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Primary Effusion Lymphoma

PEL


Presentation

  • Kaposi sarcoma was not present in the skin surface or mucous membranes.[ncbi.nlm.nih.gov]
Ascitic Fluid
  • We present a case of PEL in a 69-year-old male presenting with pleural effusion and ascites.[ncbi.nlm.nih.gov]
  • Cytocentrifuge preparation of the patient’s ascitic fluid demonstrated massive cellular infiltrate composed of marked pleomorphic lymphocytes, loose chromatin, several prominent nucleoli and deep cytoplasmatic basophilia with vacuoles in occasional cells[aclr.com.es]
  • Despite treatment with intravenous norepinephrine and ascites fluid drainage with intravenous albumin infusion the renal failure became aggravated.[wjgnet.com]
  • […] cw 老人, ロウジン, elderly person, 017321, 症例報告, ショウレイホウコク, case report, 054676, ヒト, ヒト, human(primates), 012150, human, 男性, ダンセイ(オトコ), man, 017125, ダンセイ, 生体試料固定, セイタイシリョウコテイ, fixation of biological sample, 037243, *, 腹水, フクスイ, ascitic fluid, 052787, リンパ[togodb.biosciencedbc.jp]
  • His initial ultrasound-guided paracentesis yielded 1,365 ml cloudy, yellow ascitic fluid. Analysis of the ascitic fluid was positive for a large number of atypical lymphoid cells.[karger.com]
Axillary Lymphadenopathy
  • In the first case, the patient presented with localised axillary lymphadenopathy without any other symptoms. Biopsy showed lymphoma cells located predominantly in mantle zones with extension into interfollicular areas.[ncbi.nlm.nih.gov]
Lymphocyte Disorder
  • Abstract Kaposi sarcoma-associated herpesvirus (KSHV) is linked with the development of Kaposi sarcoma and the B lymphocyte disorders primary effusion lymphoma (PEL) and multi-centric Castleman disease.[ncbi.nlm.nih.gov]
Pelvic Mass
  • A biopsy of the pelvic mass and bone marrow showed large atypical cells with irregular multi-lobulated nuclei, prominent nucleoli, and abundant amphophilic cytoplasm.[ncbi.nlm.nih.gov]
Hip Pain
  • We present a unique case of a 21-year-old male who presented with ongoing chest pain and right hip pain found to have an extensive lytic lesion of the right iliac bone, a paratracheal mass and a large pelvic mass.[ncbi.nlm.nih.gov]
Subcutaneous Mass
  • We report a case of extracavitary primary effusion lymphoma arising in a HIV-infected male, who presented with two subcutaneous masses involving the skin of the abdominal and inguinal regions as the first manifestation of the process.[ncbi.nlm.nih.gov]

Workup

Right Pleural Effusion
  • Chest radiography and computed tomography revealed right pleural effusion, but no evidence of tumor mass or lymph node enlargement.[ncbi.nlm.nih.gov]
  • Follow-up chest CT shows multiple enlarged lymph nodes in the paratracheal area (A), and a large amount of right pleural effusion with passive atelectasis in the right lung (B). Figure 5.[ekjm.org]
  • The patient returned to the hospital with recurrent ascites and a right pleural effusion after two cycles of chemotherapy. Malignant lymphocytes were found in his pleural fluid on this second admission. He died at home 2 months later.[nature.com]
Pleural Mass
  • Radiological studies revealed bilateral pleural effusion, without evidence of abnormal lymphadenopathies and lung and/or pleural masses. Thoracentesis was immediately performed.[ncbi.nlm.nih.gov]
  • mass lesion; the cells are CD10-/CD20 /CD79a /bcl-6-/MUM1 ; they are EBV but HHV8-.[e-immunohistochemistry.info]

Treatment

  • To clarify treatment issues in HIV-negative PEL patients, we report on two such patients who represent two opposing ends in the spectrum of treatment and review the literature regarding treatment options and patient outcomes.[ncbi.nlm.nih.gov]

Prognosis

  • Although the prognosis of PEL-like lymphoma may be better than PEL, our case showed poor disease course despite chemotherapy.[ncbi.nlm.nih.gov]

Etiology

  • They affect immunosuppressive patients with human herpes virus-8 being the suspected etiological agent. The prognosis is usually poor despite treatment.[ncbi.nlm.nih.gov]
  • Showing 1-10 of 18 references Japan etiology of liver cirrhosis study group. Etiology of liver cirrhosis in Japan: A national survey[semanticscholar.org]
  • Uremic pleuritis is a unique etiology for HD patients.[karger.com]

Epidemiology

  • PURPOSE OF REVIEW: To summarize the current epidemiology, management, and outcomes of primary effusion lymphoma (PEL) and highlight possible future research efforts.[ncbi.nlm.nih.gov]
  • Primary Effusion Lymphoma Epidemiology § Universally associated with HHV-8/ Kaposi sarcoma herpes virus (mediterrannean) § Often occurs in the presence of immunodeficiency Clinical Features § Effusions in the absence of lymphadenopathy/ organomegaly §[ihaematology.com]
  • Epidemiology 1992 ;3: 203 - 209 7. Jaffe HW, Choi K, Thomas PA, et al. National case-control study of Kaposi's sarcoma and Pneumocystis carinii pneumonia in homosexual men. I. Epidemiologic results. Ann Intern Med 1983 ;99: 145 - 151 8.[doi.org]
Sex distribution
Age distribution

Pathophysiology

  • These factors have been discussed in detail elsewhere in the article (see Pathophysiology and Treatment, Medical Care).[emedicine.medscape.com]
  • Pathophysiologically, it is at least possible that in pre-existing T cell defects present in HIV patients, a long-lasting rituximab-induced B cell depletion or hypoglobulinemia has particularly negative effects (Miles 2005).[hivbook.com]

Prevention

  • These preclinical findings highlight the anti-PEL actions of fucoidan, suggesting it could be potentially useful for the prevention and treatment of PEL.[ncbi.nlm.nih.gov]
  • How can Primary Effusion Lymphoma be Prevented? The cause of Primary Effusion Lymphoma is currently unknown. Hence, there are no known methods to prevent the tumor from occurring.[dovemed.com]
  • In Vaccines 87: Modern Approaches to New Vaccines: Prevention of AIDS and other Viral, Bacterial, and Parasitic Diseases, 214–224 (Eds Chanock RM et al.)[dx.doi.org]

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