Adverse drug reactions present a potentially serious problem for any patient for whom drugs are prescribed and particularly for those who must take multiple prescriptions. [books.google.com]

[…] propoxyphene intoxication.}, author={L J Bogartz and William C Miller}, journal={JAMA}, year={1971}, volume={215 2}, pages={ 259-62 } } In three consecutive cases of severe, rapid intoxication with propoxyphene hydrochloride (Darvon), pulmonary edema was present [semanticscholar.org]

Patients with salicylate poisoning are often alkalemic on presentation with hyperventilation. [calpoison.org]

Conclusions In conclusion, we report a case of opium intoxication with atypical presentation and the presented case illustrates that intoxications should be taken into consideration in differential diagnosis of aetiological factors leading to edema. [ispub.com]

• Gastric Lavage

  Gastric lavage may be helpful. Activated charcoal can absorb a significant amount of ingested propoxyphene. [home.intekom.com]

  Despite early hospitalization and treatment with gastric lavage, intubation and artificial ventilation in- ducing hypocapnia, we found a mortality rate of 8%. [docslide.us]

  lavage (in lethargic or comatose patients) • Activated charcoal (if bowel sounds are present) • Diuretics, dialysis and hemoperfusion are not indicated, because of large volume of distributions and reversibility with naloxone. [studyres.com]

  If the patient is seen within 4 hours of ingestion the stomach should be emptied by inducing vomiting or by gastric lavage as soon as possible. [ndrugs.com]

• Infertility

  […] health providers, their patients and the public about important reproductive health issues, including contraception, sexually transmitted diseases, HIV AIDS, menopause, urogenital infections, cancer prevention and detection, abortion, sexuality, and infertility [online.atspace.us]

• Antipsychotic Agent

  agents Amisulpride, Chlorpromazine, Droperidol, Haloperidol, Quetiapine, Olanzapine, Thioridazine Class 1A antidysrhythmic agents Quinidine Disopyramide Procainamide Class 1C antidysrhythmic agents Encainide, Flecainide Class III antidysrhythmic agents [lifeinthefastlane.com]

• Rhinorrhea

  […] discontinued after 53 or 54 days of addiction, all of the subjects had subjective complaints (weakness, aching, sensations of heat and cold), and showed objective signs of abstinence, which were largely confined to the mildest category (yawning, lacrimation, rhinorrhea [unodc.org]

• Abnormal Breathing

  At high doses and overdoses, opioid-induced respiratory depression can result in a shortness of breath, abnormal breathing patterns, semi-consciousness, or unconsciousness. [psychonautwiki.org]

• Hypotension

  Diagnosis Patients presenting with ventricular dysrhythmias, wide QRS complexes, or severe hypotension should be suspected of poisoning by a sodium channel antagonist. [calpoison.org]

  Decreased sensitivity of the CO2 chemoreceptors • Noncardiogenic pulmonary edema • Hypothermia • Miosis (typically, tolerance to miosis is not developed, but miosis may not present in meperidine or lomotil overdose or in severe hypoxia) • Bradycardia • Hypotension [studyres.com]

  Drugs & MedicationsPropoxyphene Capsule Conditions: suicidal thoughts alcoholism alcohol intoxication drug abuse depression cor pulmonale prolonged QT interval on EKG abnormal heart rhythm abnormal EKG with QT changes from birth orthostatic hypotension [webmd.com]

  […] hypoglycemics, insulin Liquor (alcohols) Sedative-hypnotics Hyperthermia (NASA) Neuroleptic malignant syndrome, nicotine Antihistamines, alcohol withdrawal Salicylates, sympathomimetics, serotonin syndrome Anticholinergics, antidepressants, antipsychotics Hypotension [segwfg.nl]

  A case of ischemic colitis has been reported following an overdose of propoxyphene which was complicated by severe hypotension. [drugs.com]

• Weak Pulse

  Symptoms may include: Eyes, ears, nose, and throat: Hearing loss Pinpoint pupils Heart and blood vessels: Heart rhythm disturbances Low blood pressure Weak pulse Lungs: Breathing slow, labored, or shallow No breathing Muscles: Muscle spasticity Muscle [medlineplus.gov]

  If any of the following occur, stop taking the drug immediately and call emergency medical services: Extreme drowsiness Pinpoint or dilated pupils Respiratory depression Confusion Cold or clammy skin Weak pulse Blue or purple lips Shallow breathing Slow [rehabspot.com]

• Skin Rash

  Physical and psychological symptoms of Darvon/Darvocet abuse might include: Drowsiness Dizziness Confusion Reported hallucinations Skin rash and jaundice Blurred vision Headaches Delusions of grandeur Unexplainable extended periods of sleep Frenzy-type [addictioncenter.com]

  The most common of these effects can include: Drowsiness Dizziness Sedation Confusion Sudden changes in mood Skin rash Vomiting Constipation Blurred vision Headache Unexplainable extended periods of sleep Euphoria Loss of appetite Dry mouth The FDA banned [rehabspot.com]

  Darvon or Darvocet side effects that you should report to your doctor or health care professional as soon as possible: allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue breathing difficulties, wheezing confusion [lawyersandsettlements.com]

  [Ref] Dermatologic General erythematous skin rashes associated with acetaminophen have been reported, but are rare. A rare case of bullous erythema associated with acetaminophen has been reported. [drugs.com]

• Eruptions

  Thomas RH, Munro DD "Fixed drug eruption due to paracetamol." Br J Dermatol 115 (1986): 357-9 65. [drugs.com]

• Muscle Weakness

  R. & MONTUSCHI, E. - Muscle weakness caused by bretilium tosylate. Lancet 2:789, 1960. [ Links ] 9. CHIU, S. S.; FURUYA. K.: ARAT, T.; NAKAGAWA, M. IIDA, M. - Congenital contracture of the quadriceps muscle. J. [scielo.br]

  Rest relieves pain but prolonged rest can lead to muscle weakness, so rest is recommended for only short periods of time. Physical therapy can improve flexibility and muscle strength, which is important for supporting the affected joints. [online.atspace.us]

• Delusion of Grandeur

  Physical and psychological symptoms of Darvon/Darvocet abuse might include: Drowsiness Dizziness Confusion Reported hallucinations Skin rash and jaundice Blurred vision Headaches Delusions of grandeur Unexplainable extended periods of sleep Frenzy-type [addictioncenter.com]

• Hypercapnia

  Canine experiments have indicated that reducing hypoxia and hypercapnia lowers serum catecholamine concentrations. [emj.bmj.com]

• Wide QRS Complex

  Diagnosis Patients presenting with ventricular dysrhythmias, wide QRS complexes, or severe hypotension should be suspected of poisoning by a sodium channel antagonist. [calpoison.org]

• Torsades De Pointes

  Determine QT interval Prolonged QT interval predisposes to the development of torsade de pointe, a polymorphic ventricular tachycardia. Torsade des pointes is more likely to occur where there is co-existing bradycardia. [lifeinthefastlane.com]

Pharmacology and Therapeutics for Dentistry, 6th Edition describes how to evaluate a patient’s health and optimize dental treatment by factoring in the drugs they take. [books.google.com]

There are different subtypes of both treatment programs, but essentially, inpatient treatment involves living onsite at the treatment facility throughout the recovery program, while outpatient treatment allows someone to continue living at home or a sober [newperspectivesfl.com]

Drug treatments / 002B02U Drug toxicity and drugs side effects treatment / 002B02U03 Toxicity: cardiovascular system Discipline Drugs toxicity and drug intoxications Toxicology Origin Inist-CNRS Database PASCAL INIST identifier 2686995 Sauf mention contraire [pascal-francis.inist.fr]

Home | CCC | ECG in Toxicology by, last update March 26, 2019 OVERVIEW The ECG is important in the assessment and management of poisoned patients for: screening diagnosis prognosis monitoring progression to guide management and disposition USE AS A SCREENING [lifeinthefastlane.com]

I t is surprising that six patients admitted in asystole could be discharged without any sequelae, emphasis- ing a readily reversible depressed state and a positive prognosis if treated immediately. [docslide.us]

Because chronic pain is a complex condition with intrinsic sensory, emotional, and behavioral components contributing to its etiology and severity, managing chronic pain disorders can be challenging. [hayes.web.fc2.com]

Common etiologies and new approaches to management of poisoning in pediatric practice. Curr Opin Pediatr. 1993 Oct; 5(5):524-30. View abstract Woolf AD, Lovejoy FH. Epidemiology of drug overdose in children. Drug Saf. 1993 Oct; 9(4):291-308. [childrenshospital.org]

Prescription drug misuse: Epidemiology, prevention, identification, and management. In: Saxxon AJ, ed. UpToDate. Updated April 6, 2021. [labtestsonline.it]

The epidemiology of dextropropoxyphene (Distalgesic) overdose fatalities in Birmingham and the West Midlands. J. Clin. Hosp. Pharm., 6,251-257. Google Scholar | Medline Young, D.J. (1972). Propoxyphene suicides. Arch. Intern. Med., 129, 62-66. [journals.sagepub.com]

Epidemiology of drug overdose in children. Drug Saf. 1993 Oct; 9(4):291-308. View abstract Ledley FD, Lovejoy FH. [childrenshospital.org]

This review considers the epidemiology, mechanisms, and management of opioid ... DA: 74 PA: 62 MOZ Rank: 5 9. Appendix B. [tiwebsite.com]

According to Gerald Dal Pan, M.D., M.H.S., director of the Office of Surveillance and Epidemiology, CDER, once patients stop taking propoxyphene, the risk of heart damage will go away. [lawyersandsettlements.com]

They also address the consequences of drug interactions and the basic pathophysiology of central nervous system toxicity. [books.google.com]

Pathophysiology The role of sodium bicarbonate as an antidote depends on the specific indication. Its mechanisms as an antidote for sodium channel blocking drugs are incompletely understood. [calpoison.org]

Administration of N-acetylcysteine prevented inorganic sulfate depletion usually caused by acetaminophen and may have increased the formation of acetaminophen sulfate. Some patients eliminate large overdoses of acetaminophen very slowly. [ucdavis.pure.elsevier.com]

Centers for Disease Control and Prevention. Available at https://www.cdc.gov/drugoverdose/data/index.html. July 18, 2017; Accessed: October 1, 2018. Fentanyl. Centers for Disease Control and Prevention. [emedicine.medscape.com]

The influence of sociocultural factors on drug dependence and alcohol related problems-on their cause, development, and consequences as well as on their treatment and prevention-has been taken into account in the preparation of this manual in order to [books.google.com]