Symptoma

Primary Malignant Melanoma of the Cervix

Cervix Melanoma

The cytology, histology, and electron microscopy of this lesion are presented in addition to a clinical discussion. [ncbi.nlm.nih.gov]

The present case was initially misdiagnosed and treated on the regimen for squamous cell carcinoma, but progressed despite chemotherapy. [casereports.bmj.com]

  • Subcutaneous Nodule

    We report a rare case of an amelanotic melanoma of the uterine cervix with extensive metastases and multiple subcutaneous nodules. [casereports.bmj.com]

  • Pigmented Tumor

    Gynecologic examination demonstrated a 2 cm polypoid blackish-pigmented tumor on the cervix with multiple small blackish-pigmented lesions throughout the vaginal wall. Cervical Pap smear cytology showed malignant melanoma. [hindawi.com]

  • Vaginal Bleeding

    The patient was admitted with the complaint of vaginal bleeding. Gynecological examination revealed a dark, papillary mass on the posterior lip of the cervix. [ncbi.nlm.nih.gov]

  • Dyspareunia

    The peak incidence of patients with primary MM of the cervix occurs between 60 and 70 years, and it is likely to present with vaginal discharge, bleeding, or dyspareunia [3, 7, 8]. [hindawi.com]

    Most frequent symptoms of primary MM of the cervix are vaginal bleeding, vaginal discharge, abdominal pain, dyspareunia and post-coital bleeding [15, 16]. The symptom at presentation of all patients in this study was vaginal bleeding. [ncbi.nlm.nih.gov]

  • Postcoital Bleeding

    Clinical symptoms presented with irregular vaginal bleeding, postcoital bleeding, or increase of vaginal discharge. Gynecologic examination showed polypus papilla cauliflower-shaped or nodulated black-brown or black-blue mass on the cervix. [ncbi.nlm.nih.gov]

    She had no personal history of vaginal discharge or postcoital bleeding. In her local hospital, gynecologic examination revealed a gray-white irregular mass on the right labia minora. [journals.lww.com]

An extensive clinicoradiological workup, and immunohistochemical confirmation is essential to rule out metastatic lesions and confirm primary. Diagn. Cytopathol. 2017;45:252–256. 2016 Wiley Periodicals, Inc. [onlinelibrary.wiley.com]

After radiological workup, the mass was resected in December 2012. The histopathological examination report and immunohistochemistry suggested malignant melanoma. [jcmtjournal.com]

Recognition of the etiologic role of human papillomavirus (HPV) infection in cervical cancer has led to the recommendation of adding HPV testing to the screening regimen in women 30-65 years of age (see Workup). [emedicine.medscape.com]

Surgical resection is the main treatment of choice for PMMC. [ncbi.nlm.nih.gov]

There is no standard treatment; however, radical surgery is the treatment cornerstone. [hindawi.com]

OBJECTIVE: To investigate the clinical and pathological characteristics of primary cervical malignant melanoma, and its prognosis. [ncbi.nlm.nih.gov]

Poor prognosis is considered for the neoplasia itself as well as for diagnostic tardiness. There is no standard treatment; however, radical surgery is the treatment cornerstone. [hindawi.com]

With the increasing incidence of cutaneous melanomas there is an urgent need to search for etiological and pathogenic factors other than, or additional to, UV radiation. [tandfonline.com]

"Possible etiologies of cancer of the cervix other than herpesvirus". Cancer Research. 33 (6): 1485–90. PMID 4352386. Rosenblatt A, Guidi HG (2009-08-06). Human Papillomavirus: A Practical Guide for Urologists. Springer Science & Business Media. [en.wikipedia.org]

Case Series Introduction The foremost important etiological factor for malignant melanoma is considered to be sunlight exposure. However, primary lesions are also seen in non-sun-exposed areas. [casereports.in]

Recognition of the etiologic role of human papillomavirus (HPV) infection in cervical cancer has led to the recommendation of adding HPV testing to the screening regimen in women 30-65 years of age (see Workup). [emedicine.medscape.com]

"Cancer survival and incidence from the Surveillance, Epidemiology, and End Results (SEER) program". Oncologist. 8 (6): 541–52. doi:10.1634/theoncologist.8-6-541. PMID 14657533. Cosetti M, Yu GP, Schantz SP (April 2008). [en.wikipedia.org]

Changing epidemiology of anorectal melanoma. Dis Colon Rectum. 1999;42:1203-8. 34. Coté TR, Sobin LH. Primary melanomas of the esophagus and anorectum: epidemiologic comparison with melanoma of the skin. Melanoma Res. 2009;19:58-60. 35. [cancernetwork.com]

Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA. 283:2008–2012. 2000. [spandidos-publications.com]

The change in the epidemiologic trend in the United States has been attributed to mass screening with Papanicolaou (Pap) tests, which permits detection and treatment of preinvasive disease. [emedicine.medscape.com]

Porth pathophysiology: concepts of altered health states (1st Canadian ed.). Philadelphia, PA: Wolters Kluwer Health/Lippincott Williams & Wilkins. p. 660. ISBN 978-1-60547-781-7. Robbins S, Kumar V, Abbas A, Fausto N (2007). [en.wikipedia.org]

Pathophysiology Human papillomavirus (HPV) infection must be present for cervical cancer to occur. HPV infection occurs in a high percentage of sexually active women. [emedicine.medscape.com]

However, the results are limited, even when associated with immunotherapy or chemotherapy.1,2 Survival is usually short due to metastasis, independently of the local disease control.1,2,4 Thus, only by early detection via preventive gynecological examination [scielo.br]

Vaccines that prevent some types of HPV infection are available. Exposure to miscarriage prevention drug. [mayoclinic.org]

"Human Papillomavirus Epidemiology and Prevention of Vaccine-Preventable Diseases". CDC.gov. Archived from the original on 3 February 2014. Retrieved 30 January 2014. "Human papillomavirus vaccines. WHO position paper" (PDF). [en.wikipedia.org]

Diagnosis Symptoms Treatment Causes Prognosis Screening Prevention Download PDF What is cervical cancer? Cervical cancer is the growth of abnormal cells in the lining of the cervix. [cancer.org.au]

Supportive Care: Supportive care refers to treatments designed to prevent and control the side effects of cancer and its treatment. [texasoncology.com]