Presentation
This happens to be a distinctly unusual presentation and we highlighted various features of this case. [ncbi.nlm.nih.gov]
Entire Body System
- Painter
Within each GO group genes were ordered by their peak time of transcription in vitro according to Painter et al.24. [nature.com]
Painter H. J, Morrisey J. M, Mather M. W, Vaidya A. B (2007) Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum. Nature 446: 88–91. View Article Google Scholar 37. Couto A. S, Kimura E. A, Peres V. J, Uhrig M. [doi.org]
L., Painter, H. J., Samra, J., Carrasquilla, M., Llinás, M., et al. (2016). Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways. Antimicrob. [frontiersin.org]
Gastrointestinal
- Abdominal Cramps
cramps, and somnolence.[22] They are more likely to develop hepatomegaly, splenomegaly, and severe anemia without major organ dysfunction than adults. [ncbi.nlm.nih.gov]
Neurologic
- Responsiveness Decreasing
CDC recommends making additional blood smears in infections with P. falciparum after initiating the treatment, to confirm adequate parasitological response (decrease in density) to treatment. [ncbi.nlm.nih.gov]
Workup
Serum
- Base Deficit
Uncomplicated Falciparum Malaria Uncomplicated falciparum malaria should be treated with one of the artemisinin-based combination therapies (ACT). [ncbi.nlm.nih.gov]
Treatment
respectively.[9] Travelers should be informed that malaria can be fatal with delayed treatment, and one should, therefore, seek medical attention while abroad if symptoms of malaria develop and not fly back for treatment, as medical treatment may not [ncbi.nlm.nih.gov]
Prognosis
PubMed Central View Article PubMed Google Scholar Field JW: Blood examination and prognosis in acute falciparum malaria. Trans R Soc Trop Med Hyg. 1949, 43: 33-48. 10.1016/0035-9203(49)90022-X. [malariajournal.biomedcentral.com]
Google Scholar Nguyen PH, Day N, Pram TD, Ferguson DJ, White NJ: Intraleucocytic malaria pigment and prognosis in severe malaria. Trans R Soc Trop Med Hyg. 1995, 89: 200-204. [doi.org]
Its management and prognosis depend on the awareness of a possible diagnosis in travelers returning from endemic areas, early recognition, and timely effective treatment. [ncbi.nlm.nih.gov]
Etiology
Gov't MeSH terms Animals Brain/parasitology Child Child, Preschool Coinfection/diagnosis Coinfection/parasitology* Coinfection/pathology Coma/etiology DNA, Protozoan/genetics Female Humans Malaria, Cerebral/complications Malaria, Cerebral/diagnosis* Malaria [ncbi.nlm.nih.gov]
Plasmodium falciparum is the etiological agent of malaria tropica, the leading cause of death due to a vector-borne infectious disease, claiming 0.5 million lives every year. [cell.com]
62]) and reached a 40 year high of 1,925 cases in 2011 (CDC: Malaria Facts [Accessed 9 January 2018]) Worldwide, disease generally occurs between 45° N and 40° S and rates have been declining (WHO: Malaria [Accessed 9 January 2018]) Pathophysiology / etiology [pathologyoutlines.com]
From: [2] Etiology/Bacteriology Taxonomy | Domain = Eukarya | Kingdom = Chromalveolata | Phylum = Apicomplexa | Class = Aconoidasida | Order = Haemosporida | Family = Plasmodiidae | Genus = Plasmodium | Species = P. falciparum Pathogenesis Transmission [microbewiki.kenyon.edu]
Epidemiology
The purpose of this study was to assess the immune responses against Plasmodium falciparum merozoite surface protein-1 (MSP-1 19 ) and apical membrane antigen-1 (AMA-1) in children residing in the different epidemiological strata of malaria in Cameroon [ncbi.nlm.nih.gov]
His primary research interests include clinical and epidemiologic aspects of malaria, arbovirus epidemiology, and travel medicine. Top Legros F, Arnaud A, El Mimouni B, Danis M. [doi.org]
Pathophysiology
The epidemiology of mixed infections, likely pathophysiology of his presentation, and the implications for malaria testing and treatment in returned travellers are discussed. [ncbi.nlm.nih.gov]
In animal models, the neuro-pathophysiology of cerebral malaria results from the sequestration of infected red blood cells (iRBCs) in microvessels that promotes the activation of glial cells in the brain. [hal.archives-ouvertes.fr]
The extracted information was categorized as 1) host/parasite interaction: the pathophysiological aspects; 2) clinical-pathological features; 3) diagnosis; and 4) therapy. [scielo.br]
Edition, 2011 [Chapter 62]) and reached a 40 year high of 1,925 cases in 2011 (CDC: Malaria Facts [Accessed 9 January 2018]) Worldwide, disease generally occurs between 45° N and 40° S and rates have been declining (WHO: Malaria [Accessed 9 January 2018]) Pathophysiology [pathologyoutlines.com]
Prevention
Researchers are continuing to develop and study malaria vaccines to prevent infection. Oct. 12, 2021 [mayoclinic.org]
Intermittent preventive treatment for the prevention of malaria during pregnancy in high transmission areas. Malar J. 2007 Dec 4. 6:160. [Medline]. [Full Text]. Trape JF, Tall A, Diagne N, et al. [medscape.com]
Preventing further spread and emergence Containing antimalarial drug resistance in Southeast Asia – and preventing the spread of resistance through Asia to Africa and beyond – is a global public health priority. [wwarn.org]
Whereas the former generates antibodies preventing virus entry, the latter would potentiate the cell mediated response. [doi.org]