A 13-year-old girl presented with postural hypotension, severe abdominal pain and diarrhoea, parotid pain and a transient encephalopathy. [ncbi.nlm.nih.gov]

To the Editor: A 33-year-old woman presented with tenderness of the left breast and nipple of 2 weeks’ duration and fever of 2 days’ duration. The pain was so severe it precluded nursing. [mdedge.com]

The present study demonstrates that a substantial proportion of pregnant women who are seronegative for HSV-2 are at risk for primary HSV-2 infections because their spouses are infected. [nejm.org]

Herpes simplex virus type 2 infections presenting as brainstem encephalitis and recurrent myelitis [in Japanese]. Intern Med 1995 ; 34 : 839 –42. Skoldenberg B, Forsgren M, Alestig K, et al. [jnnp.bmj.com]

• Fever

  In addition, hand-foot-mouth disease (viral etiology) needs to be considered because multiple pinpoint oral vesicles and ulcers, as well as fever, are common signs. [softdental.com]

  To the Editor: A 33-year-old woman presented with tenderness of the left breast and nipple of 2 weeks’ duration and fever of 2 days’ duration. The pain was so severe it precluded nursing. [mdedge.com]

  Fever Blister, Fever Blisters, Sore, Cold, Sores, Cold, herpes labialis, Fever sore, Cold sores lip, Cold sore (herpetic), Herpes on lip, fever blister, herpes febrilis, Herpes Labialis [Disease/Finding], fever sores, lip herpes, herpes lips, herpes [fpnotebook.com]

  Two weeks post-transplantation, she developed a fever of 37.9 C with no obvious focus of infection and her physical examination was unremarkable. [sjkdt.org]

• Malaise

  The primary episode of herpetic gingivostomatitis is characterized by constitutional symptoms such as malaise, fever and regional lymphadenopathy. Acute ulcerative gingivostomatitis occurs as a result of virus replication in the affected tissues. [softdental.com]

  Fever, malaise, headache, and sore throat are presenting features. The vesicles rupture to form ulcerative lesions with grayish exudates on the tonsils and the posterior pharynx. [emedicine.medscape.com]

  Primary maternal infection may present as a flu-like syndrome with fever, headache, malaise, and myalgias. Many individuals with HSV-2 may never have sores or have only very mild symptoms. [perinatology.com]

  The symptoms can be quite severe and may include: blisters and ulceration on external genitalia, in the vagina, or on the cervix vaginal discharge pain and itching tender, enlarged lymph nodes pain when urinating high temperature ( fever ) malaise (feeling [medicalnewstoday.com]

• Collapse

  Bilateral basal lung collapse was noted on chest radiography and intravenous amoxicillin and clavulanic acid were continued post-operatively. [sjkdt.org]

• Dysphagia

  A 63-year-old man was urgently admitted to hospital with laryngeal dyspnoea associated with dysphagia but without dysphonia. Physical examination demonstrated the vocal cords in a paramedian position with paralysis of abduction. [ncbi.nlm.nih.gov]

  Weight loss is not uncommon, either related to illness or dysphagia (in primary gingivostomatitis). [www1.cgmh.org.tw]

  Other symptoms include sore throat, dysphagia. The mouth disease can be associated with lesions elsewhere, such as primary herpetic dermatitis, ocular and nasal herpes, herpetic whitlows and even genital herpes. [virology-online.com]

  Herpes esophagitis Symptoms may include painful swallowing ( odynophagia ) and difficulty swallowing ( dysphagia ). It is often associated with impaired immune function (e.g. HIV/AIDS, immunosuppression in solid organ transplants ). [en.wikipedia.org]

• Aphthous Stomatitis

  The differential diagnosis of primary herpetic gingivostomatitis has been reviewed in the differential diagnosis of recurrent aphthous stomatitis. [softdental.com]

  RIH may appear similar to traumatic lesions (mechanical/thermal/chemical) or other types of oral mucosal disorders, such as aphthous stomatitis. [jcda.ca]

• Skin Ulcer

  Individuals who participate in contact sports such as wrestling, rugby, and football (soccer), sometimes acquire a condition caused by HSV-1 known as herpes gladiatorum, scrumpox, wrestler's herpes, or mat herpes, which presents as skin ulceration on [en.wikipedia.org]

• Vesicular Rash

  An extensive vesicular rash was noted on the posterior aspect of the right thigh, and bilaterally in the sacral and perianal areas. There were no vesicles elsewhere. [jnnp.bmj.com]

• Headache

  An initial infection starts after an incubation period of 3-7 days, after which fever, headaches, fatigue and muscle pains can occur. [americanskin.org]

  Symptoms include lymph node enlargement, fever, tiredness, headache, and muscle aches during the episode. Recurrences are preceded by a tingling, itching or burning sensation on the penis one to two days prior to visible blisters and sores. [biology.kenyon.edu]

  Fever, malaise, headache, and sore throat are presenting features. The vesicles rupture to form ulcerative lesions with grayish exudates on the tonsils and the posterior pharynx. [emedicine.medscape.com]

  On presentation she was complaining of headache, unsteadiness when walking, double vision, and photophobia. She had no significant previous medical history and, in particular, no history of genital or oral herpes. [jnnp.bmj.com]

• Oscillopsia

  Neurological examination revealed an intention tremor, marked upper limb and truncal ataxia, oscillopsia, and variable ophthalmoplegia with diplopia and multidirectional nystagmus. [jnnp.bmj.com]

• Truncal Ataxia

  Neurological examination revealed an intention tremor, marked upper limb and truncal ataxia, oscillopsia, and variable ophthalmoplegia with diplopia and multidirectional nystagmus. [jnnp.bmj.com]

• Nystagmus

  Neurological examination revealed an intention tremor, marked upper limb and truncal ataxia, oscillopsia, and variable ophthalmoplegia with diplopia and multidirectional nystagmus. [jnnp.bmj.com]

• Viral Inclusion Body

  General Pathology Corneal scrapings of HSV keratitis prepared with Giemsa stain may reveal the presence of intranuclear viral inclusion bodies. Multinucleated giant cells may also be found. [eyewiki.aao.org]

• Liver Biopsy

  Figure 2A: Liver biopsy H&E. Some hepatocytes around the necrotic areas contain "glassy" nuclei, and there are occasional multinucleate cells. Elsewhere there are scattered apoptotic bodies. Figure 2B. Immunoperoxidase staining for HSV. [sjkdt.org]

Complete resolution of respiratory symptoms was observed after 21 days of treatment with intravenous aciclovir. Gerhardt syndrome comprises inspiratory dyspnoea without dysphonia. [ncbi.nlm.nih.gov]

She was otherwise fit and well and taking no regular drug treatment. She had not travelled outside the United Kingdom in the previous 10 years. [jnnp.bmj.com]

Figure 4: Response to treatment in Case 1. Rapid improvement in AST following treatment with IV aciclovir. [sjkdt.org]

There is no specific treatment for primary herpetic gingivostomatitis. Acvclovir (Zovirax) is effective in the management of initial herpes genitalis. [softdental.com]

Demographic data, data regarding the immune status of the patient, month of infection or re-infection, average temperature during that month, treatment, duration of infection, and type of anterior segment pathology were recorded. [iovs.arvojournals.org]

Herpes simplex virus-associated acute liver failure: A difficult diagnosis with a poor prognosis. Liver Transplant 2005;11(12):1550-5. 5. Norvell J, Blei A, Jovanovic BD, et al. [sjkdt.org]

Where dissemination occurs, infection carries a grave prognosis. Infection is particularly dangerous in premature infants. In mature infants, infection 10 days or more after birth carries a much improved prognosis. [virology-online.com]

Prognosis Prognosis is usually good, but greatly varies depending on severity and number of recurrences of the disease. [eyewiki.aao.org]

It considers diagnosis and prognosis according to infection category, along with testing modalities and limitations. [cps.ca]

Prognosis Spontaneous recovery in a few days to a week, occasionally longer. Recurrence is common. The virus remains in the body for life, but it is usually dormant. Research continues in developing a vaccine. Other Nothing Specified. [rxmed.com]

In addition, hand-foot-mouth disease (viral etiology) needs to be considered because multiple pinpoint oral vesicles and ulcers, as well as fever, are common signs. [softdental.com]

Herpetic whitlow Pathogen : HSV-1 in 60% of cases; HSV-2 in 40% of cases (in the adult population) Etiology Direct contact with infected secretions through a break in the skin, e.g., torn cuticle Main groups: Children ; (via sucking of thumb/fingers [amboss.com]

Acute respiratory disease of university students with special reference to etiologic role of herpes virus hominis. Am. J. Epidemiol. 101 (1975) 111–121. Google Scholar 2. Katz, J., Mamary, I., Ben-Yehuda, A., Barak, S., Danon, Y. [link.springer.com]

Etiology HSV Keratitis is caused by the herpes simplex virus, a double stranded DNA virus made up of an icosahedral shaped capsid surrounding a core of DNA and phosphoproteins of viral chromatin. [eyewiki.aao.org]

It covers: the etiology or herpes simplex labialis, describes the symptoms associated with cold sores, discusses methods to prevent the recurrence of cold sores, identifies the categories of drugs which can be used to provide symptomatic relief, and explains [dentalresource.org]

Hiroshi Kimura, Shinji Kido, Naoki Hanada, Motohiro Shibata, Tsuneo Morishima, Yoichiro Kino Abstract The clinical features and the molecular epidemiology of primary herpes simplex virus type 1 (HSV-1) infection among children younger than 3 years of [pediatrics.aappublications.org]

Epidemiology Fetal HSV infection much less common than neonatal HSV infection. The estimated incidence is at 1 in 200,000 deliveries 3. Complications Overwhelming fetal sepsis might result in multi-organ failure, including fetal brain death. [radiopaedia.org]

Herpes simplex virus infection in pregnancy and in neonate: status of art of epidemiology, diagnosis, therapy and prevention. Virol J 2009 Occurrence of cytomegalovirus and herpes simplex virus infections in pregnancy. [perinatology.com]

Epidemiology of genital herpes in Pittsburgh: serologic, sexual, and racial correlates of apparent and inapparent herpes simplex infections. J Infect Dis 1990 ; 162: 299 –305. 8. Stavraky KM, Rawls WE, Chiavetta J, Donner AP, Wanklin JM.. [nejm.org]

Congenital cytomegalovirus infection: review of the epidemiology and outcome. Obstet Gynecol Surv. 2002; 57 :245–256. [ PubMed ] [ Google Scholar ] 8. Fowler KB, Stagno S, Pass RF. [ncbi.nlm.nih.gov]

The pathophysiology of Gerhardt syndrome remains unexplained, but the possible role of herpes simplex infection should be considered in cases of laryngeal palsy. [ncbi.nlm.nih.gov]

General information Pathophysiology Inoculation : The virus enters the body through mucosal surfaces or small dermal lesions. Neurovirulence : The virus invades, spreads, and replicates in nerve cells. [amboss.com]

Pathophysiology Add text here Primary prevention Prevention of herpetic infection includes avoidance of direct contact with known HSV. [eyewiki.aao.org]

Pathophysiology All herpes viruses are enveloped, double-stranded DNA viruses. The DNA sequences of HSV-1 and HSV-2 are very similar, but differences in their envelope proteins allow for serologic distinction between the two. [pedclerk.bsd.uchicago.edu]

Pathophysiology: HSV, belonging to the family Herpesviridae and to the subfamily Alphaherpesvirinae, is a double-stranded DNA virus characterized by the following unique biological properties: Neurovirulence (the capacity to invade and replicate in the [www1.cgmh.org.tw]

To prevent this infection, gloves should be used routinely when examining or treating patients. [softdental.com]

It does not clear the virus but prevents the virus from multiplying. It may not have much effect once the blisters and ulcers are well developed. [patient.info]

She subsequently made a gradual recovery but was maintained on aciclovir prophylaxis to prevent further episodes of disease. [jnnp.bmj.com]

N/A How can HSV-1 infection be prevented? Reducing transmission is an important aspect of prevention. Children with gingivostomatitis should be excluded from child care to prevent transmission to susceptible infants. [clinicaladvisor.com]

Centers for Disease Control and Prevention. Genital Herpes - CDC Fact Sheet. Available online at . Page last reviewed September 6, 2012. Accessed January 2013. Centers for Disease Control and Prevention. [labtestsonline.it]