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Primary Malignant Melanoma of the Cervix

Cervix Melanoma


Presentation

  • The cytology, histology, and electron microscopy of this lesion are presented in addition to a clinical discussion.[ncbi.nlm.nih.gov]
  • She then presented with a vaginal relapse and an isolated hepatic lesion, both of which were proposed for surgery. The diagnosis of MM of the cervix is a clinical and pathological challenge due to its rarity and overlapping features.[ncbi.nlm.nih.gov]
  • To present a case of primary malignant melanoma of the cervix. The patient was admitted with the complaint of vaginal bleeding. Gynecological examination revealed a dark, papillary mass on the posterior lip of the cervix.[ncbi.nlm.nih.gov]
  • Twelve (85.7%) of the 14 patients presented a history of vaginal bleeding and 11 (78.6%) underwent surgery. The overall survival was 3-70 months, with a median time of 13.7 months.[ncbi.nlm.nih.gov]
  • Clinical symptoms presented with irregular vaginal bleeding, postcoital bleeding, or increase of vaginal discharge. Gynecologic examination showed polypus papilla cauliflower-shaped or nodulated black-brown or black-blue mass on the cervix.[ncbi.nlm.nih.gov]
Pain
  • CASE REPORT A 65-year-old white woman with a 2-month history of vaginal bleeding and pelvic pain, began treatment in our care in July 1994.[scielo.br]
Skin Lesion
  • lesions in a patient with intravascular large B-cell lymphoma.[researchmap.jp]
Ulcer
  • On physical examination an exophytic cervical mass was observed, 6 cm in diameter, ulcerated with darkened borders, involving the vaginal fornices and parametrial invasion up to the pelvic wall.[scielo.br]
Vaginal Bleeding
  • Twelve (85.7%) of the 14 patients presented a history of vaginal bleeding and 11 (78.6%) underwent surgery. The overall survival was 3-70 months, with a median time of 13.7 months.[ncbi.nlm.nih.gov]
  • The patient was admitted with the complaint of vaginal bleeding. Gynecological examination revealed a dark, papillary mass on the posterior lip of the cervix.[ncbi.nlm.nih.gov]
  • We report the case of a primary MM of the cervix in a 64-year-old woman with vaginal bleeding. She presented with a cervical amelanotic lesion which on biopsy rendered the diagnosis of MM.[ncbi.nlm.nih.gov]
  • Clinical symptoms presented with irregular vaginal bleeding, postcoital bleeding, or increase of vaginal discharge. Gynecologic examination showed polypus papilla cauliflower-shaped or nodulated black-brown or black-blue mass on the cervix.[ncbi.nlm.nih.gov]
  • Cases : Our patients presented with vaginal bleeding. Case 1, a 76 year-old-woman, was initially considered as having a poorly differentiated squamous cell carcinoma. Although she had undergone irradiation, the original lesion had grown larger.[ci.nii.ac.jp]
Postcoital Bleeding
  • Clinical symptoms presented with irregular vaginal bleeding, postcoital bleeding, or increase of vaginal discharge. Gynecologic examination showed polypus papilla cauliflower-shaped or nodulated black-brown or black-blue mass on the cervix.[ncbi.nlm.nih.gov]
Vaginal Discharge
  • Clinical symptoms presented with irregular vaginal bleeding, postcoital bleeding, or increase of vaginal discharge. Gynecologic examination showed polypus papilla cauliflower-shaped or nodulated black-brown or black-blue mass on the cervix.[ncbi.nlm.nih.gov]
Pelvic Pain
  • CASE REPORT A 65-year-old white woman with a 2-month history of vaginal bleeding and pelvic pain, began treatment in our care in July 1994.[scielo.br]
Salpingitis
  • (非結核性卵管炎) 65.Pseudoxanthomatous salpingitis(偽黄色腫性卵管炎,仮性黄色腫性卵管炎) 66.Adenocarcinoma in situ of the fallopian tube(卵管上皮内腺癌) 67.Female adnexal tumor of probable wolffian origin (Wolff管由来と考えられる女性付属器腫瘍) Ⅵ.胎盤 68.Amnion nodosum(羊膜結節) 69.Chorioamnionitis(CAM)[igaku-shoin.co.jp]

Treatment

  • Surgical resection is the main treatment of choice for PMMC.[ncbi.nlm.nih.gov]
  • The treatment of this condition is not yet standardized and the overall prognosis of these patients is very poor. The authors report a case of primary malignant melanoma of the uterine cervix.[ncbi.nlm.nih.gov]
  • Radical surgery is the only treatment showing predictive benefit. BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.[ncbi.nlm.nih.gov]
  • CASE REPORT A 65-year-old white woman with a 2-month history of vaginal bleeding and pelvic pain, began treatment in our care in July 1994.[scielo.br]
  • Although there is no consensus as to a comprehensive treatment, complete radical surgery is generally the treatment cornerstone in the same manner as for melanomas in other organs. We summarized herein 2 cases of uterine cervical melanoma.[ci.nii.ac.jp]

Prognosis

  • OBJECTIVE: To investigate the clinical and pathological characteristics of primary cervical malignant melanoma, and its prognosis.[ncbi.nlm.nih.gov]
  • PMMC is a highly aggressive tumor with a poor prognosis. Surgical resection is the main treatment of choice for PMMC.[ncbi.nlm.nih.gov]
  • The treatment of this condition is not yet standardized and the overall prognosis of these patients is very poor. The authors report a case of primary malignant melanoma of the uterine cervix.[ncbi.nlm.nih.gov]
  • Abstract Malignant melanoma (MM) arising primarily in the cervix is exceedingly rare and has a poor prognosis. We report the case of a primary MM of the cervix in a 64-year-old woman with vaginal bleeding.[ncbi.nlm.nih.gov]
  • Campinas, Brazil The primary malignant melanoma of the uterine cervix is rare, usually diagnosed at an advanced stage and with poor prognosis. The diagnosis is made through histological evaluation and confirmed by special staining procedures.[scielo.br]

Prevention

  • However, the results are limited, even when associated with immunotherapy or chemotherapy. 1,2 Survival is usually short due to metastasis, independently of the local disease control. 1,2,4 Thus, only by early detection via preventive gynecological examination[scielo.br]

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