Edit concept Question Editor Create issue ticket

Prostate Sarcoma


Presentation

  • The second case was a 33 years old male who presented to the emergency room with anal pain, urinary symptoms, hematochezia and loss of 20 kg over the past 3 months.[ncbi.nlm.nih.gov]
  • OBJECTIVE: To present our institutional experience with adult prostate sarcoma over 30 years. MATERIALS AND METHODS: We reviewed 38 cases of adult prostate sarcoma diagnosed and treated at our institution between 1982 and 2012.[ncbi.nlm.nih.gov]
  • The mean age at presentation was 64 years, and urinary obstruction was the most common presenting symptom. All patients underwent surgical resection and neoadjuvant radiation and 6 had concurrent chemotherapy.[ncbi.nlm.nih.gov]
  • A patient with a history of pelvic radiation therapy for seminoma presented with a prostatic tumor, which appeared predominantly of high signal intensity on T2-weighted magnetic resonance images; low-signal-intensity tissue also extended to the pelvic[ncbi.nlm.nih.gov]
  • Factors predictive of long-term survival were negative surgical margins (p 0.0005) and absence of metastatic disease at presentation (p 0.0004).[ncbi.nlm.nih.gov]
Arthritis
  • Discussion The first clinical association between exposure to radiotherapy and sarcoma was recognized in 1992 by Beck, in a description of bone sarcomas in patients who had received radiotherapy for tuberculous arthritis [ 1 ].[acanceresearch.com]
Prostatic Disease
  • , complication, 054094, 腫瘍転移, シュヨウテンイ, metastasis, 035567, 骨腫瘍, コツシュヨウ, bone tumor, 054019, 触診, ショクシン, palpation, 040992, 生検, セイケン, biopsy, 040988, 死, シ, death, 011227 キーワード 腫瘍, シュヨウ, tumor, 011325, *, 病気, ビョウキ, disease, 017213, 前立腺疾患, ゼンリツセンシッカン, prostatic[togodb.dbcls.jp]
  • Marc Garnick, a clinical professor of medicine at Harvard Medical School, an oncologist at Beth Israel Deaconess Medical Center, and editor in chief of Harvard’s Annual Report on Prostate Diseases.[health.harvard.edu]
  • The purpose of this article is to describe the MR imaging appearance of less-common prostate diseases and how to differentiate these diseases from adenocarcinoma.[pubs.rsna.org]
Enlargement of the Prostate
  • Up to 25% of patients present with metastatic diseases at the time of diagnosis, with common sites of metastases being lungs, bones and rarely liver. [5] On digital rectal examination, there is nonspecific enlargement of the prostate.[saudisurgj.org]
Testicular Pain
  • Primary adenocarcinoma of the seminal vesicle in a 42-year-old man who presented with right testicular pain that had been present for several weeks.[pubs.rsna.org]

Workup

  • The staging workup subsequently showed a locally advanced prostate cancer. He was also started on hormonal therapy with leutinizing hormone releasing hormone (LHRH) analogue.[urologyannals.com]
  • Identify infectious, inflammatory, or congenital lesions that do not require a workup for malignancy.[pubs.rsna.org]
Pyuria
  • Urinalysis often shows sterile pyuria, so a high clinical suspicion is necessary to perform staining for acid-fast bacilli. It can be difficult to differentiate tuberculous prostatitis from adenocarcinoma at MR imaging.[pubs.rsna.org]

Treatment

  • treatment Chennai, prostate sarcoma detection, prostate sarcoma treatment protocols, brachytherapy, prostate cancer brachytherapy treatment, prostate cancer brachytherapy treatment Bangalore, prostate cancer brachytherapy treatment Chennai[indianhealthguru.com]
  • Therapy should be carried out within clinical trials to improve treatment of this rare disease.[urology-textbook.com]
  • Histology, grade, tumor size, stage, and treatment modality were analyzed. Overall survival was assessed.[journals.lww.com]
  • Inspite of multimodality treatment, prognosis of the patients is poor.[casereports.in]
  • Their rapid progression and systemic spread, despite multimodal treatment, gives a mean survival of 24 months. Main survival factors are grade, a complete resection of the tumor and a low local stage.[ncbi.nlm.nih.gov]

Prognosis

  • Some show a very good prognosis, especially with spindle cell or botryoid histology. Alveolar rhabdomyosarcoma: is more common in the extremities as in the urogenital system, it has a poor prognosis.[urology-textbook.com]
  • CONCLUSION: Adult prostate sarcoma has a poor prognosis, especially in cases of metastatic disease at the time of diagnosis.[ncbi.nlm.nih.gov]
  • CONCLUSION: Adult prostate sarcoma accounted for 0.7% of primary prostate malignancies and carried a poor prognosis. Early diagnosis and surgical resection with curative intent offer patients the best chance of survival. Copyright 2013 Elsevier Inc.[ncbi.nlm.nih.gov]
  • Inspite of multimodality treatment, prognosis of the patients is poor.[casereports.in]
  • Postradiation sarcoma (PRS) usually has a dismal prognosis and only very limited therapeutic possibilities.[karger.com]

Etiology

  • Etiology of Prostate Sarcoma Li-Fraumeni syndrome: Li-Fraumeni syndrome is associated with mutation of the p53 suppressor gene: this leads to children with sarcoma whose mothers have a high risk of breast cancer and siblings with an increased cancer risk[urology-textbook.com]
  • See also section sarcoma of the prostate for pathology and etiology.[urology-textbook.com]
  • Bladder Outlet Obstruction: Etiology and Evaluation. Rev Urol 2005; 7(Suppl 6): S3-S13 Get full text Find similar topics on :: Scholar :: Radiology search engine 2 . Krieger JN , Dobrindt U , Riley DE , Oswald E .[radiologycases.com]
  • In contrast to STUMPs, stromal sarcomas tend to affect a slightly younger population. [4] Etiology The prostate has a complex stromal-epithelial interaction that responds to hormonal stimulation that is responsible for prostatic epithelial morphogenesis[emedicine.medscape.com]

Epidemiology

  • […] tumors (like those of the breast) Essential features Cellular pleomorphism exceeding that of stromal proliferation of undetermined malignant potential Necrosis Mitotic activity Extension outside the prostate ICD coding C61 Malignant neoplasm of prostate Epidemiology[pathologyoutlines.com]
  • Epidemiology of Prostate Sarcoma Rhabdomyosarcoma has a share of 15% of all pediatric solid tumors. Of these, 20% arise from the urogenital tract, with most frequent localization in the prostate, bladder and paratesticular; rarely uterus and vagina.[urology-textbook.com]
  • […] gallbladder, heart, kidney tumor, mediastinum, ovary tumor, pancreas, prostate, testis Terminology Ewing sarcoma family of tumors ( Pediatr Dev Pathol 2012;15:108 ) Ewing sarcoma Atypical Ewing sarcoma Primitive neuroectodermal tumor (PNET) Askin tumor Epidemiology[pathologyoutlines.com]
  • Paediatric and Perinatal Epidemiology. 8 (1): 107–119. doi : 10.1111/j.1365-3016.1994.tb00439.x. ISSN 1365-3016. Yang, P.; Grufferman, S.; Khoury, M. J.; Schwartz, A. G.; Kowalski, J.; Ruymann, F. B.; Maurer, H. M. (1995-01-01).[en.wikipedia.org]
  • Epidemiologic aspects of the current outbreak of Kaposi’s sarcoma and opportunistic infections. N Engl J Med1982: 306: 248–252. Google Scholar 11. Kaposi M. Idiopathisches multiples Pigmentsarkom der Haut. Arch Dermatol Syph 1872; 4: 265–273.[link.springer.com]
Sex distribution
Age distribution

Pathophysiology

  • A number of pathophysiological extracellular perturbations (disturbed Ca2 homeostasis, oxidative stress, metabolic changes, acidosis, and nutrient deprivation) lead to the accumulation of unfolded/misfolded proteins in the ER subsequently triggering ER[mct.aacrjournals.org]

Prevention

  • […] of HIV HIV Transmission and Prevention in Specific Populations Systematic Review of HIV Behavioral Prevention Research in African Americans Lynae A.[hivinsite.ucsf.edu]
  • […] and early detection of cervical cancer: American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer.[nccn.org]
  • Bottom line: men shouldn’t take selenium or vitamin E as a way to prevent prostate cancer, or anything else for that matter.[health.harvard.edu]
  • Causes, Risk Factors, and Prevention Learn about the risk factors for prostate cancer, what you might be able to do to help lower your risk, and early detection of the disease.[cancer.org]
  • Endocrine manipulation as prevention of cancer prostate [ Figure 1 ] Endocrine manipulation as treatment of cancer prostate 5α-reductase inhibitors (ARI) are the drugs that have been evaluated for prevention of cancer prostate.[ncbi.nlm.nih.gov]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!