In contrast, the patient in the present study had a rapid decrease in VPA to 40.18 mg/L and completely recovered consciousness within 24 hr after an intensive therapy. [onlinelibrary.wiley.com]

The present results indicate that a polyene chain of greater than five carbon atoms was necessary for retinoid teratogenic activity and that the presence of the ring, the nine-carbon side chain, and the acidic polar terminus was insufficient to ensure [pubmed.ncbi.nlm.nih.gov]

NASH rat presented significantly elevated body weight and liver weight index, increased ROS content, declined SOD activity, enhanced liver function and inflammatory factors expression, and upregulated NF-κB mRNA and protein levels compared with control [x-mol.com]

• Weight Gain

  A single oral dose of each retinoid on Day 8 of gestation failed to induce signs of retinoid intoxication in the dams and the maternal weight gain was not affected significantly, except after treatment with beta-C14 aldehyde, pseudoionone, and the lowest [pubmed.ncbi.nlm.nih.gov]

• Sepsis

  Preclinical studies in mice confirmed that compound 6 had a much lower acute toxicity and higher antifungal efficacy in the model of mice candidosis sepsis compared with that of AmB (1). [pubs.acs.org]

• Liver Fibrosis

  Cutoff Values for Alcoholic Liver Fibrosis Using Magnetic Resonance Elastography Technique [J]. Alcoholism:Clinical and Experimental Research, 2012. [6] 沈薇. 非酒精性脂肪性肝病的药物治疗 [J]. [58.192.131.136]

• Generalized Seizure

  Valproic acid (VPA) is widely used to manage various clinical conditions, including partial and generalized seizure disorders, bipolar disorder and migraine prophylaxis. [onlinelibrary.wiley.com]

Due to low endogenous clearance of VPA and lack of specific antidote, extracorporeal treatment (EXTR) is reserved for severe cases in addition to standard therapy as suggested by the EXtracorporeal TReatments In Poisoning (EXTRIP) workgroup 2. [onlinelibrary.wiley.com]

Polyene phosphatidyl choline (PPC) is widely used in clinic for liver disease treatment. The effect and mechanism of PPC on NASH have not been fully elucidated. [x-mol.com]

A single oral dose of each retinoid on Day 8 of gestation failed to induce signs of retinoid intoxication in the dams and the maternal weight gain was not affected significantly, except after treatment with beta-C14 aldehyde, pseudoionone, and the lowest [pubmed.ncbi.nlm.nih.gov]

Metadoxine prevents damage produced by ethanol and acetaldehyde in hepatocyte and hepatic stellate cells in culture [J]. Pharmacological Research, 2001(5):431. [58.192.131.136]

For this reason, blood purification therapies aiming to quickly remove both protein-bound and free VPA should be considered in order to rapidly improve mental status and prevent further complications in some cases. [onlinelibrary.wiley.com]