Presentation
Additionally, rarer mitoses were present spontaneously in months, old, live flat cell cultures. [ncbi.nlm.nih.gov]
Entire Body System
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Accelerated Growth
Accelerated growth in the absence of DNA replication origins. Nature. 2013;503:544–7. View Article PubMed PubMed Central Google Scholar Jensen MR, Løbner-Olesen A, Rasmussen KV. [biologydirect.biomedcentral.com]
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Inflammation
Global gene expression analyses of tetraploid endothelial cells revealed a dysfunctional phenotype characterized by a cell cycle arrest profile (decreased CCNE2/A2, RBL1, BUB1B; increased CDKN1A) and increased expression of genes involved in inflammation [ncbi.nlm.nih.gov]
Workup
Microbiology
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Penicillium
Jeanne Ropars, Ying‐Chu Lo, Emilie Dumas, Alodie Snirc, Dominik Begerow, Tanja Rollnik, Sandrine Lacoste, Joëlle Dupont, Tatiana Giraud and Manuela López‐Villavicencio, Fertility depression among cheese‐making Penicillium roqueforti strains suggests degeneration [doi.org]
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Human Papillomavirus
Cervical and anogenital cancers are induced by the high-risk types of human papillomavirus (HPV). The HPV E6 oncoprotein induces polyploidy in human keratinocytes, yet the mechanism is not known. [ncbi.nlm.nih.gov]
Colonoscopy
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Polyps
Not to be confused with "polypoid", resembling a polyp. This image shows haploid (single), diploid (double), triploid (triple), and tetraploid (quadruple) sets of chromosomes. Triploid and tetraploid chromosomes are examples of polyploidy. [en.wikipedia.org]
Treatment
Treatment with doxorubicin, bleomycin, methotrexate, and paclitaxel significantly increased cellular IC50 values. [ncbi.nlm.nih.gov]
Prognosis
In conclusion, STMN1 overexpression could predict early tumor recurrence and poor prognosis, particularly at early stage of hepatoma. [ncbi.nlm.nih.gov]
Etiology
Genome Biology 5(12), art. no. 250 Google Scholar Veitia RA (2002) Exploring the etiology of haploinsufficiency. [doi.org]
Epidemiology
A.. 1997 Application of DNA typing methods and genetic analysis to epidemiology and taxonomy of Saccharomyces isolates. J. Clin. Microbiol. 35, 1822–1828. PubMed, Google Scholar 47 Soltis D. E.& Soltis P. [doi.org]
Prevention
Here, we studied polyploidy-associated senescence induced by BMS-777607 in breast cancer cells and its prevention by mTOR inhibitor AZD8055, leading to increased chemosensitivity. [ncbi.nlm.nih.gov]