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Pittsburgh Pneumonia

Pittsburg Pneumonia


Presentation

  • The clinical presentation is nonspecific, although in immunosuppressed hosts the presentation may mimic that of pulmonary embolus (pleuritic chest pain, nonproductive cough, pleural-based densities on chest rontgenogram).[ncbi.nlm.nih.gov]
  • The first case of Legionella micdadei (Pittsburgh Pneumonia Agent) infection in Sweden is presented. A previously healthy 68-yr-old man fell ill with diarrhoea, fever, and mental confusion.[ncbi.nlm.nih.gov]
  • We herein present our protocol for establishing rapidly the diagnosis of pneumonia in renal transplant patients with emphasis on the use of open lung biopsy.[ncbi.nlm.nih.gov]
  • 2 pneumonia etiology low risk 0 high risk (see below) 2 vital sign abnormality absent 0 present (see below) 2 age in years 0 65 years 1 pleuritic chest pain absent 0 present -2 where • High risk pneumonia etiology is present if (1) due to Staphylococcus[meducator3.net]
  • A literature review suggests a typical pattern of clinical and radiologic presentation, of which the following case is representative.[ncbi.nlm.nih.gov]
Splenomegaly
  • The rapid pulmonary cavitation and relapse of symptoms after a course of therapy in a renal transplant recipient, and the prolonged illness with hemorrhagic pleural fluid, splenomegaly, and multiple-organ dysfunction in a nonimmunocompromised host, illustrate[ncbi.nlm.nih.gov]
  • The rapid pulmonary cavitation and relapse of symptoms after a course of therapy in a renal transplant recipient, and the prolonged illness with hemorrhagic pleural fluid, splenomegaly, and multipleorgan dysfunction in a nonimmunocompromised host, illustrate[jamanetwork.com]
Malaise
  • Typically a higher fever within that 100-point mark, most folks tend to have that fatigue, that malaise, just not feeling well sensation,” Burick said. “At the same point, it's not always isolation of symptoms.[timesonline.com]
  • […] with symptoms of acute infection with or without new infiltrate on chest radiographs Clinical presentation Temperature greater than 38 C (100.4 F) Cough with or without sputum, hemoptysis Pleuritic chest pain Myalgia Gastrointestinal symptoms Dyspnea Malaise[aafp.org]
Paroxysmal Cough
  • ., unexplained cough illness of 1 week duration and paroxysmal cough) (IB) ( 286,287,297--300 ). 2.[cdc.gov]
Pleuritic Pain
  • An often intracellular bacteria, and frequent contaminant of water supplies, which may cause bronchopneumonia with consolidation and a fibrinopurulent exudate, fever, pleuritic pain and cough.[medical-dictionary.thefreedictionary.com]
Food Poisoning
  • Wednesday night's (August 11) show at Club Infinity in Buffalo (Clarence), New York didn't happen because Lawless was said to be "on [his] way to the hospital [to receive treatment] for food poisoning."[blabbermouth.net]
Irritability
  • That's because the cold or flu will irritate the lungs, creating an environment where it's easier for pneumonia germs to move in and start an infection. How Does It Feel? Most kids with pneumonia will feel sick.[kidshealth.org]
  • You may feel better in a room with a humidifier, which increases the moisture in the air and soothes irritated lungs. Make sure you drink plenty of fluids, especially if you have a fever.[kidshealth.org]
  • Even in developed countries like the United States, as many as one in 1,000 affected children may die as a complication of measles usually from pneumonia or encephalitis, which is an irritation or swelling of the brain. Measles is preventable.[childrenspgh.org]

Workup

  • (See Workup.) The Legionellaceae family consists of more than 42 species, constituting 64 serogroups.[emedicine.medscape.com]
  • Introduction Severity of illness (SOI) plays a major role in determining the site of care, the diagnostic workup and the empirical choice of antibiotics for patients with community‐acquired pneumonia (CAP) [ 1 ].[onlinelibrary.wiley.com]
Legionella Pneumophila
  • Abstract Sediment and indigenous microflora taken from water distribution systems has been shown to promote the survival of Legionella pneumophila.[ncbi.nlm.nih.gov]
  • Legionella dumoffii resembled Legionella pneumophila in being resistant to penicillin, cephalothin, and cephamandole and susceptible to moxalactam and cefoxitin. All species except L. micdadei produced beta-lactamase.[ncbi.nlm.nih.gov]
  • Abstract From July 1977 to January 1980, 5 cases of pneumonia owing to Pittsburgh pneumonia agent and 4 cases owing to Legionella pneumophila occurred in our renal transplant population.[ncbi.nlm.nih.gov]
  • Abstract Of the Legionellaceae family, Pittsburgh pneumonia agent (Tatlockia micdadei, Legionella micdadei) is second only to Legionella pneumophila in causing human pneumonia. In nosocomial infection, the patients tend to be immunosuppressed.[ncbi.nlm.nih.gov]
  • Abstract Nosocomial pneumonia caused simultaneously by two organisms, Legionella pneumophila and the Pittsburgh pneumonia agent, was documented in seven patients in one institution.[ncbi.nlm.nih.gov]

Treatment

  • We describe herein the clinical features, diagnosis, and successful treatment of two patients with Legionella micdadei pneumonia, the Pittsburgh pneumonia agent.[ncbi.nlm.nih.gov]
  • Abstract Optimal treatment of Legionella micdadei pneumonia has not been established, although in vitro studies have shown the pathogen to be sensitive to erythromycin.[ncbi.nlm.nih.gov]
  • The patient's pulmonary infection improved during treatment with penicillin.[ncbi.nlm.nih.gov]

Prognosis

  • Prognosis of patients hospitalized with community-acquired pneumonia. Am J Med. 1990; 88: 1N-8N. Fine MJ, Smith DN, et al. Hospitalization decision in patients with community-acquired pneumonia: a prospective cohort study.[meducator3.net]
  • Session Information Session Type: Abstract Submissions (ACR) Background/Purpose: Usual interstitial pneumonia associated with idiopathic pulmonary fibrosis (IPF-UIP) has a poor prognosis with a median survival of 3 years.[acrabstracts.org]
  • The box-and-whisker plots show the mean and SD of the metabolite Prognosis of mortality of H1N1 For the prognosis of 90-day mortality, prediction models were built on the basis of the training set.[ccforum.biomedcentral.com]
  • Two-year prognosis after community-acquired pneumonia , Lancet , 1993 , vol. 342 (pg. 30 - 3 ) 8 Severe community-acquired pneumonia: factors influencing need of intensive care treatment and prognosis , Scand J Infect Dis , 1985 , vol. 17 (pg. 377 - 86[academic.oup.com]
  • Hours later, Hill’s family finally gave a brief statement confirming that he is still alive, although his exactly condition and prognosis for recovery are unknown at this time.[foxsports.com]

Etiology

  • 2 pneumonia etiology low risk 0 high risk (see below) 2 vital sign abnormality absent 0 present (see below) 2 age in years 0 65 years 1 pleuritic chest pain absent 0 present -2 where • High risk pneumonia etiology is present if (1) due to Staphylococcus[meducator3.net]
  • ) Haemophilus influenzae , 18 (1.2%) viruses, 15 (1%) E coli and 121 (8%) mixed etiology.[journals.plos.org]
  • Etiologic diagnosis of bacterial pneumonia by Gram stain and quantitative culture of expectorates. Scand J Infect Dis. 1983;15:153–60. PubMed Google Scholar 6. Gleckman R, Devita J, Hibert D, Pelletier C, Martin R.[link.springer.com]
  • In many studies, the clinical manifestations for Legionnaires' disease were more severe and the mortality was higher when compared with pneumonias of other etiology.[ncbi.nlm.nih.gov]

Epidemiology

  • The difference in the ecology between the two organisms may explain the infrequent environmental recovery of PPA and, ultimately, the epidemiologic differences between Legionnaires disease and Pittsburgh pneumonia.[ncbi.nlm.nih.gov]
  • Although it was not possible, at the current time, to establish an epidemiological link to disease acquisition, this information may be significant because it provides further evidence that a water-associated reservoir of this organism exists within the[aem.asm.org]
  • Abstract An epidemiological link was found between contamination of a hospital water-supply by Legionella pneumophila and by Pittsburgh pneumonia agent (PPA) and subsequent cases of nosocomial legionnaires' disease and Pittsburgh pneumonia.[ncbi.nlm.nih.gov]
  • Pittsburgh pneumonia agent and L. pneumophila, therefore, appear to share epidemiologic features as well.[kundoc.com]
Sex distribution
Age distribution

Pathophysiology

  • Pathophysiology Legionella species are obligate or facultative intracellular parasites.[emedicine.medscape.com]
  • In this setting, a more accurate characterization of CAP-associated incident heart failure and its pathophysiology (ie, systolic versus diastolic) will likely need prospective studies in which the diagnosis of heart failure is also assisted by cardiac[ahajournals.org]
  • Biomarkers may facilitate early diagnosis and prognosis, as well as help determine response to treatment and develop new insights into ongoing pathophysiologic processes in viral pneumonia.[ccforum.biomedcentral.com]

Prevention

  • The reservoir for the organism is water, and prevention of nosocomial infections can be accomplished by disinfection of the water supply.[ncbi.nlm.nih.gov]
  • Can I Prevent Pneumonia? The routine vaccinations that most people receive as kids help prevent certain types of pneumonia and other infections.[kidshealth.org]
  • Prevention Though prevention is not always possible, there are certain steps you and your loved one can take to help boost the immune system. Eating a healthy diet filled with antioxidant-rich fruits and vegetables is important.[homehelpershomecare.com]
  • If this happens, your doctor will administer a mechanical ventilator and supplemental oxygen. [8] How can you prevent pneumonia? First and foremost, help your parent get the pneumococcal vaccine.[brightstarcare.com]
  • Pneumonia Prevention There are several ways to keep from getting pneumonia. One is to get all your shots because one of them can help to prevent a type of pneumonia called pneumococcal (say: new-mo-KOK-al) pneumonia.[kidshealth.org]

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