The first patient presented with pneumococcal pneumonia and empyema and the second patient presented with pneumococcal pneumonia and meningitis. [ncbi.nlm.nih.gov]

Infection of the blood stream (bacteraemia and sepsis) can present with joint pain and chills. It may also present along with infection at other site, such as pneumonia and meningitis. [chp.gov.hk]

• Sepsis

  The aim of the work was to assess the potential serotype coverage of three pneumococcal conjugate vaccines (7-, 10- and 13-valent) against bacteremic pneumococcal pneumonia and meningitis/sepsis in Italian children. [ncbi.nlm.nih.gov]

• Chills

  Infection of the blood stream (bacteraemia and sepsis) can present with joint pain and chills. It may also present along with infection at other site, such as pneumonia and meningitis. [chp.gov.hk]

  Pneumococcal bacteremia symptoms are similar to these and may include joint pains and chills, as well. Vaccine recommendations Two vaccines have been formulated to prevent pneumococcal infection. [sheknows.com]

  Symptoms include fever, chills, and reduced alertness. Sepsis : This is a potentially life-threatening infection response by the body. Symptoms include fever, chills, clammy skin, confusion, a rapid heart rate, difficulty breathing, and severe pain. [medicalnewstoday.com]

  The symptoms of bloodstream infection may be similar to some of the symptoms of pneumonia and meningitis, along with joint pain, fever and chills. [nfid.org]

• Shivering

  […] be dry, or produce thick yellow, green, brown or blood-stained mucus (phlegm) difficulty breathing – your breathing may be rapid and shallow, and you may feel breathless, even when resting rapid heartbeat fever feeling generally unwell sweating and shivering [nhs.uk]

  These are: pain in the muscles, joints or limbs, such as in the legs or hands shivering or unusually cold hands and feet blue lips and pale or blotchy skin As the condition gets worse it may cause: drowsiness confusion seizures or fits an inability to [your.md]

  These are: pain in the muscles, joints or limbs – such as in the legs or hands shivering or unusually cold hands and feet blue lips and pale or blotchy skin As the condition gets worse it may cause: a blotchy, red rash that does not fade or change colour [nhsdirect.wales.nhs.uk]

• Rigor

  However, MBL deficiency has not been rigorously defined, and associations with sepsis outcomes have not been subjected to multivariable analysis. [ncbi.nlm.nih.gov]

  We apply rigorous science to build knowledge and support for the value of vaccines. [jhsph.edu]

  Sometimes preceded by a viral illness, there is acute onset of high fever, rigors, productive cough, pleuritic chest pain, dyspnea, tachypnea, tachycardia, malaise, and fatigue. Patients typically appear ill and may appear anxious. [emedicine.medscape.com]

• Malaise

  People with pneumococcal meningitis have fever, headache, and a general feeling of illness (malaise). [merckmanuals.com]

  A bacterium, streptococcus pneumoniae (pneumococcus) causes pneumococcal pneumonia, the symptoms of which include high fever, cough and shortness of breath; bacteremia, an infection of the blood stream that causes fever and malaise; and pneumococcal meningitis [sheknows.com]

  Most patients with pneumococcal meningitis present with nonspecific signs and symptoms, including fever, irritability, emesis, lethargy, anorexia, and malaise. [emedicine.medscape.com]

• Cough

  Symptoms of pneumonia include: Cough - Mucus (sputum) from your lungs may be coughed up. [bccdc.ca]

  […] heartbeat fever feeling generally unwell sweating and shivering loss of appetite chest pain – which gets worse when breathing or coughing Less common symptoms include: coughing up blood (haemoptysis) headaches fatigue nausea or vomiting wheezing joint [nhs.uk]

  Cover your nose and mouth with tissue paper when sneezing or coughing. Dispose of soiled tissues into a lidded rubbish bin, then wash hands thoroughly. [chp.gov.hk]

• Sneezing

  Pneumococcal bacteria are dispersed in the air when infected people cough or sneeze. Pneumococcal infections usually cause fever and a general feeling of illness, with other symptoms depending on which part of the body is infected. [merckmanuals.com]

  Cover your nose and mouth with tissue paper when sneezing or coughing. Dispose of soiled tissues into a lidded rubbish bin, then wash hands thoroughly. [chp.gov.hk]

  When an infected individual coughs or sneezes they can spread tiny droplets of fluid which can be breathed in by others, or bacteria on a person’s hands (from touching their mouth/nose/eyes or sneezing/coughing into their hands) can end up on door handles [sweet-cures.com]

  How you get it Pneumococcal bacteria are carried in the nose and throat and are easily passed from person to person by coughing, sneezing and close contact. Children are a major reservoir for infection. [immune.org.nz]

• Common Cold

  Pneumonia can be difficult to diagnose because it shares many symptoms with other conditions, such as the common cold, bronchitis and asthma. [nhs.uk]

  Pneumococcal infection is spread in a similar way to the common cold - by sneezing, coughing and touch. Simple hygiene and care can prevent some spread such as frequent hand washing and avoiding touching the mouth and nose. [familydoctor.co.nz]

• Loss of Appetite

  Symptoms include high fever, and loss of appetite, stiff neck, headache, vomiting, fussiness (crying), difficulty waking up (drowsiness). Meningitis can cause seizures, deafness or brain damage. [caringforkids.cps.ca]

  […] of appetite chest pain – which gets worse when breathing or coughing Less common symptoms include: coughing up blood (haemoptysis) headaches fatigue nausea or vomiting wheezing joint and muscle pain feeling confused and disorientated, particularly in [nhs.uk]

  Symptoms depend on the site of infection and the age of the person, as described below: Pneumonia can cause shortness of breath, fever, lack of energy, loss of appetite, headache, chest pain and cough. [health.nsw.gov.au]

• Diarrhea

  Updates Commentary: The economic burden of pneumonia, diarrhea, and measles is significant for households in Uganda December 2018 The Decade of Vaccine Economics (DOVE) study has revealed significant household costs associated with childhood diseases [jhsph.edu]

  The symptoms of meningitis may vary depending on the age of the child, but may include diarrhea, vomiting and/or fever. In older children, meningitis symptoms may include headache, sensitivity to light and/or a stiff neck. [nfid.org]

  Reported pneumococcal vaccine reactions include fever, severe local reactions (swelling, redness, pain at site of injection), irritability, drowsiness, restless sleep, vomiting, diarrhea, rash, decreased appetite, convulsions, asthma, pneumonia and sudden [nvic.org]

  Presenting symptoms of peritonitis include abdominal pain, anorexia, emesis, diarrhea, and fever. Children may present atypically with right lower quadrant abdominal pain that may be mistaken for appendicitis. [emedicine.medscape.com]

• Heart Disease

  After following up for 18 months, no restrictive heart disease developed. Purulent pericarditis with cardiac tamponade is an extremely rare complication of pneumococcal infection. [ncbi.nlm.nih.gov]

  People most at risk for the infection include: children under two years of age elderly adults Aboriginal and Torres Strait Islander people people with lung disease, heart disease, cancer, kidney disease, HIV infection, or malnutrition people who have [health.nsw.gov.au]

  Examples include congenital heart disease, angina, heart failure or if you have ever had a heart attack. Have a serious chronic kidney disease. Examples include nephrotic syndrome, kidney failure or if you have had a kidney transplant. [patient.info]

  People at Risk The following people are more at risk of catching a pneumococcal infection: Children under 5 years of age People 65 years old and up People with one of the following illnesses: Heart disease Lung disease (e.g. emphysema, chronic bronchitis [sante.gouv.qc.ca]

• Erythema

  A few hours later, the boy developed fever 39°C and periumbilical erythema. [journals.lww.com]

[…] following: Echocardiography Middle-ear fluid aspiration Pleural fluid aspiration Chest tube thoracostomy or catheter placement Video-assisted thoracoscopy (VATS) or pleural decortication Joint fluid aspiration Biopsy of bone, soft tissue, or muscle See Workup [emedicine.medscape.com]

• Pulmonary Infiltrate

  “Bacteremic pneumococcal pneumonia” was defined as ≥1 blood culture positive for S. pneumoniae for a patient with a new pulmonary infiltrate documented by chest radiography. [doi.org]

• Gram-Positive Bacteria

  In Gram-positive bacteria, such as Corynebacterium diphtheriae ( 12, 13 ), Actinomyces spp. ( 14 ), and recently group A streptococci (GAS) and group B streptococci (GBS) ( 15, 16 ), pili-like surface structures have been identified by electron microscopy [doi.org]

• Blood Culture Positive

  These assays were used to detect capsular polysaccharide in urine from 263 adult patients with proven (blood culture-positive) invasive pneumococcal disease and pneumonia of unknown etiology and from patients with positive blood cultures yielding bacteria [ncbi.nlm.nih.gov]

  “Bacteremic pneumococcal pneumonia” was defined as ≥1 blood culture positive for S. pneumoniae for a patient with a new pulmonary infiltrate documented by chest radiography. [doi.org]

The treatment did not cause hematological toxicity, as demonstrated by platelet counts. This feasibility study establishes that RIT can be applied to the treatment of bacterial infections. [ncbi.nlm.nih.gov]

[…] penicillin or cefotaxime treatment failure [ 4 ]. [doi.org]

In this patient population, shock—and, to a lesser degree, age—acted as negative confounders of the association between inclusion of a macrolide as part of the empirical antibiotic regimen and a better prognosis. [doi.org]

Prognosis Pneumococcal conjunctivitis, otitis media, and sinusitis in developed countries where appropriate antibiotics are available usually carry an excellent prognosis; potential complications are listed above (see Complications). [emedicine.medscape.com]

[…] with functional or anatomic asplenia Those with sickle cell disease Residents of long-term care facilities Smokers Aborigines, Alaskan natives, and certain American Indian populations The elderly, even those without other disease, tend to have a poor prognosis [merckmanuals.com]

Streptococcus pneumoniae is an uncommon etiological pathogen for inducing Hemolytic uremic syndrome, and Streptococcus pneumoniae associated Hemolytic uremic syndrome is also termed as atypical hemolytic uremic syndrome. to report two pediatric cases [ncbi.nlm.nih.gov]

Etiology and ecology, Arch Intern Med, 1962, vol. 110 (pg. 847 - 55 ) 12 Severe community-acquired pneumonia: epidemiology and prognostic factors, Am Rev Respir Dis, 1991, vol. 144 (pg. 312 - 9 ) 13 Severe community-acquired pneumonia: etiology, prognosis [doi.org]

/prevention & control* Pneumococcal Infections/transmission Pneumococcal Vaccines/administration & dosage* Pneumococcal Vaccines/immunology United States/epidemiology Vaccines, Conjugate/administration & dosage Vaccines, Conjugate/immunology Substances [ncbi.nlm.nih.gov]

Publication Invasive pneumococcal disease - Annual Epidemiological Report for 2017 Peer-Reviewed Publication Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic [ecdc.europa.eu]

Overall health care utilization for otitis media has decreased, as has the incidence of recurrent otitis media in some populations and studies. [7, 23, 24, 25] Pathophysiology Capsule The capsule is composed of polysaccharides that cover the cell wall [emedicine.medscape.com]

OBJECTIVES: To assess the effectiveness of PPV in preventing disease or death in adults. Adverse events were not assessed. [ncbi.nlm.nih.gov]

Centers for Disease Control and Prevention. 2015. Active Bacterial Core Surveillance Report, Emerging Infections Program Network, Streptococcus pneumoniae, 2015. Centers for Disease Control and Prevention. [cdc.gov]

Epidemiology and Prevention of Vaccine-Preventable Diseases. 11th ed. Atlanta, GA: Centers for Disease Control and Prevention. [oxfordbibliographies.com]