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Placental Insufficiency

Placental Insufficiency Syndrome


Presentation

  • Clinical case of extremely elevated levels of alkaline phosphatase (ALP) enzyme detected in the 3rd trimester of gestation, the diagnostic and therapeutic procedures, delivery and puerperium are presented.[ncbi.nlm.nih.gov]
Dyspnea at Rest
  • A patient in the third trimester with dyspnea at rest developed right heart failure during c-section. During emergency thoracotomy the patient went into generalized shock and died after intense CPR.[ncbi.nlm.nih.gov]
Angiokeratoma
  • Novosibirsk, Russia. pathol@soramn.ru Abstract Structural reorganization of endotheliocytes was studied on models of various pathological processes: placental dysfunction, glomerular pathology, vibration syndrome, antiphospholipid syndrome, and diffuse angiokeratoma[ncbi.nlm.nih.gov]

Workup

Gliosis
  • In PC animals compared with controls there was a reduction in brain weight, persistent enlargement of the lateral ventricles, a reduction in the volume of the basal ganglia and septal region and no evidence of gliosis.[ncbi.nlm.nih.gov]

Treatment

  • Defective placentation and subsequent placental insufficiency lead to maternal and fetal adverse pregnancy outcome, but their pathologic mechanisms are unclear, and treatment remains elusive.[ncbi.nlm.nih.gov]
  • We believe orphan designation for this therapy will provide practical benefits as we bring this much needed treatment to pregnant women as rapidly as we can.[news-medical.net]
  • Treatment should address the underlying cause. Caesarean section is performed in acute cases if there are signs of fetal hypoxia or an increased maternal risk of death.[amboss.com]

Prognosis

  • My prognosis was grim at 20 weeks too. He said that he may need to deliver my son at 24 weeks. Things looked better last week so he said I should be fine till at least 27 weeks.[whattoexpect.com]
  • Placental Insufficiency Prognosis Although there is no cure for placental insufficiency, it can be managed with the correct medical assistance and intervention.[birthinjuryguide.org]
  • OBJECTIVE: To study the Doppler velocimetry of the fetal middle cerebral artery in pregnancies complicated by placental insufficiency, and to verify its role in the prognosis of neonatal survival.[ncbi.nlm.nih.gov]
  • Outlook (Prognosis) Problems with the placenta can affect the developing baby's growth. The baby cannot grow and develop normally in the womb if it does not get enough oxygen and nutrients.[pennstatehershey.adam.com]

Etiology

  • The placenta has recently been highlighted as an area of major interest in CP etiology.[brage.bibsys.no]
  • Timecourse Dependent on etiology (rapid abortion in EHV-1 infection, insidious for villous atrophy). Epidemiology Important to rule out EHV-1 and 4 in mcases of abortion/stillbirth/neonatal death.[vetstream.com]
  • BACKGROUND: Increased stillbirth rates occur among HIV-infected women, but no studies have evaluated the pathological basis for this increase, or whether highly active antiretroviral therapy (HAART) influences the etiology of stillbirths.[ncbi.nlm.nih.gov]
  • The exact etiology of insufficient placenta is not known, there are some factor that contribute to it, like smoking, conditions that make the mother susceptible to have blood clots like Anti phospholipid syndrome, or protein C or S deficiency.[answers.yahoo.com]

Epidemiology

  • However, results from epidemiological studies assessing maternal CMV antibodies in pregnancy and development of preeclampsia have been inconclusive.[brage.bibsys.no]
  • Epidemiology Important to rule out EHV-1 and 4 in mcases of abortion/stillbirth/neonatal death. Following abortion/stillbirth/neonatal death all movements off and onto a stud should be suspended whilst the cause is identified.[vetstream.com]
  • The CHARGE study: an epidemiologic investigation of genetic and environmental factors contributing to autism. Environ Health Perspect . 2006;114(7):1119-1125. PubMed Google Scholar Crossref 33. Bodnar LM, Tang G, Ness RB, Harger G, Roberts JM.[jamanetwork.com]
  • Epidemiologically, it could be argued that identifying ‘at risk’ AGA fetuses in pregnancy is even more important than identifying those fetuses that are SGA: a recent study involving over 6,000 infants confirmed that- while the incidence of adverse perinatal[journals.plos.org]
Sex distribution
Age distribution

Pathophysiology

  • The pathophysiology and potential implications are discussed.[ncbi.nlm.nih.gov]
  • It is what is Sara terms “Pathophysiological Speculation”. Pathophysiological Speculation actually occurs all the time in medicine.[birthsavvy.com.au]
  • In the first section, present knowledge of the pathophysiology of fetal hypoxemia and nutritional deficiency in the context of UPI is reviewed briefly.[neoreviews.aappublications.org]
  • Cytomegalovirus (CMV), a virus capable of infecting the placenta, has been suggested to potentially harm placentation and thereby initiate the pathophysiological cascade leading to preeclampsia.[brage.bibsys.no]

Prevention

  • This is to prevent the serious complications that may arise for the baby during labor as well as in later life. Prevention & Expectations What can be done to prevent the condition? Most cases of placental insufficiency and IUGR cannot be prevented.[medicineonline.com]
  • In pregnancies affected by placental insufficiency, a poorly functioning placenta restricts nutrient supply to the fetus and prevents normal fetal growth.[ncbi.nlm.nih.gov]
  • There is not enough being done to investigate and prevent these issue but there are few charity's out there doing some important work into hopefully one day helping women like me and our precious children.[inspire.com]

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