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Propoxyphene


Presentation

  • The degradation of norpropoxyphene presents a challenge for its analytical quantitation, and methods for circumventing these issues are presented.[ncbi.nlm.nih.gov]
  • The successful use of thioridazine in the treatment of a propoxyphene dependent patient is presented. The drug controlled the craving and anxiety associated with the stepwise reduction of the propoxyphene.[ncbi.nlm.nih.gov]
  • A baby with neonatal withdrawal from propoxyphene as evidenced by severe diarrhea, flapping tremors, shrill cry, diaphoresis, hypertonicity, and seizures is presented.[ncbi.nlm.nih.gov]
  • Three cases are presented of patients who experienced potentiation of propoxyphene's effects by different antihistamines.[ncbi.nlm.nih.gov]
  • At present, increased caution by prescribing physicians is indicated. Patients now taking the drug should be carefully monitored for signs of abuse or dependence.[ncbi.nlm.nih.gov]
Alcohol Breath
  • (breath) testing at screening or check-in Positive test for human immunodeficiency virus (HIV), hepatitis B surface antigen (HBsAg), or hepatitis C antibodies (HCV) History of hypersensitivity or allergy to propoxyphene or any opioid compound, naloxone[clinicaltrials.gov]
Rhinitis
  • These consisted of anorexia, rhinitis, and fatigue, followed by irritability and insomnia. Vomiting developed by the end of 48 hr of abstinence. Propoxyphene was then reinstituted, and within 24 hr the patient was asymptomatic.[annals.org]
  • Withdrawal is characterized by rhinitis , myalgia , abdominal cramping, and occasional diarrhea.[rxlist.com]
  • Migraine Disorders 1 3 Completed Treatment Pain NOS 2 3 Completed Treatment Parkinson's Disease (PD) 1 3 Completed Treatment Postoperative pain / Tooth Diseases 1 3 Completed Treatment Primary apnea of premature newborns 2 3 Completed Treatment Acute Rhinitis[drugbank.ca]
Food Poisoning
  • Contraindicated in patients with diarrhea, food poisoning, who are taking sodium oxybate (GHB) and hypersensitivity. The recommended adult dose is 1-2 tablets every 4 hours as needed for relief of pain.[medindia.net]
Hypotension
  • Neurogenic orthostatic hypotension. N Engl J Med 358(6):615–624 CrossRef PubMed Google Scholar 7. Low PA, Singer W (2008) Management of neurogenic orthostatic hypotension: an update.[doi.org]
  • INHALATION CAUSES RAPID HEART RATE, EXCITEMENT, DIZZINESS, PAIN, COLLAPSE, HYPOTENSION, FEVER, SHORTNESS OF BREATHE. MAY CAUSE HEADACHE, INSOMNIA, NAUSEA, VOMITING, STOMACH PAIN, COLLAPSE AND CONVULSIONS...[chm.bris.ac.uk]
  • RYYVLZVUVIJVGH-UHFFFAOYSA-N InChI InChI 1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 IUPAC Name 1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione SMILES CN1C NC2 C1C( O)N(C)C( O)N2C Indication For management of fatigue, orthostatic hypotension[drugbank.ca]
Hyperhidrosis
  • Abstract Hyperhidrosis is a condition affecting the spinal cord injured (SCI) patient that often does not respond well to medical management.[ncbi.nlm.nih.gov]
Dysthymic Disorder
  • The screening psychiatric diagnostic interview (SCID) indicated that she had current dysthymic disorder, bulimia nervosa, and binge eating disorder, and a past diagnosis of depression.[doi.org]

Workup

Decreased Central Venous Pressure
  • All patients responded with increased systolic arterial blood pressure, increased urinary output and decreased central venous pressure.[ncbi.nlm.nih.gov]
Torsades De Pointes
  • Search terms for opioids, NSAIDs, acetaminophen and other analgesics were used (including both generic and brand names), along with QTc, QTc prolongation, QTc interval, hERG, torsades de pointes (TdP), ventricular arrhythmias, and other relevant terms[ncbi.nlm.nih.gov]
Abnormal ECG
  • In two out of three patients the initially abnormal ECGs normalised during treatment. It is concluded that dopamine seems suitable for reversal of propoxyphene induced circulatory failure.[ncbi.nlm.nih.gov]

Treatment

  • The historical features, results of laboratory evaluations, and clinical course of a man with end-stage renal disease in whom hypoglycemia developed during treatment with propoxyphene are described.[ncbi.nlm.nih.gov]
  • Further investigation into the treatment of this condition with propoxyphene hydrochloride is indicated.[ncbi.nlm.nih.gov]
  • This treatment enabled patients to be rapidly weaned from the respirator.[ncbi.nlm.nih.gov]
  • The successful use of thioridazine in the treatment of a propoxyphene dependent patient is presented. The drug controlled the craving and anxiety associated with the stepwise reduction of the propoxyphene.[ncbi.nlm.nih.gov]
  • What to Expect in Propoxyphene Treatment What happens in prescription drug treatment programs? Darvon and Darvocet addiction is treated like other types of opioid addiction.[promises.com]

Prognosis

  • […] breathing machine) Blood and urine tests Chest x-ray EKG (electrocardiogram, or heart tracing) Fluids through the vein (intravenous or IV) Laxative Medicines to treat symptoms, including naloxone, an antidote to reverse the effects of the poison Outlook (Prognosis[ufhealth.org]
  • Outcome at 5 years of age of children 23 to 27 weeks’ gestation: refining the prognosis. Pediatrics 2001;108:134–141.[doi.org]
  • Maule S, Milazzo V, Maule MM, Di Stefano C, Milan A, Veglio F (2012) Mortality and prognosis in patients with neurogenic orthostatic hypotension. Funct Neurol 27(2):101–106 PubMed PubMedCentral Google Scholar 4.[doi.org]

Etiology

  • There are various etiologies for hypoglycemia in patients with chronic renal failure, and its pathogenesis is complex. Concomitant use of medications is the most common cause.[ncbi.nlm.nih.gov]
  • This pattern was present for both Alzheimer’s disease–related dementia and cerebrovascular disease etiologies, and persisted in analyses restricted to nonsmokers.[ajrccm.atsjournals.org]
  • The role of hormone use in PD etiology and its potential influence on the caffeine-PD relation should be further explored with larger sample sizes in the future.[doi.org]
  • View Article Google Scholar Suhag A, Berghella V: Intrauterine growth restriction (IUGR): etiology and diagnosis. Curr Obstet Gynecol Rep. 2013, 2: 102-111. 10.1007/s13669-013-0041-z.[doi.org]
  • […] pressure and heart rate changes indicate OH/nOH, a complete history and physical examination, as well as electrocardiogram and laboratory testing, should be focused on ruling out non-neurogenic causes of OH, including cardiogenic, vascular, or iatrogenic etiologies[doi.org]

Epidemiology

  • KEYWORDS: Drug surveillance; Epidemiology; Opioid poisoning; Propoxyphene[ncbi.nlm.nih.gov]
  • The FDA says new information, including epidemiological data, shows that the risks of taking propoxyphene-containing medicines probably outweigh the benefits.[medicalnewstoday.com]
  • Most of those deaths were drug overdoses and suicide attempts, often involving multiple drugs, Gerald Dal Pan, MD, MPH, director of the FDA's Office of Surveillance and Epidemiology, said during today's news conference.[webmd.com]
  • Epidemiology 7, 250 – 255. 42. Fenster, L, Hubbard, AE, Swan, SH et al. ( 1997 ) Caffeinated beverages, decaffeinated coffee, and spontaneous abortion. Epidemiology 8, 515 – 523. 43.[doi.org]
  • Several epidemiological studies on this issue have been published since then, warranting an update of the insights on this topic.[doi.org]
Sex distribution
Age distribution

Pathophysiology

  • Google Scholar Crossref Medline ISI Morelli, M, Carta, AR, Kachroo, A. ( 2010 ) Pathophysiological roles for purines: Adenosine, caffeine and urate. Progress in Brain Research 183: 183 – 208.[doi.org]
  • Effective strategies to prevent and treat AD remain elusive despite major efforts to understand its basic biology and clinical pathophysiology. Significant investments in therapeutic ...[doi.org]
  • The pathophysiology of BPD is based on an impairment of lung maturation with prenatal and postnatal multi‐hit insults and genetic susceptibility. This multifactorial pathophysiology of BPD suggests that no single “magic bullet” will prevent it.[doi.org]
  • Low PA (2015) Neurogenic orthostatic hypotension: pathophysiology and diagnosis. Am J Manag Care 21(13 Suppl):s248–s257 PubMed Google Scholar 30.[doi.org]
  • McDermott, Neuroimaging with magnetoencephalography: A dynamic view of brain pathophysiology, Translational Research, 10.1016/j.trsl.2016.01.007, 175, (17-36), (2016). Mohsin H.K. Roshan, Amos Tambo and Nikolai P.[dx.doi.org]

Prevention

  • Administration of N-acetylcysteine prevented inorganic sulfate depletion usually caused by acetaminophen and may have increased the formation of acetaminophen sulfate. Some patients eliminate large overdoses of acetaminophen very slowly.[ncbi.nlm.nih.gov]
  • Alendronate slows bone loss while increasing bone mass, which may prevent bone fractures. Alendronate is used to treat or prevent postmenopausal osteoporosis and steroid-induced osteoporosis.[emedicinehealth.com]
  • Electronic address: cdelcher@ufl.edu. 2 Department of Health Outcomes and Policy, College of Medicine, University of Florida, United States. 3 Department of Biostatistics and Kentucky Injury Prevention and Research Center, University of Kentucky, United[ncbi.nlm.nih.gov]
  • Put the medication in a sealable bag, empty can, or other container to prevent it from breaking out of a garbage bag." Speak with your doctor about other pain control options that include narcotics or NSAIDS that also carry risks.[emaxhealth.com]

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