Presentation
The successful use of thioridazine in the treatment of a propoxyphene dependent patient is presented. The drug controlled the craving and anxiety associated with the stepwise reduction of the propoxyphene. [ncbi.nlm.nih.gov]
Entire Body System
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Nightmare
Doctors sometimes have to prescribe drugs such as buprenorphine and naxolene to help the person endure symptoms such as anxiety, tremors, insomnia, sweats, headache, and nightmares. [teen-drug-abuse.org]
Cardiovascular
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Hypotension
Neurogenic orthostatic hypotension. N Engl J Med 358(6):615–624 CrossRef PubMed Google Scholar 7. Low PA, Singer W (2008) Management of neurogenic orthostatic hypotension: an update. [doi.org]
INHALATION CAUSES RAPID HEART RATE, EXCITEMENT, DIZZINESS, PAIN, COLLAPSE, HYPOTENSION, FEVER, SHORTNESS OF BREATHE. MAY CAUSE HEADACHE, INSOMNIA, NAUSEA, VOMITING, STOMACH PAIN, COLLAPSE AND CONVULSIONS... [chm.bris.ac.uk]
[…] risk for an abnormal cardiac rhythm) and include bundle branch block (interruption of cardiac conduction), bradycardia (slowed heartbeat), asystole (absence of contractions), diminished myocardial contractility (ability of the heart to contract), and hypotension [citizen.org]
RYYVLZVUVIJVGH-UHFFFAOYSA-N InChI InChI 1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 IUPAC Name 1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione SMILES CN1C NC2 C1C( O)N(C)C( O)N2C Indication For management of fatigue, orthostatic hypotension [drugbank.ca]
Eyes
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Eye Irritation
P337 P313 IF eye irritation persists: Get medical advice/attention. P403 P235 Store in a well-ventilated place. Keep cool. [chemicalbook.com]
Skin
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Hyperhidrosis
Abstract Hyperhidrosis is a condition affecting the spinal cord injured (SCI) patient that often does not respond well to medical management. [ncbi.nlm.nih.gov]
Psychiatrical
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Dyslexia
They may have experiences failures in school because they are dyslexia or have problems processing information. [teen-drug-abuse.org]
Workup
Central Venous Pressure
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Decreased Central Venous Pressure
All patients responded with increased systolic arterial blood pressure, increased urinary output and decreased central venous pressure. [ncbi.nlm.nih.gov]
Rhythm
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Torsades De Pointes
Search terms for opioids, NSAIDs, acetaminophen and other analgesics were used (including both generic and brand names), along with QTc, QTc prolongation, QTc interval, hERG, torsades de pointes (TdP), ventricular arrhythmias, and other relevant terms [ncbi.nlm.nih.gov]
Other ECG Findings
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Abnormal ECG
In two out of three patients the initially abnormal ECGs normalised during treatment. It is concluded that dopamine seems suitable for reversal of propoxyphene induced circulatory failure. [ncbi.nlm.nih.gov]
Treatment
Further investigation into the treatment of this condition with propoxyphene hydrochloride is indicated. [ncbi.nlm.nih.gov]
What to Expect in Propoxyphene Treatment What happens in prescription drug treatment programs? Darvon and Darvocet addiction is treated like other types of opioid addiction. [promises.com]
Prognosis
[…] breathing machine) Blood and urine tests Chest x-ray EKG (electrocardiogram, or heart tracing) Fluids through the vein (intravenous or IV) Laxative Medicines to treat symptoms, including naloxone, an antidote to reverse the effects of the poison Outlook (Prognosis [mountsinai.org]
Outcome at 5 years of age of children 23 to 27 weeks’ gestation: refining the prognosis. Pediatrics 2001;108:134–141. [doi.org]
Etiology
There are various etiologies for hypoglycemia in patients with chronic renal failure, and its pathogenesis is complex. Concomitant use of medications is the most common cause. [ncbi.nlm.nih.gov]
This pattern was present for both Alzheimer’s disease–related dementia and cerebrovascular disease etiologies, and persisted in analyses restricted to nonsmokers. [ajrccm.atsjournals.org]
The role of hormone use in PD etiology and its potential influence on the caffeine-PD relation should be further explored with larger sample sizes in the future. [doi.org]
Epidemiology
KEYWORDS: Drug surveillance; Epidemiology; Opioid poisoning; Propoxyphene [ncbi.nlm.nih.gov]
The FDA says new information, including epidemiological data, shows that the risks of taking propoxyphene-containing medicines probably outweigh the benefits. [medicalnewstoday.com]
Most of those deaths were drug overdoses and suicide attempts, often involving multiple drugs, Gerald Dal Pan, MD, MPH, director of the FDA's Office of Surveillance and Epidemiology, said during today's news conference. [webmd.com]
Epidemiology 7, 250 – 255. 42. Fenster, L, Hubbard, AE, Swan, SH et al. ( 1997 ) Caffeinated beverages, decaffeinated coffee, and spontaneous abortion. Epidemiology 8, 515 – 523. 43. [doi.org]
As a result of these data, combined with other information, which include new epidemiological data, the agency concluded that the risks of the medication outweigh the advantages. [schmidtlaw.com]
Pathophysiology
Google Scholar Crossref Medline ISI Morelli, M, Carta, AR, Kachroo, A. ( 2010 ) Pathophysiological roles for purines: Adenosine, caffeine and urate. Progress in Brain Research 183: 183 – 208. [doi.org]
McDermott, Neuroimaging with magnetoencephalography: A dynamic view of brain pathophysiology, Translational Research, 10.1016/j.trsl.2016.01.007, 175, (17-36), (2016). Mohsin H.K. Roshan, Amos Tambo and Nikolai P. [dx.doi.org]
Prevention
Alendronate slows bone loss while increasing bone mass, which may prevent bone fractures. Alendronate is used to treat or prevent postmenopausal osteoporosis and steroid-induced osteoporosis. [emedicinehealth.com]
Administration of N-acetylcysteine prevented inorganic sulfate depletion usually caused by acetaminophen and may have increased the formation of acetaminophen sulfate. Some patients eliminate large overdoses of acetaminophen very slowly. [ncbi.nlm.nih.gov]
Put the medication in a sealable bag, empty can, or other container to prevent it from breaking out of a garbage bag." Speak with your doctor about other pain control options that include narcotics or NSAIDS that also carry risks. [emaxhealth.com]