Symptoma

Prostate Sarcoma

OBJECTIVE: To present our institutional experience with adult prostate sarcoma over 30 years. MATERIALS AND METHODS: We reviewed 38 cases of adult prostate sarcoma diagnosed and treated at our institution between 1982 and 2012. [ncbi.nlm.nih.gov]

Case Presentation A 72-year-old male presented with 6 months of progressive severe lower urinary tract symptoms (LUTS) secondary to bladder outlet obstruction. [mdedge.com]

  • Prostatic Disease

    Cancerous tumors are usually detected within 0.3 cm of the capsule.6 Diffuse prostatic cancers could mimic diffuse benign prostate diseases such as nodular hyperplasia, nonspecific chronic inflammation, malakoplakia, and tuberculosis. [onlinelibrary.wiley.com]

    complication, 054094, 腫瘍転移, ｼｭﾖｳﾃﾝｲ, metastasis, 035567, 骨腫瘍, ｺﾂｼｭﾖｳ, bone tumor, 054019, 触診, ｼｮｸｼﾝ, palpation, 040992, 生検, ｾｲｹﾝ, biopsy, 040988, 死, ｼ, death, 011227 キーワード 腫瘍, ｼｭﾖｳ, tumor, 011325, *, 病気, ﾋﾞｮｳｷ, disease, 017213, 前立腺疾患, ｾﾞﾝﾘﾂｾﾝｼｯｶﾝ, prostatic [togodb.dbcls.jp]

    Marc Garnick, a clinical professor of medicine at Harvard Medical School, an oncologist at Beth Israel Deaconess Medical Center, and editor in chief of Harvard’s Annual Report on Prostate Diseases. [health.harvard.edu]

    View Article : Google Scholar : PubMed/NCBI 5 Zhao HW, Luo JH, Xu HX, Wang DH, Lai YR, Chen MN, Lv JY, Xie XY, Lu MD and Chen W: The value of contrast-enhanced transrectal ultrasound in predicting the nature of prostate diseases and the Gleason score [spandidos-publications.com]

    diseases such as nodular hyperplasia, nonspecific chronic inflammation, malakoplakia, and tuberculosis. [8] Microscopically, there is overlapping of morphological features. [ccij-online.org]

  • Enlargement of the Prostate

    […] of the prostate. [cancerjournal.net]

    Physical examination reveals nonspecific enlargement of the prostate, while serum PSA is typically within normal limits [2, 3, 7]. [hindawi.com]

    Up to 25% of patients present with metastatic diseases at the time of diagnosis, with common sites of metastases being lungs, bones and rarely liver.[5] On digital rectal examination, there is nonspecific enlargement of the prostate. [saudisurgj.org]

    Pelvic transabdominal ultrasound revealed a hypovascular enlarged prostate with a rough surface, the echo of the mass was heterogeneous. [journals.lww.com]

    Indeed, most, if not all of these can occur in men with noncancerous (benign) enlargement of the prostate (BPH), which is the more common form of prostate enlargement. [emedicinehealth.com]

Workup with urinalysis, blood biochemistry, and prostate specific antigen (PSA) levels were persistently normal. He reported no hematuria, weight loss, or perineal pain. [mdedge.com]

The staging workup subsequently showed a locally advanced prostate cancer. He was also started on hormonal therapy with leutinizing hormone releasing hormone (LHRH) analogue. [urologyannals.com]

Metastatic workup showed no nodal or distant spread, T1N0M0 stage I. After orchiectomy, the patient underwent adjuvant external beam radiotherapy to the para-aortic nodes. [emedicine.medscape.com]

Identify infectious, inflammatory, or congenital lesions that do not require a workup for malignancy. [pubs.rsna.org]

What Is Prostate Cancer Workup? If cancer is present on biopsy, workup for metastasis may be indicated. Imaging studies may reveal the size and location of the tumor in the prostate as well as the extent of spread of the disease. [emedicinehealth.com]

  • Right Pleural Effusion

    Six months postoperatively the patient was readmitted with a right pleural effusion, and a computed tomographic scan of the chest confirmed metastasis. The patient's condition gradually deteriorated, and he died 7 months after initial presentation. [archivesofpathology.org]

  • Pyuria

    Urinalysis often shows sterile pyuria, so a high clinical suspicion is necessary to perform staining for acid-fast bacilli. It can be difficult to differentiate tuberculous prostatitis from adenocarcinoma at MR imaging. [pubs.rsna.org]

Therapy should be carried out within clinical trials to improve treatment of this rare disease. [urology-textbook.com]

treatment Chennai, prostate sarcoma detection, prostate sarcoma treatment protocols, brachytherapy, prostate cancer brachytherapy treatment, prostate cancer brachytherapy treatment Bangalore, prostate cancer brachytherapy treatment Chennai [indianhealthguru.com]

Histology, grade, tumor size, stage, and treatment modality were analyzed. Overall survival was assessed. [journals.lww.com]

Inspite of multimodality treatment, prognosis of the patients is poor. [casereports.in]

Some show a very good prognosis, especially with spindle cell or botryoid histology. Alveolar rhabdomyosarcoma: is more common in the extremities as in the urogenital system, it has a poor prognosis. [urology-textbook.com]

CONCLUSION: Adult prostate sarcoma has a poor prognosis, especially in cases of metastatic disease at the time of diagnosis. [ncbi.nlm.nih.gov]

Inspite of multimodality treatment, prognosis of the patients is poor. [casereports.in]

According to the literature, the prognosis of patients with prostate leiomyosarcoma is poor. [spandidos-publications.com]

Average life expectancy is 1 year and the prognosis is poor. CTx and radiation therapy can't yield curative effects due to poor differentiation. [urologyannals.com]

Etiology of Prostate Sarcoma Li-Fraumeni syndrome: Li-Fraumeni syndrome is associated with mutation of the p53 suppressor gene: this leads to children with sarcoma whose mothers have a high risk of breast cancer and siblings with an increased cancer risk [urology-textbook.com]

There is no definitive etiology for prostate leiomysarcoma, and there has been an ongoing debate about whether radiation therapy to the prostate can induce a secondary cancer. [urotoday.com]

References:[7][3][6][8][9][10] Chondrosarcoma Description: malignant tumor arising from mesenchymal cells that produce cartilage Etiology Epidemiology Clinical findings Localization: mainly pelvis, ribs, proximal femur, and proximal humerus Diagnostics [amboss.com]

Critical Actions Assess all patients presenting with two or more SIRS criteria for the possibility of an infectious etiology. [mdcalc.com]

Etiology Etiology is unknown but tumors are thought to arise from an embryonic germ cell leading to testicular intraepithelial neoplasia (the precursor to classical seminoma). [orpha.net]

[…] tumors (like those of the breast) Essential features Cellular pleomorphism exceeding that of stromal proliferation of undetermined malignant potential Necrosis Mitotic activity Extension outside the prostate ICD coding C61 Malignant neoplasm of prostate Epidemiology [pathologyoutlines.com]

Epidemiology of Prostate Sarcoma Rhabdomyosarcoma has a share of 15% of all pediatric solid tumors. Of these, 20% arise from the urogenital tract, with most frequent localization in the prostate, bladder and paratesticular; rarely uterus and vagina. [urology-textbook.com]

Incidence of sarcoma histotypes and molecular subtypes in a prospective epidemiological study with central pathology review and molecular testing. PLoS One 2011;6:e20294. Zhang G, Chen KK, Manivel C, Fraley EE. [icurology.org]

Ewing sarcoma Description: highly malignant bone tumor arising from neuroectodermal cells; ; associated with various chromosomal translocations of the EWSR1 gene (chromosome 22) Epidemiology Incidence: peak at 10–15 years Sex: Ethnicity: primarily affects [amboss.com]

Epidemiologic clues to the etiology of Kaposi's sarcoma. AIDS 1993 ;7: 605 - 611 16. Ensoli B, Nakamura S, Salahuddin SZ, et al. AIDS-Kaposi's sarcoma-derived cells express cytokines with autocrine and paracrine growth effects. [nejm.org]

[…] primary to extragonadal sites (such as pineal gland) ICD coding ICD-10: C62.90 - malignant neoplasm of unspecified testis, unspecified whether descended or undescended ICD0: 9061/3 - seminoma, NOS Epidemiology Male, age 30 - 49 Rare in 70 or 20 years Pathophysiology [pathologyoutlines.com]

Pathophysiology Testicular seminoma is a pathologic diagnosis in which only seminomatous elements are observed upon histopathologic review after a radical orchiectomy and in which serum alpha-fetoprotein (AFP) is within the reference range. [emedicine.medscape.com]

A number of pathophysiological extracellular perturbations (disturbed Ca2 homeostasis, oxidative stress, metabolic changes, acidosis, and nutrient deprivation) lead to the accumulation of unfolded/misfolded proteins in the ER subsequently triggering ER [mct.aacrjournals.org]

However, with the development of denosumab, a treatment targeting the pathophysiology of JPD may be available. These researchers reported the effects of denosumab treatment on an 8-year old girl with a severe form of JPD. [aetna.com]

[…] of HIV HIV Transmission and Prevention in Specific Populations Systematic Review of HIV Behavioral Prevention Research in African Americans Lynae A. [hivinsite.ucsf.edu]

[…] cancer: American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer. [nccn.org]

Bottom line: men shouldn’t take selenium or vitamin E as a way to prevent prostate cancer, or anything else for that matter. [health.harvard.edu]

Causes, Risk Factors, and Prevention Learn about the risk factors for prostate cancer, what you might be able to do to help lower your risk, and early detection of the disease. [cancer.org]

Denosumab is being investigated in multiple clinical trials for the prevention and treatment of bone metastases. [aetna.com]