Presentation
Musculoskeletal
- Stiffness of the Lower Limbs
He had stiffness of both lower limbs. There was no history of numbness, imbalance while walking, and pain or paresthesias in any limb. [annalsofian.org]
Eyes
- Central Scotoma
scotoma OS Orthophoric Minimal amplitude horizontal pendular 10 CF 5′ CF 5′ 0 0 Diffuse optic atrophy OU Central scotomas OU Orthophoric None 11 20/200 20/100 Small discs with diffuse optic atrophy OU Unable OU Modest XT Moderate amplitude horizontal [iovs.arvojournals.org]
SITA Standard 30-2 Humphrey Visual Field testing from the initial visit in February 2011 shows central scotoma OS. [journal.opted.org]
(Case 6) 1 remember an experience in my early days of practice at an age when youth is synonymous with rashness, of having seen a case of optic neuritis with a central scotoma first in one eye then in the other. [ijo.in]
Psychiatrical
- Compulsive Behavior
Obsessive-compulsive behavior and autistic features have been reported in a single individual. Hypotonia may be present. [disorders.eyes.arizona.edu]
Neurologic
- Clonus
The deep tendon reflexes were all brisk with ankle clonus and plantars were both extensors. Sensory examination including joint position and vibration was normal. Rhonberg's sign was absent. [annalsofian.org]
Workup
X-Ray
- Increased Bone Density
Radiographs reveal diffuse bone sclerosis, loss of the normal corticomedullary differentiation, dense homogeneous appearance due to abnormally increased bone density with obliteration of medullary marrow spaces. [djo.org.in]
Urine
- Glycosuria
Clifford Allbutt in 1871 stated “atrophy of the optic discs … does undoubtedly occur in a sufficient number of cases of glycosuria to make the coexistence seem more than accidental.” [diabetes.diabetesjournals.org]
Visual Field Test
- Central Scotoma
scotoma OS Orthophoric Minimal amplitude horizontal pendular 10 CF 5′ CF 5′ 0 0 Diffuse optic atrophy OU Central scotomas OU Orthophoric None 11 20/200 20/100 Small discs with diffuse optic atrophy OU Unable OU Modest XT Moderate amplitude horizontal [iovs.arvojournals.org]
SITA Standard 30-2 Humphrey Visual Field testing from the initial visit in February 2011 shows central scotoma OS. [journal.opted.org]
(Case 6) 1 remember an experience in my early days of practice at an age when youth is synonymous with rashness, of having seen a case of optic neuritis with a central scotoma first in one eye then in the other. [ijo.in]