@inproceedings{Thompson2017NovelEO, title={Novel Effects of Mibefradil, An Anti-Cancer Drug, on White Adipocytes}, author={Sonia Thompson}, year={2017} } Sonia Thompson Published 2017 The present study was undertaken to investigate the effects of the [semanticscholar.org]

The following drug information is obtained from various newswires, published medical journal articles, and medical conference presentations. [centerwatch.com]

Abstract The present study was undertaken to investigate the effects of the T-type calcium channel blocker, Mibefradil, on white adipocytes. [scholarworks.gsu.edu]

Subscribe Subscriptions to The Medical Letter on Drugs and Therapeutics include: Print version published and mailed biweekly (26 issues/year) Unlimited online access to current and past issues (1988 - present) Mobile App for iOS, Android, and Kindle Fire [secure.medicalletter.org]

• Weakness

  Methanol (Slightly), Water (Slightly) Stability Hygroscopic Category Standards; Pharmaceutical/API Drug Impurities/Metabolites; Applications Mibefradil Dihydrochloride Hydrate is a nondihydropyridine calcium channel blocker with potent vasodilator but weak [trc-canada.com]

  The reasons for the pain are many, including bad posture, accidents, improper lifting, obesity, and weak muscles. Practice prevention to minimize your risk for back pain — get regular exercise, lose any excess weight, and learn good posture. [apps.childrensdmc.org]

  Tell your doctor if any of these symptoms, or those in the SPECIAL PRECAUTIONS section, are severe or do not go away: general weakness nausea vomiting diarrhea stomach pain anxiety back pain bone, joint, or muscle pain muscle cramps difficulty falling [medlineplus.gov]

  Contact your doctor immediately if you experience unexplained muscle pain, tenderness, or weakness, especially if it is accompanied by a fever or flu-like symptoms or yellowing of your skin or eyes. [drugs.com]

• Leg Edema

  [Ref] The only cardiovascular side effect that has occurred more often among treated patients compared with placebo is leg edema (4% vs. 3%). Leg edema has been dose-related. [drugs.com]

  Treatment with the 100-mg dose was associated with a slightly higher incidence compared to placebo of dizziness (2.1% vs 1.8%), leg edema (3.5% vs 1.4%), fatigue (2.1% vs 1.4%), and lightheadedness (2.1% vs 0.4%). [em-consulte.com]

  The T- and L-type calcium channel blocker (CCB) mibefradil attenuates leg edema induced by the L-type CCB nifedipine in the spontaneously hypertensive rat: a novel differentiating assay. J Pharmacol Exp Ther 325:723-31 (2008). [abcam.com]

  Mibefradil was better tolerated than amlodipine (mainly with regard to leg edema) and similarly well tolerated as diltiazem CD. References Mishra S, Hermsmeyer K: Selective inhibition of T-type Ca2+ channels by Ro 40-5967. Circ Res 1994;75:144–148. [karger.com]

• Fever

  For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. [ndrugs.com]

  Contact your doctor immediately if you experience unexplained muscle pain, tenderness, or weakness, especially if it is accompanied by a fever or flu-like symptoms or yellowing of your skin or eyes. [drugs.com]

  […] the dose of your lomitapide while you are taking your other medicine.Let your doctor know right away if you have any pain or discomfort in the upper right stomach (abdominal) area, yellowing of the skin or eyes, loss of appetite, nausea or vomiting, fever [webmd.com]

  […] weakness in the arms or legs changes in the sense of touch shortness of breath cough swelling of the feet, ankles, or lower legs hives rash itching difficulty breathing or swallowing swelling of the face, throat, tongue, lips, eyes, or hands hoarseness fever [medlineplus.gov]

• Chills

  […] legs changes in the sense of touch shortness of breath cough swelling of the feet, ankles, or lower legs hives rash itching difficulty breathing or swallowing swelling of the face, throat, tongue, lips, eyes, or hands hoarseness fever, sore throat, chills [medlineplus.gov]

• Rhinitis

  The most common headache, leg oedema and rhinitis were suffered in almost similar levels in the placebo group leaving just the feeling of light headedness as being a genuine side effect. [healthy.net]

  [Ref] Respiratory Rhinitis is the only reported respiratory system side effect that occurred significantly more often among treated patients compared with placebo (3% vs. 0%). [drugs.com]

  SELDANE (terfenadine) Approved in 1985, Seldane was a great breakthrough in the allergy arena, in that it treated the symptoms of allergic rhinitis, but without the drowsiness and fatigue of other antihistamines. And it earned its weight in gold. [drugsdb.com]

• Nausea

  Posicor side effects Side effects of Posicor include: Dizziness Headache Leg swelling Abdominal pain Nausea Unusual fatigue Nasal congestion Contact our law offices for a free case evaluation about your potential Posicor lawsuit If you or a loved one [farrin.com]

  Abdominal pain, belching, heartburn, flushing, headache, nausea and vomiting, dizziness, lightheadedness, bradycardia, peripheral oedema, chest pain. [mims.com]

  […] discontinue or adjust the dose of your lomitapide while you are taking your other medicine.Let your doctor know right away if you have any pain or discomfort in the upper right stomach (abdominal) area, yellowing of the skin or eyes, loss of appetite, nausea [webmd.com]

• Vomiting

  Drink plenty of fluids every day during your treatment with bortezomib, especially if you vomit or have diarrhea. If you miss an appointment to receive a dose of bortezomib, call your doctor right away. Bortezomib may cause side effects. [medlineplus.gov]

  Abdominal pain, belching, heartburn, flushing, headache, nausea and vomiting, dizziness, lightheadedness, bradycardia, peripheral oedema, chest pain. [mims.com]

  […] or adjust the dose of your lomitapide while you are taking your other medicine.Let your doctor know right away if you have any pain or discomfort in the upper right stomach (abdominal) area, yellowing of the skin or eyes, loss of appetite, nausea or vomiting [webmd.com]

• Abdominal Pain

  Posicor side effects Side effects of Posicor include: Dizziness Headache Leg swelling Abdominal pain Nausea Unusual fatigue Nasal congestion Contact our law offices for a free case evaluation about your potential Posicor lawsuit If you or a loved one [farrin.com]

  Abdominal pain, belching, heartburn, flushing, headache, nausea and vomiting, dizziness, lightheadedness, bradycardia, peripheral oedema, chest pain. [mims.com]

  [Ref] Gastrointestinal side effects have basically been limited to abdominal pain in 2%, dyspepsia in 2%, and nausea or vomiting in 1% of patients. [drugs.com]

  Side effects associated with Posicor include dizziness, headache, leg swelling, abdominal pain, nausea, unusual fatigue and nasal congestion. [resource4defectivedrugs.com]

• Loss of Appetite

  […] of appetite, nausea or vomiting, fever or dark/amber-colored urine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. [webmd.com]

  […] difficulty thinking clearly, using good judgment, or understanding reality hallucinating (seeing things or hearing voices that do not exist) confusion restlessness thirst decreased urination loss of appetite constipation seizures skin blisters that are [medlineplus.gov]

• Jaundice

  Incidents of severe hepatitis and liver failure in patients taking bromfenac for more than one month resulted in revision of labeling to include a box warning regarding severe hepatic reactions, including jaundice, potentially fatal fulminant hepatitis [aafp.org]

• Flushing

  Avoid alcoholic drinks because they can make you more dizzy, increase flushing, and cause rapid heartbeats. Do not suddenly stop taking mibefradil. Ask your prescriber or health care professional how you can gradually reduce the dose. [hendricks.org]

  Flushing occurred in a dose-related manner in placebo-controlled trials over a daily dose range of 50 to 100 mg. [drugs.com]

  Abdominal pain, belching, heartburn, flushing, headache, nausea and vomiting, dizziness, lightheadedness, bradycardia, peripheral oedema, chest pain. [mims.com]

  Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. [webmd.com]

• Fracture

  They are experts in this field and will offer you the best advice on your options. 8/8 What People are Saying Lucille says: I took foxamax from and have suffered 8 compressed back fractures.. [resource4thepeople.com]

  It was pulled off the market — after 48 years — for causing uncontrollable seizures, pulled muscles, and spine fractures in an estimated 42% of patients. [allthatsinteresting.com]

• Withdrawn

  Posicor - designed to treat angina and high blood pressure - was withdrawn from use eight days ago because of serious side-effects. [medical-dictionary.thefreedictionary.com]

  Jamaica February 1998 The calcium channel blocking agent, mibefradil was voluntarily withdrawn from the market by Hoffman La Roche. [apps.who.int]

  It is a very effective… Early in June 1998, Roche Laboratories of Nutley, NJ, abruptly and voluntarily withdrew its novel T-channel blocker, Posicor… Dexfenfluramine (Redux) was withdrawn from the market in the United States in 1997 amid speculation that [semanticscholar.org]

  Posicor was withdrawn from the market by Roche on June 8, 1998 due to the risk of adverse interactions with other medications. [farrin.com]

• Dizziness

  To reduce the risk of dizzy or fainting spells, do not sit or stand up quickly, especially if you are an older patient. Avoid alcoholic drinks because they can make you more dizzy, increase flushing, and cause rapid heartbeats. [hendricks.org]

  Dizziness has often been reported as one of the more common side effects, seen in approximately 7% of patients. In some controlled trials, the incidence of dizziness among treated patients exceeded that among patients who received placebo. [drugs.com]

  Posicor side effects Side effects of Posicor include: Dizziness Headache Leg swelling Abdominal pain Nausea Unusual fatigue Nasal congestion Contact our law offices for a free case evaluation about your potential Posicor lawsuit If you or a loved one [farrin.com]

  Other reported side effects include dizziness, fatigue, and light headedness. Some people may be bothered by stomach irritation, and swallowing the tablets whole may reduce this side effect. [stason.org]

• Headache

  For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. [ndrugs.com]

  Posicor side effects Side effects of Posicor include: Dizziness Headache Leg swelling Abdominal pain Nausea Unusual fatigue Nasal congestion Contact our law offices for a free case evaluation about your potential Posicor lawsuit If you or a loved one [farrin.com]

  The book provides natural, safe, and effective ways to treat a wide range of common ailments, including ADHD, allergies, diabetes, depression, erectile dysfunction, eczema, heart disease, headaches, and PMS. [books.google.com]

• Torsades De Pointes

  In particular, it has a life-threatening potential to induce cardiac arrhythmias (including torsades de pointes) especially when taken concomitantly with other medications. [apps.who.int]

  Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. J Am Coll Cardiol 2010 Mar 2;55(9):934-47. 4.US Food and Drug Administration (FDA). [webmd.com]

  Bryant's suffering an event of Torsades des Pointes, which resulted in brain injury. Dr. [caselaw.findlaw.com]

• Third Degree Atrioventricular Block

  Patients with sick sinus syndrome or second- or third-degree atrioventricular block without a pacemaker should not take mibefradil. [aafp.org]

"My experience with Posicor indicates that it is a very promising treatment," he said. [docguide.com]

Some of these opinions may contain information about treatment or uses of drug products that have not been approved by the U.S. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. [webmd.com]

A head-to-head study of hypertension treatment costs found that Posicor reduces overall treatment costs by $70 per patient, per year over amlodipine. The two drugs are equally effective and similarly priced. [reliasmedia.com]

After that, your doctor may decide to continue your treatment, but you will receive bortezomib less often. Be sure to tell your doctor how you are feeling during your treatment. [medlineplus.gov]

-- A Food and Drug Administration panel voted 5-3 Friday to recommend approval of Roche Holding AG's drug Posicor for the treatment of hypertension and for the treatment of chronic, stable angina, or chest pain. [wsj.com]

Its application to recurrent high-grade glioma, an aggressive disease with poor prognosis, underscores the vital contribution that repurposing can make to the treatment of cancer and other diseases. [liebertpub.com]

There was no treatment difference regardless of whether CHF was of ischemic etiology. [ahajournals.org]

Gillum RF, Makuc DM, Feldam JJ: Pulse rate, coronary heart disease, and death: The NHANES I epidemiologic follow-up study. Am Heart J 1991;121:172–177. [karger.com]

Pranić S, Tokalić R, Milat A, Mudnić I, Pavličević I and Marušić A (2018) Clinical trials on drug-drug interactions registered in ClinicalTrials.gov reported incongruent safety data in published articles: an observational study, Journal of Clinical Epidemiology [ahajournals.org]

Hypertension: Pathophysiology, Diagnosis, and Management. 2nd ed. New York, NY: Raven Press; 1995:673–683.Google Scholar 8 Bean B. Pharmacology of calcium channels in cardiac muscle, vascular muscle, and neurons. [ahajournals.org]

Women's Health Stay healthy and vigorous into old age by eating right, getting plenty of exercise and following recommended disease prevention practices. [apps.childrensdmc.org]

Children's Health Enjoy good health at every age: know your body and how it works, eat well and stay active, and follow a plan for disease prevention. [hendricks.org]

Recombinant coagulation factor IX is indicated for the control and prevention of hemorrhagic episodes in patients with hemophilia B, including control and prevention of bleeding in surgical settings. [aafp.org]

Lawrence, M.D., coauthor of Preventing Arthritis and The Miracle of MSM "A must-read for every person who wants to achieve better health and avoid the dangers of synthetic medications. [books.google.com]