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Pineocytoma
Presentation
- We present the first report on familial pineocytoma. The propositus, a 31-year-old man, presented with incontinence due to a cystic and haemorrhagic tumour of the pineal region.[ncbi.nlm.nih.gov]
- We present his clinical manifestations, follow-up MRI, surgical treatment, pathological findings, and review the literature.[ncbi.nlm.nih.gov]
- We report on a 62-year-old male presenting with Parinaud's syndrome and aqueduct stenosis caused by a cystic tumour in the pineal region.[ncbi.nlm.nih.gov]
- It is speculated that the retinitis might reflect an autoimmune response to S-antigen present in some tumour cells of the pineocytoma.[ncbi.nlm.nih.gov]
- Associated findings may also be present. The most-common etiologies are pineal gland tumors and midbrain infarction. Pineal gland tumors are rare tumors that show a predilection for males.[ncbi.nlm.nih.gov]
Entire Body System
Turkish
- […] patients with pineal tumor treated either by stereotactic biopsy followed by adjuvant therapy (23 patients) or open surgical resection without (18 patients) or with (7 patients) adjuvant therapy in Shohada Tajrish Hospital, Iran (1993-2008)... 2016: Turkish[read.qxmd.com]
Musculoskeletal
Myopathy
- […] in maloriented specimens. b) Pineal parenchymal tumors: Pineoblastoma, Pineocytoma (c) Embryonal Tumors: Medulloblastoma Possible differential diagnosis of DEP include blow-out fracture of the orbital floor, congenital or acquired fibrosis, endocrine myopathy[medical-dictionary.thefreedictionary.com]
Low Back Pain
- Recurrence In February 2009, the patient returned to clinic complaining of bilateral resting tremors and left hand numbness over the previous year, progressive low back pain and sciatica-like pain running down her left leg into her left foot for the past[pagepress.org]
Neurologic
Stupor
- Two days after the placement of the ventriculoperitoneal shunt, he suddenly became stuporous and Parinaud's sign appeared.[ncbi.nlm.nih.gov]
Dysarthria
- On neurologic examination, he had apraxia of eyelid opening, vertical supranuclear gaze palsy, dysarthria, and dysphagia. There was facial hypomimia, moderate axial rigidity, symmetrical bradykinesia, and no tremor.[neurology.org]
Bradykinesia
- There was facial hypomimia, moderate axial rigidity, symmetrical bradykinesia, and no tremor. Gait was characterized by freezing and postural instability. Cognitive assessment was normal.[neurology.org]
Postural Instability
- Gait was characterized by freezing and postural instability. Cognitive assessment was normal. Brain MRI revealed a multiloculated lesion of the pineal region causing midbrain (tectal plate) distortion ( figure ).[neurology.org]
Sciatica
- Recurrence In February 2009, the patient returned to clinic complaining of bilateral resting tremors and left hand numbness over the previous year, progressive low back pain and sciatica-like pain running down her left leg into her left foot for the past[pagepress.org]
Workup
- No other workup or CSF markers were obtained. MRI of 10/05: Lesion is recorded as 8 10 mm.[med.virginia.edu]
- Therefore, a rigorous and uniform preoperative workup is a requisite for all patients thought to harbor a pineal region tumor. Any endocrine abnormalities should be investigated prior to surgery.[emedicine.medscape.com]
- Therefore differences in workup, diagnosis and treatment modalities are unavoidable and comparison of the data of a long time period is difficult. PPT are not a homogeneous histological tumor entity.[ro-journal.biomedcentral.com]
Treatment
- Abstract Given its rarity, appropriate treatment for pineocytoma remains variable.[ncbi.nlm.nih.gov]
- Thus, recommendations on appropriate treatment of these tumors are highly varied.[ncbi.nlm.nih.gov]
- A 58-year-old male suffered a massive intratumoral hemorrhage after placement of a ventriculoperitoneal shunt before treatment for pineocytoma.[ncbi.nlm.nih.gov]
- Some patients will undergo other treatments such as radiation treatments for residual tumor or chemotherapy, particular in more malignant tumors.[nervous-system-diseases.com]
- […] entire tumor is considered the standard treatment.[rarediseases.info.nih.gov]
Prognosis
- Pineocytomas are pineal parenchymal tumour, are generally non-agressive and have a relatively good prognosis.[operativeneurosurgery.com]
- Pineocytomas are a relatively benign pineal parenchymal tumor that have a relatively good prognosis.[radiopaedia.org]
- They are usually associated with a good prognosis.[ebi.ac.uk]
Etiology
- The most-common etiologies are pineal gland tumors and midbrain infarction. Pineal gland tumors are rare tumors that show a predilection for males.[ncbi.nlm.nih.gov]
- There was no evidence of infection, with negligible leukocytes and negative tests for syphilis, cryptococcus, tuberculosis and other infectious etiologies. In March 2009, a left frontal craniotomy and dural biopsy were performed.[pagepress.org]
- The mechanisms behind HPG activation are complex and a clear etiology for early activation is often not elucidated.[biomedsearch.com]
Epidemiology
- This publication takes advantage of the knowledge and experience of Japanese experts in pineal tumors, with emphasis on epidemiology and pathological diagnosis.[books.google.com]
- Epidemiology Pineocytoma accounts for less than 1% of all intracranial tumors, but about 45% of all pineal parenchymal tumors. These lesions usually arise in adults between the ages of 25-35. Both sexes are affected equally.[prod.wiki.cns.org]
- Epidemiology Pineocytomas can be encountered at any age but mostly occur in young adults in the second decade of life Unlike pineal germinomas both genders are equally affected.[operativeneurosurgery.com]
- Accessed on November 20, 2015 12.0 12.1 Epidemiology of pineocytoma. Dr Bruno Di Muzio and Dr Frank Gaillard et al. Radiopaedia 2015. . Accessed on November 20, 2015 Clark, Aaron J.; Sughrue, Michael E.; Aranda, Derick; Parsa, Andrew T. (2011).[wikidoc.org]
Sex distribution
Age distribution
Pathophysiology
- […] intermediate differentiation (grade II or III) Papillary tumor of the pineal region (grade II or III) Pineoblastoma (grade IV) According to the WHO classification of tumors of the central nervous system, pineocytoma is classified into a WHO grade I tumor. [2] Pathophysiology[wikidoc.org]
- The pathophysiology of pineal region tumors is mostly a result of anatomic compression of adjacent structures, although local infiltration of neural structures can lead to symptoms in cases of highly invasive tumors.[emedicine.medscape.com]
Prevention
- This consequently prevents us from addressing the potential for systematic flaws or differences among studies in a statistically meaningful way.[link.springer.com]
- Parinaud syndrome prevents a person from moving his or her eyes up and down. The thalamus can be affected, and if so, there can be disturbances on that side of the body which would result in weakness and loss of sensation.[wikidoc.org]
- MedMaven Editor Mar 21 Neuropathy (Numbness and Tingling )- How is it Prevented and Treated? Chemotherapy damage to nerves can cause numbness, tingling, & a loss of sensation known as peripheral neuropathy.[news.cancerconnect.com]
- A standardized protocol for the prevention of clinically relevant venous air embolism during neurosurgical interventions in the semisitting position. Neurosurgery. 2009. 64: 533-8 13. Jakola AS, Bartek J, Mathiesen T.[surgicalneurologyint.com]