Neurological examination is initially normal, but patients later develop intention tremor, dysarthria, ataxia and poor coordination, thus subsequently one-third of EPM1 patients become severely incapacitated and wheelchair bound. [journals.plos.org]

Unsteadiness, muscle rigidity, and mental deterioration are often also present. Who gets it? This is a group of rare disorders. [epilepsy.com]

Lesions confined to the thalamus have been associated with asterixis [46], and hemorrhages restricted to the region lateralis of the thalamus lead to a cheiro-oral syndrome [47] or choreiform and dystonic movements associated with myorhythmia [48]. [journals.plos.org]

Dysarthria and ataxia developed in 100% of our patients. Vitamin D deficiency and recurrent viral infections were noticed in 100% of our cohort. Cognitive, learning, and motor dysfunctions were involved in 100% of our patients. [ncbi.nlm.nih.gov]

[…] myoclonic AD 5 3 KCTD7 * Epilepsy, progressive myoclonic AR 18 20 MFSD8 Ceroid lipofuscinosis, neuronal AR 27 47 NEU1 Sialidosis AR 22 62 NHLRC1 Epilepsy, progressive myoclonic AR 14 70 POLG POLG-related ataxia neuropathy spectrum disorders, Sensory ataxia, dysarthria [blueprintgenetics.com]

Their speech can become slurred (called ‘dysarthria’) in the teenage years. [epilepsy.org.uk]

On examination, it was found that the patient had bilateral action tremors along with spasticity, brisk reflexes in the upper and lower limbs, and dysarthria. [cureus.com]

The patienttruncal ataxia, tremor in both hands that couldd voluntarily, dysarthria, and bilateral dysmetriaose test).al tests, including a haemogram, renal, liver, proles, copper, ceruloplasmin, creatine kinase,al antibodies, and baseline and post-exercise [docslide.net]

Neurological examination is initially normal, but patients later develop intention tremor, dysarthria, ataxia and poor coordination, thus subsequently one-third of EPM1 patients become severely incapacitated and wheelchair bound. [journals.plos.org]

Alternatively, the clinical symptoms can be so mild that there is a delay in the diagnosis and patients may manage well. [6] Mild cognitive impairment and slow decline in intellectual level over time have been reported [6] – [9]. [journals.plos.org]

On examination, it was found that the patient had bilateral action tremors along with spasticity, brisk reflexes in the upper and lower limbs, and dysarthria. [cureus.com]

EEG: Generalized almost symmetrical high-voltage polyspikes-and-wave along with frequent bilateral independent posterior dominant (T6, O2//T5, O1) focal spikes on a slow & disorganized background which aggravated on photic stimulation Fig ure 2. [pubs.sciepub.com]