A 25-year-old male presented with features of p remature senility and progressive abdominal distension with black tarry stools of over six months duration. His clinical presentation and work-up including a biopsy were consistent with cirrhosis. [ncbi.nlm.nih.gov]

Patients typically present with widely opened fontanels, mainly truncal hypotonia, a waddling gait with hypertonia of the extremities, small hands and feet, broad great toes, scoliosis and redundant skin with lack of subcutaneous fat. [orpha.net]

Wer·ner syn·drome ( wĕr'nĕr ), [MIM*277700] a premature aging disorder presenting sclerodermalike skin changes, bilateral juvenile cataracts, progeria, hypogonadism, and diabetes mellitus; autosomal recessive inheritance, caused by mutation in the WRN [medical-dictionary.thefreedictionary.com]

• Inflammation

  Chronic inflammation can negatively affect your health and even accelerate your skin's aging. [shape.com]

  In this review, the relationship between uremic inflammation and a premature aging phenotype, as well as potential causes and consequences, are discussed. Copyright © 2017 the American Physiological Society. [ncbi.nlm.nih.gov]

• Falling

  Read also – 4 Smart Things You Can Do When You Can’t Fall Asleep 7. Boost your antioxidant intake Make sure you incorporate lots of antioxidant-rich foods into your daily diet. [womanitely.com]

  Those who spend extensive periods in the sun through outdoor work or recreation also fall into the high-risk group. Darker-skinned people show fewer signs of photoaging, although the skin can become mottled and there may be wrinkling. [dermatology.ca]

  No matter how much those high end and top notch cosmetic and pharmaceutical companies brag about the efficacy of their anti aging products, you should not fall into the trap, for no treatment, no cream, no concoction or pill can avoid the natural degradation [pcpforlife.com]

  Prevention—get into the habit of falling asleep on your back and flip over if you wake up on your stomach or side. This decreases swelling or bloating of the face that stretches skin over time. [doctorbinder.com]

• Fatigue

  Sleeping position Sleeping postures have a big role in skin fatigue. Sleeping sideways, while might feel comfortable, has the potential to damage the skin. [thejakartapost.com]

  Tests, milogram ,stress heart ehco, and nuclear, heart great, muscles NO ,NERVES NO, Xrays NT good on knees and hip I can't ride my horse ,heck I can barely walk to the barn and coming back up the slight hill has me fatigued and winded, also liver spots [patient.info]

  At the same time, hands become dry, sleep cycles are interrupted, fatigue sets in and it becomes harder to get started in the mornings. [idsmed.com]

  At the same time, hands become dry, sleep cycles are interrupted, fatigue sets in and it becomes harder to get started in the mornings. “These are the first markers of brain shrinkage,” he says. [forbes.com]

  But as you reach your 30s, your 40s and certainly your 50s, an aging face -- particularly one that's aged prematurely -- can make you appear older, more fatigued and less excited than you really are. [sixwise.com]

• Surgical Procedure

  Unfortunately, conventional medical care has focused more on symptom relief with pain medications and surgical procedures and less on reversing the accelerated aging process, which is potentially more effective over the long term. [diagnose-me.com]

  It is probably because experts have been focusing more on pain medications and surgical procedures and less on reversing the aging process. [consumerhealthdigest.com]

  "However, the fact it didn't make the top five surgical procedures can be attributed to increased consumer demand for minimally-invasive injectable wrinkle fillers and fighters as a remedy to combat facial aging." [sixwise.com]

  Ray In a surgical procedure the physician harvests mesenchymal stem cells from fatty tissue by liposuction. A cell separator separates the mesenchymal stem cells, the connective tissue and the fat cells. The connective tissue is discarded. [askdrray.com]

• Infertility

  Among these aging symptoms, spinal curvature, liver and retina degeneration, and infertility were the most remarkable. [ncbi.nlm.nih.gov]

• Visual Impairment

  Uveitis resulted in visual impairment. She also had granulomatous changes in her vessels. Renal impairment developed; however, neither renal artery stenosis nor hypercalcemia was found. [ncbi.nlm.nih.gov]

• Osteoporosis

  Her clinical findings included osteosarcoma, nuclear and subcapsular cataracts, insulin-resistant diabetes mellitus, osteoporosis, epilepsy, foot ulcers, erythroid macrocytosis, and unusual facial appearance. [ncbi.nlm.nih.gov]

  Using this broad understanding of osteoporosis, you can see how it is actually the product of an imbalanced hormonal system. [lifeextension.com]

  An autosomal recessive disorder characterized by short stature and the appearance of premature aging after puberty, with early development of conditions such as cataracts, cardiovascular disease, osteoporosis, and malignancies. [medical-dictionary.thefreedictionary.com]

  Women tend to suffer from bone loss and osteoporosis. By not providing enough calcium early on, it can cause your bones to age prematurely as well. [steptohealth.com]

• Dry Skin

  Adding in a moisturizer high in squalene and silicone-like molecules that form a barrier gives immediate relief to the symptoms of dry skin. [magazine.lneonline.com]

  Here are nine signs your skin is aging prematurely and you should go see a dermatologist. 1. Dull, Dry Skin Pexels "As skin ages, it no longer exfoliates (sheds the dead cell layer) efficiently," says Kauvar. [bustle.com]

  Keeping your body moisturized can maintain the freshness and youngness of your skin. If you leave your skin to dry all the time, your skin will look wrinkly and also saggy. You know what that means. [inlifehealthcare.com]

  At the same time, hands become dry, sleep cycles are interrupted, fatigue sets in and it becomes harder to get started in the mornings. [idsmed.com]

• Freckles

  You’ll also look younger because wrinkles, spots, and freckles will be least likely to form. When you go outside in the summer, put on at least SPF 30 sunscreen, not only on your face but also on your chest, neck, shoulders, arms, and hands. [steptohealth.com]

  Repeated overexposure to UV rays can lead to various forms of skin damage including: Fine lines Wrinkles Age spots, freckles, and other discolorations Scaly red patches, called actinic keratoses, thought to be the beginnings of skin cancer Tough, leathery [everydayhealth.com]

  This kind of skin damage is clinically known as photoaging and can lead to freckling, spider veins on the face, age spots, leathery skin, fine wrinkles that disappear only when stretched, a blotchy complexion, actinic keratosis (those rough, reddish patches [emaxhealth.com]

• Night Sweats

  Night sweats and difficulty sleeping. Low libido, vaginal dryness and pain during sex. Memory / concentration problems. Mood swings, feeling low or anxious. How long these symptoms last and how much they affect you varies from woman to woman. [avert.org]

  You can also experience insomnia, headaches, night sweats, hot flashes, acne, mood swings and weight gain. [floliving.com]

• Blonde Hair

  ‘She had fine blonde hair, blue eyes and (father) Mark and I were besotted with her,’ she told the Sunday People at the time. ‘At 10 months she walked for the first time – we were so proud. [metro.co.uk]

• Aged Face

  Following these tips can prevent skin cancer and premature skin aging. Face washing 101 How you wash your face can make a difference in your appearance. [aad.org]

  Why Your Face Ages, and How to Avoid Premature Aging by www.SixWise.com While your eyes may indeed be your window to the world, your face is like the world's window to you. [sixwise.com]

• Irritability

  Scrubbing your skin clean can irritate your skin. Irritating your skin accelerates skin aging. Gentle washing helps to remove pollution, makeup, and other substances without irritating your skin. [idsmed.com]

  Urea also helps reduce epidermal water loss and helps the skin to be less susceptible against skin irritation. [vidaspas.com]

  Warning Take care not to get any of the natural treatments in the eyes as irritation may occur. Discard the milk cleanser after one week. [livestrong.com]

As always, the best care is one that includes a combination of both professional treatments as well as proper daily home care. Let’s examine some of the more common signs as well as comprehensive treatment plans for premature aging skin. [magazine.lneonline.com]

Types & treatments Childhood eczema Adult eczema Insider secrets Types of hair loss Treatment for hair loss Causes of hair loss Hair care matters Insider secrets What is psoriasis Diagnosis & treatment Skin, hair & nail care Triggers Insider secrets What [aad.org]

To help restore a uniform appearance between a patient’s face, neck and chest, Levicke often recommends treatments varying from chemical peels, to photorejuvenation, all the way to aggressive Fraxel skin resurfacing treatments. [aboutfaceskincare.com]

Store-bought products and dermatologist treatments are effective, but they can be incredibly expensive and are often harsh on the skin. Natural treatments are also effective, and they do not promote the side effects or irritants due to chemicals. [livestrong.com]

Gov't MeSH terms Adult Aged Aged, 80 and over Aging, Premature*/etiology Aging, Premature*/metabolism Aging, Premature*/physiopathology Follow-Up Studies Hematopoiesis* Humans Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/metabolism Leukemia, Myelogenous [ncbi.nlm.nih.gov]

The etiological relationship of 21 trisomy with premature aging in DS remains unclear, which makes further studies on this topic necessary to support preventive measures and provide greater support to people with the syndrome at this stage of life. [scielo.br]

KEYWORDS: Hutchinson–Gilford Progeria Syndrome; Werner syndrome; atherosclerosis; cancer; cardiovascular diseases; epidemiology; genetics; premature aging disorders; sign and symptoms [ncbi.nlm.nih.gov]

A study in the epidemiology of « crow’s feet », Ann Intern Med, 1971 (2) Model D, Smoker’s face : Who are the smokers ?, Br Med J 1985 (3) Ernster VL, Grady D, Miike R et al, Facial wrinkling in men and women, by smoking status. [stop-tobacco.ch]

Replicated evidence from European epidemiologic studies indicates that the elevated risk for dementing disorders in adults with pre-existing mood disorders may be influenced by the number of prior affective episodes, speaking to both mechanisms, and translation [psychiatryadvisor.com]

Ness, PT, PhD, FAPTA, faculty member of the department of epidemiology and cancer control at St. Jude Children’s Research Hospital. [healio.com]

National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants. [clinicalepigeneticsjournal.biomedcentral.com]

This review focuses on Hutchinson-Gilford Progeria syndrome and Restrictive Dermopathy, two well-characterized Lamin-associated premature aging syndromes, pointing out the current knowledge concerning their pathophysiology and the development of possible [ncbi.nlm.nih.gov]

This will help prevent pigment problems and premature aging. [doctorbinder.com]

You can minimize the damage and even help skin heal itself. 1) Take every precaution All of the steps listed above for preventing aging skin can also help reverse some of the damage (and obviously prevent further damage). [bioelements.com]

Preventive Measures: Poor Diet: A diet rich in vegetables and fruits tends to makes skin healthy and also helps prevent quick aging, as it is enriched with antioxidants which defends skin from any harm and make it healthy. [extrabeautycare.com]

There are some things you can do to prevent your skin from aging prematurely. [inlifehealthcare.com]

In order to prevent premature aging in these body parts, proper care is essential throughout the duration of your lifetime. [rothmaninstitute.com]