Edit concept Question Editor Create issue ticket

Poliovirus


Presentation

  • Environmental surveillance (ES) can detect circulating polioviruses from sewage without relying on clinical presentation.[ncbi.nlm.nih.gov]
  • The structures of poliovirus bound to single-domain antibodies presented here capture the altered virus in what appear to be intermediate states.[ncbi.nlm.nih.gov]
  • The first man presented with mumps (parotitis, orchitis and encephalitis). Paired serum mumps titers were both 1:80. The second patient had conjunctivitis and dizziness. Acute and convalescent sera showed significant rise of poliovirus type 3 titer.[ncbi.nlm.nih.gov]
  • Racaniello * Present affiliation: Rockefeller University, New York.[doi.org]
  • Si of haploid PV presents cellular infectivity of a single genotype.[ncbi.nlm.nih.gov]
Anemia
  • Equine infectious anemia virus genomic evolution in progressor and nonprogressor ponies. J. Virol. 75 4570-4583. [ PMC free article ] [ PubMed ] [ Google Scholar ] 49. Li, W.-H. 1993.[ncbi.nlm.nih.gov]
  • Equine infectious anemia virus genomic evolution in progressor and nonprogressor ponies. J. Virol. 75 : 4570 -4583. Li, W.-H. 1993. Unbiased estimation of the rates of synonymous and nonsynonymous substitution. J. Mol. Evol. 36 : 96 -99. Li, W.[doi.org]
  • Equine infectious anemia virus genomic evolution in progressor and nonprogressor ponies. J. Virol. 75 : 4570 -4583. Li, W.-H. 1993 . Unbiased estimation of the rates of synonymous and nonsynonymous substitution. J. Mol. Evol. 36 : 96 -99. Li, W.[doi.org]
Hypertension
  • 14 (27) 8 (15) 4 (8) — — Seizure 19 (37) 2 (4) 1 (2) — 1 (2) Psychiatric disorder Confusion 3 (6) 5 (10) 1 (2) — — Delusions — — 1 (2) — — Hallucinations 1 (2) — — — — Renal and urinary disorder: urinary incontinence 1 (2) — — — — Vascular disorder: hypertension[nejm.org]
Bilateral Leg Weakness
  • ., gypsy) girl from Bourgas, Bulgaria, had onset of bilateral leg weakness. The National Enterovirus Laboratory in the capital city of Sofia subsequently isolated a wild type 1 poliovirus in the patient's stool.[ncbi.nlm.nih.gov]
Neglect
  • There is therefore the need to ensure that enterovirologist globally, especially those outside the global polio laboratory network, can participate in poliovirus surveillance without neglecting their enterovirus type of interest.[ncbi.nlm.nih.gov]
Tremor
  • Two adult patients with opsoclonus and tremor of the whole body associated with viral infections are reported. The first man presented with mumps (parotitis, orchitis and encephalitis). Paired serum mumps titers were both 1:80.[ncbi.nlm.nih.gov]

Workup

  • Diagnostic workup and treatment were performed in Italy. Poliovirus replicated in the gut for 7 months. The 5' non coding region (NCR), VP1, VP3 capsid proteins and the 3D polymerase genomic regions of sequential isolates were sequenced.[ncbi.nlm.nih.gov]
Chlamydia
  • Analysis of synonymous codon usage bias in Chlamydia. Acta Biochim Biophys Sin (Shanghai) 2005; 37 :1–10. doi: 10.1093/abbs/37.1.1. [ PubMed ] [ CrossRef ] [ Google Scholar ] Wright F. The 'effective number of codons' used in a gene.[ncbi.nlm.nih.gov]
  • Biologicals 2006, 34: 103-108. 10.1016/j.biologicals.2006.02.007 View Article Google Scholar Lu H, Zhao WM, Zheng Y, Wang H, Qi M, Yu XP: Analysis of synonymous codon usage bias in Chlamydia.[virologyj.com]
Gliosis
  • In a chronic case, neuronal loss in the anterior horn with replacement by gliosis was prominent below the thoracic cord down to the sacral cord, but Onuf's nucleus was well preserved.[ncbi.nlm.nih.gov]

Treatment

  • “There doesn’t seem to be any resistance to re-treatment,” Bigner says.[sciencenews.org]
  • Two patients remained alive at more than 5 years following treatment.[medpagetoday.com]
  • The results from this phase 1 clinical trial show great promise, but there is still a long way to go before the treatment receives approval. Success in phase 1 trials do not always lead to treatments.[cnet.com]
  • Duke University's poliovirus-based glioblastoma treatment burst on the scene in 2015, thanks to the CBS show "60 Minutes."[fiercebiotech.com]
  • The study tested the modified poliovirus on 61 patients whose tumors had recurred after initial treatments. Median survival was about a year, roughly the same as for a small group of similar patients given other treatments at Duke.[tampabay.com]

Prognosis

  • Intratumoral infusion of PVSRIPO is showing promise in the therapy of recurrent WHO grade IV malignant glioma (glioblastoma), a notoriously treatment-refractory cancer with dismal prognosis.[ncbi.nlm.nih.gov]
  • BACKGROUND: The prognosis of patients with recurrent World Health Organization (WHO) grade IV malignant glioma is dismal, and there is currently no effective therapy.[ncbi.nlm.nih.gov]
  • Unfortunately, it has a poor prognosis, with most patients dying about 14 months after it’s diagnosed.[abcnews.go.com]
  • “This is a devastating disease where the prognosis and outcome for patients is very poor, so for us to see long-term survivors with this new treatment is real and very encouraging,” said Dr.[scientificamerican.com]

Etiology

  • Poliovirus is the etiological agent of poliomyelitis.[ncbi.nlm.nih.gov]
  • Poliovirus was first isolated nearly 100 years ago in a landmark experiment that established the viral etiology of poliomyelitis. This discovery stimulated investigation of the pathogenesis of poliomyelitis in many laboratories.[ncbi.nlm.nih.gov]
  • Poliovirus is the etiologic agent of the paralytic disease known as poliomyelitis. It’s also the virus I’ve worked on for most of my career.[virology.ws]
  • Studies on the etiology of “Zhi-Fang Disease” Chin J Virol. 1988; 4 :118.[ncbi.nlm.nih.gov]
  • Authors’ Affiliations (1) State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou,Gansu, 730046, China References Grantham R, Gautier C, Gouy M, Mercier R, Pave A[doi.org]

Epidemiology

  • However, the Biysk outbreak completely blurred the borderline between Sabin-like viruses and VDPVs in epidemiological terms.[ncbi.nlm.nih.gov]
  • Author information 1 Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy. 2 Department of Epidemiology, Institute for Public Health of Federation Bosnia and Herzegovina, Sarajevo, Bosnia and Herzegovina. 3 Department of Epidemiology[ncbi.nlm.nih.gov]
  • KEYWORDS: clinic; epidemiology; healthcare-associated infections; infection control; poliomyelitis; poliovirus; public health policy; surveillance; viral infections[ncbi.nlm.nih.gov]
  • Author information 1 National Institute of Hygiene and Epidemiology, 1 - Yersin street, Hanoi, Vietnam; Vietnam Military Medical University, 160 - Phung Hung Road, Ha Dong, Hanoi, Vietnam.[ncbi.nlm.nih.gov]
  • Epidemiological and laboratory information for these children were analyzed and the reasons for the VDPV outbreak was explored.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • Starting in 2015, injectable trivalent inactivated poliovirus vaccine (IPV) has been introduced as a part of routine immunization program in place of oral polio vaccine (OPV). [9] Pathophysiology Poliovirus is spread by the fecal-oral route and by aerosol[emedicine.medscape.com]

Prevention

  • Author information 1 a Division of Viral Diseases , Center for Disease Control and Prevention , Atlanta , GA , USA. 2 b Department of Pediatrics , Children's Mercy Hospital , Kansas City , MO , USA.[ncbi.nlm.nih.gov]
  • High routine vaccination coverage and certification standard AFP surveillance are necessary to detect rapidly and prevent the spread of poliovirus importations in areas and countries where polio is not endemic.[ncbi.nlm.nih.gov]
  • Eradication & Endgame Strategic Plan published by WHO in 2013 included the strategy of implementation of poliovirus safe handling and containment measures to minimize the risks of facility-associated reintroduction of virus into the polio-free community to prevent[ncbi.nlm.nih.gov]
  • This report summarizes the ongoing investigation, provides information regarding poliovirus exposure risks and prevention measures in the United States, and offers recommendations to state health departments and clinicians.[ncbi.nlm.nih.gov]
  • Author information 1 Central Virology Laboratory, Public Health Services, Israel Ministry of Heath, at Sheba Medical Center, Tel Hashomer, Israel. 2 These authors contributed equally to this work. 3 Department of Epidemiology and Preventive Medicine,[ncbi.nlm.nih.gov]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!