Zaiac and Ashley Walker, Nail abnormalities associated with systemic pathologies, Clinics in Dermatology, 10.1016/j.clindermatol.2013.06.018, 31, 5, (627-649), (2013). Henner Morbach, Christian M. Hedrich, Meinrad Beer and Hermann J. [doi.org]

Wenji Wang, Jianlin Chen, Baoshan Liao, Liqun Xia, Suying Hou, Zhiwen Wang and Yishan Lu, Identification and functional characterization of Histone‐like DNA‐binding protein in Nocardia seriolae (NsHLP) involved in cell apoptosis, Journal of Fish Diseases [doi.org]

In cases of arthralgia/arthritis together with clubbed fingers, consideration must be given to hypertrophic osteoarthropathy. The primary or idiopathic form is rare and has a good prognosis. [ncbi.nlm.nih.gov]

finger 件名（キーワード） Hormone 件名（キーワード） Lung cancer 件名（キーワード） Pulmonary hypertrophic osteoarthropathy (PHO) 件名（キーワード） Bone scintigraphy 件名（キーワード） Clubbed finger 件名（キーワード） Hormone 要約・抄録 症例は75歳男性. [iss.ndl.go.jp]

Clubbed fingers: radiological evaluation of the nail bed thickness. Clin Anat. 2008 May. 21(4):314-8. [Medline]. Jajic I, Pecina M, Krstulovic B, Kovacevic D, Pavicic F, Spaventi S. [emedicine.medscape.com]

Eyelid ptosis which is caused by thickened eyelids (blepharoptosis) is a less common symptom. We report the case of a patient with a complete form of pachydermoperiostosis with bilateral ptosis as presenting feature. [ncbi.nlm.nih.gov]

Associated clinical features that have been described include clubbing of digits, with or without paronychial thickening; arthralgias; seborrheic dermatitis; mechanical ptosis of thickened eyelids; periodontal disease; and palmoplantar hyperhidrosis. [doi.org]

On examination, the patient had coarse facial features, thickened eyelids and partial blepharoptosis. [edmcasereports.com]

Ophthalmic examination revealed thickened eyelids with a clear vision. Because of the mechanical ptosis, he had a history of repeated eye infection as his upper eyelid would touch the skin of face and was under treatment for the same. [jiaomr.in]

We describe the case of a patient with the primary form of HOA, who had refractory bone pain and arthritis that responded partially to infliximab treatment. [doi.org]

Colchicine and retinoids improved skin manifestations, while tamoxifen and bisphosphonates significantly alleviated musculoskeletal symptoms, especially joint and bone pain. [medigoo.com]

Involvement of long bones may produce severe, incapacitating, or deep bone pain. Areas affected by periostitis are often painful and may be associated with overlying warmth or edema. [rheumaknowledgy.com]

Girschick, Autoinflammatory bone disorders, Clinical Immunology, 10.1016/j.clim.2012.12.012, 147, 3, (185-196), (2013). [doi.org]

Heritable sclerosing bone disorders: presentation and new molecular mechanisms. Ann N Y Acad Sci 2010; 1192(1): 269–277 PubMed CrossRef Google Scholar 29. Narayanan S, Mohamed Gani VM, Sundararaju V. [link.springer.com]

Traditionally used to treat a variety of bone disorders, such as osteoporosis, Paget’s disease, and metastatic bone malignancy, bisphosphonates exert their therapeutic effect through potent inhibition of osteoclastic bone resorption. [jcadonline.com]

Radiographic examination depicted diffuse periosteal reaction in the bilateral femurs, tibias, and fibulas with a moderate amount of bilateral knee effusions ( Fig. 2A, C ). [doi.org]

Figure 1 Bilateral knee effusion. Figure 2 Hypertrophy of his feet and ankles with edema. Figure 3 Enlargement of his hands and deformity of his fingernails (clubbing). Figure 4 Cutis verticis gyrata. [jmedicalcasereports.biomedcentral.com]

Cutis Vertis Gyrata ( ) Coarse wrinkles over forehead Tylosis & Pseudoptosis ( ) Seborrhoea ( ), Folliculitis ( ) Prominent Naso Labial folds ( ) Sparse Axillary & Pubic hair B/L painless knee effusions External genitalia – Normal Systemic examination [slideshare.net]

hands and feet; periosteal lesions, fatigability, blepharitis, arthralgia, periosteal overgrowth, and occasionally pulmonary osteoarthropathy. [whonamedit.com]

Hyperhidrosis in association with keratoderma and strikingly large hands and feet: a rare case of pachydermoperiostosis. Clin Exp Dermatol. 2010;35(3): e16–e17. 41. Benedek TG. Paraneoplastic digital clubbing and hypertrophic osteoarthropathy. [jcadonline.com]

A radiograph of the chest was unremarkable, while that of the spine revealed spondylotic changes with loss of lumbar lordosis. USG examination of the knee and ankle joints revealed mild effusion with thickened synovium bilaterally [Figure 6]. [doi.org]

Elevated prostaglandin levels in affected individuals with cytokine-mediated tissue remodelling and vascular stimulation may underlie PHO and associated features as hyperhidrosis, acroosteolysis, pachyderma, periostosis and arthritis. [ncbi.nlm.nih.gov]

Elevated prostaglandin levels in affected individuals with cytokine‐mediated tissue remodelling and vascular stimulation may underlie PHO and associated features as hyperhidrosis, acroosteolysis, pachyderma, periostosis and arthritis. [doi.org]

scleroderma) [33] In certain instances, several years after the onset pachydermoperiostosis or primary hypertropic osteoarthropathy, diseases generally known to result in secondary hypertrophic osteoarthropathy (Crohn disease, myelofibrosis, and congenital [emedicine.com]

Dermatological examination showed increased sebaceous hyperplasia with horizontal furrowing on the forehead and palmoplantar keratosis. Radiographs of forearm revealed a cortical thickening bilaterally in radius and ulna. [jiaomr.in]