The clinical consequences of the immotile cilia syndrome include chronic cough and expectoration, bronchiectasis, chronic rhinitis and nasal polyposis, chronic or recurrent sinusitis, and often an agenesis of the frontal sinuses. [ommbid.mhmedical.com]

sinusitis, bronchiectasis, infertility, and situs inversus is the defective ciliary motility/immotility. [lungindia.com]

Nevertheless, 8/29 (27.6%) children had already undergone sinus surgery for nasal polyps or recurrent sinusitis. Nasal nitric oxide levels were available for 88/168 patients (41 with DD, 34 with NU and 13 with CC). [ojrd.biomedcentral.com]

Assay Assay and technical information Invitae is a College of American Pathologists (CAP)-accredited and Clinical Laboratory Improvement Amendments (CLIA)-certified clinical diagnostic laboratory performing full-gene sequencing and deletion/duplication [invitae.com]

Recurrent bacterial infections in the lower airways and nasal passageways often lead to chronic or recurrent pneumonia, sinusitis, and otitis media. [invitae.com]

Only about 50 cases have been reported in the literature, mostly associated with other multiple congenital anomalies. [ncbi.nlm.nih.gov]

How PCD Affects Your Body In people with PCD, mucus (sputum) builds up, making them prone to infections of the airways like bronchitis and pneumonia as well as chronic, recurring ear and sinus infections. [lung.org]

No differences were found in the rate of positive sputum cultures and in the number of antibiotic courses between the two groups. Hypovitaminosis D is common in PCD patients, and is associated with poorer QoL. [altmetric.com]

Otitis media with effusion should be managed conservatively, with regular audiological assessment, hearing aids and hearing therapy (14, 15), – the use of ventilation tubes (grommets) should be avoided where possible (8, 14, 15), – regular ( 3 monthly) sputum [czytelniamedyczna.pl]

The heterogeneity (I 2 ) in prevalence of lower respiratory symptoms ranged from 89% in sputum production to 94% in cough. [erj.ersjournals.com]

Symptoms scored at ‘current evaluation’ were: chronic cough (coughing 3 days/week), chronic sputum production (expectorating sputum 3 days/week), clubbing and nasal secretions. [ojrd.biomedcentral.com]

Nasal biopsy electronic microscopy and functional evaluation of the cilia Differential diagnosis Primary ciliary dyskinesia must be differentiated mainly from the following chronic pulmonary diseases: cystic fibrosis, asthma, immunodeficiencies, chronic aspiration [jped.com.br]

[…] by means of the sweat test, immunodeficiency by means of the immunoglobulin count and the lymphocyte subpopulations in the blood, respiratory allergy by means of the prick test and specific IgE testing, and gastroesophageal reflux secondary pulmonary aspiration [archbronconeumol.org]

For example, history probing about meconium aspiration was considered irrelevant for the diagnosis of PCD. [f1000research.com]

A portable device equipped also for nNO analysis through the aspiration method is currently available ( 81, 82 ), but more experience is needed to validate its use. [frontiersin.org]

At one year of age, he was hospitalized for five days with a diagnosis of asthmatic bronchitis, with no significant lung infiltrations observed by X-ray ( Fig. 2A ). [spandidos-publications.com]

LEARN MORE PCDF 15th Anniversary Celebration Variation in treatment strategies for the eradication of Pseudomonas aerugi... READ MORE With all the research being done with PCD, it is important for pulmonologists to... [pcdfoundation.org]

Mucoid Pseudomonas aeruginosa (n 12; 15%) and nontuberculous mycobacteria (n 8; 10%) were present in older ( 30 years) patients with PCD. All subjects had defects in ciliary structure, 66% in the outer dynein arm. [cfpub.epa.gov]

In the total group of PCD patients, the Pseudomonas positive patients were significantly older (n   28, median age 23.6 y) (p 0.017) and had significantly lower FEV 1 z-scores (median FEV 1 z-score 2.2) (p 0.032) than the Pseudomonas negative patients [ojrd.biomedcentral.com]

Chronic Pseudomonas aeruginosa is found particularly in adults with advanced disease. It is unclear, if chronic Pseudomonas aeruginosa infection has similar detrimental effects on lung function in PCD as in CF. [link.springer.com]

Chronic rhinitis/sinusitis (n 78; 100%) Recurrent otitis media (n 74; 95%) Neonatal respiratory symptoms (n 57; 73%) Situs inversus (n 43; 55%) Mucoid Pseudomonas aeruginosa (n 12; 15%) ( 30 years) Nontuberculous mycobacteria (n 8; 10%) ( 30 years ) 26 [slideshare.net]