Edit concept Question Editor Create issue ticket

Polyploidy

Triploidy


Presentation

  • Additionally, rarer mitoses were present spontaneously in months, old, live flat cell cultures.[ncbi.nlm.nih.gov]
  • In the present study, we demonstrated an antitumor activity of reversine that could suppress cellular proliferation and induce cell cycle arrest and apoptosis in human breast cancer cell lines.[ncbi.nlm.nih.gov]
  • In the present report, the cytogenetic investigation of an atypical choroid plexus papilloma occurring at the posterior fossa of a 16-year-old male is described.[ncbi.nlm.nih.gov]
  • The present findings indicate that the HDAC inhibitor could exert antitumor effects by inducing polyploidy, and this effect is more marked in transformed cells with nonfunctioning p21WAF1 or p53 genes.[ncbi.nlm.nih.gov]
  • Schemske 3 1 Department of Botany, University of Washington, Box 355325, Seattle, Washington 98195-5325; email: [email protected] 2 Present address: Department of Botany, University of Guelph, Guelph, Ontario N1G 2W1, Canada; email: [email protected][doi.org]

Workup

Albuminuria
  • The pregnant mother carrying a triploidy fetus sometimes experiences increase in blood pressure (hypertension), swelling (edema), and excretion of albumin in the urine (albuminuria). This condition is called toxemia or preeclampsia.[rarediseases.org]
Penicillium
  • Jeanne Ropars, Ying‐Chu Lo, Emilie Dumas, Alodie Snirc, Dominik Begerow, Tanja Rollnik, Sandrine Lacoste, Joëlle Dupont, Tatiana Giraud and Manuela López‐Villavicencio, Fertility depression among cheese‐making Penicillium roqueforti strains suggests degeneration[doi.org]
Human Papillomavirus
  • Cervical and anogenital cancers are induced by the high-risk types of human papillomavirus (HPV). The HPV E6 oncoprotein induces polyploidy in human keratinocytes, yet the mechanism is not known.[ncbi.nlm.nih.gov]

Treatment

  • Furthermore, reversine attenuated cell death in cells pretreated with a pan-caspase inhibitor before reversine treatment.[ncbi.nlm.nih.gov]
  • Cancer cells can undergo stress-induced premature senescence, which is considered to be a desirable outcome of anticancer treatment.[ncbi.nlm.nih.gov]
  • Treatment with doxorubicin, bleomycin, methotrexate, and paclitaxel significantly increased cellular IC50 values.[ncbi.nlm.nih.gov]
  • Co-treatment with the histone deacetylase inhibitor trichostatin A (TSA) potentiated bortezomib-induced apoptosis in parental RPMI 8226 cells but did not revert bortezomib resistance in 8226/7B cells.[ncbi.nlm.nih.gov]
  • All three GBM cell lines exhibited dose dependent reductions in cell number and colony formation ( 90% at 200nM) after treatment with UNC2025. Cell cycle analysis demonstrated accumulation of cells in the G2/M phase and development of polyploidy.[ncbi.nlm.nih.gov]

Prognosis

  • In conclusion, STMN1 overexpression could predict early tumor recurrence and poor prognosis, particularly at early stage of hepatoma.[ncbi.nlm.nih.gov]
  • Abstract Mantle cell lymphoma (MCL) is characterized by genetic instability and a poor prognosis. Many blastoid variants are (hypo)tetraploid and have an even worse prognosis.[ncbi.nlm.nih.gov]
  • Structural chromosomal abnormalities are common in myelodysplastic syndromes (MDSs), and complex abnormalities are known to confer a poor prognosis. Polyploidy is rare.[ncbi.nlm.nih.gov]
  • Abstract Aneuploidy is a characteristic of most solid tumors, often associated with negative prognosis. It can arise from two principal mechanisms: from a tetraploid intermediate state, or directly from errors at cell division.[ncbi.nlm.nih.gov]
  • These results have important implications for our understanding of the role of Tbx2 in tumorigenesis because polyploidy frequently precedes aneuploidy, which is associated with high malignancy and poor prognosis.[ncbi.nlm.nih.gov]

Etiology

  • Genome Biology 5(12), art. no. 250 Google Scholar Veitia RA (2002) Exploring the etiology of haploinsufficiency.[doi.org]

Epidemiology

  • A.. 1997 Application of DNA typing methods and genetic analysis to epidemiology and taxonomy of Saccharomyces isolates. J. Clin. Microbiol. 35, 1822–1828. PubMed, Google Scholar 47 Soltis D. E.& Soltis P.[doi.org]
  • Roden MM, Zaoutis TE, Buchanan WL, Knudsen TA, Sarkisova TA, et al. (2005) Epidemiology and outcome of zygomycosis: a review of 929 reported cases. Clin Infect Dis 41: 634–653. View Article Google Scholar 7.[doi.org]
Sex distribution
Age distribution

Prevention

  • Here, we studied polyploidy-associated senescence induced by BMS-777607 in breast cancer cells and its prevention by mTOR inhibitor AZD8055, leading to increased chemosensitivity.[ncbi.nlm.nih.gov]
  • Moreover, the emergence of polyploid endothelial cells during replicative aging and glucose overload can be prevented by optimizing the Nampt-SIRT1 axis.[ncbi.nlm.nih.gov]
  • We further show that multiple small-molecule inhibitors of the phosphatidylinositol 3-kinase-related kinase (PIKK) family, including those that target ATR, ATM, and mTOR, indirectly prevent Vpr-mediated polyploidy by preventing G 2 arrest.[ncbi.nlm.nih.gov]
  • Abstract During a normal cell cycle, polyploidy and aneuploidy can be prevented by several checkpoints, which are mainly p53 dependent.[ncbi.nlm.nih.gov]
  • The spindle assembly checkpoint (SAC) is a conserved mechanism that ensures the fidelity of chromosome distribution in mitosis by preventing anaphase onset until the correct bipolar microtubule-kinetochore attachments are formed.[ncbi.nlm.nih.gov]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!