This case represents the second report in the literature of a neck mass resulting from a plasma cell dyscrasia and the first report of AL disease producing such extensive cervical lymphadenopathy as to cause significant respiratory compromise. [ncbi.nlm.nih.gov]

A 71-year-old man was admitted to our hospital because of exertional dyspnea, fatigue and fever. A chest X-ray showed right-sided moderate pleural effusion. A thoracocentesis revealed an exudative pleural effusion. [ncbi.nlm.nih.gov]

You will become lethargic and fatigued. You will lose your appetite. The medications are (and there are lots of them) essential to your recovery. The caregiver must ensure that you get the proper allotment of medications 3 times per day. [web.archive.org]

Amyloid deposits in these organs can cause shortness of breath, fatigue, edema (swelling of ankles and legs), dizziness upon standing, a feeling of fullness in the stomach (especially after eating), diarrhea, weight loss, enlarged tongue, and numbness [medicinenet.com]

Non-hematologic toxicities were mainly neurotoxicity, fatigue, peripheral edema, constipation and exacerbation of postural hypotension. [doi.org]

administration of high dose melphalan (HDM) supported by autologous stem cell transplantation (ASCT) significantly increased the hematologic and organ responses and improved survival, but at the expense of a treatment-related mortality rate ranging between [doi.org]

We describe here an extremely rare case of primary amyloidosis which presented moderate pleural effusion and high fever. A 71-year-old man was admitted to our hospital because of exertional dyspnea, fatigue and fever. [ncbi.nlm.nih.gov]

When the skin is involved, easy bruising is common, which can sometimes occur around the eyes. The tongue sometimes enlarges (macroglossia). [msdmanuals.com]

bruising Amyloidosis can be determined from any of the problems listed above. [unckidneycenter.org]

bruising or bleeding Pancreas - Diabetes Musculoskeletal system - Joint pain or swelling, weakness Skin - Lumps or purple discoloration No one knows what causes amyloidosis. [drugs.com]

bruising, and purplish patches around the eyes An irregular heartbeat Difficulty swallowing When to see a doctor See your doctor if you persistently experience any of the signs or symptoms associated with amyloidosis. [mayoclinic.org]

Typically, in amyloidosis there is a combination of symptoms affecting more than a single system - eg, fatigue, weight loss, easy bruising, breathlessness, peripheral oedema, sensory change, carpal tunnel syndrome, and postural hypotension. [patient.info]

She came to the gastroenterology clinics complaining of hematochezia, weight loss, decreased appetite and abdominal pain. Her only sign of organ damage was mild to moderate proteinuria (80mg per day). [ncbi.nlm.nih.gov]

We present the case of a 40-year-old female who presented with abdominal pain. Ultrasound abdomen was reported as massive hepatomegaly with diffuse liver parenchymal disease. [jcdr.net]

We describe a case of a patient presenting with abdominal pain, nausea, vomiting, and weight loss later to be diagnosed with localized GI amyloidosis from underlying multiple myeloma. [pagepress.org]

Dong Woog Yoon, Byung-Jo Park, In Sook Kim and Dong Seop Jeong, Isolated Tricuspid Regurgitation: Initial Manifestation of Cardiac Amyloidosis, The Korean Journal of Thoracic and Cardiovascular Surgery, 10.5090/kjtcs.2015.48.6.422, 48, 6, (422-425), [doi.org]

Involvement of the cardiac valves may result in tricuspid regurgitation, which can further aggravate the right heart failure. [circ.ahajournals.org]

NT-ProBNP is released from myocardial cells in response to increased wall stress, and levels increase with both asymptomatic and symptomatic left ventricular dysfunction, making it a useful tool in the diagnosis of cardiac failure and a strong prognostic [doi.org]

New techniques, such as diastolic color Doppler myocardial velocity imaging and strain rate imaging, should improve early detection of left ventricular dysfunction in patients with AL amyloid heart disease [ 43 ]. [ojrd.biomedcentral.com]

Thornhill, Amyloidosis: an unusual case of persistent oral ulceration, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 108, 5, (e46), (2009). [doi.org]

Abstract We describe two patients with temporal artery biopsy-proven amyloidosis presenting with symptoms of jaw claudication, visual disturbance, and proximal muscle stiffness suggestive of giant cell arteritis (GCA) and polymyalgia rheumatica. [ncbi.nlm.nih.gov]

As a result, symptoms and signs are vague and can include fatigue, shortness of breath, weight loss, lack of appetite, numbness, tingling, carpal tunnel syndrome, weakness, hearing loss, enlarged tongue, bruising, and swelling of hands and feet. [medicinenet.com]

[…] complement activation. 84, 85 In Schnitzler syndrome there is deposition of para-protein (IgM-κ is most common) at the dermoepidermal junction and in capillary walls which probably contributes to development of chronic urticaria, intermittent fever, arthralgia [doi.org]

This is usually associated with AL amyloidosis, but AA amyloidosis has also been reported. 39 Hepato/splenomegaly in patients with Schnitzler syndrome (IgM monoclonal gammopathy, urticarial rash, arthralgia, bone pain, lymphadenopathy) should alert one [bloodjournal.org]

In addition, he had intense nocturia, 10-12 times per night, and occasional urgency. Physical examination of the abdomen and genitals was unremarkable. Urine sediment and blood tests were normal. [ncbi.nlm.nih.gov]

Peripheral neuropathy in primary (AL) amyloidosis is usually lower-limb predominant, length-dependent, symmetrical, and affects small (pain and autonomic) fibers, as much or more than large fibers. [ncbi.nlm.nih.gov]

AL amyloidosis can affect many organs, resulting in the following signs and symptoms: Symptoms indicating the arms are affected include: Carpal tunnel syndrome Numbness, buring and/or tingling (peripheral neuropathy) Weak fingernails Symptoms indicating [my.clevelandclinic.org]

One was African-American, one had peripheral neuropathy, and the third was referred for evaluation of hereditary amyloidosis and was diagnosed with Durie-Salmon stage I multiple myeloma. [doi.org]

And the presence of cardiomyopathy, sensorimotor peripheral neuropathy and micturition disorders were also not highlighted in previous medical referrals. [bmcgastroenterol.biomedcentral.com]

It has been postulated that amyloidogenic light chains may have a direct toxic effect on myocardial cells. 43, 44 This is in concordance with the observation that NT-proBNP levels in patients achieving a hematologic response decrease along with clinical [doi.org]

Xianrui Zhang and Meiyun Fang, TEMPI Syndrome: Erythrocytosis in Plasma Cell Dyscrasia, Clinical Lymphoma Myeloma and Leukemia, 10.1016/j.clml.2018.07.284, 18, 11, (724-730), (2018). M Hasib Sidiqi, Mohammed A. Aljama, Eli Muchtar, Francis K. [doi.org]

Katsura Soma, Masataka Takizawa, Hiroki Uozumi, Naoshi Kobayakawa, Tamiko Takemura, Junichi Shiraishi and Teruhiko Aoyagi, A Case of ST-Elevated Myocardial Infarction Resulting From Obstructive Intramural Coronary Amyloidosis, International Heart Journal [doi.org]