Edit concept Question Editor Create issue ticket

Presenile Dementia


Presentation

  • Thirty-three family members agreed to be interviewed for the present study.[tandfonline.com]
  • In this paper, we present the novel molecular neuropathological characteristics.[pnas.org]
  • We present a case of x.p. with progressive presenile dementia. This combination has, to our knowledge, not yet been reported in the literature. Although no hints on another aetiology have been found, the coincidental combination of x.p. with M.[neuro.uni-luebeck.de]
  • In this study, a case report of a 41-yr old medical doctor whose mental illness spanned 8 yrs is presented.[ajol.info]
  • Bouras C, Vallet PG, Hof PR, et al: Substance P immunoreac-tivity in Alzheimer disease: A study in cases presenting symmetric or asymmetric cortical atrophy. Alzheimer Dis Assoc Disord 1990 ; 4: 24 – 34. Google Scholar 8.[journals.sagepub.com]
Swelling
  • In spinal cord, axonal swellings and a mild loss of nerve cells in conjunction with fibrillary lesions were observed in anterior horn and dorsal gray.[pnas.org]
Progressive Mental Retardation
  • The association with progressive mental retardation, usually with onset in childhood, is well known. We present a case of x.p. with progressive presenile dementia. This combination has, to our knowledge, not yet been reported in the literature.[neuro.uni-luebeck.de]
Formication
  • When the anti-Aβ- antibody was used, tissue sections were preincubated for 5 min in 90% formic acid before incubation with the first antibody. Tau Extraction, Dephosphorylation, and Immunoblotting.[pnas.org]
Fracture
  • Interactive Medical Cases Image Challenge Images in Clinical Medicine Videos in Clinical Medicine Quick Takes View all multimedia Treating Chronic Spontaneous Urticaria State-Level Action on Drug Prices The Element of Surprise Closed Reduction of a Fractured[nejm.org]
Apraxia
  • Abstract Dementia is the development of multiple cognitive deficits that includes memory impairment and at least one of the following--Aphasia, apraxia, agnosia or disturbances in executive functioning.[ncbi.nlm.nih.gov]
  • […] dementia [ dĕ-men shah ] a general loss of cognitive abilities, including impairment of memory as well as one or more of the following: aphasia, apraxia, agnosia, or disturbed planning, organizing, and abstract thinking abilities.[medical-dictionary.thefreedictionary.com]
Neurologic Manifestation
  • Title [Presenile dementia in xeroderma pigmentosum] Abstract Neurological manifestations of xeroderma pigmentosum, a rare autosomal recessive neurocutaneous syndrome, are variable.[neuro.uni-luebeck.de]
Babinski Sign
  • Neurological examination has shown increased tendon reflexes and a positive Babinski sign. The last stage is characterized by a severe global cognitive decline, superior gaze palsy, and rigidity.[pnas.org]
Bradykinesia
  • DISCUSSION MSTD is a familial disease that is inherited in an autosomal dominant manner, with dementia, generalized bradykinesia and rigidity, as well as superior gaze palsy, as the major symptoms.[pnas.org]

Workup

  • Standard Medical Workup for Alzheimer's Disease. Alzheimer Research Forum [On-line information]. Available online at . Family Caregiver Alliance. Fact Sheet: Alzheimer's Disease [On-line information]. Available online at .[labtestsonline.org]

Treatment

  • Note that before alkaline phosphatase treatment, two major tau bands of 64 and 68 kDa and a minor band of 72 kDa are present; after alkaline phosphatase treatment, two major bands are visible that align with recombinant tau isoforms (lane 1) of 383 and[pnas.org]
  • Treatment Treatment is symptomatic and will work to slow the progression of the disease. Treatment will combine psychological care and drug treatment: namely cholinesterase inhibitors.[health.ccm.net]
  • Conditions six hours after electroshock treatment. Acta Psychiatr Neurol Scand 1954;32:280. Nilsson L-G, Bäckman L, Erngrund K, Nyberg L, Adolfsson R, Bucht G, Karlsson S, Widing M, Winblad B: The Betula cohort study: Memory, health and aging.[karger.com]
  • It is a public health problem due its expensive treatment and dependence of patients for governmental sources for sustainability.[scielo.br]

Etiology

  • AD is the most frequent etiology in studies with early onset dementia 2,4,23-27, although in one report VaD is the most prevalent (Southampton area) 26 as well as in the Japanese study 28.[scielo.br]
  • It can be differentiated from postencephalitic syndrome (F07.1) and postconcussional syndrome (F07.2) by its different etiology, more restricted range of generally milder symptoms, and usually shorter duration.[apps.who.int]
  • […] and Neurodevelopmental disorders F01-F09 2020 ICD-10-CM Range F01-F09 Mental disorders due to known physiological conditions Note This block comprises a range of mental disorders grouped together on the basis of their having in common a demonstrable etiology[icd10data.com]

Epidemiology

  • We do not have data about this prevalence by epidemiological surveys. Alcohol dementia was more frequent in epidemiological study in England 24 than in our clinic perhaps due to evaluation by psychiatrists in our environment.[scielo.br]
  • • A nationwide epidemiologic study of presenile dementia of the Alzheimer type (PDAT) with onset through age 60 years was carried out in Israel.[jamanetwork.com]
  • Affiliations Laboratory of Neurogenetics, Department of Biochemistry, Born Bunge Foundation, University of Antwerp (UIA), Universiteitsplein 1, B-2610, Antwerpen, Belgium Lydia Hendriks , Marc Cruts , Wim Van Hul & Christine Van Broeckhoven Department of Epidemiology[nature.com]
  • Using a Medline and Embase search we found a number of studies using the search terms “Dementia/Prevalence/Epidemiology” or “Early onset dementia/Incidence/Prevalence/Epidemiology.”[alzheimer-europe.org]
  • Professor of Neurology, Genetics and Epidemiology. Director, Alzheimer's Disease Clinical and Research Program. Boston University Schools of Medicine and Public Health, Boston, MA. Ian R.A. Mackenzie, MD FRCPC.[labtestsonline.org]
Sex distribution
Age distribution

Pathophysiology

  • It is also important to investigate the pathophysiological mechanism in relation to genetic abnormalities, environmental factors, physical illnesses, and metabolic disturbances to understand the processes underlying the development of dementia with early[ncbi.nlm.nih.gov]

Prevention

  • Centers for Disease Control and Prevention. Available online at . Accessed on 11/10/18. Lane, C. et. al. (2017 September 4). Alzheimer's disease. European Journal of Neurology 2018, 25: 59–70. Available online at . Accessed on 11/10/18.[labtestsonline.org]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!