Presentation
Rarely there is choriocarcinoma, and syncytiotrophoblast and hepatoid cells are occasionally present. [ncbi.nlm.nih.gov]
One presented with isosexual precocity, 8 while the remainder presented with abdominal pain and/or pelvic mass. [nature.com]
It presents a novel multidisciplinary approach to the subject as described by clinicians, surgeons, pathologists, basic scientists and related medical researchers. [books.google.com]
Entire Body System
- Pain
Symptoms of a polyembryoma may include an unusual bump or mass in the abdomen which can cause pain in some individuals; puberty at an unusually young age (known as precocious puberty); or irregularities in a female's menstruation. [diseaseinfosearch.org]
[…] if uterus in situ, D+C -indolent growth pattern -secondary debulking encouraged for recurrence pregnancy - incidence, management -1/800, 5% malignant -45% germ cell (dysgerminoma) -40% low grade epithelial -10% sex cord stroma -75% dx at stage 1 - pain [quizlet.com]
Side effects of treatment, which can be severe and include abdominal pain, bloating, fatigue, and infection, may prevent patients from completing all 6 cycles. [healthcommunities.com]
[…] distinctive look because they are composed of many parts that are shaped like embryos, one of the earliest stages of a developing human during pregnancy. [1] Symptoms of a polyembryoma may include an unusual bump or mass in the abdomen which can cause pain [rarediseases.info.nih.gov]
- Precocious Puberty
A 4.5-year-old boy presented with isosexual precocious puberty and an anterior mediastinal mass. Surgical resection demonstrated a teratoma with foci of malignant mixed germ cell tumor elements of polyembryoma. [ncbi.nlm.nih.gov]
puberty if E2 secreted -syncytiotrophoblast giant cells -unilateral -HIGH hCG -poor prognosis (worse than gestational associated) -rare -precocious puberty -2% bilateral -cal-exner bodies -inhibinA/B, E2 -90% survival -95% presenting at age 50 - 50% [quizlet.com]
Symptoms of a polyembryoma may include an unusual bump or mass in the abdomen which can cause pain in some individuals; puberty at an unusually young age (known as precocious puberty); or irregularities in a female's menstruation. [diseaseinfosearch.org]
[…] at an unusually young age (known as precocious puberty ); or irregularities in a female's menstruation. [rarediseases.info.nih.gov]
- Hodgkin Lymphoma
Abstracts: Polyembrioma of the testis: case report following chemotherapy for non-Hodgkin's lymphoma. G Chir.2002 Mar;23(3):65-70. Testicular tumours represent 2% of all male malignancies, mostly concerning young men (20-40 years old). [diagnostichistopathology.blogspot.com]
Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2 12 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2 13 Ipilimumab [malacards.org]
- Swelling
These symptoms may include bloating, pelvic pain, abdominal swelling, and loss of appetite, among others. [howlingpixel.com]
Case reports Case 1 A 41-year-old previously healthy Caucasian male presented with swelling of the right testis. [nature.com]
- Surgical Procedure
procedure and who had teratomatous elements in their primary tumor.[ 11 ] Surgical resection of residual masses detected by clinical examination, by radiographic procedures, or at re-exploration should be undertaken since reversion to germ cell tumor [northshore.org]
Unilateral salpingo-oophorectomy is the recommended surgical procedure. Although these tumors are highly malignant, cisplatin-based combination chemotherapy has resulted in some long-term survivors. [clinicalgate.com]
Gastrointestinal
- Abdominal Pain
Abdominal pain associated with a palpable pelvic–abdominal mass is present in approximately 85% of patients with germ cell tumors. [obgynkey.com]
[…] omentum, peritoneal bx -TAHBSO if childbearing complete -BEP x 4 cycles (unless Ia dysgerminoma or IaI immature teratoma) -RT for dysgerminoma curative 100% unilateral schiller-duval bodies AFP 80% survival - most aggressive rapid/ aggressive growth -75% abdominal [quizlet.com]
Side effects of treatment, which can be severe and include abdominal pain, bloating, fatigue, and infection, may prevent patients from completing all 6 cycles. [healthcommunities.com]
Abdominal enlargement and pelvic pain are the most common presenting symptoms. [clinicalgate.com]
pain with a large abdominal or pelvic mass, commonly with extraovarian spread (peritoneum, retroperitoneal nodes). • Tumor marker- elevated serum AFP is almost always present; a very high level is suggestive of the diagnosis 19. [slideshare.net]
- Pelvic Mass
[…] pressure due to the presence of a pelvic mass and menstrual irregularities. [academic.oup.com]
Abdominal pain associated with a palpable pelvic–abdominal mass is present in approximately 85% of patients with germ cell tumors. [obgynkey.com]
• Second most common malignant ovarian germ cell neoplasm • Common age- – second and third decades – first and fourth decades • Usual presentation is abdominal pain with a large abdominal or pelvic mass, commonly with extraovarian spread (peritoneum [slideshare.net]
One presented with isosexual precocity, 8 while the remainder presented with abdominal pain and/or pelvic mass. [nature.com]
Psychiatrical
- Suggestibility
The finding about AFP synthesis suggests that normal embryo at 15- or 16-day stage may begin AFP synthesis. Electron microscopic study showed that each part of the embryoid bodies had some characteristic structures. [ncbi.nlm.nih.gov]
Brenner tumors are occasionally found in mucinous cyst adenomas suggesting that these tumors arise from coelomic epithelial inclusion cysts through metaplasia of the cyst lining of transitional epithelium. [gradestack.com]
Several genes including KRAS2, JAW1 and SOX5 have been suggested as the candidate genes on 12p in TGCT. The candidate genes were searched in the 12p11.2p12.1 amplicon, and suggested that DAD-R is the most likely candidate. [atlasgeneticsoncology.org]
For more information on the types and their prognosis, we suggest you visit http://www.healthcommunities.com/ovarian-cancer/types.shtml [normaleah.org]
Urogenital
- Testicular Mass
Delia Perez Mexico City, Mexico 40 year old man with 6 cm testicular mass, 50% teratoma, 50% polyembryoma elements; AFP is 560 ng/ml (0 - 8.5), hGC is 111 mUI/ml (0 - 4), LDH is 176 UI/ml (119 - 230): various images Images hosted on other servers : Various [pathologyoutlines.com]
METHODS: Data were collected by searching our center's database using "testicular tumor" or "testicular mass" as keywords. Patients not operated in our hospital were excluded. [read.qxmd.com]
The testicular mass has been the presenting manifestation in almost 10% of the reported cases. Most of these tumors have distinctive features that enable them to be distinguished from primary testicular cancers. [archivesofpathology.org]
With the exception of one patient who presented with gynecomastia, 5 the clinical presentation is that of a testicular mass. [nature.com]
- Scrotal Mass
The tumors are generally large, more so in females in whom gonadal tumors are generally larger than in the male due to the later clinical presentation of an intra-abdominal as opposed to intra-scrotal mass. [nature.com]
Treatment
Cost for treatment Diagnostics of polyembryoma ovarian Chemotherapy of polyembryoma ovarian (1 course) Surgery treatment of polyembryoma ovarian University Hospital Rechts der Isar Munich location_on Germany, Munich Department of Gynecology, Mammology [bookinghealth.com]
CLOSE Medical Disclaimer The medical information on this site is provided as an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes. [diseaseinfosearch.org]
[…] part of treatment. [healthcommunities.com]
The breadth of information provided by this book will appeal to clinicians and researchers involved in the study and treatment of ovarian disorders. [books.google.ro]
Prognosis
[…] bodies -inhibinA/B, E2 -90% survival -95% presenting at age 50 - 50% hyperplasia -can present as: puberty, secondary amenorrhea, PMB, hemoperitoneum -unilateral -testosterone, androgens, AFP, inhibin A/B -90% survival - good prognosis -50% virilzation [quizlet.com]
General Poor prognosis. Almost never in pure form, i.e. usu. a component of a mixed germ cell tumour. [1] Microscopic Features: Disc shaped structure (embryo-like) with: The one side endoderm. Skin/CNS. The other side ectoderm. [librepathology.org]
The authors of this study suggest that prognosis might vary depending on the precise make-up of each tumor. [3] Last updated: 3/20/2012 Research helps us better understand diseases and can lead to advances in diagnosis and treatment. [rarediseases.info.nih.gov]
Etiology
The Authors analyse some aspects concerning etiology, pathology and clinical approach to such rare neoplasm. [diagnostichistopathology.blogspot.com]
Mostofi, FK 1973 Proceedings: testicular tumors Epidemiologic, etiologic and pathologic features. Cancer 32 1186 1201 Google Scholar 10. Exelby, P 1980 Testicular cancer in children Cancer 45 1803 1809 Google Scholar 11. [link.springer.com]
The etiology of embryonal cancer is not known. [bigmed.info]
Etiology No factors have been associated with the aetiology of GCT, apart from an increased incidence associated with dysgenetic gonads. 5% of patients with dysgerminomas are associated with constitutional cytogenetic abnormalities involving the entirety [atlasgeneticsoncology.org]
Epidemiology
The national database of the Saudi Cancer Registry (SCR) on testicular cancer over the last two decades was studied including epidemiological and histological patterns... [read.qxmd.com]
Mostofi, FK 1973 Proceedings: testicular tumors Epidemiologic, etiologic and pathologic features. Cancer 32 1186 1201 Google Scholar 10. Exelby, P 1980 Testicular cancer in children Cancer 45 1803 1809 Google Scholar 11. [link.springer.com]
Nonepithelial cancers among adults, Epidemiology, 1992, vol. 3 (pg. 490 - 495 ) 4. Clinicopathologic review of 118 granulosa and 82 theca cells tumors, Obstet Gynecol, 1980, vol. 55 (pg. 231 - 238 ) 5. [academic.oup.com]
Well-established epidemiologic causes of GCTs are listed in Table 4.2. The average age of patients at presentation significantly correlates with the pathologic type of GCTs (Table 4.3 ). [abdominalkey.com]
Epidemiology GCT predominantly affect young women, but they do sometimes occur in infants and older women. GCT account for over 60% of ovarian neoplasms in children and adolescents, one-third of which are malignant. [atlasgeneticsoncology.org]
Pathophysiology
The book emphasizes the correlation between clinical and pathologic features of female genital tract disease by examining the pathophysiology of individual organ systems. [books.google.com]
Mutism and pseudobulbar symptoms after resection of posterior fossa tumors in children: incidence and pathophysiology. Neurosurgery 37 (5): 885-93, 1995. [cancerinfo.tri-kobe.org]
Prevention
Those at very high risk may have their ovaries removed as a preventive measure. If caught and treated in an early stage, ovarian cancer is often curable. Treatment usually includes some combination of surgery, radiation therapy, and chemotherapy. [howlingpixel.com]
[…] cyclophosphamide 2 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin 3 Itraconazole Compared With Fluconazole to Prevent [malacards.org]
Side effects of treatment, which can be severe and include abdominal pain, bloating, fatigue, and infection, may prevent patients from completing all 6 cycles. [healthcommunities.com]
Prevention is not developed, however in emergence E. the river should consider a role genetic, a factor. Embryonal cancer of a small egg and an ovary — see the Small egg, tumors; Ovaries, tumors. Bibliography: Blochin H. [bigmed.info]