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Prostate Metastasis

Metastatic Prostate Cancer


Presentation

  • These lesions are commonly present in multiple myeloma, renal cell carcinoma, thyroid cancer, and melanoma.[frontiersin.org]
  • Together, these data suggest that docetaxel should be considered for patients with more aggressive (de novo [those who initially present with metastatic disease] and/or high-volume metastatic) HSPC. Full Text[jamanetwork.com]
  • Among patients who are symptomatic at presentation, it makes sense to add radium-223 to abiraterone or enzalutamide.[hematologyandoncology.net]
  • In the other 20 (95.2%) patients, metastases were also present in the lumbar spine and pelvifemoral areas and therefore were detected solely with prostate MRI ( Fig. 1 ).[ajronline.org]
Anemia
  • Clinical biomarkers that can be used to predict survival include anemia, elevated lactate dehydrogenase, and elevated alkaline phosphatase.[hematologyandoncology.net]
  • Multiple myeloma was clinically suspected on the basis of normocytic anemia, increased serum creatinine, and elevated globulin levels.[frontiersin.org]
Asymptomatic
Weight Loss
  • There may be decreased appetite and weight loss. The absolute percentage of weight loss might be minimal, at 3% or 5%, but this could translate to 10 or 15 pounds in a larger person.[hematologyandoncology.net]
Pathologist
  • These meetings include pathologists and radiologists, who provide insight into how to interpret images. In addition to these tumor boards, we also maintain close communication, via phone, e-mail, or texts, to establish common practice patterns.[hematologyandoncology.net]
Hodgkin Lymphoma
  • Osteoblastic lesions are radiographically dense and sclerotic, and are typically present in prostate adenocarcinoma, small cell lung cancer, Hodgkin’s lymphoma, and carcinoid tumors.[frontiersin.org]
Constipation
  • Patients can experience reflux, diarrhea, or constipation. For the most part, adverse events tend to be grade 1, or maybe grade 2 for a limited period. They depend on the timing of treatment and the extent of disease.[hematologyandoncology.net]
Diarrhea
  • Patients can experience reflux, diarrhea, or constipation. For the most part, adverse events tend to be grade 1, or maybe grade 2 for a limited period. They depend on the timing of treatment and the extent of disease.[hematologyandoncology.net]
Excitement
  • DG An exciting aspect of the field today is that there are many options for the management of patients with metastatic castration-resistant prostate cancer (mCRPC).[hematologyandoncology.net]

Workup

  • Multiparametric MRI has been recognized as an essential modality in the initial workup of prostate cancer.[ajronline.org]
Normocytic Anemia
  • Multiple myeloma was clinically suspected on the basis of normocytic anemia, increased serum creatinine, and elevated globulin levels.[frontiersin.org]

Treatment

  • Patients have to believe that the treatment will be beneficial, and this can be enhanced with a better understanding of the treatment’s activity.[hematologyandoncology.net]
  • In a subgroup analysis of CHAARTED, early docetaxel treatment was associated with improved OS (51.2 vs 34.4 months; HR, 0.63; 95% CI, 0.50-0.79; P P  .86).[jamanetwork.com]
  • Treatment was started with bicalutamide and leuprolide for androgen deprivation therapy (ADT), which achieved PSA suppression after 3 months.[frontiersin.org]
  • It is a major cause of pain and death of prostate cancer, and whether a patient has bone metastasis or not can drastically alter the treatment strategy [ 1 ].[ajronline.org]

Prognosis

  • Vascular endothelial growth factor C expression correlates with lymphatic involvement and poor prognosis in patients with esophageal squamous cell carcinoma. Oncol Rep. 2003; 10 (6):1747–1751. [ PubMed ] [ Google Scholar ] 57.[ncbi.nlm.nih.gov]

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