache, unexpected seizures, visual disturbances, memory loss, cognitive decline, muscle fasciculations, nausea, weakness, fatigue, light sensitivity, tinnitus [youtube.com]

    An ischemic mechanism can be hypothesized when neuroimaging exams do not show signs of hemorrhage, as happened in a case of a vanishing pineal gland in a girl after acute onset of headaches, vomiting, dizziness, and tinnitus described by Patriarca et [gs.amegroups.com]

    Some symptoms without correlation to the disease such as epilepsy, hemifacial edema, tinnitus, cervicalgia, and sarcoidosis, were also encountered. [surgicalneurologyint.com]

Eyes

  • Blurred Vision

    Since been 14 years old iv had strange symptoms since a bang to the head such as migraines, dizzy, nausea, hallucinations at night and waking up screaming, depression/anxiety, blurred vision, tingling on my head and face and well lots more like feeling [medhelp.org]

    Presenting features in 20 symptomatic cases included: headache in 19; nausea and/or vomiting in seven; papilledema in five; visual disturbances in five (diplopia in three, “blurred vision” in two, and unilateral partial oculomotor nerve palsy in one); [thejns.org]

    Presenting features in 20 symptomatic cases included: headache in 19; nausea and/or vomiting in seven; papilledema in five; visual disturbances in five (diplopia in three, 'blurred vision' in two, and unilateral partial oculomotor nerve palsy in one); [mayoclinic.pure.elsevier.com]

    It is something to worry about when you have a bunch of symptoms such as blurred vision, double vision, eyes not focusing, spots in the eye that flicker, weakness in your legs, blacking out, dizziness, sick at your stomach, ringing in the ears, sezuires [change.org]

    Occasionally a cyst may enlarge and press on surrounding structures causing symptoms such as headaches and blurred vision. If this occurs, the cyst can be removed using surgery. [healthunlocked.com]

  • Diplopia

    Presenting features in 20 symptomatic cases included: headache in 19; nausea and/or vomiting in seven; papilledema in five; visual disturbances in five (diplopia in three, “blurred vision” in two, and unilateral partial oculomotor nerve palsy in one); [thejns.org]

    Symptoms include: • headache • nausea • papilledema • diplopia • vertical gaze paralysis • seizure • ataxia • hemiparesis Radiolographic findings: On CT: • sharply defined wall • hypodense to CSF • calcification in cyst wall in half of cases • if present [radrounds.com]

    Presenting features in 20 symptomatic cases included: headache in 19; nausea and/or vomiting in seven; papilledema in five; visual disturbances in five (diplopia in three, 'blurred vision' in two, and unilateral partial oculomotor nerve palsy in one); [mayoclinic.pure.elsevier.com]

    The symptoms includes: diplopia which is double vision, blurred vision, dizziness, ataxia which is inability to coordinate voluntary movements and parinaud's syndrome. Rarely, some additional symptoms might occur. [epainassist.com]

    Compression of the pituitary infundibulum could lead to diabetes insipidus (most common), hypopituitarism or optic chiasm compression with diplopia. [gs.amegroups.com]

  • Photophobia

    Clinic, Warangal, India Correspondence to Dr Anirudda Deshpande, dr.anirudda.deshpande{at}gmail.com Statistics from Altmetric.com radiology neurology Description A 24-year-old female patient presented with acute-onset, vertex headache associated with photophobia [casereports.bmj.com]

    These types of issues include overstimulation problems, fatigue, headaches, memory problems, anxiety, depression, photophobia and many other symptoms can occur. For me, I mainly experience these problems when I am over tired or stressed out. [mypinealcyst.com]

    She also had headache, photophobia, and phonophobia. Clinical and neurological examinations were unremarkable. [jcsm.aasm.org]

  • Visual Impairment

    Symptoms in children and adults may include headaches, nausea, fatigue, visual impairments, double vision, memory problems, and seizures. In children, precocious puberty has been identified as a key indicator of a pineal tumor. [skullbaseinstitute.com]

Psychiatrical

  • Fear

    I quickly gripped the railing, I was accompanied by feelings of anxiety or fear. When I stepped out of the elevator everything turned back to normal and all the problems were gone. [pinealglandcystsurgery.com]

    I it's not the constant health panic, it's the fear that I'm going crazy or schizophrenic. I can't even try any SSRIs because I'll take one and go straight into panic. I got prescribe Paxil and boom.. [nomorepanic.co.uk]

    I've experienced the full range of emotions, anger, scared, fear of death, sadness, resolve, determination, etc, just depends on the moment and time and day. [inspire.com]

    I have eaten very little in 3 days for fear of the pain with the cramps. Any idea on what I should do, or suggestions would be appreciated. XXXXXXX MD Brief Answer: Cramps under right ribs/ Under Evaluation Detailed Answer: Hi Dear !! [healthcaremagic.com]

Neurologic

  • Headache

    Abstract Pineal cysts are usually asymptomatic; however, they may rarely cause symptoms such as chronic headache, paroxysmal headache with gaze paresis, postural syncope, loss of consciousness, and sudden death. [doi.org]

    Abstract The cyclic nature of some of headache disorders is closely related to melatonin, which is secreted by the pineal gland. We report a 29-year-old male patient with a 2.5-year history of headaches that woke him in the middle of the night. [ncbi.nlm.nih.gov]

    Usually, they are asymptomatic; however, clinical signs such as headache, sight disorders, dizziness or hydrocephalia may occur. [termedia.pl]

    One year post-operatively the patient is totally free of symptoms, headache and double vision. [www2.medizin.uni-greifswald.de]

    Since your headaches might not be due to the pineal gland cyst, discuss with your doctor other possible causes for your headaches. A variety of primary headache and medical conditions can lead to chronic headaches. [newsnetwork.mayoclinic.org]

  • Seizure

    (these seizures have started recently) and more. [gofundme.com]

    Although most pineal cysts are small, large pineal cysts can cause a variety of symptoms such as: headaches, normal pressure hydrocephalus (increased pressure on the brain due to build-up excess fluid), and even seizures and loss of consciousness in extreme [med.uth.edu]

    We report a new complication of intracystic hemorrhage in a large pineal gland cyst in a 40-year-old man with new onset seizures. [ncbi.nlm.nih.gov]

    Not to mention, after the three seizures I have had I am extremely hesitant in driving a motor vehicle. I day dream all the time about the possibilities. [braintumor.org]

    This especially struck home when I read the fact that "large symptomatic pineal cysts may potentially cause serious conditions such as seizures and loss of consciousness", as our son has most recently been exhibiting "seizure-like episodes" and "vision [ourabrammayhem.weebly.com]

  • Ataxia

    Pineal cyst apoplexy is a very rare entity with previously reported symptoms of severe frontal or occipital headache, gaze paresis and visual field defects, nausea or vomiting, syncope, ataxia, hearing loss and sudden death. [ncbi.nlm.nih.gov]

    […] all 24 cases (range 3 months to 10 years) revealed no complications in 21, mild ocular movement deficit in one, gradually resolving Parinaud's syndrome in one, and radiographic evidence of a postoperative venous infarct of the superior cerebellum with ataxia [thejns.org]

    If narrowing of the cerebral aqueduct occurs, many neurological symptoms may exist, including headaches, vertigo, nausea, muscle fasciculations, eye sensitivity, and ataxia. [youtube.com]

    Symptoms include: • headache • nausea • papilledema • diplopia • vertical gaze paralysis • seizure • ataxia • hemiparesis Radiolographic findings: On CT: • sharply defined wall • hypodense to CSF • calcification in cyst wall in half of cases • if present [radrounds.com]

  • Stroke

    Had a 9mm x 8mm pineal gland cyst on my In 2010 mri showed I had a cyst on my brain and then may of 2017 I had a subarachnoid hemorrhage stroke... [practo.com]

    When I was 19 or 20 I suffered a migraine with stroke-like symptoms that landed me in the ER. [migraine.com]

    I have a pineal cyst 9mm for 5 years but as far as i know as long as the cyst as not changed i am ok. i just had mri of brain but no ct since last year can mri detect anything like cva.. sorry but very concerned that supposedly i had a stroke (cva) i [healthcaremagic.com]

    Secondary arachnoid cysts, which is the name used for cysts that develop later in life, may be caused by an injury to the brain or as a complication of brain surgery, explains the National Institute of Neurological Disorders and Stroke. [livestrong.com]

    The Neuro-ICU cares for patients with all types of neurosurgical and neurological injuries, including stroke, brain hemorrhage, trauma and tumors. [uclahealth.org]

  • Tremor

    I’ve ever dealt with in my life. main symptoms and constant : nausea/vertigo, loss of vision, blurred vision and speech, extreme fatigue or insomnia some nights, vomiting, light sensitivity, memory loss, migraines, bilateral ear pain, muscle spasms, tremors [gofundme.com]

    Additional symptoms include memory problems, lack of coordination and tremor. Diagnosis Scans A magnetic resonance imaging (MRI) of the brain is the most important imaging study. It will show the location, size, and shape of the tumor. [uclahealth.org]

    […] nausea and vomiting visual problems light sensitivity lack of muscle coordination lethargy vertigo sleep problems coma In addition to the above, there are also some core anecdotal symptoms derived from forums with people with pineal gland cysts: fatigue tremors [hubpages.com]

    He also said the tremors I was having in my arms and head was just my body's reaction to pain. I guess this is true since I only have them when the pain's severe. [healthboards.com]

Workup

Measurement of AFP and b-hCG in serum and CSF is routine in the preoperative workup. [aboutcancer.com]

Therefore, a rigorous and uniform preoperative workup is a requisite for all patients thought to harbor a pineal region tumor. Any endocrine abnormalities should be investigated prior to surgery. [emedicine.medscape.com]

Treatment

SRS is increasingly being used to treat pineal region tumors, either as an additional therapy after conventional treatments or as a primary treatment. [wikidoc.org]

No controlled trials of treatment interventions were identified; evidence on treatment is mainly found in case reports. No evidence-based guidelines for the diagnosis and treatment of pineal gland cysts were identified. [crd.york.ac.uk]

Disclaimer : The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. [practo.com]

The patient underwent oral melatonin treatment (6 mg/day). After 1 month he experienced a 70% reduction in his symptoms. [ncbi.nlm.nih.gov]

Prognosis

Extragonadal GCTs (including pineal region) have a poorer prognosis than gonadal GCTs. [aboutcancer.com]

Prognosis The response of tumours to various treatment modalities depends on the tumour subtype. [ 3 ] Generally, intracranial germinomas have an excellent prognosis on account of their sensitivity to radiotherapy (the five-year overall survival rate [patient.info]

It is quite difficult for me to recount the exact timing of my prognosis, but, with the help of my boyfriend documenting for me, we could recall that my first seizure had occurred around February of last year. [braintumor.org]

[…] postcontrast imaging is delayed (60-90 min), gadolinium may diffuse into the cyst fluid and may lead to the mass appearing solid in atypical cases enhancement may be nodular, or there may be evidence of previous hemorrhage into the cysts Treatment and prognosis [radiopaedia.org]

Etiology

The underlying etiological association is unclear and this case exemplifies the enigmatic role of the pineal gland in puberty. Contributors : KVS, AV worked up the patient clinically. [indianpediatrics.net]

The etiology of pineal cysts is still under debate; however, several postulates have been presented in an attempt to explain their origin. [thejns.org]

Epidemiology

Objective Epidemiological and clinical evaluation of the occurrence of pineal cysts in children treated in a single oncological ward over a period of 7 years. [termedia.pl]

Epidemiology, pathophysiology, and surgical approaches. 9:239–266 Google Scholar 15. Sano K, Matsutani M (1981) Pineal (germinoma) treated by direct surgery and postoperative irradiation. Child's Brain 8:81–97 Google Scholar 16. [link.springer.com]

diagnostic dilemmas] 2005 ► Hicheri J; Badri T; Fazaa B; Zermani R; Kourda N; Ben-Jilani S; Kamoun MR Scrotal calcinosis: pathogenesis and case report 2005 ► Šoba Barbara; Logar Jernej Molekularna epidemiologija humane kriptosporidioze [Molecular epidemiology [ricinus2.mf.uni-lj.si]

Epidemiology [ 3 ] They account for 0.4-1% of adult intracranial tumours. They make up 3-8% of childhood intracranial tumours, with most occurring between the first and second decade of life. [patient.info]

Currently, initial surgical management for tissue diagnosis, and possible resection, is the standard of care for most children with pineal region tumors. [16] Epidemiology Pineal region tumors make up 0.4-1.0% of intracranial tumors in adults and 3-8% [emedicine.medscape.com]

Pathophysiology

It also provides further support that the pineal region may play a role in the pathophysiology of psychiatric diseases, although more studies will be needed to elucidate this interesting connection. [mdanderson.elsevierpure.com]

Epidemiology, pathophysiology, and surgical approaches. 9:239–266 Google Scholar 15. Sano K, Matsutani M (1981) Pineal (germinoma) treated by direct surgery and postoperative irradiation. Child's Brain 8:81–97 Google Scholar 16. [link.springer.com]

Pathophysiology Tumors and Cysts Due to the pineal gland's location, any tumor or cyst formation would lead to the compression of the aqueduct of Sylvius. It is the aqueduct of Sylvius that allows the cerebrospinal fluid (CSF) to circulate out. [statpearls.com]

We review present an up-to-date review including the anatomy, embryology, and physiology of the pineal gland and its ability to secrete hormones including melatonin, pathophysiology of pineal gland tumors, cysts, and calcifications, their clinical presentation [read.qxmd.com]

The pathophysiology of pineal region tumors is mostly a result of anatomic compression of adjacent structures, although local infiltration of neural structures can lead to symptoms in cases of highly invasive tumors. [emedicine.medscape.com]

Prevention

The wedge that you must sleep on 3 weeks after surgery to prevent brain bleeding. [annaelizmon.wordpress.com]

I have also been put on tablets to prevent my absent seizures I am now experiencing daily! [gofundme.com]

Centers for Disease Control and Prevention says. Certain brain cysts, such as arachnoid cysts, can form later in life from causes other than developmental abnormalities. [livestrong.com]

Also Read: Pineal Cyst or Pineal Gland Cyst: Treatment, Recovery Period, Prognosis, Complications Pineal Cyst or Pineal Gland Cyst: Prevention, Social Security Disability, Coping [epainassist.com]

Parinaud syndrome prevents a person from moving his or her eyes up and down. The thalamus can be affected, and if so, there can be disturbances on that side of the body which would result in weakness and loss of sensation. [statpearls.com]

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