A 25-year-old male presented with features of p remature senility and progressive abdominal distension with black tarry stools of over six months duration. His clinical presentation and work-up including a biopsy were consistent with cirrhosis. [ncbi.nlm.nih.gov]

Patients typically present with widely opened fontanels, mainly truncal hypotonia, a waddling gait with hypertonia of the extremities, small hands and feet, broad great toes, scoliosis and redundant skin with lack of subcutaneous fat. [orpha.net]

Wer·ner syn·drome ( wĕr'nĕr ), [MIM*277700] a premature aging disorder presenting sclerodermalike skin changes, bilateral juvenile cataracts, progeria, hypogonadism, and diabetes mellitus; autosomal recessive inheritance, caused by mutation in the WRN [medical-dictionary.thefreedictionary.com]

• Inflammation

  Chronic inflammation can negatively affect your health and even accelerate your skin's aging. [shape.com]

  In this review, the relationship between uremic inflammation and a premature aging phenotype, as well as potential causes and consequences, are discussed. Copyright © 2017 the American Physiological Society. [ncbi.nlm.nih.gov]

• Weight Gain

  Sugary sodas don't get a whole lot of positive ink— research has linked them with weight gain, increased stroke risk, and elevated blood pressure. [glamour.com]

  On the other hand, junk food will leave you without energy to exercise (see point #1 above) and could contribute to weight gain, which can put unnecessary pressure on your joints, causing injury. [rothmaninstitute.com]

  Weight Excess weight – especially around the waist and jowls – can add years to a person’s appearance. Because alcohol is full of empty calories and often excess sugar and carbohydrates, chronic consumption can quickly lead to weight gain. [addictioncampuses.com]

  This is due to stress, toxins, sun exposure, weight gain, disease and damaging free radicals. [pioneerthinking.com]

• Weight Loss

  We found that the life long treatment with antioxidant significantly increased average and maximal lifespan and reduced the rate of age-dependent weight loss and development of cataracts. [ncbi.nlm.nih.gov]

  The laxity and folding of the skin resulting from weight loss should not be confused with aging of the skin, although these occur most frequently in elderly, debilitated people. [jamanetwork.com]

  Drugs and alcohol abuse Both can lead to malnutrition with weight loss and loss of subcutaneous fatty tissue, which causes sagging breasts in women. In men “beer tits” are common. [askdrray.com]

• Swelling

  This decreases swelling or bloating of the face that stretches skin over time. Sipping out of a straw—sipping out of a straw causes fine lines around your mouth, which is a clear indication of premature aging. [doctorbinder.com]

  Redness, heat and/or swelling can also occur alongside inflammation. When the fight is over, the army of inflammation-triggering substances is supposed to retreat, but in many cases they don't. [shape.com]

  Bromelain is a composition of enzymes, which has anti-inflammatory properties that reduces swelling and redness on the skin. Bromelain is touted for most of pineapples anti aging and skin care benefits. [pioneerthinking.com]

• Malnutrition

  High stress, paranoia, lack of hygiene, malnutrition and other issues only make the premature aging process worse. Smoking drugs often produces the most visible signs of premature again. [selfgrowth.com]

  Drugs and alcohol abuse Both can lead to malnutrition with weight loss and loss of subcutaneous fatty tissue, which causes sagging breasts in women. In men “beer tits” are common. [askdrray.com]

  Thinning hair can be the result of malnutrition or excessive stress, so ask a doctor about that, too. If you’re concerned about the signs of aging — what’s normal, what’s not, and if there’s anything you can do differently — talk to a doctor. [healthline.com]

• Gagging

  It can be concluded that definition of GAG and MDA in blood is one of the significant criteria, reflecting adaptative tension and premature aging of shift-workers. [ncbi.nlm.nih.gov]

  A daily regimen containing serums that mimic GAGs including seaweeds, hyaluranates and plant extracts replenish and plump dehydrated skin. [magazine.lneonline.com]

  HA is a member of the class of amino-sugars containing polysaccharides known as the glycosaminoglycans, aka (GAGS), widely distributed in body tissues. [dermascope.com]

• Nausea

  It can cause nausea, vomiting, and diarrhea or constipation. Rarely, it can cause rashes, fever, headache, drowsiness, low blood pressure, and liver problems. Add broccoli sprouts to your diet. [nontoxicforhealth.com]

• Vomiting

  It can cause nausea, vomiting, and diarrhea or constipation. Rarely, it can cause rashes, fever, headache, drowsiness, low blood pressure, and liver problems. Add broccoli sprouts to your diet. [nontoxicforhealth.com]

• Heart Disease

  Before long, the patient may suffer episodes of angina or even a heart attack, and be diagnosed with heart disease. [lifeextension.com]

  Age is undoubtedly a major risk factor for heart disease. However, the reason for this is not entirely clear. [ncbi.nlm.nih.gov]

• Dry Skin

  Adding in a moisturizer high in squalene and silicone-like molecules that form a barrier gives immediate relief to the symptoms of dry skin. [magazine.lneonline.com]

  Here are nine signs your skin is aging prematurely and you should go see a dermatologist. 1. Dull, Dry Skin Pexels "As skin ages, it no longer exfoliates (sheds the dead cell layer) efficiently," says Kauvar. [bustle.com]

  Keeping your body moisturized can maintain the freshness and youngness of your skin. If you leave your skin to dry all the time, your skin will look wrinkly and also saggy. You know what that means. [inlifehealthcare.com]

  At the same time, hands become dry, sleep cycles are interrupted, fatigue sets in and it becomes harder to get started in the mornings. [idsmed.com]

• Hyperpigmentation

  There are products that a doctor can prescribe to treat hyperpigmentation in your chest area. Mild steroids and bleaching agents can fade the look of hyperpigmentation over time. [healthline.com]

• Freckles

  You’ll also look younger because wrinkles, spots, and freckles will be least likely to form. When you go outside in the summer, put on at least SPF 30 sunscreen, not only on your face but also on your chest, neck, shoulders, arms, and hands. [steptohealth.com]

  Repeated overexposure to UV rays can lead to various forms of skin damage including: Fine lines Wrinkles Age spots, freckles, and other discolorations Scaly red patches, called actinic keratoses, thought to be the beginnings of skin cancer Tough, leathery [everydayhealth.com]

  This kind of skin damage is clinically known as photoaging and can lead to freckling, spider veins on the face, age spots, leathery skin, fine wrinkles that disappear only when stretched, a blotchy complexion, actinic keratosis (those rough, reddish patches [emaxhealth.com]

• Exfoliation of the Skin

  Exfoliating that dead skin is crucial, as it makes it much easier for skin to go through its natural rejuvenation process at night. 3. [bustle.com]

  Anyone looking to repair and restore prematurely aged skin should start with the prevention steps and go from there. 2) Exfoliation is your best friend Exfoliation is crucial when it comes to visibly erasing years of damage. [bioelements.com]

  Products like this typically contain a cream and a stack of face-wipe pads with a slightly textured surface to help with exfoliation of dead skin cells to reveal the underlying healthy facial skin cells. [emaxhealth.com]

• Alopecia

  Our report expands the clinical spectrum of systemic granulomatosis to include the development of premature aging with alopecia. [ncbi.nlm.nih.gov]

• Irritability

  Scrubbing your skin clean can irritate your skin. Irritating your skin accelerates skin aging. Gentle washing helps to remove pollution, makeup, and other substances without irritating your skin. [idsmed.com]

  Urea also helps reduce epidermal water loss and helps the skin to be less susceptible against skin irritation. [vidaspas.com]

  Warning Take care not to get any of the natural treatments in the eyes as irritation may occur. Discard the milk cleanser after one week. [livestrong.com]

• Burning Sensation

  At the same time, the damaged skin cells release chemicals that send messages through the body until they are translated as a painful burning sensation by the brain. [fda.gov]

• Glucose Increased

  […] association with increasing age, such that for each 1 year increase in age, the odds ratio increases by a factor of 1.002 toward the null value (and beyond). [clinicalepigeneticsjournal.biomedcentral.com]

As always, the best care is one that includes a combination of both professional treatments as well as proper daily home care. Let’s examine some of the more common signs as well as comprehensive treatment plans for premature aging skin. [magazine.lneonline.com]

Types & treatments Childhood eczema Adult eczema Insider secrets Types of hair loss Treatment for hair loss Causes of hair loss Hair care matters Insider secrets What is psoriasis Diagnosis & treatment Skin, hair & nail care Triggers Insider secrets What [aad.org]

To help restore a uniform appearance between a patient’s face, neck and chest, Levicke often recommends treatments varying from chemical peels, to photorejuvenation, all the way to aggressive Fraxel skin resurfacing treatments. [aboutfaceskincare.com]

Store-bought products and dermatologist treatments are effective, but they can be incredibly expensive and are often harsh on the skin. Natural treatments are also effective, and they do not promote the side effects or irritants due to chemicals. [livestrong.com]

Gov't MeSH terms Adult Aged Aged, 80 and over Aging, Premature*/etiology Aging, Premature*/metabolism Aging, Premature*/physiopathology Follow-Up Studies Hematopoiesis* Humans Leukemia, Myelogenous, Chronic, BCR-ABL Positive*/metabolism Leukemia, Myelogenous [ncbi.nlm.nih.gov]

The etiological relationship of 21 trisomy with premature aging in DS remains unclear, which makes further studies on this topic necessary to support preventive measures and provide greater support to people with the syndrome at this stage of life. [scielo.br]

KEYWORDS: Hutchinson–Gilford Progeria Syndrome; Werner syndrome; atherosclerosis; cancer; cardiovascular diseases; epidemiology; genetics; premature aging disorders; sign and symptoms [ncbi.nlm.nih.gov]

A study in the epidemiology of « crow’s feet », Ann Intern Med, 1971 (2) Model D, Smoker’s face : Who are the smokers ?, Br Med J 1985 (3) Ernster VL, Grady D, Miike R et al, Facial wrinkling in men and women, by smoking status. [stop-tobacco.ch]

Replicated evidence from European epidemiologic studies indicates that the elevated risk for dementing disorders in adults with pre-existing mood disorders may be influenced by the number of prior affective episodes, speaking to both mechanisms, and translation [psychiatryadvisor.com]

Ness, PT, PhD, FAPTA, faculty member of the department of epidemiology and cancer control at St. Jude Children’s Research Hospital. [healio.com]

National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants. [clinicalepigeneticsjournal.biomedcentral.com]

This review focuses on Hutchinson-Gilford Progeria syndrome and Restrictive Dermopathy, two well-characterized Lamin-associated premature aging syndromes, pointing out the current knowledge concerning their pathophysiology and the development of possible [ncbi.nlm.nih.gov]

This will help prevent pigment problems and premature aging. [doctorbinder.com]

You can minimize the damage and even help skin heal itself. 1) Take every precaution All of the steps listed above for preventing aging skin can also help reverse some of the damage (and obviously prevent further damage). [bioelements.com]

Preventive Measures: Poor Diet: A diet rich in vegetables and fruits tends to makes skin healthy and also helps prevent quick aging, as it is enriched with antioxidants which defends skin from any harm and make it healthy. [extrabeautycare.com]

There are some things you can do to prevent your skin from aging prematurely. [inlifehealthcare.com]

In order to prevent premature aging in these body parts, proper care is essential throughout the duration of your lifetime. [rothmaninstitute.com]