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Polydactyly of a Biphalangeal Thumb

PPD1


Presentation

  • The anomalies are organized by anatomical system and presented in a consistent manner, including details of the clinical presentation, epidemiology, embryology, treatment and prevention for each anomaly.[books.google.de]
  • Of special value is the thorax and various conditions that exhibit that sign. presentation of variability of the condition with age.[books.google.de]
  • An extra biphalangeal thumb, complete with thumbnail, was present in the left hand (Fig. 1).[deepdyve.com]
  • It is also presented as a part of a broader phenotypic spectrum.[docslide.net]
  • When present, one should search for an associated syndrome (particularly if a triphalangeal thumb is present), such as Holt-Oram syndrome (atrial and ventricular septal defects, abnormal thumb - from absent to triphalangeal), short ribs polydactyly syndromes[humpath.com]
Collapse
  • The SLAC wrist: scapholunate advanced collapse pattern of degenerative Arthritis. J Hand Surg [Am] 1984: 9-A:358-65. ‎ Seite 308 - Arnett FC, Edworthy SM, Bloch DA. McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS.[books.google.de]
  • The excursion of extrinsic digital flexors and extensors may be focused upon digital motion and not frustrated by collapse of the hand and wrist at the ulnocarpal level.[oandplibrary.org]
Pathologist
  • All clinicians and scientists interested in birth defects, including pediatricians, geneticists, genetic counselors, obstetricians, and pediatric pathologists, will find this book to be an invaluable source of information.[books.google.de]
Rigor
  • By condensing much of the information presented in the first volume of the previous edition, and exercising rigorous editorial control, Drs.[books.google.de]
Single Transverse Palmar Crease
  • Typical features of DS were noted, including hypotonia, brachycephaly, upslanting palpebral ï ssures, ï ‚at nasal bridge, low-set ears, a single transverse palmar crease in the right hand, bilateral ï fth ï nger clinodactyly and bilateral wide gaps[deepdyve.com]
Turkish
  • Acropectoral syndrome is autosomal dominant and best described in 22 patients of a Turkish family spanning six generations. The prevalence of this disease is less than 1 in 1 million.[monsterologist.blogspot.com]
Low Set Ears
  • Typical features of DS were noted, including hypotonia, brachycephaly, upslanting palpebral ï ssures, ï ‚at nasal bridge, low-set ears, a single transverse palmar crease in the right hand, bilateral ï fth ï nger clinodactyly and bilateral wide gaps[deepdyve.com]
Arthritis
  • Wilder RL, Hunder GG: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. ‎[books.google.de]
  • Unlabelled : All reported rheumatoid arthritis (RA) forefoot deformities in the literature thus far have arisen from shoe wearing populations.[pubfacts.com]
Cutis Laxa
  • laxa type 2 Autosomal recessive cutis laxa type 2, classic type Autosomal recessive cutis laxa type 2A Autosomal recessive cutis laxa type 2B Autosomal recessive distal osteolysis syndrome Autosomal recessive hypophosphatemic rickets Autosomal recessive[se-atlas.de]
Dry Eyes
  • PubMed Dermatochalasis and dry eye. Dermatochalasis and dry eye. Am J Ophthalmol. 1993 Feb 15;115(2):216-20. PubMed Your browsing activity is empty. Activity recording is turned off. Turn recording back on See more...[ncbi.nlm.nih.gov]
Meningism
  • PubMed Tuberculous meningitis. Tuberculous meningitis. Handb Clin Neurol. 2013;112:1135-8. doi: 10.1016/B978-0-444-52910-7.00033-7. PubMed Postcoital antifertility effect of Mentha arvensis. Postcoital antifertility effect of Mentha arvensis.[ncbi.nlm.nih.gov]

Workup

  • […] technique a segmental distal transfer (on-top plasty) Postaxial Polydactyly (Small Finger Duplication) Epidemiology demographics Genetics inherited as autosomal dominant (AD) in African Americans more complex genetics in caucasians and a thorough genetic workup[orthobullets.com]

Treatment

  • The anomalies are organized by anatomical system and presented in a consistent manner, including details of the clinical presentation, epidemiology, embryology, treatment and prevention for each anomaly.[books.google.de]
  • In the past, surgical treatment of the triphalangeal thumb was not indicated, [11] but now it is generally agreed that operative treatment improves function and appearance.[en.wikipedia.org]
  • Food and Drug Administration has chosen Wave Life Sciences’ planned phase 2/3 study of suvodirsen, its lead experimental therapy for the treatment of Duchenne muscular dystrophy, to break new ground.[globalgenes.org]
  • Tajima T, Watanabe Y, Uchiyama J: Treatment and study of the hypoplastic thumb.[docslide.net]
  • […] operative goals of treatment to construct a thumb that is 80% of the size of the contralateral thumb resect smaller thumb (usually radial component) preserve / reconstruct medial collateral structures in order to preserve pinch function reconstruction[orthobullets.com]

Prognosis

  • Life-long hormone replacement therapy (gluco- and mineralocorticoids for the classical forms with salt wasting, and glucocorticoids for the simple virilizing forms) requires close follow-up (pediatric through to adulthood) and has improved the prognosis[codelay.com]

Etiology

  • Classification PPD1: preaxial polydactyly type 1 (thumb polydactyly) (MIM.174400) Etiology Holt-Oram syndrome (atrial and ventricular septal defects, abnormal thumb - from absent to triphalangeal) short ribs polydactyly syndromes Carpenter syndrome trisomy[humpath.com]
  • However, only a few genetic factors have been discovered which have a potential role in the etiology of polydactyly.[docslide.net]
  • […] used until healed Syndactyly Treatment aimed at maintaining and improving function with cosmetic benefits Involves surgery and may require skin graft from groin area Surgery usually done after 1 year and may be delayed as late as 18-24 months Genetic Etiology[psychology.wikia.com]
  • The results suggested that the etiology of lesser digital deformity was associated with the etiology of hallux abductovalgus more so than it was with hallux limitus.[pubfacts.com]

Epidemiology

  • The anomalies are organized by anatomical system and presented in a consistent manner, including details of the clinical presentation, epidemiology, embryology, treatment and prevention for each anomaly.[books.google.de]
  • Introduction A congential malformation of the hand Three forms exist preaxial polydactlyly thumb duplication postaxial polydactlyly small finger duplication central polydactlyly Preaxial Polydactyly (Thumb Duplication) Epidemiology incidence 1 per 1,000[orthobullets.com]
  • To investigate whether thumb and hallux duplication have different clinical and epidemiological characteristics, Orioli's group studied 920 newborn infants with 1st digit duplication, who were ascertained among 3,444,374 births by the Latin-American Collaborative[rrnursingschool.biz]
  • Read More Epidemiological aspects of the surgical correction of structural forefoot pathology. J Foot Ankle Surg 2009 Sep-Oct;48(5):543-51. Epub 2009 Jun 30. INOVA Fairfax Hospital, Podiatric Surgical Residency Office, Falls Church, VA 20042, USA.[pubfacts.com]
  • It constituted the highest proportion among the congenital limb defects in various epidemiological surveys.[docslide.net]
Sex distribution
Age distribution

Prevention

  • The anomalies are organized by anatomical system and presented in a consistent manner, including details of the clinical presentation, epidemiology, embryology, treatment and prevention for each anomaly.[books.google.de]
  • […] amputate before 1 year of age indications Type B Central Polydactyly Epidemiology commonly associated with syndactyly extra digit may lead to angular deformity or impaired motion Treatment osteotomy and ligament reconstructions indications perform early to prevent[orthobullets.com]
  • Some birth defects can be prevented. Taking folic acid can help prevent some birth defects. Talk to your doctor about any medicines you take. Some medicines can cause serious birth defects.[codelay.com]
  • Surgical corrections to prevent problems in adulthood may cause complications and lead to an undesirable outcome.[pubfacts.com]
  • In young children the treatment of the triphalangeal thumb with a delta phalanx consists of removal of the delta phalanx and K-wire fixation for at least 6 weeks to prevent displacement of the joint.[docslide.net]

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