The current study presents the case of a patient diagnosed with pituitary cancer three months after completing surgery and post-operative chemoradiotherapy for hypopharyngeal cancer. [tmu.pure.elsevier.com]

In children, hypopituitarism commonly presents with delayed puberty or impairment of growth. Diabetes insipidus is rarely a presenting feature but may occur following surgery for a pituitary adenoma. [patient.info]

Abstract Purpose To present a case of renal cell carcinoma metastatic to the pituitary gland. [jim.bmj.com]

We present here the first case of pituitary metastasis of hepatocellular carcinoma presenting with panhypopituitarism diagnosed by magnetic resonance imaging. [bmccancer.biomedcentral.com]

Levy A (2004) Pituitary disease: presentation, diagnosis, and management. J Neurol Neurosurg Psychiatry.; 75(3): 47-52. [medcraveonline.com]

• Weight Gain

  Low TSH causes fatigue, low energy, sensitivity to cold temperatures, constipation, and weight gain. Prolactin. Too little prolactin causes an inability to breastfeed after a woman gives birth to a baby. ACTH. [cancer.net]

  Depending on which hormones are affected, symptoms might include: Nausea Weakness Unexplained weight loss or weight gain Loss of body hair Feeling cold Feeling tired or weak Menstrual changes or loss of menstrual periods in women Erectile dysfunction [cancer.org]

  Symptoms include unexpected weight gain, easy bruising of the skin and muscle weakness. TSH-secreting pituitary adenoma ( thyrotropinoma ). Excessive TSH hormone production leads to hyperthyroidism. These tumors are very rare. [pituitary.ucla.edu]

  For example: prolactinomas can cause infertility, loss of sex drive in men and milk production in the breasts of women steroid producing hormones can cause weight gain, diabetes and high blood pressure (Cushing's syndrome) growth hormone producing tumours [cancerresearchuk.org]

  Too much ACTH leads to Cushing’s disease (excess weight gain, thin skin and easy bruising), and these functioning adenomas are called corticotroph adenomas. Thyroid-stimulating hormone (TSH) regulates our thyroid. [siteman.wustl.edu]

• Fatigue

  Too little of this hormone causes fatigue and low energy, low blood pressure, low blood sugar, and upset stomach. Gonadotropins. [cancer.net]

  People with this condition, known as secondary adrenal insufficiency, may have low blood pressure, low blood sugar, fatigue, and a low tolerance for stress because of low cortisol levels. [nyulangone.org]

  Methods A 68-year-old white male who previously underwent a right radical nephrectomy for renal cell cancer presented with a 2-month history of diplopia and fatigue. [jim.bmj.com]

  Get plenty of sleep and relax often to prevent fatigue. Consider meditation and yoga. Cancer treatments can make you feel weak. [healthline.com]

  Symptoms of this syndrome include enlarged hands, feet, and facial bones; headache; high blood pressure; and fatigue. A prolactin-producing tumor overproduces the hormone prolactin, which stimulates the breasts to make milk. [dartmouth-hitchcock.org]

• Galactorrhea

  Galactorrhea is the production of breast milk in men or in women who are not breastfeeding. The most common cause of galactorrhea is a tumor in the pituitary gland. [merckmanuals.com]

  Diagnosis and Management of Galactorrhea. American Family Physician [On-line journal]. [labtestsonline.it]

  In women, this can cause loss of menstrual periods (amenorrhea) and fluid discharge from the breasts (galactorrhea). [willseye.org]

  High levels of prolactin will cause galactorrhea, which can be the presenting symptom of this condition. Here, too, menstrual irregularity is common as are infertility and loss of libido. [pituitary.org]

• Pathologist

  Otolaryngologists (ENT) – doctors who specializes in ear, nose and throat care Ishii, Masaru Ramanathan, Murugappan Pathologists – doctors who specialize in interpreting specimens obtained during surgery Rodriguez, Fausto Jose Radiation Oncologists – [hopkinsmedicine.org]

  The Center for Neuro-Oncology features a multidisciplinary team of specialists, including radiation oncologists, medical oncologists, surgeons, physicists, radiologists, interventional radiologists, endoscopists, pathologists, specialized nursing staff [brighamandwomens.org]

  […] in disorders of hormone production (endocrinologist) a doctor who operates on the brain (neurosurgeon) a doctor who specialises in disorders of the eyes (ophthalmologist) a doctor who specialises in examining tissue samples collected during surgery (pathologist [macmillan.org.uk]

  In addition to neurosurgeons, your specialized medical team may include endocrinologists, neuroradiologists, pathologists, neuro-ophthalmologists and radiation oncologists. [mdanderson.org]

  Biopsy: The removal of cells or tissues so they can be viewed under a microscope by a pathologist to check for signs of cancer. [rarecancers.org.au]

• Male Hypogonadism

  hypogonadism Cushing's Disease Pituitary Cushing's Ectopic Cushing's Adrenal Cushing's Iatrogenic Cushing's Recurrent Cushing's Hypopituitarism Hypoadrenalism Hypogonadism Hypothyroidism (central) Growth hormone deficiency Posterior Pituitary Dysfunction [massgeneral.org]

• Easy Bruising

  It can also cause high blood pressure, high blood sugar, brittle bones, emotional changes, stretch marks on the skin, and easy bruising. Gonadotropins (FSH and LH). [cancer.net]

  Too much ACTH leads to Cushing’s disease (excess weight gain, thin skin and easy bruising), and these functioning adenomas are called corticotroph adenomas. Thyroid-stimulating hormone (TSH) regulates our thyroid. [siteman.wustl.edu]

  bruising High blood sugar levels or even diabetes mellitus High blood pressure Decreased interest in sex Changes in menstrual periods in women Weakening of the bones, which can lead to osteoporosis or even fractures Most of these symptoms can also occur [cancer.org]

  bruising Aching joints Carpal tunnel syndrome Disrupted menstruation Early menopause Muscle weakness Galactorrhea (spontaneous breast-milk flow not associated with childbirth or the nursing of an infant) When a pituitary tumor is suspected, a physician [aans.org]

  Symptoms include unexpected weight gain, easy bruising of the skin and muscle weakness. TSH-secreting pituitary adenoma ( thyrotropinoma ). Excessive TSH hormone production leads to hyperthyroidism. These tumors are very rare. [pituitary.ucla.edu]

• Polydipsia

  Case Report: This is a 45-year-old woman who was presented with headache, visual disorders, polyuria, polydipsia, significant hypernatremia and dyspnea. [medcraveonline.com]

• Visual Impairment

  […] palsy, visual impairment Hypopituitarism, diabete insipidus enhanced NR Weber et al. [19] 62/F Headache, Visual impairment Normal enhanced NR Djimi et al. [9] 45/M Visual impairment Normal enhanced Lung Basaria et al. [7] 77/F Visual impairment Hypopituitarism [oatext.com]

  This pressure can result in headache, visual impairment, and behavioral changes. Tumors can also either produce excessive amounts of hormone or limit how much hormone is produced. [rarecancers.org.au]

• Hirsutism

  Some women also have reduced libido and hirsutism (excessive hair growth on the face and body). A high prolactin level can cause infertility in both men and women. [merckmanuals.com]

  Hirsutism and acne indicating excessive androgen production, proximal myopathy and bone fractures all point to Cushing’s syndrome. Only 3 cases of pregnancy in women with thyroid stimulating hormone (TSH)-secreting adenomas have been reported. [clinicaladvisor.com]

  In women it may cause excessive growth of facial hair ( hirsutism ) and in men erectile dysfunction. Psychiatric manifestations may include depression, anxiety, easy irritability and emotional instability. [en.wikipedia.org]

• Osteoporosis

  Low estrogen levels usually accompany amenorrhea and increase the risk of osteoporosis in women. Low testosterone levels increase the risk of osteoporosis in men. [merckmanuals.com]

  It can also cause osteoporosis, which is weakening of the bones; loss of sex drive; infertility; irregular menstrual cycles; and erectile dysfunction. Adrenocorticotropic hormone. [cancer.net]

  In men, high prolactin levels can cause breast growth and erectile dysfunction (trouble with erections) Both men and women can have: Loss of interest in sex Infertility Weakening of the bones called osteoporosis If the tumor continues to grow, it can [cancer.org]

  Symptoms include high blood pressure, high blood sugar ( type 2 diabetes ), weight gain, loss of muscle mass, and fragile bones ( osteoporosis ). [nyulangone.org]

  In women, high prolactin results in loss of regular menstrual cycles, infertility, low estrogen with risk of osteoporosis and bone fractures. [med.virginia.edu]

• Large Hand

  The stage is determined by how large the cancer is and to what extent it has spread. Staging is used to plan a treatment plan and to help determine the outlook. [healthline.com]

  Lurch from the James Bond movie — large hands, protruding jaw, severe arthritis, huge size, protruding eyebrows, plus other systemic problems — is a classic example of gigantism. [brain-surgery.com]

  […] very large hands and feet, and sometimes, behavioral and visual problems. [drugs.com]

• Amenorrhea

  Amenorrhea Amenorrhea is a menstrual condition characterized by absent menstrual periods for more than three monthly menstrual cycles. [massgeneral.org]

  Low estrogen levels usually accompany amenorrhea and increase the risk of osteoporosis in women. Low testosterone levels increase the risk of osteoporosis in men. [merckmanuals.com]

  In women, this can cause loss of menstrual periods (amenorrhea) and fluid discharge from the breasts (galactorrhea). [willseye.org]

  Hypopituitarism may manifest itself as nausea, vomiting, weakness, decreased mental function, loss of sexual drive, infertility and in women, irregular or absent periods (amenorrhea). The vast majority of these tumors are benign. [pituitary.org]

  Much more often, it causes absent periods (amenorrhea). In men, it causes impotence and decreased sex drive. [drugs.com]

• Oligomenorrhea

  In women, the majority of prolactinomas are microadenomas and occur during the reproductive age period, presenting with oligomenorrhea or amenorrhea, galactorrhea, and infertility. [28, 29] In contrast, in men and elderly women, prolactinomas are usually [emedicine.medscape.com]

• Headache

  Case report We present a 67-year-old Italian female complained of severe headache and visual impairment. For increasing of headache she was transferred to our department. There was no history of trauma or other systemic disease. [oatext.com]

  They present with headaches, visual field defects and hypopituitarism (including growth failure, as often present in childhood and adolescence). Other causes of headache, visual field defects, visual disturbance and endocrine dysfunction. [patient.info]

  The major symptoms of patients with endocrine-inactive tumors are those of pituitary failure (hypopituitarism), visual loss and headache. [pituitary.org]

  Headaches Vision problems Unexplained tiredness Mood changes Irritability Changes in menstrual cycles in women Erectile dysfunction, which is the inability to achieve or maintain an erection in men and is caused by hormone changes Infertility, which is [cancer.net]

  These tumors may grow large enough to cause symptoms such as headaches and vision problems before they are found. (See the symptoms for large tumors above.) [cancer.org]

• Tremor

  Symptoms of hyperthyroidism may include: fast heart rate unintended weight loss tremor increased appetite feelings of being warm or hot, or not tolerating cold trouble falling asleep feeling anxious frequent bowel movements a lump in the front of the [urmc.rochester.edu]

  This can cause symptoms of hyperthyroidism (overactive thyroid), such as: Rapid or irregular heartbeat Tremors (shaking) Weight loss Increased appetite Feeling warm or hot Sweating Trouble falling asleep Anxiety Frequent bowel movements A lump in the [cancer.org]

Most endocrinologists can perform an effective workup of a pituitary tumor and make appropriate diagnosis and, where appropriate, medical treatment recommendations from that workup. [pituitary.org]

While a majority of patients with endogenous Cushing syndrome have thyrotrophic adenomas (called Cushing Disease - see below), other tumors should also be considered as part of the endocrinologic workup, including adrenal tumors and especially ACTH-secreting [eyewiki.aao.org]

Six patients had complete radiological and biochemical workup preoperatively: a cystic-appearing pituitary mass was identified in all six patients (100%) with a mean size of 2.0 cm (range 1.4-2.5 cm) on imaging, and pituitary endocrine dysfunction was [cancerindex.org]

Your healthcare team will suggest treatments based on your needs and work with you to develop a treatment plan. [cancer.ca]

Despite aggressive treatment and surgical excision with postoperative chemoradiotherapy, the disease progressed rapidly and the patient succumbed due to multiple metastases and organ failure. [tmu.pure.elsevier.com]

Although effective for recurrent Cushing syndrome, chronic ketoconazole treatment is limited by AEs (e.g., hepatotoxicity). 43 Ketoconazole for pituitary carcinoma treatment requires further study. [uspharmacist.com]

When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment. Patients may want to think about taking part in a clinical trial. [cancer.gov]

No medical treatment can be given without your consent. Benefits and disadvantages of treatment Treatment can be given for different reasons and the potential benefits will vary for each person. [macmillan.org.uk]

Immunohistochemical hormone content in medullary and undifferentiated thyroid carcinoma and prognosis after surgery. Acta Histochem (Jena) 83:51–56, 1988. Google Scholar 9. Johnson PM, Atkins HL. [link.springer.com]

Prognosis Remission can be obtained in up to 90% of patients with microadenomas and in about 50% to 60% of those with macroadenomas. [ 1 ] [patient.info]

Prognosis remains poor and depends on the primary cancer. [blog.cellavision.com]

Certain factors affect prognosis (chance of recovery) and treatment options. [rarecancers.org.au]

If the presenting symptom is sudden monocular visual loss, a pituitary adenoma may be acutely missed, as other more common etiologies are evaluated. [eyewiki.aao.org]

Epidemiology [ 1 ] Pituitary tumours account for 10% to 25% of all intracranial neoplasms. Adenomas account for the largest portion of pituitary neoplasms (estimated at approximately 17%). Only a minority of adenomas are symptomatic. [patient.info]

“Using this remarkable database (UPDB), we previously had determined that pituitary tumors cluster in families,” says Lisa Cannon-Albright, Ph.D., professor of medicine and chief of the Division of Genetic Epidemiology in the School of Medicine. [healthcare.utah.edu]

The epidemiology and genetics of pituitary adenomas. Best Pract Res Clin Endocrinol Metab. 2009;23:543-554. 11. Kontogeorgos G. Classification and pathology of pituitary tumors. Endocrine. 2005;28:27-35. 12. Colao A, Ochoa AS, Auriemma RS, et al. [uspharmacist.com]

[…] less commonly patients may also have Ocular motility deficits and/or Diplopia, certain forms of Nystagmus, signs and symptoms of Increased intracranial pressure due to mass effect, Optic atrophy, or sequelae of Pituitary apoplexy. [3] [4] [5] General Epidemiology [eyewiki.aao.org]

Recent clinical and pathophysiological advances in non-functioning pituitary adenomas. Horm Res. 2009;71(suppl 2):123-130. 22. van der Klaauw AA, Kienitz T, Strasburger CJ, et al. [uspharmacist.com]

The exact pathophysiology of this phenomenon is unknown; however, as most of these lesions involve the chiasm and/or diencephalon, many have proposed that disruption of visual and vestibular input contribute to this pathology. [eyewiki.aao.org]

It may be recommended as additional therapy after surgery to prevent regrowth of the tumor. Radiation may also be used as the sole treatment if the tumor cannot be removed surgically, or if the tumor regrows after surgery. [mskcc.org]

Clinical trials look at new ways to prevent, find and treat cancer. Find out more about clinical trials. central nervous system (CNS) The brain and spinal cord, which work together to control all the functions of the body. [cancer.ca]

We believe seeing both specialists at the same time reduces anxiety and uncertainty for the patient, and prevents having to go back and forth between specialists. [uofmhealth.org]

Prevention Because doctors do not know why pituitary tumors develop, there is no way to prevent them. [drugs.com]

However, a user would be allowed to write a sentence such as “NCI’s PDQ cancer information summary about breast cancer prevention states the risks in the following way: [include excerpt from the summary].” [cancer.gov]