The first patient presented with pneumococcal pneumonia and empyema and the second patient presented with pneumococcal pneumonia and meningitis. [ncbi.nlm.nih.gov]

Infection of the blood stream (bacteraemia and sepsis) can present with joint pain and chills. It may also present along with infection at other site, such as pneumonia and meningitis. [chp.gov.hk]

• Chills

  Infection of the blood stream (bacteraemia and sepsis) can present with joint pain and chills. It may also present along with infection at other site, such as pneumonia and meningitis. [chp.gov.hk]

  Pneumococcal bacteremia symptoms are similar to these and may include joint pains and chills, as well. Vaccine recommendations Two vaccines have been formulated to prevent pneumococcal infection. [sheknows.com]

  The symptoms of pneumococcal blood infection may be similar to some of the symptoms of pneumonia and meningitis, along with joint pain and chills. [adolescentvaccination.org]

  Symptoms include fever, chills, and reduced alertness. Sepsis : This is a potentially life-threatening infection response by the body. Symptoms include fever, chills, clammy skin, confusion, a rapid heart rate, difficulty breathing, and severe pain. [medicalnewstoday.com]

• Rigor

  However, MBL deficiency has not been rigorously defined, and associations with sepsis outcomes have not been subjected to multivariable analysis. [ncbi.nlm.nih.gov]

  We apply rigorous science to build knowledge and support for the value of vaccines. [jhsph.edu]

  Sometimes preceded by a viral illness, there is acute onset of high fever, rigors, productive cough, pleuritic chest pain, dyspnea, tachypnea, tachycardia, malaise, and fatigue. Patients typically appear ill and may appear anxious. [emedicine.medscape.com]

• Malaise

  People with pneumococcal meningitis have fever, headache, and a general feeling of illness (malaise). [merckmanuals.com]

  A bacterium, streptococcus pneumoniae (pneumococcus) causes pneumococcal pneumonia, the symptoms of which include high fever, cough and shortness of breath; bacteremia, an infection of the blood stream that causes fever and malaise; and pneumococcal meningitis [sheknows.com]

  Most patients with pneumococcal meningitis present with nonspecific signs and symptoms, including fever, irritability, emesis, lethargy, anorexia, and malaise. [emedicine.medscape.com]

• Edema of Lower Extremity

  To the Editors: We report the case of a 7-year-old boy with a 5-day history of mild anorexia and asthenia with transient periorbital edema and progressive edema of lower extremities and scrotum. [journals.lww.com]

• Cough

  People have fever, chills, a general feeling of illness (malaise), shortness of breath, and a cough. The cough brings up sputum that becomes rust-colored. Commonly, sharp, stabbing chest pains occur on one side. [merckmanuals.com]

  Cover your nose and mouth with tissue paper when sneezing or coughing. Dispose of soiled tissues into a lidded rubbish bin, then wash hands thoroughly. [chp.gov.hk]

  […] heartbeat fever feeling generally unwell sweating and shivering loss of appetite chest pain – which gets worse when breathing or coughing Less common symptoms include: coughing up blood (haemoptysis) headaches fatigue nausea or vomiting wheezing joint [nhs.uk]

• Acute Abdomen

  An assessment by the pediatric surgeon ruled out an acute abdomen. A few hours later, the boy developed fever 39°C and periumbilical erythema. [journals.lww.com]

• Gastropathy

  In Menetrier disease, protein-losing gastropathy may cause hypogammaglobulinemia, predisposing to invasive infections such as invasive pneumococcal infection. [journals.lww.com]

[…] following: Echocardiography Middle-ear fluid aspiration Pleural fluid aspiration Chest tube thoracostomy or catheter placement Video-assisted thoracoscopy (VATS) or pleural decortication Joint fluid aspiration Biopsy of bone, soft tissue, or muscle See Workup [emedicine.medscape.com]

• Pulmonary Infiltrate

  “Bacteremic pneumococcal pneumonia” was defined as ≥1 blood culture positive for S. pneumoniae for a patient with a new pulmonary infiltrate documented by chest radiography. [doi.org]

• Blood Culture Positive

  These assays were used to detect capsular polysaccharide in urine from 263 adult patients with proven (blood culture-positive) invasive pneumococcal disease and pneumonia of unknown etiology and from patients with positive blood cultures yielding bacteria [ncbi.nlm.nih.gov]

  “Bacteremic pneumococcal pneumonia” was defined as ≥1 blood culture positive for S. pneumoniae for a patient with a new pulmonary infiltrate documented by chest radiography. [doi.org]

• Gram-Positive Bacteria

  Survival in different concentrations of exogenously added H 2 O 2 varied widely among the species of gram-negative and gram-positive bacteria tested. [doi.org]

• Ancylostoma Duodenale

  The non-vaccinated children were at risk of Ascaris lumbricoides, Ancylostoma duodenale, Trichuris trichura, Schistosoma mansoni, S. haematobium, bancroftian microfilaria, Enterobius vermicularis, Hymenolepis nana, Giadia lamblia, Entaemeba histolytica [ncbi.nlm.nih.gov]

The treatment did not cause hematological toxicity, as demonstrated by platelet counts. This feasibility study establishes that RIT can be applied to the treatment of bacterial infections. [ncbi.nlm.nih.gov]

[…] penicillin or cefotaxime treatment failure [ 4 ]. [doi.org]

Contacts do not require antibiotic treatment or vaccination. Treatment: Antibiotics as recommended by doctor – refer to doctor. [ww2.health.wa.gov.au]

In this patient population, shock—and, to a lesser degree, age—acted as negative confounders of the association between inclusion of a macrolide as part of the empirical antibiotic regimen and a better prognosis. [doi.org]

Prognosis Pneumococcal conjunctivitis, otitis media, and sinusitis in developed countries where appropriate antibiotics are available usually carry an excellent prognosis; potential complications are listed above (see Complications). [emedicine.medscape.com]

[…] with functional or anatomic asplenia Those with sickle cell disease Residents of long-term care facilities Smokers Aborigines, Alaskan natives, and certain American Indian populations The elderly, even those without other disease, tend to have a poor prognosis [merckmanuals.com]

Streptococcus pneumoniae is an uncommon etiological pathogen for inducing Hemolytic uremic syndrome, and Streptococcus pneumoniae associated Hemolytic uremic syndrome is also termed as atypical hemolytic uremic syndrome. to report two pediatric cases [ncbi.nlm.nih.gov]

Etiology and ecology, Arch Intern Med, 1962, vol. 110 (pg. 847 - 55 ) 12 Severe community-acquired pneumonia: epidemiology and prognostic factors, Am Rev Respir Dis, 1991, vol. 144 (pg. 312 - 9 ) 13 Severe community-acquired pneumonia: etiology, prognosis [doi.org]

/prevention & control* Pneumococcal Infections/transmission Pneumococcal Vaccines/administration & dosage* Pneumococcal Vaccines/immunology United States/epidemiology Vaccines, Conjugate/administration & dosage Vaccines, Conjugate/immunology Substances [ncbi.nlm.nih.gov]

Publication Invasive pneumococcal disease - Annual Epidemiological Report for 2017 Peer-Reviewed Publication Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic [ecdc.europa.eu]

Overall health care utilization for otitis media has decreased, as has the incidence of recurrent otitis media in some populations and studies. [7, 23, 24, 25] Pathophysiology Capsule The capsule is composed of polysaccharides that cover the cell wall [emedicine.medscape.com]

Epidemiology and Prevention of Vaccine-Preventable Diseases. 11th ed. Atlanta, GA: Centers for Disease Control and Prevention. [oxfordbibliographies.com]

OBJECTIVES: To assess the effectiveness of PPV in preventing disease or death in adults. Adverse events were not assessed. [ncbi.nlm.nih.gov]

Centers for Disease Control and Prevention. 2015. Active Bacterial Core Surveillance Report, Emerging Infections Program Network, Streptococcus pneumoniae, 2015. Centers for Disease Control and Prevention. [cdc.gov]