METHODS: The medical records were reviewed for clinical presentation, staging, laboratory data, radiological studies, treatments, and outcomes. [ncbi.nlm.nih.gov]

• Soft Tissue Mass

  Computed tomography (CT) revealed innumerable enhancing soft tissue masses within the subcutaneous soft tissues and lymphadenopathy. [ncbi.nlm.nih.gov]

  Biopsy from soft tissue mass in the upper arm showed sheets of plasmacytic cells that were LCA+, CD138+, CD56+, CD10+, CD1a−, CD3−, MPO−, TdT−, and CD20−. Viral screen was negative. A final diagnosis for PBL was made. [ijpmonline.org]

  It showed a large mass (10 cm x 9.8 cm) in the pelvis that extended from the vaginal introitus to the sacral promontory (Figure 1). Additionally, 3 soft tissue masses were attached to the large mass. [hematologyandoncology.net]

  A CT scan after 2 cycles demonstrated complete response to treatment with complete resolution of the left lower quadrant soft tissue mass (fig. 1 C). [karger.com]

• Rectal Bleeding

  Other symptoms included abdominal distention, diarrhea, vomiting, and rectal bleeding. The locations of these primary lesions consisted of the stomach (43%), small intestine (21%), anal region (21%), cecum (14%), colon (7%), and esophagus (7%). [doi.org]

  She also complained of intermittent episodes of rectal bleeding. In the emergency room evaluation, a gynecologist identified a mass that extended onto the vaginal introitus. Another mass was noted during a rectal examination. [hematologyandoncology.net]

• Rectal Pain

  We describe a patient with acquired immunodeficiency syndrome who presented with rectal pain and bright red blood per rectum. He was diagnosed with stage IVA PBL with anorectal, nodal, calvarial and hepatic involvement. [ncbi.nlm.nih.gov]

• Liver Mass

  Here, we report a case of PBL of the liver in a 79-year-old HIV-negative male. The patient died approximately 1.5 mo after examination and autopsy showed that the main lesion was a very large liver mass. [ncbi.nlm.nih.gov]

  […] involvement is common in disseminated NHL, but less than 1% of extranodal lymphomas compromise the liver.12 Hepatic involvement in NHL, either primary or secondary, includes diffuse parenchymal infiltration or single/ multiple liver masses.13 Patients [elsevier.es]

• Lesion of the Tongue

  Herein, we report a case of PBL presenting as an ulcerated lesion of the tongue in an HIV-negative patient, 6 years after renal transplantation. [ncbi.nlm.nih.gov]

• No Pubic Hair

  She had no pubic hair. Her extremities were mildly edematous and clubbing was obvious on her fingers. Laboratory data are shown in table-1. [ircmj.com]

• Large Breast

  This case is unusual in that the patient presented with a large breast mass and her recovery was extremely rapid. [ncbi.nlm.nih.gov]

• Vaginal Discharge

  Her vaginal discharge improved and she was discharged in stable condition. Discussion PBL most frequently presents in the oral cavity,3 with local invasion and rapid dissemination to extra-oral sites. [hematologyandoncology.net]

• Microscopic Hematuria

  Urinalysis was remarkable for microscopic hematuria. Enhanced computed tomography showed a well-defined mass in the left ureteropelvic junction, and retrograde pyelography revealed a filling defect at the same site [Figure 1]. [indianjurol.com]

As PBL is frequently seen in patients with chronic HIV and/or EBV co-infection, viral serologies must be included in the diagnostic workup [13]. Our patient, however, had a negative HIV/EBV status. [cureus.com]

A 69‐year‐old male was referred to our university hospital for workup of rapid deterioration and abdominal pains. [onlinelibrary.wiley.com]

After a staging workup including radiographic skeletal survey, positron emission tomography/computed tomography, and bone marrow biopsy, there was no evidence of other organ involvement, and serum and urine protein electrophoresis were normal. [indianjurol.com]

In subsequent staging workup, bone marrow biopsy showed 10% involvement by the plasmablastic lymphoma. CT of the abdomen and pelvis found several enlarged left femoral lymph nodes, the largest of which measured 21 x 12 mm. [jaadcasereports.org]

Workup of the anemia was most consistent with anemia of chronic disease. After 18 months, lenalidomide and dexamethasone were stopped. Imaging at 24 months continued to show complete remission. [karger.com]

As a distinct type of aggressive mature large B-cell lymphoma, plasmablastic lymphoma (PBL) poses diagnostic and treatment challenges. [ncbi.nlm.nih.gov]

PBL represents a diagnostic challenge given its characteristic morphology and lack of CD20 expression, and also a therapeutic challenge, with early responses to therapy, but with high relapse rates and poor prognosis. [ncbi.nlm.nih.gov]

Although its exact etiology is poorly understood, Epstein-Barr virus infection and MYC gene aberrations have been implicated in its development in both HIV-positive and HIV-negative patients. [ncbi.nlm.nih.gov]

Table 1: Demographic, clincipathological, etiological, and genetic characteristics, as well as treatments of the included plasmablastic lymphoma cases in this study. Notably, all the included PBL patients were HIV-negative. [cdn.journals.lww.com]

(Etiology) Currently, the cause of Plasmablastic Lymphoma (PBL) is unknown. [dovemed.com]

The objectives of this review are to summarize the current knowledge on the epidemiology, biology, clinical and pathological characteristics, differential diagnosis, therapy, prognostic factors, outcomes, and potential novel therapeutic approaches in [ncbi.nlm.nih.gov]

Epidemiology of AIDS-defining Malignancies William A. Blattner and Rebecca G. Nowak 3. Epidemiology of non-AIDS Defining Malignancies Andrew E. Grulich 4. HIV Cancers in Resource-Limited Regions Sam M. Mbulaiteye 5. [books.google.de]

Fever (for no known reason) Pain in the chest, abdomen, or bone s (for no known reason) Skin rash or itchy skin Weight loss (for no known reason) Diagnostic Exams Flow cytometry Immunohistochemistry Immunophenotyping Progression and Transformation None Epidemiology [seer.cancer.gov]

The main goal of this article is to systematically review the most recent advances in epidemiology; pathophysiology; clinical, pathologic, and molecular characteristics; therapy; and prognosis in patients with PBL. [ncbi.nlm.nih.gov]

Specify search Access for MEFAPERSON (127) Access for all (125) Include results that cannot be accessed (127) Medical disciplines Haematology (51) Internal Medicine (51) Pathology and Forensic Medicine (48) Oncology, Radiation Therapy (35) Physiology and Pathophysiology [portal.mefanet.cz]

Awareness of this distinctive lymphoma can prevent misdiagnosis by the clinicians and/or the pathologists. [ncbi.nlm.nih.gov]

Making healthy choices, like quitting smoking and managing ongoing medical conditions, can also help prevent pneumonia. [cdc.gov]

With Non-Myeloid Malignancies Receiving Multiple Chemotherapy Completed NCT00070382 Phase 3 darbepoetin alfa;epoetin alfa 17 A Phase III Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effects of Fragmin (5,000 IU Subcutaneously) in Preventing [malacards.org]