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Porphyromonas Gingivalis


Presentation

  • ., Australia Authors who contributed equally to the work presented in this article. Search for more papers by this author A.[doi.org]
  • The present study aimed to investigate the effects of lipopolysaccharides (LPS) derived from Porphyromonas gingivalis on ephrin/Eph signalling in periodontal ligament fibroblasts (PDLFs).[ncbi.nlm.nih.gov]
  • Analysis of these patterns indicated that two strains of P. gingivalis were present in 41 individuals (45.6%) and three strains were present in 13 individuals (14.4%).[ncbi.nlm.nih.gov]
  • In addition, some useful clinical biomarkers and novel proteins were also presented.[ncbi.nlm.nih.gov]
  • Abstract A 67-year-old man presented with a rare case of cavernous sinus thrombophlebitis (CST) caused by Porphyromonas gingivalis with abscess formation extending to the orbital cavity.[ncbi.nlm.nih.gov]
Pharyngitis
  • It has been reported that the oral bacterium Streptococcus anginosus is associated with esophageal, gastric, and pharyngeal cancers. We previously reported occurrence of Porphyromonas gingivalis (P. gingivalis) DNA in esophagus cancer.[ncbi.nlm.nih.gov]
  • Pharyngeal aspiration in normal adults and patients with depressed consciousness. The American journal of medicine. 1978;64(4):564-8. Mojon P. Oral health and respiratory infection. J Can Dent Assoc. 2002;68(6):340-5. Scannapieco FA, Rethman MP.[revistas.ces.edu.co]
Homonymous Hemianopsia
  • The patient presented with right-sided homonymous hemianopsia and right hemiparesis. Emergent surgical drainage was performed and antibiotics were administered. P. gingivalis was identified from the anaerobic culture of the abscess.[ncbi.nlm.nih.gov]

Workup

Colitis
  • Ulcerative colitis and irritable bowel patients exhibit distinct abnormalities of the gut microbiota. BMC Gastroenterol. 10,134 ( 2010 ). Crossref , Medline , Google Scholar 99 Pédron T, Sansonetti P.[futuremedicine.com]
  • It was recently demonstrated that a small-molecule inhibitor of a Clostridium difficile cysteine protease virulence factor, TcdB, reduced disease pathology in a mouse model of C. difficile– induced colitis but did not reduce the C. difficile bacterial[doi.org]
Trophoblastic Cells
  • METHODS: The immortalized trophoblast cell line HTR-8/SVneo was cultured on plates or via hanging drop to evaluate viability, apoptosis, and morphology in the presence of the culture supernatant of Pg (PG-sup).[ncbi.nlm.nih.gov]

Treatment

  • Moreover, internalized P. gingivalis can survive antibiotic treatment in vitro.[ncbi.nlm.nih.gov]
  • Many protocols for the prevention and treatment of oral infections have been described, yet no golden standard has been developed so far. The antiseptic chlorhexidine and antibiotics are often used in these treatment procedures.[ncbi.nlm.nih.gov]
  • RESULTS: Compared with cells incubated with IFNγ or IL-4 alone in the "polarisation" phase, macrophages that were incubated with LPS during the first 24h displayed a down-regulation of TNF and IL-1β production upon secondary LPS treatment in the "activation[ncbi.nlm.nih.gov]
  • Successful treatment of perio-endo lesions with photo-activated disinfection (PAD) as a novel therapeutic approach depends on the selection of an appropriate target site, specific photosensitizer (PS), and wavelength of light.[ncbi.nlm.nih.gov]
  • ICG-sPAD with the maximum ability to reduce rgpA gene expression compared with other photosensitizers can be an appropriate candidate for the treatment of endodontic infections.[ncbi.nlm.nih.gov]

Prognosis

  • Abstract Major obstacles to improving the prognosis of patients with oral squamous cell carcinoma (OSCC) are the acquisition of resistance to chemotherapeutic agents and development of metastases.[ncbi.nlm.nih.gov]
  • However, it is clear that the prognosis for periodontal health after dental treatment is much better for patients whose blood sugar levels are well controlled.[herenciageneticayenfermedad.blogspot.com]

Etiology

  • The chief etiologic agent for aggressive periodontitis is considered to be Actinobacillus actinomycetemcomitans in localized juvenile periodontitis.[ncbi.nlm.nih.gov]
  • This provides evidence that the specificity of interbacterial coadhesion may influence directly the etiology of pulpal and periapical diseases.[ncbi.nlm.nih.gov]
  • Although the exact etiology is still unclear, Gram-negative bacteria, especially Porphyromonas gingivalis in subgingival pockets are thought to be one of the major etiologic agents of periodontitis.[ncbi.nlm.nih.gov]
  • Porphyromonas gingivalis, an important etiological agent of periodontal disease, is frequently found associated with Treponema denticola, an anaerobic spirochete, in pathogenic biofilms.[ncbi.nlm.nih.gov]
  • BACKGROUND: Porphyromonas gingivalis is one of the etiological agents in the initiation of combined periodontal-endodontic (perio-endo) lesions.[ncbi.nlm.nih.gov]

Epidemiology

  • Involvement of Porphyromonas gingivalis in atherosclerosis is supported by observations from epidemiological, clinical, immunological, and molecular studies.[ncbi.nlm.nih.gov]
  • Abstract Strong epidemiological evidence supports an association between cardiovascular and periodontal disease and furthermore, the periodontopathogen Porphyromonas gingivalis has been identified in blood and from atheromatous plaques.[ncbi.nlm.nih.gov]
  • In addition, epidemiological studies have demonstrated that periodontitis, the most common chronic inflammatory condition of the oral cavity, is closely associated with oral cancer.[ncbi.nlm.nih.gov]
  • Abstract Recent epidemiological studies revealed a significant association between oral squamous cell carcinoma (OSCC) and Porphyromonas gingivalis , a major pathogen of periodontal disease.[ncbi.nlm.nih.gov]
  • Several epidemiological studies have suggested that periodontitis may be a risk factor for CVD.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • An increased risk of pregnancy complications has been reported in patients with periodontitis; however, its pathophysiology remains uncharacterized to date.[ncbi.nlm.nih.gov]
  • Altogether, these findings underline a biological function of gingipain K as an IgG protease of pathophysiological importance.[ncbi.nlm.nih.gov]
  • Footnotes Address correspondence to Fusanori Nishimura, Department of Pathophysiology/Periodontal Science, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8525, Japan.[care.diabetesjournals.org]
  • Know its frequency and other microorganisms Red complex and Aggregatibacter actinomycetemcomitans in diabetic and non-diabetic patients to determine the role of microbiota in the pathophysiology of periodontitis in diabetics.[revistas.javeriana.edu.co]
  • Qazazi, Jun Sun and Ikuko Kato , Oral Microbiome: Potential Link to Systemic Diseases and Oral Cancer , Mechanisms Underlying Host-Microbiome Interactions in Pathophysiology of Human Diseases , 10.1007/978-1-4939-7534-1_9 , (195-246) , (2018) .[doi.org]

Prevention

  • The lack of effective treatments has emphasised in an intense search for alternative methods to prevent bacterial colonisation and disease progression.[ncbi.nlm.nih.gov]
  • A variety of substances, such as vitamin D, have growth-inhibitory effects on some bacterial pathogens and have shown chemo-preventive and anti-inflammatory activity.[ncbi.nlm.nih.gov]
  • These data demonstrate that P. gingivalis CPS is a vaccine candidate for prevention of P. gingivalis-elicited oral bone loss.[ncbi.nlm.nih.gov]
  • Despite this, there are no vaccines in use for the prevention of adult periodontitis.[doi.org]
  • Given the above properties, green tea catechins may represent promising preventive and therapeutic molecules against periodontal disease.[ncbi.nlm.nih.gov]

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