We herein report a case of PSS in a 40-year-old man who presented with urinary retention. CASE REPORT A 40-year-old man presented at a local hospital with urinary distention and was catheterized. [academic.oup.com]

However, a ductal prostatic carcinoma was present at the initial diagnostic, and this variant is considered a higher-grade epithelial tumour. [hindawi.com]

Necrosis is present. Tumor is positive for CD34 and has high Ki67 index, confirming the diagnosis. [pathologyoutlines.com]

Histopathological presentation of the prostatic stromal sarcoma. [ncbi.nlm.nih.gov]

Figure 2: Histopathological presentation of the prostatic stromal sarcoma. [journals.lww.com]

• Fever

  The patient had no pain, fever or abdominal distension. The results of a physical examination were normal and all other blood routine indexes were within normal limits. [academic.oup.com]

  The patient had no pain, fever, or abdominal distension when he was suffering from the urinary tract symptoms. The physical examination was unremarkable. [journals.lww.com]

  Age in yr Clinical presentation Pattern of H and E Pattern of IH Treatment Outcome Yokota et al[4] 45 Hematuria, dysuria, episodes of intermittent fever Striking proliferation of undifferentiated cells of mesenchymal type with round and spindle-shaped [wjgnet.com]

• Confusion

  Immunophenotypically, these myofibroblastic proliferations often express low-molecular-weight cytokeratin, which may cause confusion with sarcomatoid carcinoma; however, they do not express high-molecular-weight cytokeratins. [nature.com]

• Urinary Retention

  PSS is a rare prostate sarcoma and the most common symptom is urinary retention [2]. We herein report a case of PSS in a 40-year-old man who presented with urinary retention. [academic.oup.com]

  Case Report A 59-year-old man presented to emergency with acute urinary retention and perineal pain in December 2006. He reported a previous history of hematuria and urinary retention and denied any constitutional symptoms. [hindawi.com]

  Several scholars reported that the common symptom of PSS was urinary retention and the prostatic-specific antigen (PSA) in the blood often remains at a normal level.[2] However, with the low incidence, the clinical information was still unclear. [journals.lww.com]

  Here we reported a case of PSS in a 49-year-old man presented with urinary retention and a large prostate mass, and discussed the imaging findings, treatment strategy and differential diagnosis. 2. Case report 2.1. [ncbi.nlm.nih.gov]

  Definition / general Prostatic stromal sarcoma (PSS) is a rare entity (Pathology 2013;45:104) Usually presents with urinary retention; also abnormal digital rectal examination, hematuria or hematospermia, palpable rectal mass Includes phyllodes tumors [pathologyoutlines.com]

• Dysuria

  For general PSS, the tumors occur in adult patients of all ages, who usually present with severe urinary obstruction, hematuria, and dysuria. [wjgnet.com]

  Patient concerns: we reported a 49-year-old man presented with dysuria and hematuria, whose computed tomography examination showed an enlarged prostate gland with an irregular shape. [ncbi.nlm.nih.gov]

  When an adult male shows the same CT or MRI findings as mentioned above, and symptoms like dysuria, hematuria, PSS should be taken into consideration. Author contributions Formal analysis: Jingjun Wu, Miao Niu. Supervision: Ailian Liu. [journals.lww.com]

  Although the majority of PSS patients have dysuria, urinary retention and hematuria, there are no specific clinical symptoms of PSS. [academic.oup.com]

  A history of frequent micturition, dysuria, poor urinary stream, and nocturia of approximately 12-month duration was also present. There was no family history of genitourinary cancer. No exposure to hazardous chemicals was confirmed. [hindawi.com]

• Enlargement of the Prostate

  BPH occurs in elderly men, the imaging differences from prostate sarcoma are that BPH patients show an evenly enlarged prostate with even density. [journals.lww.com]

He was referred to our hospital for further examination and treatment. The patient had no pain, fever or abdominal distension. The results of a physical examination were normal and all other blood routine indexes were within normal limits. [academic.oup.com]

Due to the limited experience, there are no standard treatment recommendations the management of CSs of the prostate. Operable tumours are treated with surgery [6, 7]. [hindawi.com]

The optimal treatment for PSS with rhabdoid features is still unknown. [wjgnet.com]

Differentiating between prostate sarcoma and other prostatic disorders is quite important since the difference of their treatments and prognoses. [journals.lww.com]

Independently of the sarcomatoid-type finding, the prognosis seems similar. [hindawi.com]

Typically, the disease course is rapid and portends a short and dismal prognosis. We report a case of prostatic stromal sarcoma (PSS) which likely lay dormant for several years after a transurethral resection of the prostate. [pubmed.ncbi.nlm.nih.gov]

Prognosis is poor, with a median survival time of less than 15 mo and only 10% of patients survive for more than 3 years. [wjgnet.com]

Prognosis and Predictive Factors Because prostatic stromal sarcoma is a rare tumor, there are limited data about its prognosis, mostly in a very few case reports or from series with a small number of cases. [emedicine.medscape.com]

DISCUSSION Prostate sarcoma is a very rare malignancy with a poor prognosis. It originates from the mesoderm in the reproductive tract. [academic.oup.com]

Small cell (neuroendocrine) carcinoma of the prostate: etiology, diagnosis, prognosis, and therapeutic implications— a retrospective study of 30 patients from the rare cancer network. Am J Med Sci 2008; 336:478–488 [Google Scholar] 22. [ajronline.org]

In contrast to STUMPs, stromal sarcomas tend to affect a slightly younger population. [4] Etiology The prostate has a complex stromal-epithelial interaction that responds to hormonal stimulation that is responsible for prostatic epithelial morphogenesis [emedicine.medscape.com]

[…] malignant potential (STUMP) Necrosis Mitotic activity Extension outside the prostate Terminology Phyllodes tumor, cystic epithelial - stromal tumor, cystadenoleiomyofibroma, cystosarcoma phyllodes ICD coding ICD-10: C61 - malignant neoplasm of prostate Epidemiology [pathologyoutlines.com]

Epidemiology The true incidence of prostatic stromal sarcomas has not been established because of the rarity of this tumor. [1, 2, 3, 4, 14, 15, 16, 17, 18, 19, 20] However, it is estimated to account for 0.1% of all prostate malignancies. [21, 22, 23 [emedicine.medscape.com]

Active Wnt signaling can prevent GSK-3β-induced degradation of Snail, and thereby promote epithelial-to-mesenchymal transition[10]. [wjgnet.com]

Although it is still unclear whether the adjuvant radiotherapy and chemotherapy improve patients’ survival, they are needed to prevent local relapse and distant metastasis. [journals.lww.com]