Presentation
Adverse drug reactions present a potentially serious problem for any patient for whom drugs are prescribed and particularly for those who must take multiple prescriptions. [books.google.com]
}, author {L J Bogartz and William C Miller}, journal {JAMA}, year {1971}, volume {215 2}, pages { 259-62 } } In three consecutive cases of severe, rapid intoxication with propoxyphene hydrochloride (Darvon), pulmonary edema was present and represented [semanticscholar.org]
This communication presents data on the value of osmotic diuresis, peritoneal, and hemodialysis for the therapy of propoxyphene poisoning. [jamanetwork.com]
Patients with salicylate poisoning are often alkalemic on presentation with hyperventilation. [calpoison.org]
Entire Body System
-
Gastric Lavage
Gastric lavage may be helpful. Activated charcoal can absorb a significant amount of ingested propoxyphene. [home.intekom.com]
lavage (in lethargic or comatose patients) • Activated charcoal (if bowel sounds are present) • Diuretics, dialysis and hemoperfusion are not indicated, because of large volume of distributions and reversibility with naloxone. [studyres.com]
Despite early hospitalization and treatment with gastric lavage, intubation and artificial ventilation in- ducing hypocapnia, we found a mortality rate of 8%. [docslide.us]
If the patient is seen within 4 hours of ingestion the stomach should be emptied by inducing vomiting or by gastric lavage as soon as possible. [ndrugs.com]
-
Developmental Disabilities
She is a former Chair of the Committee on Developmental Disabilities for the American Psychiatric Association, Assistant Professor of Psychiatry at Johns Hopkins Hospital in Baltimore, Maryland, and Medical Director of the National Center for Children [tiwebsite.com]
-
Malnutrition
Bonkovsky HL, Kane RE, Jones DP, Galinsky RE, Banner B "Acute hepatic and renal toxicity from low doses of acetaminophen in the absence of alcohol abuse or malnutrition - evidence for increased susceptibility to drug toxicity due to cardiopulmonary and [drugs.com]
-
Surgical Procedure
Ketamine Ketamine was once widely used as a surgical/procedural sedative because, in contrast with PCP, it was associated with a much shorter and less frightening emergence delirium. [drugabuse.com]
Gastrointestinal
-
Abdominal Cramps
cramps) Seek medical help right away. [medlineplus.gov]
Withdrawal symptoms (after either abrupt cessation or fast tapering) have been reported to include agitation, restlessness, anxiety, insomnia, tremor, tachycardia, hallucinations, psychosis, abdominal cramps, vomiting, sweating, and seizures. [drugs.com]
Cardiovascular
-
Hypotension
Diagnosis Patients presenting with ventricular dysrhythmias, wide QRS complexes, or severe hypotension should be suspected of poisoning by a sodium channel antagonist. [calpoison.org]
Decreased sensitivity of the CO2 chemoreceptors • Noncardiogenic pulmonary edema • Hypothermia • Miosis (typically, tolerance to miosis is not developed, but miosis may not present in meperidine or lomotil overdose or in severe hypoxia) • Bradycardia • Hypotension [studyres.com]
[…] hypoglycemics, insulin Liquor (alcohols) Sedative-hypnotics Hyperthermia (NASA) Neuroleptic malignant syndrome, nicotine Antihistamines, alcohol withdrawal Salicylates, sympathomimetics, serotonin syndrome Anticholinergics, antidepressants, antipsychotics Hypotension [segwfg.nl]
Drugs & MedicationsPropoxyphene Capsule Conditions: suicidal thoughts alcoholism alcohol intoxication drug abuse depression cor pulmonale prolonged QT interval on EKG abnormal heart rhythm abnormal EKG with QT changes from birth orthostatic hypotension [webmd.com]
A case of ischemic colitis has been reported following an overdose of propoxyphene which was complicated by severe hypotension. [drugs.com]
-
Heart Disease
disease Keyword (es) Agudo Analgésico Corazón Dextropropoxifeno Estudio caso Hombre Intoxicación Toxicidad Trastorno conducción Aparato circulatorio patología Cardiopatía Classification Pascal 002 Biological and medical sciences / 002B Medical sciences [pascal-francis.inist.fr]
Heart disease. 6th Edition. Philadelphia: Saunders. p. 167. Siegel RJ [1997]. Myocardial Hypertrophy. In: S. Bloom (ed). Diagnostic Criteria for Cardiovascular Pathology Acquired Diseases. Philadelphia, PA: Lippencott-Raven, pp. 55-57. [cdc.gov]
No anatomic explanation for the deaths was found, excluding patient no, 5287 with a congenital heart disease (Table 1). [docslide.us]
A patient with other co-existing diseases like liver disease, heart disease, kidney disease should take special precautions. sponsored General Salicylates should be used with extreme caution in the presence of peptic ulcer or coagulation abnormalities [ndrugs.com]
Zumwalt found no evidence that Teresita Eldridge might have died from causes such as heart disease, myocarditis, infection of the heart, brain hemorrhage, pulmonary emboli, or other structural abnormalities or infection. 3. Dr. [caselaw.findlaw.com]
Psychiatrical
-
Suggestibility
This suggests that pulmonary edema plays an important role in the natural history of such intoxications. [semanticscholar.org]
In fact, suggestions have been included for adapting the manual for use in the training of such varied groups of students. [books.google.com]
Recent evidence suggests that the sodium component plays a more important role by helping to drive sodium through both blocked and unblocked channels. [calpoison.org]
The histological f indings in the myocard ium are suggestive of cardiotoxicity. A fol low-up determinat ion of myocardia l tissue concentrat ion might be very useful. [documents.tips]
-
Delusion
Physical and psychological symptoms of Darvon/Darvocet abuse might include: Drowsiness Dizziness Confusion Reported hallucinations Skin rash and jaundice Blurred vision Headaches Delusions of grandeur Unexplainable extended periods of sleep Frenzy-type [addictioncenter.com]
Pentazocine overdose • Clinical picture of pentazocine intoxication is different from typical opioids, because pentazocine activates sigma opioid receptors and causes dysphoria, delusions and hallucinations. • In addition, pentazocine intoxication is [studyres.com]
Dissociatives - This combination can unpredictably potentiate the amnesia, sedation, motor control loss and delusions that can be caused by each other. [psychonautwiki.org]
-
Type A Personality
The Medical Examiner concluded: And so in my experience, she was the type of person who would or could have a lethal overdose of a prescription drug in an accidental manner. [law.justia.com]
-
Denial
The court's denial of summary judgment to the plaintiffs, even though usually not appealable because it is an interlocutory decision, has merged into the final judgment and is therefore appealable as well. See Swaback v. American Info. Techs. [law.justia.com]
This case involves the denial of accidental death benefits claimed under an ERISA-regulated employee welfare benefit plan. In these cases, we apply the traditional de novo standard to the review of a summary judgment ruling. Casey v. [caselaw.findlaw.com]
-
Anxiety Disorder
Diazepam Diazepam is used to treat muscle spasms, anxiety disorder, and seizures. It is also prescribed to minimize the risk of agitation and seizures in the setting of acute alcohol withdrawal. [drugabuse.com]
Neurologic
-
Average Intelligence
Under those federal common law rules we are to "interpret the terms of the policy in an ordinary and popular sense, as would a person of average intelligence and experience," and "construe all plan ambiguities in favor of the insured." [law.justia.com]
Under those federal common law rules we are to “interpret the terms of the policy in an ordinary and popular sense, as would a person of average intelligence and experience,” and “construe all plan ambiguities in favor of the insured.” [caselaw.findlaw.com]
-
Giddiness
Hill on laughing gas side effect: It makes you feel giddy with poor recall - too high of a dose can cause respiratory depression. It should not be abused. DA: 72 PA: 45 MOZ Rank: 23 18. N.C. [tiwebsite.com]
Workup
X-Ray
-
Pericardial Effusion
Effusion & Cardiac Activity. [books.google.com]
QRS Wave
-
Wide QRS Complex
Diagnosis Patients presenting with ventricular dysrhythmias, wide QRS complexes, or severe hypotension should be suspected of poisoning by a sodium channel antagonist. [calpoison.org]
Serum
-
Hypercapnia
Canine experiments have indicated that reducing hypoxia and hypercapnia lowers serum catecholamine concentrations. [emj.bmj.com]
Treatment
Pharmacology and Therapeutics for Dentistry, 6th Edition describes how to evaluate a patient’s health and optimize dental treatment by factoring in the drugs they take. [books.google.com]
The patient's complete recovery was remarkable because of the large amounts of drugs ingested, the delayed treatment, and prior exposure to enzyme inducers (known to increase acetaminophen hepatotoxicity). [ucdavis.pure.elsevier.com]
Drug treatments / 002B02U Drug toxicity and drugs side effects treatment / 002B02U03 Toxicity: cardiovascular system Discipline Drugs toxicity and drug intoxications Toxicology Origin Inist-CNRS Database PASCAL INIST identifier 2686995 Sauf mention contraire [pascal-francis.inist.fr]
Prognosis
Home CCC ECG in Toxicology by, last update March 26, 2019 OVERVIEW The ECG is important in the assessment and management of poisoned patients for: screening diagnosis prognosis monitoring progression to guide management and disposition USE AS A SCREENING [lifeinthefastlane.com]
I t is surprising that six patients admitted in asystole could be discharged without any sequelae, emphasis- ing a readily reversible depressed state and a positive prognosis if treated immediately. [docslide.us]
Etiology
Because chronic pain is a complex condition with intrinsic sensory, emotional, and behavioral components contributing to its etiology and severity, managing chronic pain disorders can be challenging. [hayes.web.fc2.com]
Common etiologies and new approaches to management of poisoning in pediatric practice. Curr Opin Pediatr. 1993 Oct; 5(5):524-30. View abstract Woolf AD, Lovejoy FH. Epidemiology of drug overdose in children. Drug Saf. 1993 Oct; 9(4):291-308. [childrenshospital.org]
Epidemiology
This review considers the epidemiology, mechanisms, and management of opioid ... DA: 74 PA: 62 MOZ Rank: 5 9. Appendix B. [tiwebsite.com]
The epidemiology of dextropropoxyphene (Distalgesic) overdose fatalities in Birmingham and the West Midlands. J. Clin. Hosp. Pharm., 6,251-257. Google Scholar Medline Young, D.J. (1972). Propoxyphene suicides. Arch. Intern. Med., 129, 62-66. [journals.sagepub.com]
Epidemiology of drug overdose in children. Drug Saf. 1993 Oct; 9(4):291-308. View abstract Ledley FD, Lovejoy FH. [childrenshospital.org]
director of the Office of Surveillance and Epidemiology, CDER, once patients stop taking propoxyphene, the risk of heart damage will go away. [lawyersandsettlements.com]
Epidemiology Drugs and toxins that act as sodium channel antagonists include agents listed in List 1. Together they comprise perhaps the largest group of cardiotoxic agents. [calpoison.org]
Pathophysiology
They also address the consequences of drug interactions and the basic pathophysiology of central nervous system toxicity. [books.google.com]
Pathophysiology The role of sodium bicarbonate as an antidote depends on the specific indication. Its mechanisms as an antidote for sodium channel blocking drugs are incompletely understood. [calpoison.org]
Prevention
Administration of N-acetylcysteine prevented inorganic sulfate depletion usually caused by acetaminophen and may have increased the formation of acetaminophen sulfate. Some patients eliminate large overdoses of acetaminophen very slowly. [ucdavis.pure.elsevier.com]
The influence of sociocultural factors on drug dependence and alcohol related problems-on their cause, development, and consequences as well as on their treatment and prevention-has been taken into account in the preparation of this manual in order to [books.google.com]
Estradiol is known to exert no protective effect against most toxicants amenable to prophylaxis by catatoxic steroids, yet it is highly efficacious in preventing propoxyphene poisoning; conversely, triamcinolone and thyroxine aggravate this intoxication [karger.com]