Presentation
[…] secondary to inhaled allergens Alternate/Historical Names Extrinsic allergic alveolitis (equvalent term) Many allergen specific names, a few of which are: Bird fancier's lung Farmer's lung Hot tub lung Humidifier lung Diagnostic Criteria Clinical May present [surgpathcriteria.stanford.edu]
Upon physical examination, the patient presented no fever, tachycardia (140 bpm), tachypnea (36 breaths per minute) and baseline oxygen saturation (breathing room air) of 91%. [archbronconeumol.org]
[…] obliterans Infectious pneumonia – especially M. tuberculosis Usual interstitial pneumonia Desquamative interstitial pneumonia Nonspecific interstitial pneumonia Drug-induced pneumonitis Chronic presentation Nonspecific interstitial pneumonia Unusual [arupconsult.com]
The first is always to consider a reaction to e-cigarettes in someone presenting with an atypical respiratory illness. [adc.bmj.com]
However, the potential for massive inhalation with the use of vaping devices could account for the more acute presentations of the current cases. [reliasmedia.com]
Entire Body System
- Fatigue
The subacute form is characterized by the insidious onset of productive cough, dyspnea, and fatigue over weeks to months. Chronic hypersensitivity pneumonitis is characterized by long-term progressive dyspnea, weight loss, cough, and fatigue. [amboss.com]
To save this word, you'll need to log in. pneu·mo·ni·tis | \ ˌnü-mə-ˈnī-təs, ˌnyü- \ : acute or chronic inflammation of the lungs that is characterized especially by cough, shortness of breath, fatigue, and fever, and may result in the development of [merriam-webster.com]
Subacute and chronic patients may present with acute exacerbation Subacute Gradual onset of dyspnea, cough over days or weeks Follows continued intermittent exposure Good response to steroids and avoidance/removal of antigen Chronic Chronic dyspnea, fatigue [surgpathcriteria.stanford.edu]
Other symptoms include wheezing, fatigue, decreased pulse oximetry, and chest pain. Time to onset after initiation of therapy varies (reported at 9 days to 19 months), but the median is 2.8 months. [voice.ons.org]
Workup
Grade it per the Common Terminology Criteria for Adverse Events and direct further workup and management by the toxicity grade. For grade 2 or higher, perform a nasal swab and sputum and urine culture and sensitivity as part of an infectious workup. [voice.ons.org]
Workup Recommendations Workup of patients with suspected pneumonitis includes sputum cultures and nasopharyngeal swabs. It is especially important to look for evidence of viral infection in the winter months. [ascopost.com]
Blood workup revealed normal ionogram, C-reactive protein 80 g/dl, leukocytes 11 430 mm 3 (90% neutrophils and 1.4% eosinophils), hemoglobin 12.4 g/dl, hematocrits 36.4%, platelets 309 000 mm 3. [archbronconeumol.org]
Treatment
The most common risk factor is related to treatment protocols. [curetoday.com]
His symptoms improved with corticosteroid treatment, worsened when corticosteroids were tapered, and then finally resolved after treatment with the TNF-alpha-inhibitor infliximab. [jitc.biomedcentral.com]
In this study, opacity confined to the ipsilateral lung was observed after nivolumab treatment. [futuremedicine.com]
It is not intended as medical advice for individual conditions or treatments. [drugs.com]
It most commonly develops 1 to 3 months after treatment is over, but it can happen up to 6 months after treatment. Chronic pneumonitis can lead to permanent scarring of the lungs (called pulmonary fibrosis ). [cancer.ca]
Prognosis
Steroid therapy is helpful for symptomatic relief, but probably does not affect the long-term prognosis. [mayoclinic.pure.elsevier.com]
Prognosis Prognosis is good with early diagnosis and management. Late-diagnosed chronic pneumonitis may lead to progressive, irreversible lung disease. [patient.info]
However, when smokers do develop hypersensitivity pneumonitis, it is more commonly fibrosing disease with a worse prognosis 10. [radiopaedia.org]
Centrilobular accentuation of peribronchiolar fibrosis is very suggestive of hypersensitivity pneumonitis Surrounds and may occlude bronchiole Fibrosis may bridge from centrilobular to peripheral zones Fibrosis is generally not reversible and imparts a poor prognosis [surgpathcriteria.stanford.edu]
The prognosis for the acute form is good. Once severe damage to lung structures has occurred, however, few treatment options remain. Chronic hypersensitivity pneumonitis may lead to pulmonary fibrosis, which may ultimately require transplantation. [amboss.com]
Etiology
They received empiric antibiotics recommended for treatment of community-acquired pneumonia, but tests for microbiological etiologies proved negative. [reliasmedia.com]
One is confronted with the same difficulty in placing the pneumonias, though some progress is being made toward adoption of an etiological classification. [annals.org]
[…] type of pulmonary inflammation on the basis of roentgen findings alone, it is both sensible and convenient for the radiologist to report findings which suggest chronic fibroid pneumonia as “interstitial pneumonitis,” making no attempt to identify the etiologic [pubs.rsna.org]
He has also reviewed more or less extensively the facts as to the etiology, pathology, anatomy, symptomatology, etc., of the disease, and it may be taken as—for its size—a fairly exhaustive and critical discussion of the subject. [jamanetwork.com]
Etiology Combined type III and type IV hypersensitivity reaction with genetic predisposition Inhalation of organic particles ( < 5 microns ), primarily through occupational exposure (notifiable occupational disease) Antigen Source Disease Animal proteins [amboss.com]
Epidemiology
Epidemiology It is common, if all causes of pneumonitis are considered. [patient.info]
Chronic presentation Nonspecific interstitial pneumonia Unusual interstitial pneumonia Bronchiolitis obliterans Chronic obstructive pulmonary disease (COPD) Idiopathic pulmonary fibrosis Sarcoidosis Asthma Silicosis Drug-induced pneumonitis Background Epidemiology [arupconsult.com]
Epidemiological study of farmer's lung in five districts of the French Doubs province. Thorax. 1988 Jun. 43(6):429-35. [Medline]. [Full Text]. Terho EO. Work-related respiratory disorders among Finnish farmers. Am J Ind Med. 1990. 18(3):269-72. [emedicine.medscape.com]
Pathophysiology
[…] s lung, paprika slicer’s lung, wine maker’s lung, tobacco grower’s lung Animal proteins Pituitary snuff taker’s lung, pigeon breeder's lung, bird fancier’s disease, furrier’s lung, poultry worker's lung Chemicals Bathtub finisher's lung, Coptic lung Pathophysiology [arupconsult.com]
Details of the pathophysiology of this disease are still unknown, but for drugs with a high volume of distribution, one possibility would be specific accumulation of the mTOR inhibitor or its metabolites in the lung parenchyma. [revistanefrologia.com]
Despite the frequency with which both radiation- and ICB- related pneumonitis occur, the pathophysiology remains unclear, and there is little data to suggest which clinical risk factors might be the most relevant. [jitc.biomedcentral.com]
The precise pathophysiology of the differences between PD1/PDL-1 inhibitors and CTL-4 inhibitors is yet to be uncovered. [frontiersin.org]
Prevention
Oxygen therapy to prevent a low level of oxygen in the body. Bronchodilators may be given to help open up the lungs for better oxygenation. Steroids may be given to lessen inflammation and help the lungs heal. If you smoke, stop. [oncolink.org]
The chronic form of this condition can be prevented by avoiding the material that causes the lung inflammation. [uihc.org]
The chronic form can be prevented by avoiding the material that causes the lung inflammation. [medlineplus.gov]
Managers and workers should learn about methods of storing materials to prevent mould formation and to reduce dust. [ccohs.ca]
The inflammation can make it hard to breathe and prevent you from getting enough oxygen. Anything that irritates your lung tissues can lead to pneumonitis. The longer you are exposed, the more damage your lungs will develop. [drugs.com]