Presentation
The lack of early specific symptoms results in more advanced disease at presentation. [ncbi.nlm.nih.gov]
Individuals most commonly present with signs and symptoms of urinary obstruction as in our case. [cancerjournal.net]
PMID: 11474287 Malignant smooth muscle tumors presenting as mediastinal soft tissue masses. A clinicopathologic study of 10 cases. Moran CA, Suster S, Perino G, Kaneko M, Koss MN. Moran CA, et al. [pubmed.ncbi.nlm.nih.gov]
Entire Body System
- Surgical Procedure
Diagnosis is made by TRUS guided needle biopsy or transurethral resection in most patients, and less commonly by open surgical procedures.2, 3 Tumors range in size from 3 to 21 cm and are highly infiltrative.3 Gross examination reveals an ill-defined [ncbi.nlm.nih.gov]
Diagnosis is usually accomplished with ultrasoundguided transrectal needle biopsy or transurethral resection in most patients, and rarely by open surgical procedures. [3],[6] The majority of leiomyosarcomas are high-grade hypercellular lesions composed [cancerjournal.net]
Treatment
Though definite treatment modalities are not recommended till now, innovative combined multimodality treatment strategies may help to improve the prognosis of patients with this tumor of poor survival rate. [cancerjournal.net]
[…] and prognosis Treatment options of leiomyosarcoma of the prostate gland include radical surgery from radical prostatectomy to pelvic exenteration, chemotherapy or radiotherapy or any combination of the three 1. [radiopaedia.org]
Radical surgery was the treatment of choice in the current series, but complete excision was difficult in most cases and did not result in cure. [pubmed.ncbi.nlm.nih.gov]
For all these reasons, intraarterial chemotherapy should be considered as a treatment option in palliative, oncological patient care. … [publikationen.ub.uni-frankfurt.de]
Prognosis
[…] adults and constitutes 38–52% of them.2 It has an aggressive clinical course.3 Here we present a case of prostate leiomyosarcoma and a literature review regarding the clinical and pathological features, diagnostic modalities, therapeutic aspects and prognosis [ncbi.nlm.nih.gov]
Generally, the overall prognosis of leiomyosarcoma of the prostate has been reported to be poor. Best survival rates have been reported for curative surgery with no tumor residue and no metastatic disease 1. [radiopaedia.org]
The relationship of prognosis with histologic and immunohistochemical findings has not, to the authors' knowledge, been described in a large series of cases, and the efficacy of various treatments is uncertain. [pubmed.ncbi.nlm.nih.gov]