CT scan revealed a 5-cm anterior mediastinal mass and mediastinal lymphadenopathy. Endoscopic ultrasound-guided FNA of a 4.5-cm subcarinal lymph node showed medium to large atypical lymphocytes with scant to moderate finely vacuolated cytoplasm. [ncbi.nlm.nih.gov]

CT imaging also revealed superior and anterior mediastinal lymphadenopathy. [hindawi.com]

A 57-yr-old woman presented with bilateral axillary lymphadenopathy and intermittent shortness of breath. CT scan revealed a 5-cm anterior mediastinal mass and mediastinal lymphadenopathy. [ncbi.nlm.nih.gov]

The patient, a 33-year-old man, had cough, dyspnea, fever, superior vena cava syndrome, and a mediastinal bulky tumor. A biopsy showed that the latter was characterized by large cells, sclerosis, and compartmentalization. [ncbi.nlm.nih.gov]

Systemic symptoms, mainly fever or weight loss, are present in AB - Primary mediastinal large B-cell lymphoma (PMLBCL) is a unique type of B-cell lymphoma probably arising from a putative thymic medulla B-cell. [moh-it.pure.elsevier.com]

[…] in the multicenter group (2.5 years follow-up).Short-term toxicity was manageable, but required hospitalization: the rates of grade 3 or 4 toxicity were 20% (for mucositis), 42% (for neutropenia), 29% (for thrombocytopenia), and 9% (for neutropenic fever [hal.archives-ouvertes.fr]

The most common adverse reactions (reported in at least 20% of patients) were fatigue, decreased appetite, and dyspnea. [businesswire.com]

Clinical History A 15-year-old male patient presented with a 3-months history of shortness of breath, decreased appetite, fatigue and fever. A chest radiograph revealed a massive left-sided pleural effusion. [eurorad.org]

She also experienced fatigue, prominent facial swelling, engorged neck vasculature, headaches, and a 25-pound weight loss. Climbing even four individual stairs caused this former soccer athlete significant fatigue and lightheadedness. [hindawi.com]

The cause of the condition is also unknown, though genetic mutations have been implicated The condition can cause chest pain, breathing difficulties, fatigue, and other general signs and symptoms, such as fever, weight loss, and appetite loss. [dovemed.com]

She denied having fevers, chills, or night sweats. She is a full-time college student living with her parents and sibling in Mexico. She was evaluated there and diagnosed with Cushing syndrome and hypothyroidism and was prescribed levothyroxine. [hindawi.com]

Monitor patients for signs and symptoms of infusion-related reactions, including rigors, chills, wheezing, pruritus, flushing, rash, hypotension, hypoxemia, and fever. For Grade 3 or 4 reactions, stop infusion and permanently discontinue KEYTRUDA. [businesswire.com]

The swelling was so marked that it was initially interpreted as Cushingoid. In a young female, a large anterior mediastinal mass is most likely lymphoma, thymoma, germ cell tumor, or sarcoma. [hindawi.com]

The patient, a 33-year-old man, had cough, dyspnea, fever, superior vena cava syndrome, and a mediastinal bulky tumor. A biopsy showed that the latter was characterized by large cells, sclerosis, and compartmentalization. [ncbi.nlm.nih.gov]

PMLBCL is characterized by a locally invasive anterior mediastinal mass, often producing cough, chest pain, dyspnea, and superior vena cava syndrome. [moh-it.pure.elsevier.com]

Also called thymus gland. superior vena cava syndrome A group of symptoms that include coughing, difficulty breathing, headache, dizziness, fainting and swelling or flushing of the neck, face and upper arms. [cancer.ca]

Poor prognostic indicators are 1,2: advanced stage at diagnosis direct involvement of thoracic viscera infra-diaphragmatic spread pleural effusion Complications SVC syndrome respiratory compromise due to tracheal compression pleural effusions The differential [radiopaedia.org]

The two groups of patients were similar as regard to age, gender, presence of bulky mediastinal mass, pleural effusion, stage and international prognostic indexes category of risk. Overall, 75.5% of patients in CR received IF-RT as consolidation. [ncbi.nlm.nih.gov]

Ultrasound of the left hemithorax showed a minimal loculated pleural effusion and an extensive heterogeneous mass within the left chest cavity. [eurorad.org]

RA The mediastinal mass can be associated with superior vena cava syndrome and pleural effusions. Patients can be fairly symptomatic, so they often need to start treatment relatively quickly. [hematologyandoncology.net]

Breathing problems, shortness of breath, pleural effusions, superior vena cava syndrome, fevers. etc. [nhlcyberfamily.org]

The patient, a 33-year-old man, had cough, dyspnea, fever, superior vena cava syndrome, and a mediastinal bulky tumor. A biopsy showed that the latter was characterized by large cells, sclerosis, and compartmentalization. [ncbi.nlm.nih.gov]

PMLBCL is characterized by a locally invasive anterior mediastinal mass, often producing cough, chest pain, dyspnea, and superior vena cava syndrome. [moh-it.pure.elsevier.com]

[…] usually presents with a bulky and rapidly expanding anterior mediastinal mass, often with pleural and pericardial effusions, and that can invade the lungs, superior vena cava, pleura, pericardium, and chest wall, leading to manifestations of cough, dyspnea [orpha.net]

The most common adverse reactions (reported in at least 20% of patients) were fatigue, decreased appetite, and dyspnea. [businesswire.com]

A chest X-ray revealed a homogenous opacification on her right side with a left-sided tracheal deviation while a computed tomography scan of her chest revealed a solid mass on her right side. [ncbi.nlm.nih.gov]

A respiratory examination revealed reduced chest expansion, stony dull percussion note, and absent breath sounds on her entire right side with a left-sided tracheal deviation. [jmedicalcasereports.biomedcentral.com]

The cause of the condition is also unknown, though genetic mutations have been implicated The condition can cause chest pain, breathing difficulties, fatigue, and other general signs and symptoms, such as fever, weight loss, and appetite loss. [dovemed.com]

Common symptoms breathlessness* cough or chest pain* fatigue loss of appetite enlarged lymph nodes - painless swelling in the neck, armpit or groin - often in more than one group. [lymphomation.org]

Fatigue and loss of appetite are also quite common, and some people experience severe itching. Back to top Diagnosis and staging of DLBCL Carole talks about her experience of being diagnosed and treated for DLBCL. [lymphoma-action.org.uk]

This particular patient’s case was interesting because of the clear infiltration through the cardiac wall and invasion of the right atrium leading to tricuspid regurgitation. [hindawi.com]

An apex beat was felt at the ninth intercostal space along the mid clavicular line and auscultation revealed a murmur of tricuspid regurgitation. A local breast examination revealed an edematous right breast that was otherwise normal. [jmedicalcasereports.biomedcentral.com]

[…] the pressure of the mass on the lungs or gut, or on the superior vena cava (the second largest vein in the body which returns blood from the upper half of the body to the heart).Symptoms include breathlessness, persistent cough, difficulty swallowing (dysphagia [leukaemia.org.au]

PMLBCL is characterized by a locally invasive anterior mediastinal mass, often producing cough, chest pain, dyspnea, and superior vena cava syndrome. [ncbi.nlm.nih.gov]

The mass can cause symptoms as it grows bigger, such as: shortness of breath cough chest pain a partial blockage of the main vein that carries blood from the upper body to the heart (called the superior vena cava), which can lead to superior vena cava [cancer.ca]

PMBCL is a large, fast growing tumor that causes symptoms of cough, rapid breathing, difficulty in swallowing and chest pain which are due to the presence of the tumor mass and resulting compression of surrounding tissues. [drugs.com]

A faint diastolic murmur was heard best over the right sternal border. No lymphadenopathy was noted. [hindawi.com]

In addition, cardiac MRI and CT scan of the chest revealed the large mediastinal mass completely surrounding and eroding into the superior vena cava (SVC) wall causing a collar of stokes. [hindawi.com]

Our simple indicators of International Prognostic Index score and the presence of pleural or pericardial effusion could stratify patients with primary mediastinal large B-cell lymphoma and help guide selection of treatment. [ncbi.nlm.nih.gov]

Most PMLBCL patients have stage I-II, bulky disease, with pleural or pericardial effusions in a third of cases. [moh-it.pure.elsevier.com]

Other features include parenchymal invasion, pleural effusion, pericardial effusion, chest wall invasion, tracheal, oesophageal and vascular compression. [eurorad.org]

The presence of pleural or pericardial effusions has been proposed as a negative prognostic indicator. [connect.springerpub.com]

Plain radiograph Chest radiography demonstrates a soft tissue anterior mediastinal mass. [radiopaedia.org]

CT scan revealed a 5-cm anterior mediastinal mass and mediastinal lymphadenopathy. Endoscopic ultrasound-guided FNA of a 4.5-cm subcarinal lymph node showed medium to large atypical lymphocytes with scant to moderate finely vacuolated cytoplasm. [ncbi.nlm.nih.gov]

Germ cell tumours are common in young adults and constitute 15% of all anterior mediastinal masses in adults. [eurorad.org]

Computed tomography of the chest and abdomen demonstrated a bulky mass in the left anterior mediastinum, multiple pulmonary nodules, axillary lymph node swelling, and a pancreatic tumor. [ncbi.nlm.nih.gov]

A CT-guided biopsy of the mass revealed atypical large lymphoid cells with prominent nucleoli, abundant cytoplasm, and nodular fibrosis. [hindawi.com]

Poor prognostic indicators are 1,2: advanced stage at diagnosis direct involvement of thoracic viscera infra-diaphragmatic spread pleural effusion Complications SVC syndrome respiratory compromise due to tracheal compression pleural effusions The differential [radiopaedia.org]

The two groups of patients were similar as regard to age, gender, presence of bulky mediastinal mass, pleural effusion, stage and international prognostic indexes category of risk. Overall, 75.5% of patients in CR received IF-RT as consolidation. [ncbi.nlm.nih.gov]

Ultrasound of the left hemithorax showed a minimal loculated pleural effusion and an extensive heterogeneous mass within the left chest cavity. [eurorad.org]

RA The mediastinal mass can be associated with superior vena cava syndrome and pleural effusions. Patients can be fairly symptomatic, so they often need to start treatment relatively quickly. [hematologyandoncology.net]

Breathing problems, shortness of breath, pleural effusions, superior vena cava syndrome, fevers. etc. [nhlcyberfamily.org]