A clinicopathological and immunohistochemical study of a fatal case of placental site trophoblastic tumor (PSTT) is presented. PSTT is a rare variant of trophoblastic disease. [ncbi.nlm.nih.gov]

• Splenomegaly

  Spider angiomata and splenomegaly are interesting clinical features previously described in association with placental-site trophoblastic tumors, and were demonstrated in this patient. [ncbi.nlm.nih.gov]

• Fishing

  FISH study showed a gain on the short arm of chromosome 12 in the placental site trophoblastic tumor, proving that this component is of germ cell origin. The patient is alive and well 3 years after the orchiectomy without additional treatment. [ncbi.nlm.nih.gov]

• Internal Bleeding

  A case of tubal PSTT with the primary manifestation of internal bleeding at 30 weeks' gestation is presented. Emergency exploratory laparotomy and right partial salpingectomy were performed initially. [ncbi.nlm.nih.gov]

• Sputum

  Upon her first visit to our clinic, she was in respiratory distress, and had cough with bloody sputum. Physical examination revealed no abnormal finding except wheezing. [wjso.biomedcentral.com]

• Respiratory Distress

  Upon her first visit to our clinic, she was in respiratory distress, and had cough with bloody sputum. Physical examination revealed no abnormal finding except wheezing. [wjso.biomedcentral.com]

• Short Arm

  FISH study showed a gain on the short arm of chromosome 12 in the placental site trophoblastic tumor, proving that this component is of germ cell origin. The patient is alive and well 3 years after the orchiectomy without additional treatment. [ncbi.nlm.nih.gov]

• Cesarean Section

  She delivered by cesarean section at 35 weeks for fetal distress at which time a biopsy of the uterus revealed a placental site trophoblastic tumor (PSTT). [ncbi.nlm.nih.gov]

• Secondary Amenorrhea

  A 20-year-old woman presented with secondary amenorrhea and irregular vaginal bleeding. Examination of the patient revealed elevated serum hCG and a uterine mass. The specimen obtained by curettage was diagnosed as possible PSTT. [ncbi.nlm.nih.gov]

• Foul Smelling Vaginal Discharge

  A case of placental site trophoblastic tumor that extended to the cervix, with primary manifestation of amenorrhea and yellow foul-smelling vaginal discharge, is presented. [ncbi.nlm.nih.gov]

• Testicular Mass

  We present a case of a 24-year-old man with a right testicular mass, 2.5 cm in largest diameter. Before orchiectomy, the serum level of beta-human chorionic gonadotropin (hCG) was elevated, whereas that of alpha-fetoprotein was normal. [ncbi.nlm.nih.gov]

The tumor was confined to the ovary as proven by the preoperative staging workup and the exploratory laparotomy. Microscopically, it was composed of intermediate trophoblastic cells with angioinvasive growth and deposition of fibrinoid material. [ncbi.nlm.nih.gov]

Primary treatment was simple hysterectomy in three patients and radical hysterectomy in one patient. [ncbi.nlm.nih.gov]

PSTT limited to the uterus is in a good prognosis group, but PSTT with metastasis is a lethal disease. We document a case of PSTT with multiple metastases and extremely poor prognosis. [ncbi.nlm.nih.gov]

Etiology Etiology is unknown. Diagnostic methods Chorionic gonadotropin (hCG) levels are usually low at about 10 to 100 IU/l (N < 2 to 5 IU/l). [orpha.net]

The woman was noted to have polycythemia of uncertain etiology and was treated with serial phlebotomy. Placental-site trophoblastic tumor was diagnosed and hysterectomy was performed, with subsequent resolution of the polycythemia. [ncbi.nlm.nih.gov]

Etiology is variable (Rh incompatibility, chomosomal abberations) and others. [atlases.muni.cz]

Diagnostic criteria and microbial and epidemiologic associations. Am J Med. ‎ Seite 193 - Henson D, Tarone R. An epidemiologic study of cancer of the cervix, vagina, and vulva based on the Third National Cancer Survey in the United States. [books.google.de]

Summary Epidemiology About 200 cases have been described in the literature. [orpha.net]

Gestational Trophoblastic Disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole. American Journal of Obstetrics & Gynecology, 531-539. [revistamedicacr.com]

[…] cells at the implantation site often arranged as sheets of polyhedral, round, or occasionally spindle-shaped cells that infiltrate the myometrium extensively. [2], [3] Because of the rarity of this type of tumor, there is little information about its epidemiology [advbiores.net]

Cole LA et al. (2006) Gestational trophoblastic diseases: pathophysiology of hyperglycosylated hCG. Gynecol Oncol 102 : 145–150 11. [nature.com]

[…] hydatidiform molar pregnancy Asian or American Indian ancestry, or (for GTN only) African ancestry Older maternal age – women >40 years Familial disease – rare, more common in recurrent CHM NLRP7 and (rarely) KHDC3L gene mutations implicated (Wang, 2009) Pathophysiology [arupconsult.com]

Its function is to prevent degeneration of the corpus luteum. [nursingcenter.com]

You’ve had difficulty conceiving or infertility problems Can It Be Prevented? The only way to be certain you won’t have a molar pregnancy is not to get pregnant. If you’ve had a molar pregnancy in the past, talk to your doctor. [webmd.com]

DHSA is working in five broad areas; Awareness, Prevention of Disasters, Provision of basic needs, Livelihood and ... Read More [dhsa.af]

Pregnancy should be prevented for 6 months after treatment because pregnancy would increase beta-hCG levels, making it difficult to determine whether treatment has been successful. [merckmanuals.com]