Symptoma

Primary Cutaneous Follicle Center Lymphoma

PCFCL

Features contributing to the diagnostic conundrum in this case included an atypical clinical and histological presentation, lack of pertinent clinical history and multiple presentations at different institutions. [ncbi.nlm.nih.gov]

  • Falling

    […] in reporting this case is to emphasize that in the context of primary cutaneous B-cell lymphoma, the 9p21 deletion while characteristic of the leg-type lymphoma is not a unique signature of the leg-type lymphoma and is not exclusionary to lymphomas falling [ncbi.nlm.nih.gov]

    Skin lymphomas that don't fall into any of these three categories are called primary cutaneous peripheral T-cell lymphoma, unspecified. [seattlecca.org]

    The treatments mentioned in this section fall into 2 main groups: Skin-directed treatments Whole-body (systemic) treatments T-cell lymphomas Mycosis fungoides (MF) Many forms of treatment can be used for MF. [cancer.org]

  • Papule

    The last patient had miliary papules on the entire face, back, upper aspect of arms, and scattered on the front of the chest. [ncbi.nlm.nih.gov]

    Clinical Features: Presents as solitary or grouped papules, plaques or tumors Most common on the scalp, forehead and back Good prognosis Histologic Features: Nodular or diffuse infiltrate occupying the entire dermis and sometimes extending into the subcuataneous [dermpedia.org]

  • Subcutaneous Nodule

    A 62-year-old man presented with a solitary indolent subcutaneous nodule for 3 years duration, without other abnormalities. [ncbi.nlm.nih.gov]

    Whole-body Positron Emission Tomography--Computed Tomography scan revealed a 1.9 cm subcutaneous nodule in the anteromedial soft tissues of the left thigh with marked increased radiotracer uptake. [ijdvl.com]

     Clinical Features :  Multiple subcutaneous nodules involving trunk and extremities, rarely, the face.  Constitutional symptoms : fever, fatigue, and weight loss may be present.  Pancytopenia : usually, due to cytokine mediated BM suppression [slideshare.net]

  • Skin Papule

    Seven patients with cutaneous B-cell pseudolymphoma (2 males, 5 females; mean age, 36.3 years; range, 9 to 60 years) had solitary, erythematous skin papules or small nodules located on the face (n   1), ear (n   3), trunk (n   2), or upper extremities [bloodjournal.org]

    You may have small, raised, solid areas of skin ( papules) or flatter, thickened areas of skin (plaques). Some people have larger lumps called nodules or tumours, which are often deep-red or purplish in colour. They can ulcerate and become infected. [lymphomas.org.uk]

  • Skin Plaque

    You may have small, raised, solid areas of skin ( papules) or flatter, thickened areas of skin (plaques). Some people have larger lumps called nodules or tumours, which are often deep-red or purplish in colour. They can ulcerate and become infected. [lymphomas.org.uk]

  • Long Arm

    We report a reciprocal translocation between the long arms of chromosomes 12 and 21, t(12;21)(q13;q22), in a patient with primary cutaneous follicle center lymphoma. [ncbi.nlm.nih.gov]

    The other interesting finding in this case is the deletion present on the long arm of one chromosome 10. [path.upmc.edu]

    arms of chromosomes 12 and 21, t(12;21)(q13;q22), has been found in a patient with primary cutaneous FCL, [67] which again may suggest a potential pathogenetic pathway of these tumors, but so far has no practical diagnostic relevance. [emedicine.medscape.com]

Follow-up Patients should be seen in an outpatient setting at least every 6 months for a clinical workup. They do not require any additional laboratory workup unless enlargement of the regional lymph nodes has occurred. [emedicine.medscape.com]

For further workup, a 6 mm punch biopsy was done from the lesion. Histologically, the skin biopsy showed an unremarkable epidermis. [ijpmonline.org]

  • Lymphocytic Infiltrate

    Punch biopsy taken from a left arm skin lesion showed a diffuse and nodular large cell lymphocytic infiltrate in the 15-20 μm range exhibiting round to oval nuclei and prominent eosinophilic nucleoli. [ncbi.nlm.nih.gov]

    infiltrate •Chronic lymphocytic leukaemia, B cell type•Inflammatory pseudotumour •Plasmacytoma •Marginal zone B-cell lymphoma 89. [slideshare.net]

Due to a refusal to treatment, the lesion progressively grew until now. [ncbi.nlm.nih.gov]

In patients who do require some treatment intervention, complete surgical excision of the lesion or lesions in question is common practice, as is radiotherapy. [lymphomainfo.net]

You can help by adding to it. ( May 2018 ) Treatment [ edit ] Surgical removal and/or radiotherapy is given for localized disease. [2] : 314 [6] Radiation using multiple radiation fields is given if the disease has wider extent with grouped lesions. [ [en.wikipedia.org]

The distinction between primary and secondary B-cell lymphomas is essential for defining prognosis/course of action. [ncbi.nlm.nih.gov]

The relapse rate is about 30 percent, but often relapse does not correlate with prognosis. Where prognosis gets a little tricky is on the legs. [lymphomainfo.net]

[…] with the presence of bcl-6 and occasional network of follicular dendritic cells in the background. [4] An association with Borrelia burgdorferi, hepatitis C, or human herpesvirus 8 has been described in sporadic patients but does not seem to be a major etiological [bioline.org.br]

The etiology may involve microbial, physical, chemical, Borrelia burgdorferi infection, insect bite, tattoo, and drugs Clinically, several variants of C-PSL exist. .... [lymphomation.org]

(Etiology) Lymphocytes are a type of white blood cells that are responsible for providing immunity in the human body. B-cells and T-cells are the two different types of lymphocytes. [dovemed.com]

Association with infections such as Borrelia burgdorferi, hepatitis C, or human herpesvirus 8 (HHV-8) has been described in sporadic patients, but does not seem to be an important etiologic factor for cutaneous follicle center lymphoma [15, 16]. [plasticsurgerykey.com]

Most probably it is a multifactorial and multistep process, with various etiologic factors intervening over a long period. The disease likely begins as a hyperreactive inflammatory process. [emedicine.medscape.com]

B-cell lymphoma of follicle center cells, primary in skin Disease limited to skin for 6 months after diagnosis Distinct disease from systemic follicular lymphoma Better prognosis Fewer BCL2 rearrangements than systemic follicular lymphoma CLINICAL ISSUES Epidemiology [basicmedicalkey.com]

Immunohistochemistry Immunophenotyping Progression and Transformation Cutaneous relapses noted in 30% of patients Recurrences usually proximate to the initial site of the tumor Untreated skin lesion s increase in size, rarely metastases to other site s Epidemiology [seer.cancer.gov]

considered indolent instead of aggressive) Epidemiology [ edit ] Overall (data from SEER, PMID 15908651 ) Mean age 64 yrs. Male 54%. [en.wikibooks.org]

Epidemiology : occurs mostly in adults, but may occasionally affect children and adolescents. [ufrgs.br]

Peñate Y, Hernández-Machín B, Pérez-Méndez LI, Santiago F, Rosales B, et al. (2012) Intralesional rituximab in the treatment of indolent primary cutaneous B-cell lymphomas: an epidemiological observational multicentre study. [omicsonline.org]

Pathophysiology The development of cutaneous lymphoma is only partially understood. Most probably it is a multifactorial and multistep process, with various etiologic factors intervening over a long period. [emedicine.medscape.com]

Skin-directed therapies Topical chemotherapy – creams containing drugs which may be used to kill and prevent the growth and division of cancer cells Phototherapy UVB – broad and narrow band, and PUVA – the use of ultraviolet light to treat the skin Radiation [leukaemia.org.au]

How can Primary Cutaneous Follicular Center Lymphoma be Prevented? Presently, the cause of Primary Cutaneous Follicular Center Lymphoma is unknown and there are no known methods to prevent its formation. [dovemed.com]

Microdissection was performed as follows: 4-μm sections cut from formalin-fixed, paraffin-embedded tissues were mounted on glass slides with a thickness of 0.17 mm (very thin glass slides are needed to prevent laser energy from being dispersed before [bloodjournal.org]

IRB 14321: A Single-Arm, Open-Label, Multicenter, Study of Folotyn (Pralatrexate Injection) in Combination with Oral Leucovorin to Prevent or Reduce Mucositis in Patients with Relapsed or Refractory (R/R) Peripheral T-Cell Lymphoma (PTCL). [cityofhope.org]