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Propofol

Disoprofol


Presentation

  • Here we present a case of a 17-year-old boy with ulcerative colitis who presented with ballismus, torticollis, tongue thrusting, and oculogyric movements after colonoscopy under general anesthesia with propofol.[ncbi.nlm.nih.gov]
  • In this section, the impact of the study drugs on ERP measures of recollection, which occur in the parietal region 400–600 ms after picture presentation, is presented.[dx.doi.org]
Intravenous Administration
  • An endotracheal intubation was performed after induction with intravenous administration of muscle relaxant. Total intravenous anesthesia via propofol drip infusion (4-7 mg/kg/h) was used during the scanning.[ncbi.nlm.nih.gov]
  • To prevent that pain, anesthesiologists will often an inject a local anesthetic like lidocaine before the intravenous administration of propofol, she said.[health.harvard.edu]
  • Description PropoFlo Injection is a sterile, nonpyrogenic emulsion containing 10 mg/mL of propofol suitable for intravenous administration. Propofol is chemically described as 2, 6-diisopropylphenol and has a molecular weight of 178.27.[drugs.com]
Intravenous Drugs
  • Propofol is an intravenous drug used commonly for the induction and maintenance of anesthesia. It is also used for sedation for non-surgical procedures and for patient intensive care.[thesun.co.uk]
  • Case 2 A 36 year old man with history of psychotic illness attributed to longstanding alcoholic and intravenous drug misuse came to the emergency room with right leg cellulitis.[emj.bmj.com]
  • It is well known that patients with advanced oncological and haematological disease, including solid organ and bone marrow transplantation, intravenous drug users and HIV patients, have a higher incidence of complications during bronchoscopy [ 23 ].[erj.ersjournals.com]
Splenectomy
  • Case 3 A 32-year-old female patient had an emergency splenectomy after a traffic accident.[doi.org]
  • Not Available CompletedTreatment Rupture of Anterior Cruciate Ligament / Tear of Anterior Cruciate Ligament 1 Not Available CompletedTreatment Sedation therapy 1 Not Available CompletedTreatment Sepsis / Shock 1 Not Available CompletedTreatment Status;Splenectomy[drugbank.ca]
Developmental Delay
  • Children with cognitive impairment or developmental delay were not excluded.[web.archive.org]
Crying
  • Discharge readiness was achieved, when a modified Aldrete score of 8 (each parameter from scale of 0–2 for activity, respiration, circulation, consciousness, and colour) and a comfort scale of 3 (crying, agitation, and pain complaints; scale 0–2) were[web.archive.org]
Tonsillar Hypertrophy
  • Exclusion criteria were ASA status III, severe pulmonary or cardiovascular disease, anatomic airway abnormalities or extreme tonsillar hypertrophy, a history of propofol intolerance, known fat metabolism disorder, and diagnostic imaging for acute trauma[web.archive.org]
Hemoptysis
  • We report a case of a 23-year-old healthy male who developed acute cough, hemoptysis and hypoxia following administration of propofol for splinting of a foot fracture. Chest radiography showed bilateral patchy infiltrates.[ncbi.nlm.nih.gov]
Acute Cough
  • We report a case of a 23-year-old healthy male who developed acute cough, hemoptysis and hypoxia following administration of propofol for splinting of a foot fracture. Chest radiography showed bilateral patchy infiltrates.[ncbi.nlm.nih.gov]
Torticollis
  • Here we present a case of a 17-year-old boy with ulcerative colitis who presented with ballismus, torticollis, tongue thrusting, and oculogyric movements after colonoscopy under general anesthesia with propofol.[ncbi.nlm.nih.gov]
Decreased Renal Function
  • renal function has not been observed in clinical studies to date in patients with normal or impaired renal function receiving propofol (Diprivan ). 1 Manufacturer of Diprivan recommends that laboratory analysis of urine (including urine sediment) be[web.archive.org]
Uremia
  • ., shock, intestinal obstruction, malnutrition, anemia, burns, advanced malignancy, ulcerative colitis, uremia, alcoholism), and type and amount of premedication or concomitant medication(s) used. 1 2 118 Use the smallest effective dosage. 1 2 Pediatric[web.archive.org]
Seizure
  • One risk to the fetus is cardiac deceleration during the grand mal seizure. We present a case of a young woman in her second trimester of pregnancy with bipolar depression.[ncbi.nlm.nih.gov]
  • These movements may include: dystonia chorea athetosis twitches opisthotonus Abnormal movements may mimic tonic and clonic movements during seizures, especially during the postoperative period. 76 In several cases, cortical epilepsy was activated during[epilepsy.com]
Asthenia
  • […] ocular pain / Early / 0-1.0 diplopia / Early / 0-1.0 tinnitus / Delayed / 0-1.0 urine discoloration / Early / 0-1.0 leukocytosis / Delayed / 0-1.0 hiccups / Early / 0-1.0 weakness / Early / 0-1.0 sneezing / Early / 0-1.0 pharyngitis / Delayed / 0-1.0 asthenia[pdr.net]
Difficulty Concentrating
  • ., insomnia, anxiety, difficulty concentrating), suggesting physical dependence, observed rarely. 202 Signs of tolerance also observed. 109 200 206 Sensitivity Reactions Sulfite Sensitivity Some formulations contain sulfites that may cause allergic-type[web.archive.org]
Extrapyramidal Symptoms
  • Extrapyramidal symptoms are an uncommon but well-recognized side effect after the administration of general anesthesia in patients without a significant neurologic history.[ncbi.nlm.nih.gov]
Lower Extremity Spasticity
  • Following a propofol anesthetic, a 5-year-old girl with lower extremity spasticity seized and developed hypertriglyceridemia, hyperkalemia, and metabolic acidosis.[ncbi.nlm.nih.gov]

Workup

Triglycerides Elevated
  • He did not have any elevation of triglycerides and on propofol re-challenge, had recurrence of pancreatitis with the absence of triglyceride elevation.[ncbi.nlm.nih.gov]
Colitis
  • Here we present a case of a 17-year-old boy with ulcerative colitis who presented with ballismus, torticollis, tongue thrusting, and oculogyric movements after colonoscopy under general anesthesia with propofol.[ncbi.nlm.nih.gov]
  • ., shock, intestinal obstruction, malnutrition, anemia, burns, advanced malignancy, ulcerative colitis, uremia, alcoholism), and type and amount of premedication or concomitant medication(s) used. 1 2 118 Use the smallest effective dosage. 1 2 Pediatric[web.archive.org]

Treatment

  • A total of 22 metabolites were detected varied after propofol posthypoxia treatment.[ncbi.nlm.nih.gov]

Prognosis

  • Priapism: a three-phase concept of management according to aetiology and prognosis. Br J Urol 1986 ;58: 113 – 8. Google Scholar Crossref Medline 5. van Arsdalen, KN, Chen, JW, Smith, MJ. Penile erections complicating transurethral surgery.[oadoi.org]
  • As Joan Rivers ’ prognosis grows more dire each day, RadarOnline.com has learned that medical investigators are growing ever closer to uncovering the real reason the healthy 81-year-old was sent spiraling into a coma after a standard medical procedure[radaronline.com]
  • In Diamond’s case, it would be helpful to have an interdisciplinary team meeting to clarify her prognosis and goals of care.[pediatrics.aappublications.org]

Etiology

  • CONCLUSION: We report a case of hypertriglyceridemia independent propofol induced pancreatitis possibly related to an idiosyncratic reaction and propose that this drug to be reassigned as a class Ia drug as an etiologic factor for acute pancreatitis.[ncbi.nlm.nih.gov]
  • Our limited knowledge on the etiology and pathophysiology of PRIS preclude effectively preventing its occurrence. High doses and long-term infusion are the main risk factors.[n.neurology.org]
  • At five of seven hospitals, an etiologic agent was isolated from the case patients ( Table 4 ).[nejm.org]
  • Evaluation of the patient's medical history and drug profile allowed us to exclude possible etiologies of green urine, such as methylene blue, indigo, biliverdin, medicines or infection.[omicsonline.org]

Epidemiology

  • Chen MD Epidemic Intelligence Service, Office of Workforce and Career Development, Centers for Disease Control and Prevention, Atlanta, GA, USA Division of Infectious Disease Epidemiology, Pennsylvania Department of Health, Harrisburg, PA, USA Search[dx.doi.org]
  • In: Program and abstracts of the 2nd Annual Meeting of the Society for Hospital Epidemiology of America, Baltimore, April 12–14, 1992. West Deptford, N.J.: Society of Hospital Epidemiology of America, 1992. abstract. 41.[nejm.org]
  • The epidemiology of propofol abuse is unfamiliar to most of the anesthesia providers. Propofol generally has not been listed as a controlled substance.[journals.lww.com]
  • Solís Herruzo Department of Gastroenterology. 1 Department of Epidemiology. Hospital Unviersitario 12 de Octubre.[scielo.isciii.es]
  • Risk of bias and methodological appraisal practices in systematic reviews published in anaesthetic journals: a meta-epidemiological study. Anaesthesia. 2016;71:955–68. View Article Google Scholar Berning V, Laupheimer M, Nübling M, Heidegger T.[bmcanesthesiol.biomedcentral.com]
Sex distribution
Age distribution

Pathophysiology

  • Her brain magnetic resonance imaging (MRI) and computed tomography (CT) scans reveal prominent bilateral brain lesions, matching with the proposed pathophysiologic mechanism of the syndrome.[ncbi.nlm.nih.gov]
  • Aetiology and pathophysiology PRIS is thought to be secondary to an imbalance between energy demand and utilization caused by impairment of mitochondrial oxidative phosphorylation and free fatty acid utilization, ultimately leading to lactic acidosis[academic.oup.com]
  • Our limited knowledge on the etiology and pathophysiology of PRIS preclude effectively preventing its occurrence. High doses and long-term infusion are the main risk factors.[n.neurology.org]
  • In: Fleckstein A, Rona G (eds) Recent advances in studies of cardiac structure and metabolism, pathophysiology and morphology of myocardial cell alteration, Vol 6. University Park Press, Baltimore, pp 385–397 Google Scholar 43.[oadoi.org]

Prevention

  • , Atlanta, GA, USA Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA Centers for Disease Control and Prevention, 1600 Clifton Rd MS‐A35, Atlanta, GA 30333, USA.[dx.doi.org]
  • BACKGROUND: Preconditioning is one of the most powerful mechanisms preventing the myocardial ischemic damage that occurs during coronary artery bypass grafting.[ncbi.nlm.nih.gov]
  • […] substance that can react readily with, and thereby eliminate, radicals. intravenous anaesthetic sedative A central nervous system depressant used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. antiemetic A drug used to prevent[ebi.ac.uk]

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