Presentation
Additionally, rarer mitoses were present spontaneously in months, old, live flat cell cultures. [ncbi.nlm.nih.gov]
Many present day advance generation hybrids are the results of hybridization of these polyploids. [scholarspace.manoa.hawaii.edu]
Polyploidy and It’s Application in plant breeding PRESENTED BY: Pawan Nagar Reg. no.: 04-2690- 2015 M.Sc.(Fruit Science) 2. [slideshare.net]
Entire Body System
- Accelerated Growth
Accelerated growth in the absence of DNA replication origins. Nature. 2013;503:544–7. View Article PubMed PubMed Central Google Scholar Jensen MR, Løbner-Olesen A, Rasmussen KV. [biologydirect.biomedcentral.com]
- Inflammation
Global gene expression analyses of tetraploid endothelial cells revealed a dysfunctional phenotype characterized by a cell cycle arrest profile (decreased CCNE2/A2, RBL1, BUB1B; increased CDKN1A) and increased expression of genes involved in inflammation [ncbi.nlm.nih.gov]
- Hunting
Hunt, T. Webb, W. Beezhold, and J. F. Harmon. Accelerator-based radiation sources for next-generation radiobiological research. Nucl. Instrum. Methods Phys. Res. A 562:981–984.2006. Google Scholar W. [doi.org]
Cardiovascular
- Hypertension
This review focuses on relevant questions in deciphering the regulation of polyploidization of vascular smooth muscle cells (VSMC) in mammals and the role of polyploidy in various vascular pathologies, such as hypertension and aging. [ncbi.nlm.nih.gov]
The pregnant mother carrying a triploidy fetus sometimes experiences increase in blood pressure (hypertension), swelling (edema), and excretion of albumin in the urine (albuminuria). This condition is called toxemia or preeclampsia. [rarediseases.org]
Workup
Microbiology
- Gram-Positive Bacteria
The genomes of many Firmicutes (low G+C Gram-positive bacteria) have multiple (as many as 15) rRNA operons ( 25 ). The ribosomal RNA operon is preferentially amplified in some eukaryotes ( 26 – 28 ). [doi.org]
- Penicillium
Jeanne Ropars, Ying‐Chu Lo, Emilie Dumas, Alodie Snirc, Dominik Begerow, Tanja Rollnik, Sandrine Lacoste, Joëlle Dupont, Tatiana Giraud and Manuela López‐Villavicencio, Fertility depression among cheese‐making Penicillium roqueforti strains suggests degeneration [doi.org]
- Human Papillomavirus
Cervical and anogenital cancers are induced by the high-risk types of human papillomavirus (HPV). The HPV E6 oncoprotein induces polyploidy in human keratinocytes, yet the mechanism is not known. [ncbi.nlm.nih.gov]
Treatment
Treatment with doxorubicin, bleomycin, methotrexate, and paclitaxel significantly increased cellular IC50 values. [ncbi.nlm.nih.gov]
Colchicine Treatments : Colchicine treatment is the most effective and the most widely used treatment for chromosome doubling. [slideshare.net]
Based on Table 1 above, it can be said that the formation of polyploidy T1 treatment provides the highest triploid and T5 treatment provides the highest tetraploid formation. [omicsonline.org]
Prognosis
In conclusion, STMN1 overexpression could predict early tumor recurrence and poor prognosis, particularly at early stage of hepatoma. [ncbi.nlm.nih.gov]
Epidemiology
Roden MM, Zaoutis TE, Buchanan WL, Knudsen TA, Sarkisova TA, et al. (2005) Epidemiology and outcome of zygomycosis: a review of 929 reported cases. Clin Infect Dis 41: 634–653. View Article Google Scholar 7. [doi.org]
Prevention
Here, we studied polyploidy-associated senescence induced by BMS-777607 in breast cancer cells and its prevention by mTOR inhibitor AZD8055, leading to increased chemosensitivity. [ncbi.nlm.nih.gov]