Presentation
The lower alkanol in which the podofilox may be dissolved in accordance with the present invention is any alkanol of up to 8 carbon atoms. [google.com]
Therefore, this review presents up-to-date coverage of podophyllotoxin in regard to hemisynthesis, biosynthesis, biological activities, mode of action and structure-activity relationship. [doi.org]
Entire Body System
- Burning Pain
Irritation in area of use, for example itching, burning, pain, redness or ulceration. Inflammation of the foreskin or head of the penis. The side effects listed above may not include all of the side effects reported by the medicine's manufacturer. [netdoctor.co.uk]
It is not recommended to be used in the vagina or cervix, because it may cause burning, pain, and ulcers in the skin. [ic.steadyhealth.com]
[…] topically applied podophyllum resin is distributed into milk. 100 Contraindicated in breast-feeding women. 100 Pediatric Use Safety and efficacy not established in pediatric patients. b Common Adverse Effects Local reactions (erythema, tenderness, pruritus, burning [drugs.com]
- Severe Pain
(44-48%) Mild to moderate pruritus (44-48%) Mild to moderate bleeding (22%) 1-10% Stinging (7%) Erythema (5%) Severe inflammation (8-12%) Severe burning (8-12%) Severe erosion (8-12%) Severe pain (8-12%) Severe pruritus (8-12%) Headache (6-9%) Insomnia [thehealthscience.com]
Condyline Possible Side Effects Redness, itching, burning, and pain may occur in the treated area. If any of these effects persist or worsen, or if you have bleeding, severe swelling, or severe pain, wash the medication off with soap and water. [antiviraltabs.org]
SIDE EFFECTS: Redness, itching, burning, and pain may occur in the treated area. If any of these effects persist or worsen, or if you have bleeding, severe swelling, or severe pain, wash the medication off with soap and water. [medicinenet.com]
Gastrointestinal
- Vomiting
Vol. 28, Pg. 32, 1891. dog LDLo subcutaneous 1mg/kg (1mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Archiv fuer Experimentelle Pathologie und Pharmakologie. [chem.nlm.nih.gov]
(solution only) Symptoms of overdose Nausea vomiting diarrhea chills fever sore throat unusual bleeding or bruising oral ulcers Some side effects may occur that usually do not need medical attention. [mayoclinic.org]
If you experience any of the following symptoms, call your doctor immediately: fever, sore throat, ongoing cough and congestion, or other signs of infection; unusual bleeding or bruising; bloody or black, tarry stools; bloody vomit; or vomiting blood [medlineplus.gov]
Gel include: application site reactions (swelling, pain, burning, itching, peeling skin, small sores, irritation, tenderness, bleeding, tingling, scarring, blistering, or crusting), headache, sleep problems (insomnia), unpleasant skin odor, nausea, vomiting [rxlist.com]
[…] feeling of treated skin; dizziness; headache; itching of treated skin; pain during sexual intercourse; pain of treated skin; problems with foreskin of penis; redness or swelling of treated skin; scarring of treated skin; skin ulcers of treated skin; vomiting [web.stanford.edu]
- Abdominal Pain
IRMeeting-070418-Abd Pain in A Nephrotic Child-ppt - HKSN ; Abdominal Pain in a Child with Nephrotic Syndrome Winnie KY Chan Department of Paediatrics Queen Elizabeth Hospital April 2007 Epstein-Barr Virus (EBV) complications following HSCT ... ; Epstein-Barr [yukwthpe.ga]
GI: Nausea, vomiting, diarrhea, abdominal pain, hepatotoxicity, increased serum concentrations of LDH, AST, and alkaline phosphatase. Urogenital: Renal failure, urinary retention. Respiratory: Decreased respirations, apnea, hyperventilation. [robholland.com]
Initial manifestations of systemic toxicity include dizziness, lethargy, nausea, vomiting, abdominal pain, and diarrhea (sometimes severe and protracted). 108 109 Adverse CNS effects may be delayed in onset and prolonged in duration. a Cerebral toxicity [drugs.com]
In 1947, Hartwell and Shear demonstrated that a single dose of resin was effective in reducing tumors, but severe abdominal pains were associated with the treatment. [hort.purdue.edu]
- Severe Abdominal Pain
In 1947, Hartwell and Shear demonstrated that a single dose of resin was effective in reducing tumors, but severe abdominal pains were associated with the treatment. [hort.purdue.edu]
Skin
- Blister
Common side effects of Condylox Gel include: application site reactions (swelling, pain, burning, itching, peeling skin, small sores, irritation, tenderness, bleeding, tingling, scarring, blistering, or crusting), headache, sleep problems (insomnia), [rxlist.com]
If Condylox spreads to other unaffected skin, wash immediately to avoid burning or blistering of healthy skin. Store all medications out of children’s reach and never share this or any medicine with others, even if they have the same symptoms. [northwestpharmacy.com]
See your doctor as soon as possible if the following side effects occur: bad odor; bleeding of treated skin; blistering, crusting, or scabbing of treated skin; bloody urine; burning feeling of treated skin; dizziness; headache; itching of treated skin [web.stanford.edu]
Check with your doctor as soon as possible if any of the following side effects occur: More common Bad odor (solution only) bleeding of treated skin blistering, crusting, or scabbing of treated skin bloody urine (solution only) burning feeling of treated [mayoclinic.org]
Side effects that you should report to your doctor or health care professional as soon as possible: allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue bleeding, blistering, burning, crusting, or scabbing of treated [carefirst.staywellsolutionsonline.com]
- Pruritus
[…] days May repeat in 1 week, cycle up to 4 times Safety & efficacy not established Adverse Effects >10% Mild to moderate inflammation (63%) Mild to moderate burning (63%) Mild to moderate erosion (44-48%) Mild to moderate pain (44-48%) Mild to moderate pruritus [thehealthscience.com]
Tolerable moderate to mild frequent side effects were pruritus (20.6%) and erythema (18%), with no dropouts. No recurrence was seen after 9 months of follow-up. [ncbi.nlm.nih.gov]
- Skin Rash
[…] or tingling of treated skin trouble in sleeping (solution only) Less common Changes in color of treated skin (gel only) skin rash (gel only) Other side effects not listed may also occur in some patients. [mayoclinic.org]
Side effects that you should report to your doctor or health care professional as soon as possible: bleeding, blistering, burning, crusting, or scabbing of treated skin blood in the urine dizziness severe skin rash or swelling vomiting (may indicate excessive [carefirst.staywellsolutionsonline.com]
Side effects that you should report to your doctor or health care professional as soon as possible: •bleeding, blistering, burning, crusting, or scabbing of treated skin •blood in the urine •dizziness •severe skin rash or swelling •vomiting (may indicate [my.clevelandclinic.org]
Side effects that you should report to your doctor or health care professional as soon as possible: -bleeding, blistering, burning, crusting, or scabbing of treated skin -blood in the urine -dizziness -severe skin rash or swelling -vomiting (may indicate [planetdrugsdirect.com]
Side Effects Side effects that may occur while taking this medicine include: sleeping trouble (solution only) swelling treated skin becomes dry soreness skin rash (gel only) headache itching treated skin starts to peel Contact your doctor if you experience [psychcentral.com]
Psychiatrical
- Suggestibility
Our experience suggests that these agents can be used safely and effectively in young children. [ncbi.nlm.nih.gov]
However, etoposide and teniposide were shown not to be inhibitors of microtubule assembly which suggested that their antitumor properties were due to another mechanism of action, via their interaction with DNA and inhibition of DNA topoisomerase II. [doi.org]
These changes suggest that the autophagic cell death pathway is also involved in the effects of PA on the tested NSCLC cell lines. [spandidos-publications.com]
Neurologic
- Irritability
Only one patient stopped treatment because of irritation. Our experience suggests that these agents can be used safely and effectively in young children. [ncbi.nlm.nih.gov]
The drug should reach only condyloma because if the drug reaches the healthy parts of the skin or mucous, it may lead to severe irritation. [antibact.net]
Moderate to severe irritant to the skin and eyes. 4. [selleckchem.com]
By the third day of treatment, skin around warts may become mildly irritated; red, tender, sore, itchy, and skin may peel. [buy-podophyllotoxin.kiwidrug.com]
Side effects that are considered to be common include skin irritation, but this is usually mild. If more serious or persistent skin irritation is felt, you should stop using Warticon, wash the area, and talk to your doctor. [pharmacy2u.co.uk]
- Seizure
Vol. 28, Pg. 32, 1891. dog LDLo subcutaneous 1mg/kg (1mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Archiv fuer Experimentelle Pathologie und Pharmakologie. [chem.nlm.nih.gov]
If accidentally swallowed, you may experience symptoms such as: nausea, vomiting, diarrhea, change in mental status, weakness or fatigue, unusually slowed breathing, and seizures. Notes This medication is prescribed for your current condition only. [webmd.com]
If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. Keep all appointments with your doctor and the laboratory. [medlineplus.gov]
Symptoms may include nausea, vomiting, diarrhea, fever, flu symptoms, sores in your mouth and throat, numbness or tingling in your hands or feet, confusion, trouble breathing, or seizure (convulsions). Use the missed dose as soon as you remember. [everydayhealth.com]
- Confusion
[…] cheap podophyllotoxin 40 mg from canada effect of podophyllotoxin on the cell brand ben podophyllotoxin last steve podowarts canada prescription required harvesting natural podophyllotoxin in your local forest for use in treating genital warts pure confusion [highlanderrun.it]
Symptoms may include nausea, vomiting, diarrhea, fever, flu symptoms, sores in your mouth and throat, numbness or tingling in your hands or feet, confusion, trouble breathing, or seizure (convulsions). Use the missed dose as soon as you remember. [everydayhealth.com]
[…] studies following non-surgical weight loss, this small study which explains that bothersome symptoms can lead to improved sex drive and does not meet the minimum amount possible for the treatment of elevated metabolic disorders and impaired judgment, confusion [bonnerlibrary.org]
Solution of 20% of podofilox is known to cause quite a few side effects, including: nausea, vomiting, fever, confusion, leukopenia, and even renal failure and coma. [ic.steadyhealth.com]
- Insomnia
Common side effects of Condylox Gel include: application site reactions (swelling, pain, burning, itching, peeling skin, small sores, irritation, tenderness, bleeding, tingling, scarring, blistering, or crusting), headache, sleep problems (insomnia), [rxlist.com]
[…] pain (44-48%) Mild to moderate pruritus (44-48%) Mild to moderate bleeding (22%) 1-10% Stinging (7%) Erythema (5%) Severe inflammation (8-12%) Severe burning (8-12%) Severe erosion (8-12%) Severe pain (8-12%) Severe pruritus (8-12%) Headache (6-9%) Insomnia [thehealthscience.com]
Common side effects may include: mild skin irritation (pain, swelling, burning, redness, itching, tingling, blisters, crusting, dryness, peeling) where the medicine was applied; headache, dizziness; sleep problems (insomnia); unpleasant skin odor; vomiting [mottchildren.org]
- Convulsions
Vol. 28, Pg. 32, 1891. dog LDLo subcutaneous 1mg/kg (1mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Archiv fuer Experimentelle Pathologie und Pharmakologie. [chem.nlm.nih.gov]
Symptoms may include nausea, vomiting, diarrhea, fever, flu symptoms, sores in your mouth and throat, numbness or tingling in your hands or feet, confusion, trouble breathing, or seizure (convulsions). Use the missed dose as soon as you remember. [everydayhealth.com]
Symptoms may include nausea, vomiting, diarrhea, fever, flu symptoms, sores in your mouth and throat, numbness or tingling in your hands or feet, confusion, trouble breathing, or seizure (convulsions). [mottchildren.org]
Workup
Microbiology
- Human Papillomavirus
Under the trade names Condylox, a gel, and Wartec, a solution or cream, it is used on the skin as a topical treatment of external genital warts, caused by some types of the human papillomavirus (HPV), and other warts. [dbpedia.org]
Genital warts are caused by infection of skin cells with a virus; the Human Papillomavirus (HPV). [inhousepharmacy.vu]
Condylox Description Condylox, also called Condyline in Canada, is a topical solution prescribed to treat external genital warts caused by the human papillomavirus (HPV). [northwestpharmacy.com]
The human DNA tumor viruses: human papilloma virus and Epstein-Barr virus. Cancer Treatment Res. 1989; 47:285-302. 19. Verdon ME. Issues in the management of human papillomavirus genital disease. [drugs.com]
- Chlamydia
Podofilox is not a cure for genital warts, and it will not protect against sexually transmitted diseases such as chlamydia, gonorrhea, herpes, HIV, syphilis, and trichomoniasis. [mottchildren.org]
Treatment
Podophyllotoxin in the treatment of molluscum contagiosum. J Dermatol Treatment. 1991; 2:99-101. 37. Neff JM. Parapoxviruses, molluscum contagiosum, and tanapox viruses. In: Mandell GL, Bennett JE, and Dolin R, eds. [drugs.com]
Complete disappearance of warts was observed in 25 (53.3%) of 45 treatment courses, including open-label treatment. Recurrences of warts after therapy were frequent. [ncbi.nlm.nih.gov]
Prognosis
Circadian clocks are with metabolism and increase transplant prognosis. Health care of these findings are really very similar, so many avoidable deaths from opioid overdose in women. [bonnerlibrary.org]
Epidemiology
A new section on hospital epidemiology and infection control is included in this Ninth Edition. A Brandon-Hill recommended title. [books.google.ro]
Condyloma acuminatum: epidemiological, clinical and therapeutic aspects. Eur J Epidemiol. 1987; 3:209-15. http://www.ncbi.nlm.nih.gov/pubmed/3308509?dopt=AbstractPlus 16. Stone KM. [drugs.com]
Ferenczy A Epidemiology and clinical pathophysiology of condyloma acuminata. Am J Obstet Gynecol. 1995;1721331- 1339Google ScholarCrossref 5. von Krogh G Topical treatment of outer genital warts. [jamanetwork.com]
Pathophysiology
Ferenczy A Epidemiology and clinical pathophysiology of condyloma acuminata. Am J Obstet Gynecol. 1995;1721331- 1339Google ScholarCrossref 5. von Krogh G Topical treatment of outer genital warts. [jamanetwork.com]
Prevention
[…] other gymnosperms. microtubule-destabilising agent Any substance that interacts with tubulin to inhibit polymerisation of microtubules. antimitotic Any compound that inhibits cell division (mitosis). antineoplastic agent A substance that inhibits or prevents [ebi.ac.uk]
It and it's derivates bind Topo II and prevent its ability to catalyze rejoining of DNA that has been broken for replication. [en.wikipedia.org]