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Priapism
Prolonged Erection
Priapism is an abnormally persistent, usually painful erection of the penis. It must be defined as either a low-flow or a high-flow type.

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WIKIDATA, Public Domain
WIKIDATA, CC BY 4.0

Presentation

Symptoms vary depending on the type of priapism that has occurred. The following is a list of symptoms explaining both type of priapism.

Ischemic (low flow) priapism

  • Involuntary erection that lasts for 4 hours or even longer
  • Pain during erection
  • The penis is tender to touch and is rigid
  • Several bouts of involuntary erection – a condition referred to as stuttering priapism [6]

Non-ischemic (high flow) priapism

  • Involuntary erection that lasts for at least 4 hours
  • The penis is erect but not painful

Respiratoric

  • Nasal Congestion

    Burnett reported on headache, flushing, nasal congestion, abnormal vision, dyspepsia, myalgia whilst Olujohungbe reported on palpitations, tachycardia, lack of sleep, hand shaking, anxiety and dry mouth (Burnett 2014; Olujohungbe 2011). [cochranelibrary.com]

Urogenital

  • Painful Erection

    Priapism may occur in one of the following ways: There may be repeated, reversible painful erections occurring over several hours (penis becomes erect then erection goes away, then becomes erect again, then erection goes away, etc.) [dshs.texas.gov]

    ICD-9-CM Volume 2 Index entries containing back-references to 607.3 : Erection, painful (persistent) 607.3 Painful - see also Pain erection 607.3 Priapism (penis) 607.3 ICD-9-CM codes are used in medical billing and coding to describe diseases, injuries [icd9data.com]

    Painful Erection in Men with Sickle Cell Disease Males with sickle cell disease may experience a pain crisis in the penis, called priapism. [ihtc.org]

    Priapism is a painful and persistent erection that can last for several hours. Unlike a normal erection, it is often not related to being sexually aroused and it doesn’t subside after ejaculating. [onlinedoctor.superdrug.com]

    […] noun mass noun Medicine Persistent and painful erection of the penis. ‘Another important genitourinary problem is priapism: a painful, persistent erection due to vaso-occlusive obstruction of the venous drainage of the penis.’ [en.oxforddictionaries.com]

  • Penile Pain

    A 42-year-old man presented to the emergency room with penile pain and partial erection. Examination revealed partial erection and palpable space-occupying lesion of the corpus cavernosum without lymphadenopathy. Malignant workup was negative. [ncbi.nlm.nih.gov]

    He appears uncomfortable from penile pain but is nontoxic. [pedsinreview.aappublications.org]

    Follow-up: The patient reported complete resolution of the deep, dull penile pain which is characteristic of ischemic priapism pain within 36 hours after surgery. [tau.amegroups.com]

    Signs and symptoms include: Erection lasting more than four hours or unrelated to sexual interest or stimulation Rigid penile shaft, but the tip of penis (glans) is soft Progressive penile pain Recurrent or stuttering priapism, a form of ischemic priapism [mayoclinic.org]

  • Dysuria

    Abstract A 51-year-old man presented at our department 2 days after the onset of a painful mass in the perineum and dysuria. [ncbi.nlm.nih.gov]

    Review of systems should seek symptoms suggesting a cause, including dysuria (urinary tract infections), urinary hesitancy or frequency (prostate cancer), fever and night sweats (leukemia), and lower-extremity weakness (spinal cord pathology). [msdmanuals.com]

    He is not sexually active and denies penile discharge or dysuria. In addition, he cannot recall any recent trauma or injury to his penis, scrotum, or perineum. Vitals are notable for a HR of 102. [emdocs.net]

Workup

In the preliminary phase, the individual will be asked about the length of the penile erection and frequency of the condition. Following this, a thorough physical examination will be carried out to understand the cause behind the development of priapism. In addition to this, the following methods will be carried out to diagnose the condition [7]:

  • Blood gas measurement: In this blood is drawn from the penis to be analyzed for the type of gases present in the sample. Such a type of test determines the type of priapism present.
  • Blood tests would be done to detect the presence of any underlying disease conditions such as sickle cell anemia or leukemia.
  • Color duplex ultrasound examination will be carried out to detect presence of tumor or any other abnormality inside the penis. This test would also provide insight into the type of priapism present.
  • Toxicology test would help in revealing whether drug abuse is the cause of priapism.

Treatment

Treatment of priapism is geared towards relieving the erection and preserving the erectile function. If treatment is initiated within 4 to 6 hours of erection, then medications should be enough to correct the condition. In addition, the following methods are employed to treat priapism [8]:

  • Ice packs: Application of ice packs to the penis and neighboring areas may help relieve the condition.
  • Surgical ligation is employed when there is arterial rupture. In this process, the artery is tied in order to restore the blood supply.
  • Shunt: In this a shunt is surgically inserted to divert the blood flow in order to restore the normal blood circulation in the penis [9] [10].
  • Needle aspiration: In this method, a needle is inserted into the penis to drain out the blood in order to correct the erection.

Prognosis

The prognosis of the condition can be favorable only if prompt treatment is initiated. Failure to do so can result in development of permanent damage to the penis. When priapism continues for more than 24 hours then erectile dysfunction can set in permanently [5].

Etiology

In many cases, the exact cause of priapism remains a mystery. However individuals with sickle cell anemia are known to fall easy prey to this condition. Sickle cell anemia is a heredity blood disorder in which the abnormally shaped red blood cells inhibit blood flow to the penis giving rise to priapism [2].

In addition to sickle cell anemia, other type of blood disease such as leukemia is also known to play a role in causation of the disease. Research has also pointed towards the fact that certain drugs commonly used for treating sexual dysfunction, depression and psychotic disorder can also lead to development of priapism.

There have been instances that have reported injury to be one of the major causes of non-ischemic priapism. Other causes of priapism include injury to the spinal cord, blood clots or poisonous venom.

Epidemiology

Priapism is an uncommon condition accounting for 1.5 cases per 100,000 individuals-years globally. A rise in the rate of incidence of priapism has been noted for men aged 40 years and above. It has been estimated that in this older population the incidence increased to 2.9 cases per 100,000 individuals-years [3]. The condition can strike males at any age, but is more common in boys below 10 years and in men above 20 years.

Pathophysiology

Under normal conditions, penis erection occurs in response to sexual stimulation. Due to stimulation, the blood vessels relax and expand increasing the blood flow to the penis. Such sequence of events causes the penis to erect. When the stimulation ends, the blood flows out and the penis returns to its normal (flaccid) state [4].

When some kind of disruption occurs in these normal events, priapism develops. Ischemic (low flow) priapism is the most common type and occurs when the blood gets trapped in the penis and is unable to flow out. Such an event does not allow the penis to return to its normal state.

Non-ischemic (high flow) priapism is pretty uncommon compared to the former type. It occurs when an artery gets ruptured that prevents the normal circulation of blood within the penis.

Prevention

Several steps can be followed to prevent recurrent attacks of priapism. If the cause of the underlying condition is known then appropriate treatment should be initiated to treat the condition. In case, drugs were the cause then attempts should be made to change the medications.

Men are also advised against use of recreational drugs and alcohol which have a known association with priapism episodes. The practice of self-injection of phenylephrine should be discouraged as it can trigger development of priapism.

Summary

Priapism is characterized by penile erection that occurs without any kind of sexual stimulation. It is a painful condition requiring prompt treatment. Such condition occurs in young boys aged 5 to 10 years or in adults between 20 to 50 years of age. Priapism can be either ischemic or non-ischemic in nature. The condition can last for as long as 4 hours or even more. Priapism requires immediate medical intervention in order to avoid onset of irreversible conditions. Failure to treat the condition can call for development of erectile dysfunction [1].

Patient Information

Definition

Priapism is prolonged erection of the penis without any physical or psychological stimulation. It is an extremely painful condition that should receive prompt treatment. Priapism can affect males of all age groups, but is more common in young boys and adult males.

Cause

Underlying disease conditions such as sickle cell anemia and leukemia are known to be major contributory factors. In addition, trauma or injury to the genital can also cause development of priapism. Individuals in the habit of using illegal drugs or alcohol are also susceptible. In many cases, it has been noticed that prescription drugs that have been advised for treatment of various disease conditions also predisposes males to develop priapism.

Symptoms

Symptoms of priapism include painful penile erection for 4 hours or more. The penis become rigid and may be tender to touch.

Diagnosis

Diagnosis is made through blood gas measurement in which blood that is trapped in the penis is tested for certain gases which confirms the presence of priapism. In addition, blood tests and ultrasound for detecting the presence of various disease conditions are also done.

Treatment

Treatment of priapism is done through medications and surgical intervention. If the duration of erection is less than 4 hours then medications alone help rectify the condition.

References

  1. Quan D, Ruha AM. Priapism associated with Latrodectus mactans envenomation. Am J Emerg Med. Jul 2009;27(6):759.e1-2. 
  2. Pryor J, Akkus E, Alter G, et al. Priapism. J Sex Med 2004; 1:116.
  3. Eland IA, van der Lei J, Stricker BH, Sturkenboom MJ. Incidence of priapism in the general population.Urology. May 2001;57(5):970-2.
  4. Burnett AL, Bivalacqua TJ. Priapism: current principles and practice. Urol Clin North Am 2007; 34:631.
  5. Dubin J, Davis JE. Penile emergencies. Emerg Med Clin North Am. Aug 2011;29(3):485-99.
  6. Muneer A, Minhas S, Arya M, Ralph DJ. Stuttering priapism--a review of the therapeutic options. Int J Clin Pract 2008; 62:1265.
  7. Bassett J, Rajfer J. Diagnostic and therapeutic options for the management of ischemic and nonischemic priapism. Rev Urol. Winter 2010;12(1):56-63.
  8. Montague DK, Jarow J, Broderick GA, et al. American Urological Association guideline on the management of priapism. J Urol 2003; 170:1318.
  9. Mains E, Aboumarzouk O, Ahmad S, El-Mokadem I, Nabi G. A minimally invasive temporary cavernoso-saphenous shunt in the management of priapism after failed conservative treatment. Minim Invasive Ther Allied Technol. Dec 5 2011
  10. Brant WO, Garcia MM, Bella AJ, et al. T-shaped shunt and intracavernous tunneling for prolonged ischemic priapism. J Urol 2009; 181:1699.
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