These results are difficult to reconcile with the literature presented earlier and with other results. [ncbi.nlm.nih.gov]

Abstract Summary: The present study explores the relationship between childhood maltreatment experiences and spectral power in high-frequency EEG activity during sleep in a sample of adults experiencing primary insomnia. [insights.ovid.com]

It may be secondary either to trouble falling asleep and/or to night‐time waking, which must be persistently present (i.e. three to four times a week for several weeks) [ 2 ]. [academic.oup.com]

In the present study, we found an abnormal interhemispheric homotopic resting-state FC in the ACC. [frontiersin.org]

Activities not related to the present article: disclosed no relevant relationships. Other relationships: disclosed no relevant relationships. [pubs.rsna.org]

• Fatigue

  As for GS, prolonged cognitive testing most likely did not contribute to cognitive arousal but more to mental fatigue, as they slept relatively well during naps. [ncbi.nlm.nih.gov]

  Daytime fatigue, mood disruption, and cognitive impairments that affect primary insomnia patients reduce social productivity and quality of life and increase risk of accidents and health care utilization ( 4 – 6 ). [pubs.rsna.org]

• Erythema

  LLT 9.1 10017869 Gastritis NOS LLT 9.1 10017888 Gastroenteritis LLT 9.1 10017885 Gastrooesophageal reflux disease LLT 9.1 10019022 Haemorrhoids LLT 9.1 10000060 Abdominal distension LLT 9.1 10013781 Dry mouth LLT 9.1 10001760 Alopecia LLT 9.1 10015150 Erythema [clinicaltrialsregister.eu]

There is little evidence to suggest that melatonin is an effective treatment for PI. [eurekaselect.com]

Although the absolute benefit of melatonin compared to placebo is smaller than other pharmacological treatments for insomnia, melatonin may have a role in the treatment of insomnia given its relatively benign side-effect profile compared to these agents [ncbi.nlm.nih.gov]

EudraCT Number: 2005-002711-25 Sponsor Protocol Number: 039SC04253 Start Date * : 2005-08-01 Sponsor Name: ANGELINI Full Title: DOSE-FINDING STUDY OF TRAZODONE IN THE TREATMENT OF PATIENTS WITH PRIMARY INSOMNIA Medical condition: TREATMENT OF THE INSOMNIA [clinicaltrialsregister.eu]

SETTING Outpatient with sleep laboratory assessments in months 1 and 8 of treatment. PARTICIPANTS Ninety-five primary insomniacs, 32-64 years old and 55 age- and sex-matched general population-based, representative controls. [semanticscholar.org]

All patients in each unit were surveyed by their nephrologist during routine treatment using a simple yes/no questionnaire as described previously by Holley et al. [ 11 ]. [academic.oup.com]

Further studies that collect fMRI dynamics of wakefulness and deep sleep will contribute to our better understanding the etiology and pathogenesis underlying this disorder. [frontiersin.org]

According to an epidemiologic study, insomnia is a remarkably prevalent disorder, and primary insomnia disorder affects 3%–5% of the general adult population ( 3 ). [pubs.rsna.org]

The epidemiology of insomnia: associations with physical and mental health. the HUNT-2 study. J. Psychosom. [frontiersin.org]

Epidemiology of insomnia: What we know and what we still need to learn. Sleep Med Rev. 2002; 6 :97–111. [ PubMed ] [ Google Scholar ] 3. Morin CM, LeBlanc M, Bélanger L, Ivers H, Mérette C, Savard J. [ncbi.nlm.nih.gov]

Although the significance of these findings for pathophysiologic models of primary insomnia remains unclear, our study suggests that primary insomnia is characterized by altered structural connectivity related to regulation of sleep and wakefulness, particularly [pubs.rsna.org]

Prior studies have reported that the imbalance between left and right hemispheric activity and poor coordination may contribute to the pathophysiology of insomnia. [frontiersin.org]

Full Title: A RANDOMIZED, DOUBLE-BLIND, PLACEBOCONTROLLED, FLEXIBLE-DOSE, PARALLEL-GROUP STUDY OF LURASIDONE ADJUNCTIVE TO LITHIUM OR DIVALPROEX FOR THE PREVENTION OF RECURRENCE IN SUBJECTS WITH BIPOLAR I DISO... [clinicaltrialsregister.eu]

One explanation might be that completing the battery of cognitive tests increased the cognitive load, which in turn contributed to hyperactivation of cognitive functions in INS, and prevented them from falling asleep. [ncbi.nlm.nih.gov]