Case Presentation A 72-year-old male presented with 6 months of progressive severe lower urinary tract symptoms (LUTS) secondary to bladder outlet obstruction. [mdedge.com]

The most common presenting manifestations (among 38 patients for whom clinical data regarding presenting symptoms were available) included obstructive urinary symptoms in 89.4% and perineal or rectal pain in 25.6% of the patients. [hindawi.com]

OBJECTIVE: To present our institutional experience with adult prostate sarcoma over 30 years. MATERIALS AND METHODS: We reviewed 38 cases of adult prostate sarcoma diagnosed and treated at our institution between 1982 and 2012. [ncbi.nlm.nih.gov]

Figure 2 A 76-year-old man with leiomyosarcoma presented with urinary obstruction. Axial, unenhanced CT image shows that the tumour appears as a lobular, heterogeneous mass. [clinicalradiologyonline.net]

• Prostatic Disease

  017213, 前立腺疾患, ｾﾞﾝﾘﾂｾﾝｼｯｶﾝ, prostatic disease, 054554, 男性生殖器疾患, ﾀﾞﾝｾｲｾｲｼｮｸｷｼｯｶﾝ, male genital disease, 054555, 生殖器疾患, ｾｲｼｮｸｷｼｯｶﾝ, genital disease, 040276, 男性生殖器腫瘍, ﾀﾞﾝｾｲｾｲｼｮｸｷｼｭﾖｳ, male genital tumor, 054257, 報告, ﾎｳｺｸ, reporting, 008583, 行為, ｺｳｲ, action [togodb.dbcls.jp]

  Marc Garnick, a clinical professor of medicine at Harvard Medical School, an oncologist at Beth Israel Deaconess Medical Center, and editor in chief of Harvard’s Annual Report on Prostate Diseases. [health.harvard.edu]

  Cancerous tumors are usually detected within 0.3 cm of the capsule.6 Diffuse prostatic cancers could mimic diffuse benign prostate diseases such as nodular hyperplasia, nonspecific chronic inflammation, malakoplakia, and tuberculosis. [onlinelibrary.wiley.com]

  […] often misdiagnosed and confused with diffuse benign prostate diseases such as nodular hyperplasia, nonspecific chronic inflammation, malakoplakia, and tuberculosis. [8] Microscopically, there is overlapping of morphological features. [ccij-online.org]

  However, there appears to no specific tumor marker for the disease in the serum. The present study reports a case of a young male patient who was diagnosed with prostate rhabdomyosarcoma. [spandidos-publications.com]

• Enlargement of the Prostate

  On examination, the bladder was palpable, genitalia were normal and on digital rectal examination, the prostate was non tender, lobulated, asymmetrically enlarged with variegated consistency. [cancerjournal.net]

  Physical examination reveals nonspecific enlargement of the prostate, while serum PSA is typically within normal limits [2, 3, 7]. [hindawi.com]

  Figure 1: (a) Ultrasound of prostate showing enlarged size with normal parenchymal echotexture along with an ill-defined, hypoechoic lesion in the left lobe of prostate suggesting of neoplastic nodule. [saudisurgj.org]

  BPH occurs in elderly men, the imaging differences from prostate sarcoma are that BPH patients show an evenly enlarged prostate with even density. [journals.lww.com]

  Indeed, most, if not all of these can occur in men with noncancerous (benign) enlargement of the prostate (BPH), which is the more common form of prostate enlargement. [emedicinehealth.com]

Workup with urinalysis, blood biochemistry, and prostate specific antigen (PSA) levels were persistently normal. He reported no hematuria, weight loss, or perineal pain. [mdedge.com]

Metastatic workup showed no nodal or distant spread, T1N0M0 stage I. After orchiectomy, the patient underwent adjuvant external beam radiotherapy to the para-aortic nodes. [emedicine.medscape.com]

The staging workup subsequently showed a locally advanced prostate cancer. He was also started on hormonal therapy with leutinizing hormone releasing hormone (LHRH) analogue. [urologyannals.com]

If there is hemorrhage, internal complexity, or a solid component within the cyst, further workup for malignancy is warranted. [pubs.rsna.org]

What Is Prostate Cancer Workup? If cancer is present on biopsy, workup for metastasis may be indicated. Imaging studies may reveal the size and location of the tumor in the prostate as well as the extent of spread of the disease. [emedicinehealth.com]

• Right Pleural Effusion

  Six months postoperatively the patient was readmitted with a right pleural effusion, and a computed tomographic scan of the chest confirmed metastasis. The patient's condition gradually deteriorated, and he died 7 months after initial presentation. [archivesofpathology.org]

treatment Chennai, prostate sarcoma detection, prostate sarcoma treatment protocols, brachytherapy, prostate cancer brachytherapy treatment, prostate cancer brachytherapy treatment Bangalore, prostate cancer brachytherapy treatment Chennai [indianhealthguru.com]

Therapy should be carried out within clinical trials to improve treatment of this rare disease. [urology-textbook.com]

Histology, grade, tumor size, stage, and treatment modality were analyzed. Overall survival was assessed. [journals.lww.com]

Inspite of multimodality treatment, prognosis of the patients is poor. [casereports.in]

Some show a very good prognosis, especially with spindle cell or botryoid histology. Alveolar rhabdomyosarcoma: is more common in the extremities as in the urogenital system, it has a poor prognosis. [urology-textbook.com]

Inspite of multimodality treatment, prognosis of the patients is poor. [casereports.in]

According to the literature, the prognosis of patients with prostate leiomyosarcoma is poor. [spandidos-publications.com]

Average life expectancy is <1 year and the prognosis is poor. CTx and radiation therapy can't yield curative effects due to poor differentiation. [urologyannals.com]

Postradiation sarcoma (PRS) usually has a dismal prognosis and only very limited therapeutic possibilities. [karger.com]

References:[7][3][6][8][9][10] Chondrosarcoma Description: malignant tumor arising from mesenchymal cells that produce cartilage Etiology Epidemiology Clinical findings Localization: mainly pelvis, ribs, proximal femur, and proximal humerus Diagnostics [amboss.com]

Critical Actions Assess all patients presenting with two or more SIRS criteria for the possibility of an infectious etiology. [mdcalc.com]

Etiology Etiology is unknown but tumors are thought to arise from an embryonic germ cell leading to testicular intraepithelial neoplasia (the precursor to classical seminoma). [orpha.net]

Etiology of Prostate Sarcoma Li-Fraumeni syndrome: Li-Fraumeni syndrome is associated with mutation of the p53 suppressor gene: this leads to children with sarcoma whose mothers have a high risk of breast cancer and siblings with an increased cancer risk [urology-textbook.com]

Ewing sarcoma Description: highly malignant bone tumor arising from neuroectodermal cells; ; associated with various chromosomal translocations of the EWSR1 gene (chromosome 22) Epidemiology Incidence: peak at 10–15 years Sex: ♂ > ♀ Ethnicity: primarily [amboss.com]

[…] tumors (like those of the breast) Essential features Cellular pleomorphism exceeding that of stromal proliferation of undetermined malignant potential Necrosis Mitotic activity Extension outside the prostate ICD coding C61 Malignant neoplasm of prostate Epidemiology [pathologyoutlines.com]

Incidence of sarcoma histotypes and molecular subtypes in a prospective epidemiological study with central pathology review and molecular testing. PLoS One 2011;6:e20294. Zhang G, Chen KK, Manivel C, Fraley EE. [icurology.org]

Epidemiology of Prostate Sarcoma Rhabdomyosarcoma has a share of 15% of all pediatric solid tumors. Of these, 20% arise from the urogenital tract, with most frequent localization in the prostate, bladder and paratesticular; rarely uterus and vagina. [urology-textbook.com]

Essentially all patients with KS of any epidemiological type have serological evidence of HHV-8 infection. [academic.oup.com]

[…] primary to extragonadal sites (such as pineal gland) ICD coding ICD-10: C62.90 - malignant neoplasm of unspecified testis, unspecified whether descended or undescended ICD0: 9061/3 - seminoma, NOS Epidemiology Male, age 30 - 49 Rare in > 70 or < 20 years Pathophysiology [pathologyoutlines.com]

Pathophysiology Testicular seminoma is a pathologic diagnosis in which only seminomatous elements are observed upon histopathologic review after a radical orchiectomy and in which serum alpha-fetoprotein (AFP) is within the reference range. [emedicine.medscape.com]

A number of pathophysiological extracellular perturbations (disturbed Ca2 + homeostasis, oxidative stress, metabolic changes, acidosis, and nutrient deprivation) lead to the accumulation of unfolded/misfolded proteins in the ER subsequently triggering [mct.aacrjournals.org]

However, with the development of denosumab, a treatment targeting the pathophysiology of JPD may be available. These researchers reported the effects of denosumab treatment on an 8-year old girl with a severe form of JPD. [aetna.com]

[…] of HIV HIV Transmission and Prevention in Specific Populations Systematic Review of HIV Behavioral Prevention Research in African Americans Lynae A. [hivinsite.ucsf.edu]

[…] cancer: American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer. [nccn.org]

Bottom line: men shouldn’t take selenium or vitamin E as a way to prevent prostate cancer, or anything else for that matter. [health.harvard.edu]

Causes, Risk Factors, and Prevention Learn about the risk factors for prostate cancer, what you might be able to do to help lower your risk, and early detection of the disease. [cancer.org]

Where possible, most doctors will elect to surgically remove the tumor and surrounding tissue to prevent the spread of sarcoma. That said, CyberKnife can often play a role even if it isn’t the primary treatment. [pasadenacyberknife.com]