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Pituicytoma

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WIKIDATA, CC BY-SA 3.0

Presentation

The present case study reports three cases of histopathologically diagnosed pituicytoma. Clinical presentations, surgical strategies and treatment outcomes are presented and the relevant published literature is discussed. [ncbi.nlm.nih.gov]

[…] diabetes insipidus) is rare despite the involvement of the infundibulum (3 - 5%) Apoplexy exceptional Rarely causes hypercortisolism or acromegaly without the presence of a synchronous corticotroph or somatotroph pituitary tumors Pituicytoma can also present [pathologyoutlines.com]

Neurologic

  • Frontal Headache

    Case report: We report the case of a Caucasian male with no significant medical history who develops isolated frontal headache at the age of 48. [endocrine-abstracts.org]

Workup

During the course of his workup, an MRI of the brain was performed, which showed a pituitary/sellar mass. In 1997, the patient had a recurrence of the tumor and underwent surgery, which suggested the diagnosis of pituicytoma. [academic.oup.com]

The lab workup of acromegaly is straightforward. Your screening test is a spot blood insulin-like growth factor I (IGF-I). If this is normal, acromegaly is unlikely. [pathguy.com]

Treatment

Total resection is the treatment of choice, since subtotal removal can often lead to recurrence or progression. [endocrine-abstracts.org]

Tumor resection is the primary treatment option, but remains subtotal due to excessive bleeding in many cases. The search for alternative or additional treatment regimens is necessary. [ncbi.nlm.nih.gov]

Treatment Review Less than 50 cases have been reported in the world literature till 2013 13). [operativeneurosurgery.com]

To round out the clinician's understanding of the illness, a patient describes the experience of diagnosis, treatment, and follow-up. [books.google.com]

Prognosis

The prognosis and role of adjuvant therapy remain unclear for this discrete noninfiltrative glioma. [ncbi.nlm.nih.gov]

This fourteenth volume of the series provides comprehensive, current information on the diagnosis, therapy and prognosis of brain tumors and spinal tumors. [books.google.com]

Treatment and prognosis As the tumors are benign and slow-growing if asymptomatic then expectant management is sufficient. If mass effect is present then resection may be required. [radiopaedia.org]

Etiology

Although three cases of pituicytoma with elevated plasma adrenocorticotropic hormone (ACTH) have been reported previously, the etiological mechanisms remain unknown. [file.scirp.org]

Little is known of the etiology or genetics (J. Neurosurg. 98 : 162, 2003). Grossly, most of these tumors usually filled with little cysts that contain an unsavory, cholesterol-rich fluid ("machine oil"). [pathguy.com]

Epidemiology

Epidemiology PTs had a higher prevalence in the fifth and sixth decades of life, with a slight male predominance. 6). [operativeneurosurgery.com]

[…] protein and GFAP Surgical resection is curative; excellent outcome Terminology Not recommended: Infundibuloma Low grade glioma of sella and suprasellar region Pilocytic astrocytoma ICD coding ICD-0: 9432/1 - Pituicytoma ICD-11: XH59V4 - Pituicytoma Epidemiology [pathologyoutlines.com]

However, the epidemiology is not well known because of low incidence of the tumor. The clinical symptoms of pituicytomas are variable according to tumor size and location. [btrt.org]

Pathophysiology

2007;156:203) About 50% of posterior pituitary tumors (World Neurosurg 2021;145:148) Usually in adults: 40 - 60 years No obvious male or female predominance Exceptional in children (3% of posterior pituitary tumors) Sites Sella and suprasellar region Pathophysiology [pathologyoutlines.com]

[…] pituitary { 02294 } anterior pituitary, histology; curious stain, don't worry about the colors { 14948 } posterior pituitary, histology (arrow: Herring body) OBJECTIVES; Know when to suspect each of these clinical syndromes, and give the likely etiologies, pathophysiology [pathguy.com]

Prevention

We removed the suprasellar tumor by the transcranial approach to decompress the optic nerves and chiasm to prevent permanent visual loss after angiography and recognition of the unusual pathology. [btrt.org]

POU1F prevents productions of GH, prolactin, and TSH (J. Clin. Endo. Metab. 90 : 4762, 2005). Even ACTH usually is insufficient: J. Clin. Endo. Metab. 89 : 5256, 2004. [pathguy.com]

At present, most patients are treated as having a clinically nonfunctioning adenoma, and the therapeutic goals are restoration of visual deficits, preservation of pituitary function, and prevention of recurrence. [15] Null cell adenomas and oncocytomas [emedicine.medscape.com]

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