Presentation
Case Presentation A 72-year-old male presented with 6 months of progressive severe lower urinary tract symptoms (LUTS) secondary to bladder outlet obstruction. [mdedge.com]
The most common presenting manifestations (among 38 patients for whom clinical data regarding presenting symptoms were available) included obstructive urinary symptoms in 89.4% and perineal or rectal pain in 25.6% of the patients. [hindawi.com]
Figure 2 A 76-year-old man with leiomyosarcoma presented with urinary obstruction. Axial, unenhanced CT image shows that the tumour appears as a lobular, heterogeneous mass. [clinicalradiologyonline.net]
OBJECTIVE: To present our institutional experience with adult prostate sarcoma over 30 years. MATERIALS AND METHODS: We reviewed 38 cases of adult prostate sarcoma diagnosed and treated at our institution between 1982 and 2012. [ncbi.nlm.nih.gov]
Entire Body System
- Hodgkin Lymphoma
The lymphomas are subclassified into two categories: Hodgkin lymphoma and Non-Hodgkin lymphoma. The presence of Reed-Sternberg cells in Hodgkin lymphoma diagnostically distinguishes Hodgkin lymphoma from Non-Hodgkin lymphoma. [training.seer.cancer.gov]
Non-Hodgkin lymphoma ( NHL ) are cancers of the cells of the immune system (T and B lymphocytes, natural killer cells). [stbaldricks.org]
lymphoma due to prominent nucleoli and mixed inflammatory infiltrate Tumors misinterpreted as lymphoma: nasopharyngeal carcinoma - undifferentiated (tumor cells mix with lymphocytes and tumor does not appear cohesive), melanoma (tumor cells separate [pathologyoutlines.com]
Pathological diagnosis demonstrated leiomyosarcoma in one case, malignant fibrous tissue tumor in two, undifferentiated lobus intermedius-source tumor in one, rhabdomyosarcoma in one and non-Hodgkin lymphoma with low malignancy in one. [dict.cnki.net]
Myelodysplastic Syndromes Myeloproliferative Neoplasms Neuroendocrine and Adrenal Tumors Non-Hodgkin Lymphomas Pediatric Aggressive Mature B-Cell Lymphomas Primary Cutaneous Lymphomas Non-Melanoma Skin Cancers Dermatofibrosarcoma Protuberans Squamous [nccn.org]
- Falling
If you have more than one of the symptoms of sepsis, especially if there are signs of an infection or you fall into one of the higher risk groups, your doctor will likely suspect sepsis. [sepsis.org]
Difference between sarcoma and carcinoma All cancers fall into one of two categories: Carcinoma or Sarcoma. Carcinomas are found in tissues that line the inside of major organs such as the colon, lung or prostate. [stepsforsarcomaevent.com]
[…] have one or more of the following signs to be diagnosed with severe sepsis: patches of discolored skin decreased urination changes in mental ability low platelet (blood clotting cells) count problems breathing abnormal heart functions chills due to fall [healthline.com]
Lois S READ FULL BIO Ronald R It was in the fall of 2016.. Ronald R READ FULL BIO Bernadette K 8 years ago I lost my only.. Bernadette K READ FULL BIO James S A brother had beat the worst Gleason.. James S READ FULL BIO Jorge L TO MY DEAR ESTHER. [pcf.org]
Ein Fall von Osteoid-chondrosarcom der Harnblase (mit Bemerkungen uber Metaplasie). Virchows Arch 1900. 161:70–114. [Google Scholar] Nourse, M. H. Primary osteogenic sarcoma of the bladder. J Urol 1957. 77:634–638. [Google Scholar] Pang, L. S. C. [archivesofpathology.org]
Gastrointestinal
- Failure to Thrive
She presented with fractures during the 1st year of life followed by bone deformities, delayed development, failure-to-thrive, and pneumonias. [aetna.com]
Psychiatrical
- Aggressive Behavior
The distinction between low-grade prostatic stromal sarcomas and stromal tumors of uncertain malignant potential (STUMPs) is based on the degree of cytologic atypia, and they are supported by the local aggressive behavior found in low-grade sarcomas. [emedicine.medscape.com]
Solitary fibrous tumors, when completely excised, most commonly follow a benign clinical course, but more aggressive behavior can occur.18 There are several prognostic models provided for risk assessment in solitary fibrous tumors and they generally include [nature.com]
Urogenital
- Incontinence
Some authors advocate a transient incontinent urinary diversion until the oncological risk can be finally assessed and re-operations are unlikely. [urology-textbook.com]
[…] fecal incontinence Treatment Treatment is different for early and advanced prostate cancers. [medicalnewstoday.com]
Case Presentation A seventy-five year-old Caucasian male presented with rapidly progressive incontinence and obstipation eight years after high dose radiotherapy for prostate adenocarcinoma. [acanceresearch.com]
- Prostatic Disease
017213, 前立腺疾患, ゼンリツセンシッカン, prostatic disease, 054554, 男性生殖器疾患, ダンセイセイショクキシッカン, male genital disease, 054555, 生殖器疾患, セイショクキシッカン, genital disease, 040276, 男性生殖器腫瘍, ダンセイセイショクキシュヨウ, male genital tumor, 054257, 報告, ホウコク, reporting, 008583, 行為, コウイ, action [togodb.dbcls.jp]
Marc Garnick, a clinical professor of medicine at Harvard Medical School, an oncologist at Beth Israel Deaconess Medical Center, and editor in chief of Harvard’s Annual Report on Prostate Diseases. [health.harvard.edu]
Cancerous tumors are usually detected within 0.3 cm of the capsule.6 Diffuse prostatic cancers could mimic diffuse benign prostate diseases such as nodular hyperplasia, nonspecific chronic inflammation, malakoplakia, and tuberculosis. [onlinelibrary.wiley.com]
[…] often misdiagnosed and confused with diffuse benign prostate diseases such as nodular hyperplasia, nonspecific chronic inflammation, malakoplakia, and tuberculosis. [8] Microscopically, there is overlapping of morphological features. [ccij-online.org]
However, there appears to no specific tumor marker for the disease in the serum. The present study reports a case of a young male patient who was diagnosed with prostate rhabdomyosarcoma. [spandidos-publications.com]
- Enlargement of the Prostate
On examination, the bladder was palpable, genitalia were normal and on digital rectal examination, the prostate was non tender, lobulated, asymmetrically enlarged with variegated consistency. [cancerjournal.net]
Physical examination reveals nonspecific enlargement of the prostate, while serum PSA is typically within normal limits [2, 3, 7]. [hindawi.com]
Figure 1: (a) Ultrasound of prostate showing enlarged size with normal parenchymal echotexture along with an ill-defined, hypoechoic lesion in the left lobe of prostate suggesting of neoplastic nodule. [saudisurgj.org]
BPH occurs in elderly men, the imaging differences from prostate sarcoma are that BPH patients show an evenly enlarged prostate with even density. [journals.lww.com]
Indeed, most, if not all of these can occur in men with noncancerous (benign) enlargement of the prostate (BPH), which is the more common form of prostate enlargement. [emedicinehealth.com]
Workup
Workup with urinalysis, blood biochemistry, and prostate specific antigen (PSA) levels were persistently normal. He reported no hematuria, weight loss, or perineal pain. [mdedge.com]
Metastatic workup showed no nodal or distant spread, T1N0M0 stage I. After orchiectomy, the patient underwent adjuvant external beam radiotherapy to the para-aortic nodes. [emedicine.medscape.com]
The staging workup subsequently showed a locally advanced prostate cancer. He was also started on hormonal therapy with leutinizing hormone releasing hormone (LHRH) analogue. [urologyannals.com]
If there is hemorrhage, internal complexity, or a solid component within the cyst, further workup for malignancy is warranted. [pubs.rsna.org]
What Is Prostate Cancer Workup? If cancer is present on biopsy, workup for metastasis may be indicated. Imaging studies may reveal the size and location of the tumor in the prostate as well as the extent of spread of the disease. [emedicinehealth.com]
Treatment
Therapy should be carried out within clinical trials to improve treatment of this rare disease. [urology-textbook.com]
treatment Chennai, prostate sarcoma detection, prostate sarcoma treatment protocols, brachytherapy, prostate cancer brachytherapy treatment, prostate cancer brachytherapy treatment Bangalore, prostate cancer brachytherapy treatment Chennai [indianhealthguru.com]
Prostatic leiomyosarcoma is an aggressive malignancy with a high risk of metastasis and a poor prognosis that poses unique diagnostic and treatment challenges. [mdedge.com]
Both treatments locally failed with an increasing prostate-specific antigen (PSA). [urotoday.com]
Prognosis
Some show a very good prognosis, especially with spindle cell or botryoid histology. Alveolar rhabdomyosarcoma: is more common in the extremities as in the urogenital system, it has a poor prognosis. [urology-textbook.com]
Postradiation sarcoma (PRS) usually has a dismal prognosis and only very limited therapeutic possibilities. [karger.com]
According to the literature, the prognosis of patients with prostate leiomyosarcoma is poor. [spandidos-publications.com]
If you have soft tissue sarcoma, you may have questions about your prognosis. A prognosis is the doctor’s best estimate of how cancer will affect someone and how it will respond to treatment. Prognosis and survival depend on many factors. [cancer.ca]
Average life expectancy is <1 year and the prognosis is poor. CTx and radiation therapy can't yield curative effects due to poor differentiation. [urologyannals.com]
Etiology
References:[7][3][6][8][9][10] Chondrosarcoma Description: malignant tumor arising from mesenchymal cells that produce cartilage Etiology Epidemiology Clinical findings Localization: mainly pelvis, ribs, proximal femur, and proximal humerus Diagnostics [amboss.com]
Critical Actions Assess all patients presenting with two or more SIRS criteria for the possibility of an infectious etiology. [mdcalc.com]
Etiology Etiology is unknown but tumors are thought to arise from an embryonic germ cell leading to testicular intraepithelial neoplasia (the precursor to classical seminoma). [orpha.net]
Etiology of Prostate Sarcoma Li-Fraumeni syndrome: Li-Fraumeni syndrome is associated with mutation of the p53 suppressor gene: this leads to children with sarcoma whose mothers have a high risk of breast cancer and siblings with an increased cancer risk [urology-textbook.com]
Epidemiology
Ewing sarcoma Description: highly malignant bone tumor arising from neuroectodermal cells; ; associated with various chromosomal translocations of the EWSR1 gene (chromosome 22) Epidemiology Incidence: peak at 10–15 years Sex: ♂ > ♀ Ethnicity: primarily [amboss.com]
[…] tumors (like those of the breast) Essential features Cellular pleomorphism exceeding that of stromal proliferation of undetermined malignant potential Necrosis Mitotic activity Extension outside the prostate ICD coding C61 Malignant neoplasm of prostate Epidemiology [pathologyoutlines.com]
Incidence of sarcoma histotypes and molecular subtypes in a prospective epidemiological study with central pathology review and molecular testing. PLoS One 2011;6:e20294. Zhang G, Chen KK, Manivel C, Fraley EE. [icurology.org]
Epidemiology of Prostate Sarcoma Rhabdomyosarcoma has a share of 15% of all pediatric solid tumors. Of these, 20% arise from the urogenital tract, with most frequent localization in the prostate, bladder and paratesticular; rarely uterus and vagina. [urology-textbook.com]
Essentially all patients with KS of any epidemiological type have serological evidence of HHV-8 infection. [academic.oup.com]
Pathophysiology
[…] primary to extragonadal sites (such as pineal gland) ICD coding ICD-10: C62.90 - malignant neoplasm of unspecified testis, unspecified whether descended or undescended ICD0: 9061/3 - seminoma, NOS Epidemiology Male, age 30 - 49 Rare in > 70 or < 20 years Pathophysiology [pathologyoutlines.com]
Pathophysiology Testicular seminoma is a pathologic diagnosis in which only seminomatous elements are observed upon histopathologic review after a radical orchiectomy and in which serum alpha-fetoprotein (AFP) is within the reference range. [emedicine.medscape.com]
A number of pathophysiological extracellular perturbations (disturbed Ca2 + homeostasis, oxidative stress, metabolic changes, acidosis, and nutrient deprivation) lead to the accumulation of unfolded/misfolded proteins in the ER subsequently triggering [mct.aacrjournals.org]
However, with the development of denosumab, a treatment targeting the pathophysiology of JPD may be available. These researchers reported the effects of denosumab treatment on an 8-year old girl with a severe form of JPD. [aetna.com]
Prevention
[…] of HIV HIV Transmission and Prevention in Specific Populations Systematic Review of HIV Behavioral Prevention Research in African Americans Lynae A. [hivinsite.ucsf.edu]
[…] cancer: American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer. [nccn.org]
Bottom line: men shouldn’t take selenium or vitamin E as a way to prevent prostate cancer, or anything else for that matter. [health.harvard.edu]
Causes, Risk Factors, and Prevention Learn about the risk factors for prostate cancer, what you might be able to do to help lower your risk, and early detection of the disease. [cancer.org]
Where possible, most doctors will elect to surgically remove the tumor and surrounding tissue to prevent the spread of sarcoma. That said, CyberKnife can often play a role even if it isn’t the primary treatment. [pasadenacyberknife.com]