scaly lesions on his forearms that had been present for several months. [escholarship.org]

It has been associated with systemic diseases and malignant tumors, though many cases present no associated disorders.1 We present a case of intense PR associated with hyperprolactinemia. [actasdermo.org]

Case Report A 7-year-old female presented to us with a 6-month history of an asymptomatic, dry, scaly circular lesion over the left arm. [ijpd.in]

We report the case of a 20-year old male Congolese presenting with PR and ichthyosis vulgaris. This rarely described association raises the problem, discussed here, of whether PR belongs to ichthyosis vulgaris. [unboundmedicine.com]

Cutaneous examination revealed slightly pigmented well defined circular patches varying in size from 2-10 cms in diameter present on back, buttocks, legs and the volar aspect of left wrist. [ijdvl.com]

• Recurrent Respiratory Infections

  Pityriasis rotunda with recurrent respiratory infections. G Ital Dermatol Venereol. 2017 Apr;152(2):190-191. [PubMed: 28166620] 4. Lefkowitz EG, Natow AJ. Pityriasis Rotunda: A Case Report of Familial Disease in an American-Born Black Patient. [ncbi.nlm.nih.gov]

• Hyperkeratosis

  Discrete changes of the surface epithelium with moderate ortho-hyperkeratosis and follicular hyperkeratosis. No formation of a keratohyalin layer. [altmeyers.org]

  The histologic characteristics are identical to those of ichthyosis vulgaris, namely, hyperkeratosis, a sparse granular layer, and basal hyperpigmentation.The diagnosis of pityriasis versicolor was considered by Sarkany and Hare,3 but no organism could [jamanetwork.com]

  Histopathology revealed hyperkeratosis, parakeratosis, a reduction in the granular layer, increased pigmentation of the basal keratinocytes, loss of the crest pattern, and a mild superficial perivascular lymphocytic infiltrate (Fig. 1). [actasdermo.org]

  Histologically, findings are often subtle, but hyperkeratosis, thinned granular layer, pigmented basal layer, and mild perivascular lymphocytic infiltrate are commonly reported, resembling ichthyosis vulgaris.[5] The management of pityriasis rotunda is [ijpd.in]

  Histopathologic examination often shows hyperkeratosis, a thin or absent granular layer, increased pigmentation of the basal layer, pigment incontinence, and a sparse superficial, perivascular infiltrate. [escholarship.org]

• Skin Lesion

  In some patients, associated skin lesions of ichthyosis vulgaris may be observed. [ncbi.nlm.nih.gov]

• Skin Disease

  Abstract Pityriasis rotunda (PR) is a well-known skin disease in Japan, but it is seldom observed in Europe. [unboundmedicine.com]

  Overview Pityriasis rotunda is a rare skin disease characterized by round, scaly, pigmented patches that mainly occur on the trunk, arms and legs. There are two types of pityriasis rotunda. [rarediseases.org]

  disease characterized by the presence of multiple, round or oval, sharply demarcated hyperpigmented scaly patches. [onlinelibrary.wiley.com]

  On DermNet NZ Cutaneous markers of internal malignancy Ichthyosis Other websites Pityriasis rotunda – Medscape Reference Books about skin diseases See the DermNet NZ bookstore. [dermnetnz.org]

  Pityriasis rotunda is a rare skin disease characterized by round, scaly, pigmented patches that mainly occur on the trunk, arms and legs. There are two types of pityriasis rotunda. [rarediseases.info.nih.gov]

• Hyperpigmentation

  They had a characteristic circular or arcuate configuration with scaling and varying degrees of hyperpigmentation. Pityriasis rotunda may prove to be a useful cutaneous marker of hepatocellular carcinoma in South African blacks. [meta.org]

  […] between 1 and 100,1 and they can persist for months to years, with exacerbations during the winter.4 Various changes can be seen on histopathology, including hyperkeratosis, flattening of the epidermal crests, a reduction or absence of the granular layer, hyperpigmentation [actasdermo.org]

• Follicular Hyperkeratosis

  Discrete changes of the surface epithelium with moderate ortho-hyperkeratosis and follicular hyperkeratosis. No formation of a keratohyalin layer. [altmeyers.org]

• Suggestibility

  — Commenting in a letter to the Archives, Lewis suggested that pityriasis rotunda may be a variant of tinea corporis. [jamanetwork.com]

  On further probing, there was no history suggestive of a illness. Family history was noncontributory. [ijdvl.com]

  The age of onset, distribution, distinct circular appearance, and lack of inflammatory changes usually suggest the diagnosis. [karger.com]

  These findings were suggestive that pityriasis rotunda was more related to congenital ichthyosis than to ichthyosis vulgaris. History and Physical The diagnosis of pityriasis rotunda usually is based on clinical examination. [ncbi.nlm.nih.gov]

• Hyperprolactinemia

  The patient was a 38-year-old African American woman with a history of hyperprolactinemia on treatment with cabergoline for the previous 7 months. [actasdermo.org]

  Pityriasis Rotunda and Hyperprolactinemia. Actas Dermosifiliogr. 2016 Jul-Aug;107(6):535-7. [PubMed: 27006018] 6. Makino T, Mizawa M, Seki Y, Hayashi M, Shimizu T. Decreased filaggrin-2 expression in the epidermis in a case of pityriasis rotunda. [ncbi.nlm.nih.gov]

• Hepatocellular Carcinoma

  Discover the latest research on Hepatocellular Carcinoma here. [meta.org]

  carcinoma in racially predisposed groups.[3] See also[edit] Skin lesion List of cutaneous conditions References[edit] ^ a b James, William; Berger, Timothy; Elston, Dirk (2005). [en.wikipedia.org]

  Pityriasis rotunda is also considered a potential paraneoplastic dermatosis since it may be observed during certain malignancies, mainly hepatocellular carcinoma in South African black patients but also in the following: IgG myeloma, multiple myeloma [ncbi.nlm.nih.gov]

There is no specific treatment for pityriasis rotunda. Lesions usually improve or resolve with treatment of the underlying internal disease or malignancy. [dermnetnz.org]

She reported no associated symptoms or previous treatment. [actasdermo.org]

Treatment of the disease can be challenging, and several different pharmacological treatments have been tried with limited success. [karger.com]

There is no specific treatment for pityriasis rotunda. [rarediseases.info.nih.gov]

Follow-up of pityriasis rotunda skin lesions without treatment is the other option because of possible spontaneous resolution. [ncbi.nlm.nih.gov]

The prognosis for pityriasis rotunda is excellent. [emedicine.medscape.com]

They rarely itch, slowly enlarge, and coalesce and may be hypo- or hyper-pigmented.[2],[3],[4] Onset in childhood has been reported to have a better prognosis, with remission in later childhood in almost 50%.[6] Lesions are commonly seen on the buttocks [ijpd.in]

Discussion The etiology of pityriasis rotunda remains unknown. [ijpd.in]

Pityriasis rotunda, not commonly encountered in some regions of the world, is not always easy to diagnose.[1][2][3] Etiology The etiology of pityriasis rotunda is not established. [ncbi.nlm.nih.gov]

Clinical and epidemiological study and follow-up on 47 cases observed in north Sardinia (1981-1995). Ena P., Chiarolini F., Gallus D., Spano G., Masotti A., Leigheb G. Università degli Studi - Sassari, Istituto di Clinica Dermatologica Background. [minervamedica.it]

Occurrence/Epidemiology This section has been translated automatically. w:m=3:1; worldwide only a few hundred patients have been described (Al-Refu et al. 2018). Etiopathogenesis This section has been translated automatically. [altmeyers.org]

However, researchers have not eliminated the idea that the association of some of these conditions associated with pityriasis rotunda, especially favism, could be due to chance.[4][5][6][7] Epidemiology Pityriasis rotunda affects both genders equally, [ncbi.nlm.nih.gov]

Pathophysiology The pathophysiology of pityriasis rotunda is still not completely understood. It may be a variant of ichthyosis vulgaris. [emedicine.medscape.com]

Pathophysiology Hashimoto et al. described a diminished expression of loricrin and filaggrin in pityriasis rotunda lesions. According to Yoneda et al., a complete absence of the profilaggrin-N terminus domain is observed in the lesional skin. [ncbi.nlm.nih.gov]