A 34-year-old lady presented with a 3 year history of central weight gain, hypertension and secondary amenorrhoea. [endocrine-abstracts.org]

Methods (b): A 14-1/2 year old Caucasian male was referred for accelerated weight gain, which first became apparent at 8 years of age. [digitalcommons.hsc.unt.edu]

CASE REPORT: We report the case of a 20-year-old patient with a history of weight gain, hirsutism, acne, secondary amenorrhea and facial lentiginosis. [scielo.br]

[…] a clinical and in vitro investigation. ( 24512486 ) Bram Z....Stratakis C.A. 2014 15 A rare case of familial Cushing's syndrome with a common presentation of weight gain due to a mutation of the PRKAR1A gene causing isolated primary pigmented nodular [malacards.org]

Briefly, a 24-year-old woman (the second daughter of the index patient; born in November 1975) ( Figure 1 ) was admitted in May 2000 due to cushingoid appearance for about 6 months and weight gain of 10 kg over the preceding 9 months. [omicsonline.org]

Easy bruising, facial plethora and proximal myopathy are the most sensitive features of Cushing’s syndrome. [clinicaladvisor.com]

Skin: skin atrophy, purple striae, easy bruising, hirsutism, acne; pigmentation occurs with ACTH-dependent causes. Psychological problems: depression, cognitive dysfunction and emotional lability. Osteopenia or osteoporosis. Oedema. [patient.info]

Cushing’s syndrome in Carney complex is always due to primary pigmented nodular adrenocortical disease (PPNAD), and symptoms may be a combination of weight gain, high blood pressure, diabetes, and easy bruising, caused by the overproduction of the hormone [cancer.net]

On clinical examination, skin atrophy, buffalo hump, moon facies, proximal muscle weakness and elevated blood pressure (145/90 mmHg) were documented. [jmedicalcasereports.biomedcentral.com]

On examination, she had abdominal adiposity with violaceous striae, facial plethora and hirsutism, atrophic skin, multiple ecchymoses and proximal muscle weakness consistent with Cushing’s syndrome. She had never used exogenous steroids. [edmcasereports.com]

Additional symptoms include high blood pressure (hypertension), fatigue, purple or red stretch marks (striae) on the abdomen, excessive thirst, weakness of the muscles closest to the body (proximal muscle weakness) and psychological disturbances. [rarediseases.org]

The patient reported a three-year history of hirsutism, acne, menstrual disturbances and mood disorders. [jmedicalcasereports.biomedcentral.com]

CASE REPORT: We report the case of a 20-year-old patient with a history of weight gain, hirsutism, acne, secondary amenorrhea and facial lentiginosis. [scielo.br]

[…] adrenocortical disease in Chinese adrenocorticotropic hormone-independent Cushing syndrome. ( 29094256 ) Chen S....Lu Z. 2018 4 Primary pigmented nodular adrenocortical disease (PPNAD) as an underlying cause of symptoms in a patient presenting with hirsutism [malacards.org]

The patient reported weight gain, secondary amenorrhoea of 2year duration and a recent onset of facial hirsutism. [edmcasereports.com]

Skin: skin atrophy, purple striae, easy bruising, hirsutism, acne; pigmentation occurs with ACTH-dependent causes. Psychological problems: depression, cognitive dysfunction and emotional lability. Osteopenia or osteoporosis. Oedema. [patient.info]

Hirsutism and alopecia, nephrolithiasis (often subclinical), osteoporosis with pathologic fracture, gonadal dysfunction, neurologic difficulties including impairment in cognition and memory, and psychiatric symptoms ranging from anxiety or depression [path.upmc.edu]

Cronkhite-Canada syndrome is characterized by a diffuse pattern of hyperpigmentation (rather than lentigines), multiple gastrointestinal polyps, and a variety of ectodermal defects, including alopecia (52). [bioscience.org]

Carney complex: report of a kindred with predominantly cutaneous manifestations. Br J Dermatol 1997 ;136:578-82. [ Links ] 21. Liebler GA, Magovern GJ, Park SB, Cushing WJ, Begg FR, Joyner CR. Familial myxomas in four siblings. [scielo.br]