Edit concept Question Editor Create issue ticket

Pleural Fibrosis


Presentation

  • Pleural fibrosis is the most common presentation of all asbestos fiber types.[libbyasbestos.org]
  • We present a case of SLS in an adolescent in whom imaging and electrophysiology studies demonstrate pleural fibrosis as the fundamental defect accounting for the restrictive lung physiology.[ncbi.nlm.nih.gov]
  • DISCUSSION Pleural, mediastinal and retroperitoneal fibrosis usually present as distinct entities.[thorax.bmj.com]
Metal Worker
  • All 24 study participants were sheet metal workers who were nonsmokers with normal parenchyma on posteroanterior chest radiograph. These subjects had either normal pleura (n 7), circumscribed plaques (n 9), or diffuse pleural thickening (n 8).[ncbi.nlm.nih.gov]
Asymptomatic
  • A slowly enlarging pleural effusion and significant pleural fibrosis occurred in an asymptomatic patient with a subpleural histoplasmoma. The pleural disease may be a reaction to antigen diffusing into the pleural space from the histoplasmoma.[ncbi.nlm.nih.gov]
  • They are frequently asymptomatic and are recognized only on chest imaging. Macroscopic calcification is common. Plaques are not associated with the development of a malignant mesothelioma.[preventmesothelioma.com]
  • […] associated with apical lung fibrosis 3 or be asymmetrical. 2 4 7 Conversely, three presentations of mediastinal fibrosis have been suggested: 5 granulomatous mediastinitis (often resulting from tuberculosis) with enlarged mediastinal lymph nodes and usually asymptomatic[thorax.bmj.com]
  • DPT usually progresses slowly and is asymptomatic in many cases, and parietal plaques cause no symptoms. Only patients with acute asbestos pleurisy may have local and systemic symptoms and a moderately elevated erythrocyte sedimentation rate [ 27 ].[ojrd.biomedcentral.com]
  • However, if this selection may influence the parameter values in the model of estimated prevalence for asbestosis in our sample, this selection bias is probably minor for pleural plaques as this disease is usually asymptomatic [ 23 ].[ehjournal.biomedcentral.com]
Localized Pain
  • RPF is usually symptomatic, causing poorly localized pain in the abdominal, flank, or back region.[ojrd.biomedcentral.com]
Military Personnel
  • . * Memorial plaque, issued to next of kin of dead British military personnel after WWI * Plaque, a… … Wikipedia Pleuraschwarte — Pleuraschwarte, auch pleural fibrosis (engl.), Fibrothorax, Pleuraschwiele, ist eine Verdickung des Rippenfells (Pleura),[medicine.academic.ru]
Pleural Disorder
  • How Are Pleurisy and Other Pleural Disorders Diagnosed? National Heart Lung and Blood Institute [On-line information]. Available online at . Accessed June 2012. Crawford Mechem, C. (Updated 2011 July 8). Emergent Management of Pleural Effusion.[labtestsonline.it]
Thrombosis
  • The CT scan showed bilateral ureteral stenosis, a non-functional atrophic right kidney and thrombosis of the splenic and left renal veins. An exploratory laparotomy showed a hard fibrous mass in the retroperitoneum adherent to adjacent vessels.[thorax.bmj.com]

Workup

  • Extensive workups including repeated pulmonary ventilation-perfusion scans and cardiac catheterisation have not yielded other diagnoses to explain the pain.[ncbi.nlm.nih.gov]
Chest X-Ray Abnormal
  • Chest X-ray abnormalities detected at the initial medical examination, and interpreted according to the International Labour Office Classification of Radiographs of Pneumoconioses are reported in this paper.[ncbi.nlm.nih.gov]
  • Home » Tutorials » Chest X-ray Tutorials » Chest X-ray Abnormalities » Introduction » 1 2 3 4 5 6 7 8 9 10 11 » Conclusion Key points The pleura and pleural spaces are only visible when abnormal There should be no visible space between the visceral and[radiologymasterclass.co.uk]
X-Ray Abnormal
  • Chest X-ray abnormalities detected at the initial medical examination, and interpreted according to the International Labour Office Classification of Radiographs of Pneumoconioses are reported in this paper.[ncbi.nlm.nih.gov]
  • Home » Tutorials » Chest X-ray Tutorials » Chest X-ray Abnormalities » Introduction » 1 2 3 4 5 6 7 8 9 10 11 » Conclusion Key points The pleura and pleural spaces are only visible when abnormal There should be no visible space between the visceral and[radiologymasterclass.co.uk]
Mediastinal Mass
  • B: An anterior mediastinal mass with maximum dimensions of 30 mm in thickness and 190 mm in width (arrowheads), bilateral diffuse pleural thickening (white arrows) with a rounded atelectasis on the right side (black arrow); this 62-year-old RPF patient[ojrd.biomedcentral.com]
Anterior Mediastinal Mass
  • B: An anterior mediastinal mass with maximum dimensions of 30 mm in thickness and 190 mm in width (arrowheads), bilateral diffuse pleural thickening (white arrows) with a rounded atelectasis on the right side (black arrow); this 62-year-old RPF patient[ojrd.biomedcentral.com]
Air Bronchogram
  • With pneumonia there usually are aerated alveoli and bronchi interspersed within the infiltrate (air-alveolograms and air bronchograms) that gives pneumonia a mottled appearance (inhomogeneous opacification).[mhmedical.com]
Electrocardiogram Change
  • Exercise was continued until the subjects indicated they could no longer continue or electrocardiogram changes indicated that continuing would be dangerous.[cdc.gov]
Pleural Adhesions
  • This implies, like in the case of malignancy, that there is continuing low-grade inflammation, which over time can lead to pleural adhesions, loculation, and sometimes an entrapped lung.[journals.lww.com]
  • One limitation of medical thoracoscopy is the limited visualisation of the pleural cavity in patients with significant pleural adhesions.[academic.oup.com]

Treatment

  • Serosal fibrosis is a rarely reported adverse effect of pergolide treatment, although it is well described with other dopamine agonists.[ncbi.nlm.nih.gov]
  • We also propose new potential therapies for the treatment of this disease.[grantome.com]
  • Updated to reflect the latest scientific advances and technologies in the diagnosis and treatment of pleural diseases, this new Second Edition explores the structure and function of these diseases and malignancies, from tuberculosis and asbestos to pleurisy[books.google.es]

Prognosis

  • High-resolution computed tomography in idiopathic pulmonary fibrosis: diagnosis and prognosis . American Journal of Respiratory and Critical Care Medicine 2005 ; 172 : 488 – 493 . 11. Markowitz , SB , et al.[journals.cambridge.org]
  • The prognosis for patients with pulmonary fibrosis varies, but the prognosis for mesothelioma is always bleak; most mesothelioma patients succumb to the disease within a year.[allaboutmalignantmesothelioma.com]
  • Identification of this disorder is very important for defining its prognosis and promoting the development of alternative treatments. References [1] S.K. Frankel, C.D. Cool, D.A. Lynch, K.K.[archbronconeumol.org]

Etiology

  • The etiology of restrictive lung physiology in SLS is not well-defined, and has been hypothesized to be due to defects in lung recoil, phrenic nerve function and diaphragmatic strength.[ncbi.nlm.nih.gov]
  • The findings suggest a shared etiology for RPF and pleural fibrosis and furthermore possibly a similar pathogenetic mechanisms.[tampub.uta.fi]
  • The etiology of RPF is generally unknown.[ojrd.biomedcentral.com]
  • According to etiology it may be classified as: benign pleural thickening following recurrent inflammation following recurrent pneumothoraces following a pleural empyema as a delayed complication of a hemothorax collagen-vascular disease (rheumatoid arthritis[radiopaedia.org]

Epidemiology

  • Epidemiology of community-acquired pneumonia in adults: a population-based study . European Respiratory Journal 2000 ; 15 : 757 – 763 . 14. Vila-Corcoles , A , et al.[journals.cambridge.org]
  • Department of Epidemiology and Health McGill University Canada 2. Respiratory Division of the Notre-Dame Hospital University of Montreal Canada 3. Respiratory Division McGill University Montreal Canada 4.[link.springer.com]
Sex distribution
Age distribution

Pathophysiology

  • Wuhan, Hubei, China; Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; 6 Key Laboratory of Respiratory Diseases, Ministry of Health of China, Wuhan, Hubei, China; Department of Pathophysiology[ncbi.nlm.nih.gov]
  • Chest 121:2079–2080 PubMed CrossRef Google Scholar Miserocchi G (1997) Physiology and pathophysiology of pleural fluid turnover.[link.springer.com]
  • The etiology and pathophysiology of this entity are unknown.[nature.com]

Prevention

  • In selected patients, resection of the histoplasmoma may be necessary to prevent impairment of ventilation from pleural fibrosis.[ncbi.nlm.nih.gov]
  • ;2) via targeting miR-26a by intrapleural gene therapy to prevent fibrosis in pleural empyema.[grantome.com]
  • In the present study, we found that tuberculous pleural effusion (TPE) induced calpain activation in PMCs and that inhibition of calpain prevented TPE-induced collagen-I synthesis and cell proliferation of PMCs.[augusta.pure.elsevier.com]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!