Presentation
This happens to be a distinctly unusual presentation and we highlighted various features of this case. [ncbi.nlm.nih.gov]
Eyes
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Retinal Hemorrhage
The retinopathy in association with malaria fever described so far includes retinal hemorrhages, vessel changes, retinal discoloration/whitening and papilledema. [ncbi.nlm.nih.gov]
Neurologic
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Papilledema
The retinopathy in association with malaria fever described so far includes retinal hemorrhages, vessel changes, retinal discoloration/whitening and papilledema. [ncbi.nlm.nih.gov]
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Hyperactivity
In contrast, stabilization of one of the interfaces resulted in increased thermal stability, increased substrate/cofactor affinity and hyperactivity of the enzyme towards malate production at sub-millimolar substrate concentrations. [ncbi.nlm.nih.gov]
Workup
Serum
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Hypertriglyceridemia
We report a case of an 11-month-old infant with fever, hepatosplenomegaly, pancytopenia, high serum ferritin, hypertriglyceridemia, and bone marrow hemophagocytosis, consistent with hemophagocytic syndrome. [ncbi.nlm.nih.gov]
Microbiology
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Complement Fixing Antibody
The central repeat region of CSP, included in leading vaccines, was a key target of complement-fixing antibodies. [ncbi.nlm.nih.gov]
Treatment
She completely recovered after the DHA-PPQ treatment but 32 days after the end of therapy she had a recrudescence. [ncbi.nlm.nih.gov]
Prognosis
Plasmodium falciparum infection carries a poor prognosis with a high mortality if untreated, but it has an excellent prognosis if diagnosed early and treated appropriately. [ncbi.nlm.nih.gov]
PubMed Central View Article PubMed Google Scholar Field JW: Blood examination and prognosis in acute falciparum malaria. Trans R Soc Trop Med Hyg. 1949, 43: 33-48. 10.1016/0035-9203(49)90022-X. [malariajournal.biomedcentral.com]
Google Scholar Nguyen PH, Day N, Pram TD, Ferguson DJ, White NJ: Intraleucocytic malaria pigment and prognosis in severe malaria. Trans R Soc Trop Med Hyg. 1995, 89: 200-204. [doi.org]
[…] because adrenergic signs are not always present and because stupor already may have occurred in the patient Lactic acidosis - This occurs when the microvasculature becomes clogged with P falciparum ; if the venous lactate level reaches 45 mg/dL, a poor prognosis [medscape.com]
The prognosis for this infectious process is closely related to the initiation of early therapy, the appropriate supportive measures and the management of complications. [scielo.br]
Etiology
Gov't MeSH terms Animals Brain/parasitology Child Child, Preschool Coinfection/diagnosis Coinfection/parasitology* Coinfection/pathology Coma/etiology DNA, Protozoan/genetics Female Humans Malaria, Cerebral/complications Malaria, Cerebral/diagnosis* Malaria [ncbi.nlm.nih.gov]
85% of malaria cases Because its infection is potentially life threatening, its presence must be considered in the differential diagnosis of unexplained fever and history of travel to endemic geographic areas should always be sought Pathophysiology / etiology [pathologyoutlines.com]
An improved understanding of the etiological basis of suppression of erythropoietic responses in children with SMA may offer the much needed therapeutic alternatives for control of this global disease burden. [doi.org]
The etiological agents for malaria are a family of unicellular protozoan pathogens of the genus Plasmodium. The parasite has a complex two-host lifecycle with a sexual stage occurring in the mosquito vector and an asexual stage in the human host. [elifesciences.org]
Epidemiology
The purpose of this study was to assess the immune responses against Plasmodium falciparum merozoite surface protein-1 (MSP-1 19 ) and apical membrane antigen-1 (AMA-1) in children residing in the different epidemiological strata of malaria in Cameroon [ncbi.nlm.nih.gov]
His primary research interests include clinical and epidemiologic aspects of malaria, arbovirus epidemiology, and travel medicine. Top Legros F, Arnaud A, El Mimouni B, Danis M. [doi.org]
Pathophysiology
The epidemiology of mixed infections, likely pathophysiology of his presentation, and the implications for malaria testing and treatment in returned travellers are discussed. [ncbi.nlm.nih.gov]
The extracted information was categorized as 1) host/parasite interaction: the pathophysiological aspects; 2) clinical-pathological features; 3) diagnosis; and 4) therapy. [scielo.br]
[…] falciparum causes 85% of malaria cases Because its infection is potentially life threatening, its presence must be considered in the differential diagnosis of unexplained fever and history of travel to endemic geographic areas should always be sought Pathophysiology [pathologyoutlines.com]
The pathophysiology of falciparum malaria. Pharmacol Ther. 2003;99:221-60. 23. Tripathi AK, Sullivan DJ, Stins MF. [revistabiomedica.org]
Prevention
This is also due to an inadequate knowledge and implementation of health prevention measures. [ncbi.nlm.nih.gov]
Intermittent preventive treatment for the prevention of malaria during pregnancy in high transmission areas. Malar J. 2007 Dec 4. 6:160. [Medline]. [Full Text]. Trape JF, Tall A, Diagne N, et al. [medscape.com]
Preventing further spread and emergence Containing antimalarial drug resistance in Southeast Asia – and preventing the spread of resistance through Asia to Africa and beyond – is a global public health priority. [wwarn.org]