Physicians should consider DMI in the differential diagnosis of patients with diabetes who present with painful, swollen muscles without systemic signs of infection. [ncbi.nlm.nih.gov]

Four years after diagnosis he presented following a school camp with respiratory distress, decreased level of consciousness (GCS 10), poor perfusion (capillary refill time 4 seconds) and pH 6.92. [nzma.org.nz]

His presentation, clinical examination and imaging all suggested the diagnosis of muscle infarction. He was managed conservatively with analgesia, and allowed to mobilise. He made a good recovery. [endocrine-abstracts.org]

Based on her imaging, laboratory data, and clinical presentation she was diagnosed with HGB. [pancreas.imedpub.com]

• Weight Loss

  Weight loss. Since sugars can’t be used to produce energy, your body tries to produce it using fats, which causes sugars stored in fat tissue to mobilize. This is one of the possible reasons for weight loss in people with diabetes. [ihhub.org]

  At the time of presentation, he reported nausea and a 10-kg weight loss. Physical examination revealed epigastric tenderness without rebound tenderness. Abdominal computed tomography revealed periduodenal edema. [acgcasereports.gi.org]

  For many Type II diabetics, weight loss may be an important goal in helping them to control their diabetes. [medical-dictionary.thefreedictionary.com]

  Ten-year followup of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study. Lancet. 2009 Nov 14;374(9702):1677-86. 3 Centers for Disease Control and Prevention. [healthypeople.gov]

  The common symptoms are fatigue, extreme thirst and hunger, excessive urination, and weight loss. This type of diabetes requires a person to receive insulin, either through multiple injections each day, or a continuous pump. [verywell.com]

• Inflammation

  A muscle biopsy demonstrated coagulation necrosis in the skeletal muscle with inflammation and infarction in the walls of small blood vessels. [ncbi.nlm.nih.gov]

  This systemic inflammation can reduce tissue response to circulating insulin, thereby reducing glucose uptake by cells and causing hyperglycemia. [decisionsindentistry.com]

  Ferritin synthesis in inflammation. Br. J. Haematol. 1977: 37, 7–16. Google Scholar 11. Woo, I., Mak, Y. T., Law, L. K. et al. Plasma ferritin in an elderly population living in the community. J. Med. 1989: 20, 123–34. PubMed Google Scholar 12. [link.springer.com]

• Fatigue

  Tags: acromegaly, alcohol abuse, ancreatitis, beta-cell failure, chest pain, Cushing's syndrome, cystic fibrosis, depression, Diabetes, diabetes mellitus, easy bruising, edema, endogenous, exogenous glucocorticoids, facial plethora, fatigue, hemochromatosis [blogs.nejm.org]

  Symptoms Extreme fatigue and excessive hunger. As a consequence of lack of food in the cells, they do not produce energy and their functions become altered. [ihhub.org]

  Signs of diabetes When undiagnosed or uncontrolled, the effects of diabetes on the body can be noticed by the classic symptoms of diabetes, namely: Increased thirst Frequent need to urinate Fatigue Blurred vision and Tingling or pain in the hands, feet [diabetes.co.uk]

  The common symptoms are fatigue, extreme thirst and hunger, excessive urination, and weight loss. This type of diabetes requires a person to receive insulin, either through multiple injections each day, or a continuous pump. [verywell.com]

  Fatigue. If your cells are deprived of sugar, you may become tired and irritable. Blurred vision. If your blood sugar is too high, fluid may be pulled from the lenses of your eyes. This may affect your ability to focus. [mayoclinic.org]

• Epilepsy

  Chirch, MD, et al December 7, 2017 More Education Center October 3, 2018 Recommendations to Improve Asthma Outcomes: Work Group Call to Action October 3, 2018 October 3, 2018 June 20, 2018 Neurology Board Review: Epilepsy June 20, 2018 June 20, 2018 May [jcomjournal.com]

• Polydipsia

  This leads to a certain level of dehydration that can be perceived by the person with diabetes as an increase in thirst (polydipsia). Water elimination makes people with poorly controlled diabetes tend to urinate more often than normal (polyuria). [ihhub.org]

  Characteristically the course is progressive and includes polyuria, polydipsia, weight loss, polyphagia, hyperglycemia, and glycosuria. [medical-dictionary.thefreedictionary.com]

  In both children and adults, obesity increases the risk of developing type 2 diabetes. 3 Symptoms of both types of diabetes include fatigue, weight loss, polyuria and polydipsia, resulting from hyperglycemia. [decisionsindentistry.com]

  Clinical manifestations include the following: Classic symptoms: Polyuria, polydipsia, polyphagia, and weight loss Blurred vision Lower-extremity paresthesias Yeast infections (eg, balanitis in men) See Presentation for more detail. [emedicine.medscape.com]

• Jaundice

  Newborn complications : These include breathing problems, low blood sugar levels and jaundice (yellowing of the skin). These complications can be treated, but it's better to prevent them by controlling blood sugar levels during pregnancy. [health.am]

  Children of women with gestational diabetes are more likely to be born prematurely, have hypoglycemia, or have severe jaundice at birth. The condition usually is treated by diet, however, insulin injections may be required. [medical-dictionary.thefreedictionary.com]

• Hepatomegaly

  The next day, following administration of intravenous fluids and insulin, he was noted to have hepatomegaly. [nzma.org.nz]

• Blurred Vision

  Signs of diabetes When undiagnosed or uncontrolled, the effects of diabetes on the body can be noticed by the classic symptoms of diabetes, namely: Increased thirst Frequent need to urinate Fatigue Blurred vision and Tingling or pain in the hands, feet [diabetes.co.uk]

  Blurred vision. If your blood sugar is too high, fluid may be pulled from the lenses of your eyes. This may affect your ability to focus. Slow-healing sores or frequent infections. Type 2 diabetes affects your ability to heal and resist infections. [mayoclinic.org]

  Other symptoms may include sudden weight loss, slow wound healing, urinary tract infections, gum disease, or blurred vision. [medical-dictionary.thefreedictionary.com]

  These include: Frequent urination Excessive thirst and/or hunger Dry mouth Unexplained weight loss Blurred vision Lack of energy and extreme tiredness What to do if you have high blood sugar: Call the doctor to see if a change in medication is needed. [onetouch.com]

  Clinical manifestations include the following: Classic symptoms: Polyuria, polydipsia, polyphagia, and weight loss Blurred vision Lower-extremity paresthesias Yeast infections (eg, balanitis in men) See Presentation for more detail. [emedicine.medscape.com]

• Ulcer

  Endoscopic view of a 2.5-cm ulcer in the proximal descending duodenum without stigmata of recent hemorrhage. Part of the ulcer base is concealed by surrounding edema. Note the mural spasm near the ulcer. [acgcasereports.gi.org]

  Specific diabetes codes require additional codes in order to identify the manifestation further, such as diabetes with foot ulcer to identify the site of the ulcer, or diabetes with chronic kidney disease to identify the stage of chronic kidney disease [codeitrightonline.com]

  […] al piede è inversamente proporzionale al controllo glicemico Quadri clinici (stadi di gravità crescente): ulcere superficiali senza infezione ulcere profonde spesso infette ulcere profonde con ascessi/osteomielite gangrena distale gangrena estesa Prevenzione [federica.unina.it]

  Neuropathy can allow injuries to go unnoticed, leading to ulcers, serious infections and in some cases, amputations. [onetouch.com]

  E11.622 Type 2 diabetes mellitus with other skin ulcer E11.628 Type 2 diabetes mellitus with other skin complications E11.63 Type 2 diabetes mellitus with oral complications E11.630 Type 2 diabetes mellitus with periodontal disease E11.638 Type 2 diabetes [icd10data.com]

• Delayed Wound Healing

  Poor blood circulation in the legs and feet contribute to delayed wound healing. [medical-dictionary.thefreedictionary.com]

  Diabetic patients have increased frequency of periodontitis and tooth loss [ 2 ], delayed wound healing [ 3 ], and impaired response to infection. [journalimplantdent.springeropen.com]

• Polyuria

  Water elimination makes people with poorly controlled diabetes tend to urinate more often than normal (polyuria). [ihhub.org]

  Characteristically the course is progressive and includes polyuria, polydipsia, weight loss, polyphagia, hyperglycemia, and glycosuria. [medical-dictionary.thefreedictionary.com]

  In both children and adults, obesity increases the risk of developing type 2 diabetes. 3 Symptoms of both types of diabetes include fatigue, weight loss, polyuria and polydipsia, resulting from hyperglycemia. [decisionsindentistry.com]

  Clinical manifestations include the following: Classic symptoms: Polyuria, polydipsia, polyphagia, and weight loss Blurred vision Lower-extremity paresthesias Yeast infections (eg, balanitis in men) See Presentation for more detail. [emedicine.medscape.com]

• Peripheral Neuropathy

  At presentation, his glycosylated hemoglobin was 9.1% with known diabetic complications of proliferative diabetic retinopathy, peripheral neuropathy, and nephropathy (stage 4 chronic kidney disease). [pancreas.imedpub.com]

  Peripheral neuropathy also increases the risk for diabetic foot infections. Immune system in diabetes mellitus Hyperglycemia may compromise the immune system. [diapedia.org]

  Nerve damage Nerve damage (neuropathy) results from prolonged high blood glucose levels and can result in damage to any nerve in the body. The most common form is peripheral neuropathy, which mainly affects the sensory nerves in the feet. [onetouch.com]

  However, peripheral neuropathy is probably the most common complication, present in approximately 40% of patients with diabetes and leading to limb amputation in conjunction with peripheral vascular disease in many [ 11 ]. [em-consulte.com]

  For example, diabetic retinopathy (loss of peripheral vision or visual acuity), or peripheral neuropathy (loss of feeling in the feet) can impair a driver’s ability to read street signs, control the speed of the vehicle, apply appropriate pressure to [en.wikipedia.org]

• Dizziness

  Symptoms of low blood sugar: dizziness, sweating, shaking, tingling of the lips or tongue, racing heart, confusion, difficulty speaking. If low blood sugar goes untreated, it can result in unconsciousness, coma, or even death. [verywell.com]

  These may include nausea, vomiting, dizziness on arising, intoxication, delirium, coma, or death. [medical-dictionary.thefreedictionary.com]

Overweight and 1 or more other risk factors for diabetes (eg, first-degree relative with diabetes, BP >140/90 mm Hg, and HDL < 35 mg/dL and/or triglyceride level >250 mg/dL) ADA recommends screening at age 45 years in the absence of the above criteria See Workup [emedicine.medscape.com]

Antidiabetic treatment was readjusted. Three months after treatment, her gait and ideomotor apraxia had improved but the cognitive sequelae persisted. [elsevier.es]

In all patients, intensive insulin treatment had been applied for 6 months. After 6 months, HbA 1c was measured. [termedia.pl]

The pathology, clinical features, diagnosis and treatment of this disorder are discussed. [ncbi.nlm.nih.gov]

Treatment of malignant otitis externa always includes antimicrobial treatment, and in most cases also surgical debridement. No conclusive evidence exists for the role of hyperbaric oxygen therapy. [diapedia.org]

Guidelines for the diagnosis and treatment of diabetes and its complications were also identified. [em-consulte.com]

Cortical involvement in Marchiafava-Bignami disease can be a predictor of a poor prognosis: a case report and review of the literatura. [elsevier.es]

The increased occurrence of Staphylococcus aureus as a causative organism is a likely explanation for the worse prognosis of patients with endocarditis and diabetes mellitus. [diapedia.org]

Macroangiopatia Patologia cerebrovascolare Il rischio di patologia cerebrovascolare è aumentato nel diabetico, con incremento di 3 volte dell’ictus La prognosi è peggiore nel diabetico che nel non diabetico (minori possibilità di ricupero funzionale e [federica.unina.it]

Prognosis Uncontrolled diabetes is a leading cause of blindness, end-stage renal disease, and limb amputations. It also doubles the risks of heart disease and increases the risk of stroke. [medical-dictionary.thefreedictionary.com]

Prognosis The prognosis in patients with diabetes mellitus is strongly influenced by the degree of control of their disease. [emedicine.medscape.com]

The etiology of type 2 diabetes mellitus appears to involve complex interactions between environmental and genetic factors. [emedicine.medscape.com]

Etiology Type 1 DM is caused by autoimmune destruction of the insulin-secreting beta cells of the pancreas. The loss of these cells results in nearly complete insulin deficiency; without exogenous insulin, type 1 DM is rapidly fatal. [medical-dictionary.thefreedictionary.com]

Clinical and epidemiological research Poorly controlled type 2 diabetes mellitus is associated with a decreased risk of incident gout: a population-based case-control study Saskia G Bruderer 1, 2, Michael Bodmer 3, Susan S Jick 4, Christoph R Meier 1, [ard.bmj.com]

Epidemiological studies indicate that diabetes is likely to reach epidemic proportions within the next few decades. [em-consulte.com]

National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants. [healthypeople.gov]

OBJECTIVES After reading this course, the participant should be able to: Describe the epidemiology of diabetes in pediatric patients, and common oral complications in this population. [decisionsindentistry.com]

In comparison, the thrifty phenotype hypothesis is based on epidemiological observations linking low birth weight with the risk of adult disease (obesity, diabetes and hypertension). [federica.unina.it]

Recent studies propose a common pathophysiology between diabetes and Alzheimer’s disease. The similarities in the pathophysiology have given way to the thought that Alzheimer’s disease could be viewed as a new form of diabetes mellitus. [brainblogger.com]

These authors suggest that osmotic changes secondary to glycaemic fluctuations constitute the pathophysiological mechanism. These descriptions match those of our patient, who had been admitted repeatedly due to hyperglycaemic episodes. [elsevier.es]

[…] settings where the test may be helpful Evaluating the long-term control of blood glucose concentrations in diabetic patients Diagnosing diabetes Identifying patients at increased risk for diabetes (prediabetes) Clinical Information Discusses physiology, pathophysiology [mayomedicallaboratories.com]

Diabetes Care 1992; 15: 318-354 Pathophysiology of type 2 diabetes Type 2 diabetes is a heterogeneous disorder Characterised by two fundamental defects Insulin Resistance + Beta-cell dysfunction = Type 2 diabetes Part of the Insulin Resistance Syndrome [federica.unina.it]

A simplified scheme for the pathophysiology of abnormal glucose metabolism in type 2 diabetes mellitus is depicted in the image below. Simplified scheme for the pathophysiology of type 2 diabetes mellitus. [emedicine.medscape.com]

JAMA. 2015;314(10):1052-62. 2 Knowler WC, Fowler SE, Hamman RF, et al; Diabetes Prevention Program Research Group. Ten-year followup of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study. [healthypeople.gov]

A well‐rounded diabetes management plan can help prevent diabetes‐related health problems. [onetouch.com]

Rodondi: University Outpatient Clinic and University Institute of Social and Preventive Medicine, Department of Community Medicine and Public Health, University of Lausanne, Bugnon 44, 1011 Lausanne, Switzerland. Ms. Peng and Drs. [annals.org]

Vas deferens is cut, preventing sperm from entering the urethra and thus preventing fertilization. [quizlet.com]

Diabetes has a substantial effect on the body Knowing how diabetes affects your body can help you look after your body and prevent diabetic complications from developing. [diabetes.co.uk]