The aim of this retrospective study was to investigate the frequency of gastric involvement in 204 consecutive patients with PMLBCL that presented at 23 hospitals in Greece. Two out of 204 patients (1.0%) had gastric involvement at presentation. [ncbi.nlm.nih.gov]

• Mediastinal Lymphadenopathy

  CT scan revealed a 5-cm anterior mediastinal mass and mediastinal lymphadenopathy. Endoscopic ultrasound-guided FNA of a 4.5-cm subcarinal lymph node showed medium to large atypical lymphocytes with scant to moderate finely vacuolated cytoplasm. [ncbi.nlm.nih.gov]

  CT imaging also revealed superior and anterior mediastinal lymphadenopathy. [hindawi.com]

• Axillary Lymphadenopathy

  A 57-yr-old woman presented with bilateral axillary lymphadenopathy and intermittent shortness of breath. CT scan revealed a 5-cm anterior mediastinal mass and mediastinal lymphadenopathy. [ncbi.nlm.nih.gov]

• Fever

  The patient, a 33-year-old man, had cough, dyspnea, fever, superior vena cava syndrome, and a mediastinal bulky tumor. A biopsy showed that the latter was characterized by large cells, sclerosis, and compartmentalization. [ncbi.nlm.nih.gov]

  Systemic symptoms, mainly fever or weight loss, are present in AB - Primary mediastinal large B-cell lymphoma (PMLBCL) is a unique type of B-cell lymphoma probably arising from a putative thymic medulla B-cell. [moh-it.pure.elsevier.com]

  […] in the multicenter group (2.5 years follow-up).Short-term toxicity was manageable, but required hospitalization: the rates of grade 3 or 4 toxicity were 20% (for mucositis), 42% (for neutropenia), 29% (for thrombocytopenia), and 9% (for neutropenic fever [hal.archives-ouvertes.fr]

• Fatigue

  The most common adverse reactions (reported in at least 20% of patients) were fatigue, decreased appetite, and dyspnea. [businesswire.com]

  Clinical History A 15-year-old male patient presented with a 3-months history of shortness of breath, decreased appetite, fatigue and fever. A chest radiograph revealed a massive left-sided pleural effusion. [eurorad.org]

  She also experienced fatigue, prominent facial swelling, engorged neck vasculature, headaches, and a 25-pound weight loss. Climbing even four individual stairs caused this former soccer athlete significant fatigue and lightheadedness. [hindawi.com]

  The cause of the condition is also unknown, though genetic mutations have been implicated The condition can cause chest pain, breathing difficulties, fatigue, and other general signs and symptoms, such as fever, weight loss, and appetite loss. [dovemed.com]

• Chills

  She denied having fevers, chills, or night sweats. She is a full-time college student living with her parents and sibling in Mexico. She was evaluated there and diagnosed with Cushing syndrome and hypothyroidism and was prescribed levothyroxine. [hindawi.com]

  Monitor patients for signs and symptoms of infusion-related reactions, including rigors, chills, wheezing, pruritus, flushing, rash, hypotension, hypoxemia, and fever. For Grade 3 or 4 reactions, stop infusion and permanently discontinue KEYTRUDA. [businesswire.com]

• Cushingoid

  The swelling was so marked that it was initially interpreted as Cushingoid. In a young female, a large anterior mediastinal mass is most likely lymphoma, thymoma, germ cell tumor, or sarcoma. [hindawi.com]

• Cough

  The patient, a 33-year-old man, had cough, dyspnea, fever, superior vena cava syndrome, and a mediastinal bulky tumor. A biopsy showed that the latter was characterized by large cells, sclerosis, and compartmentalization. [ncbi.nlm.nih.gov]

  PMLBCL is characterized by a locally invasive anterior mediastinal mass, often producing cough, chest pain, dyspnea, and superior vena cava syndrome. [moh-it.pure.elsevier.com]

  Also called thymus gland. superior vena cava syndrome A group of symptoms that include coughing, difficulty breathing, headache, dizziness, fainting and swelling or flushing of the neck, face and upper arms. [cancer.ca]

• Pleural Effusion

  Poor prognostic indicators are 1,2: advanced stage at diagnosis direct involvement of thoracic viscera infra-diaphragmatic spread pleural effusion Complications SVC syndrome respiratory compromise due to tracheal compression pleural effusions The differential [radiopaedia.org]

  The two groups of patients were similar as regard to age, gender, presence of bulky mediastinal mass, pleural effusion, stage and international prognostic indexes category of risk. Overall, 75.5% of patients in CR received IF-RT as consolidation. [ncbi.nlm.nih.gov]

  Ultrasound of the left hemithorax showed a minimal loculated pleural effusion and an extensive heterogeneous mass within the left chest cavity. [eurorad.org]

  RA The mediastinal mass can be associated with superior vena cava syndrome and pleural effusions. Patients can be fairly symptomatic, so they often need to start treatment relatively quickly. [hematologyandoncology.net]

  Breathing problems, shortness of breath, pleural effusions, superior vena cava syndrome, fevers. etc. [nhlcyberfamily.org]

• Dyspnea

  The patient, a 33-year-old man, had cough, dyspnea, fever, superior vena cava syndrome, and a mediastinal bulky tumor. A biopsy showed that the latter was characterized by large cells, sclerosis, and compartmentalization. [ncbi.nlm.nih.gov]

  PMLBCL is characterized by a locally invasive anterior mediastinal mass, often producing cough, chest pain, dyspnea, and superior vena cava syndrome. [moh-it.pure.elsevier.com]

  […] usually presents with a bulky and rapidly expanding anterior mediastinal mass, often with pleural and pericardial effusions, and that can invade the lungs, superior vena cava, pleura, pericardium, and chest wall, leading to manifestations of cough, dyspnea [orpha.net]

  The most common adverse reactions (reported in at least 20% of patients) were fatigue, decreased appetite, and dyspnea. [businesswire.com]

• Tracheal Deviation

  A chest X-ray revealed a homogenous opacification on her right side with a left-sided tracheal deviation while a computed tomography scan of her chest revealed a solid mass on her right side. [ncbi.nlm.nih.gov]

  A respiratory examination revealed reduced chest expansion, stony dull percussion note, and absent breath sounds on her entire right side with a left-sided tracheal deviation. [jmedicalcasereports.biomedcentral.com]

• Loss of Appetite

  The cause of the condition is also unknown, though genetic mutations have been implicated The condition can cause chest pain, breathing difficulties, fatigue, and other general signs and symptoms, such as fever, weight loss, and appetite loss. [dovemed.com]

  Common symptoms breathlessness* cough or chest pain* fatigue loss of appetite enlarged lymph nodes - painless swelling in the neck, armpit or groin - often in more than one group. [lymphomation.org]

  Fatigue and loss of appetite are also quite common, and some people experience severe itching. Back to top Diagnosis and staging of DLBCL Carole talks about her experience of being diagnosed and treated for DLBCL. [lymphoma-action.org.uk]

• Regurgitation

  This particular patient’s case was interesting because of the clear infiltration through the cardiac wall and invasion of the right atrium leading to tricuspid regurgitation. [hindawi.com]

  An apex beat was felt at the ninth intercostal space along the mid clavicular line and auscultation revealed a murmur of tricuspid regurgitation. A local breast examination revealed an edematous right breast that was otherwise normal. [jmedicalcasereports.biomedcentral.com]

• Dysphagia

  […] the pressure of the mass on the lungs or gut, or on the superior vena cava (the second largest vein in the body which returns blood from the upper half of the body to the heart).Symptoms include breathlessness, persistent cough, difficulty swallowing (dysphagia [leukaemia.org.au]

• Chest Pain

  PMLBCL is characterized by a locally invasive anterior mediastinal mass, often producing cough, chest pain, dyspnea, and superior vena cava syndrome. [ncbi.nlm.nih.gov]

  The mass can cause symptoms as it grows bigger, such as: shortness of breath cough chest pain a partial blockage of the main vein that carries blood from the upper body to the heart (called the superior vena cava), which can lead to superior vena cava [cancer.ca]

  PMBCL is a large, fast growing tumor that causes symptoms of cough, rapid breathing, difficulty in swallowing and chest pain which are due to the presence of the tumor mass and resulting compression of surrounding tissues. [drugs.com]

• Diastolic Murmur

  A faint diastolic murmur was heard best over the right sternal border. No lymphadenopathy was noted. [hindawi.com]

• Collar of Stokes

  In addition, cardiac MRI and CT scan of the chest revealed the large mediastinal mass completely surrounding and eroding into the superior vena cava (SVC) wall causing a collar of stokes. [hindawi.com]

Workup of such cases should include extended panel of immunohistochemical stains including the B-cell transcription factors PAX-5, OCT-2 and BOB.1. [arup.utah.edu]

• Pericardial Effusion

  Our simple indicators of International Prognostic Index score and the presence of pleural or pericardial effusion could stratify patients with primary mediastinal large B-cell lymphoma and help guide selection of treatment. [ncbi.nlm.nih.gov]

  Most PMLBCL patients have stage I-II, bulky disease, with pleural or pericardial effusions in a third of cases. [moh-it.pure.elsevier.com]

  Other features include parenchymal invasion, pleural effusion, pericardial effusion, chest wall invasion, tracheal, oesophageal and vascular compression. [eurorad.org]

  The presence of pleural or pericardial effusions has been proposed as a negative prognostic indicator. [connect.springerpub.com]

• Anterior Mediastinal Mass

  Plain radiograph Chest radiography demonstrates a soft tissue anterior mediastinal mass. [radiopaedia.org]

  CT scan revealed a 5-cm anterior mediastinal mass and mediastinal lymphadenopathy. Endoscopic ultrasound-guided FNA of a 4.5-cm subcarinal lymph node showed medium to large atypical lymphocytes with scant to moderate finely vacuolated cytoplasm. [ncbi.nlm.nih.gov]

  Germ cell tumours are common in young adults and constitute 15% of all anterior mediastinal masses in adults. [eurorad.org]

• Multiple Pulmonary Nodules

  Computed tomography of the chest and abdomen demonstrated a bulky mass in the left anterior mediastinum, multiple pulmonary nodules, axillary lymph node swelling, and a pancreatic tumor. [ncbi.nlm.nih.gov]

• Nodular Fibrosis

  A CT-guided biopsy of the mass revealed atypical large lymphoid cells with prominent nucleoli, abundant cytoplasm, and nodular fibrosis. [hindawi.com]

• Pleural Effusion

  Poor prognostic indicators are 1,2: advanced stage at diagnosis direct involvement of thoracic viscera infra-diaphragmatic spread pleural effusion Complications SVC syndrome respiratory compromise due to tracheal compression pleural effusions The differential [radiopaedia.org]

  The two groups of patients were similar as regard to age, gender, presence of bulky mediastinal mass, pleural effusion, stage and international prognostic indexes category of risk. Overall, 75.5% of patients in CR received IF-RT as consolidation. [ncbi.nlm.nih.gov]

  Ultrasound of the left hemithorax showed a minimal loculated pleural effusion and an extensive heterogeneous mass within the left chest cavity. [eurorad.org]

  RA The mediastinal mass can be associated with superior vena cava syndrome and pleural effusions. Patients can be fairly symptomatic, so they often need to start treatment relatively quickly. [hematologyandoncology.net]

  Breathing problems, shortness of breath, pleural effusions, superior vena cava syndrome, fevers. etc. [nhlcyberfamily.org]

CONCLUSIONS: Our data indicate that a third-generation regimen like MACOP-B could be considered a suitable first-line treatment. [ncbi.nlm.nih.gov]

The prognosis and therapy of patients with PMLBCL is still controversial. We summarize our experience with PMLBCL at the Medical University of South Carolina between 1997 and 2000. [ncbi.nlm.nih.gov]

[…] unspecified site ICD-10: C85.29 - mediastinal (thymic) large B cell lymphoma, extranodal and solid organ sites Sites Presents with localized anterosuperior mediastinal mass arising in thymic area Regional supraclavicular and cervical lymph node involvement Etiology [pathologyoutlines.com]

The use of tocilizumab directed at IL-6 has been shown to mitigate CRS, but the etiology and treatment of neurologic complications remain more elusive. [hematology.org]

For suspected immune-mediated adverse reactions, ensure adequate evaluation to confirm etiology or exclude other causes. Based on the severity of the adverse reaction, withhold KEYTRUDA (pembrolizumab) and administer corticosteroids. [businesswire.com]

(Etiology) Lymphocytes are a type of white blood cells that are responsible for providing immunity in the human body. B-cells and T-cells are the two different types of lymphocytes. [dovemed.com]

Gov't MeSH terms B7-H1 Antigen/genetics* Cell Line, Tumor Chromosomes, Human, Pair 9 DNA Copy Number Variations Gene Expression Regulation, Neoplastic Gene Frequency Humans In Situ Hybridization, Fluorescence Lymphoma, Large B-Cell, Diffuse/epidemiology [ncbi.nlm.nih.gov]

navigation, search Primary mediastinal large B-cell lymphoma Microchapters Home Patient Information Overview Historical Perspective Classification Pathophysiology Causes Differentiating Primary Mediastinal Large B-cell Lymphoma from other Diseases Epidemiology [wikidoc.org]

(Redirected from Mediastinal large B-cell lymphoma ) Jump to: navigation, search Primary mediastinal large B-cell lymphoma Microchapters Home Patient Information Overview Historical Perspective Classification Pathophysiology Causes Differentiating Primary [wikidoc.org]

[…] diffuse large B-cell lymphoma involving the mediastinum, recognized in the WHO 2008 classification.[1][2]:370–374 Signs and symptoms[edit] Superior vena cava syndrome occurs in 30–50%, and pleural or pericardial effusions occur in about one-third.[3] Pathophysiology [en.wikipedia.org]

This case suggests that long-term administration of an LMWH contributes to the primary improvement and secondary prevention of VTE even in patients who are at high risk for thrombosis. [ncbi.nlm.nih.gov]

Secondary Prevention Cost-Effectiveness of Therapy Future or Investigational Therapies Case Studies Case #1 Primary mediastinal large B-cell lymphoma On the Web Most recent articles Most cited articles Review articles CME Programs Powerpoint slides Images [wikidoc.org]

How can Primary Mediastinal Large B-Cell Lymphoma be Prevented? Currently, it is not possible to prevent Primary Mediastinal Large B-Cell Lymphoma. However, controlling certain factors may help lower one’s risk for the condition. [dovemed.com]