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Proteinuria

Pathological Proteinuria


Presentation

  • This is the first case of a paraganglioma presenting with massive proteinuria in a child.[ncbi.nlm.nih.gov]
  • A 35-year-old female presented to our clinic with history of small joint pain of 6 months duration. In addition she complained of pedal edema off and on for the last 12 years.[ncbi.nlm.nih.gov]
  • Case presentation We describe a 35-year-old man who was taking steroids and diuretics for relapse of minimal change disease who presented after a syncopal event. The patient was hypotensive and had distended neck veins.[ncbi.nlm.nih.gov]
  • A young middle-aged female with a long-standing history of diabetes presented to the hospital with worsening proteinuria in her second trimester of pregnancy.[ncbi.nlm.nih.gov]
  • BACKGROUND: Nephrotic-range proteinuria as a paraneoplastic syndrome (PNS) is an exceptional presentation, especially in children. It is usually associated with hematologic malignancies. Solid tumors are very rare causes of proteinuria.[ncbi.nlm.nih.gov]
Distractibility
  • An infuriating distraction Although some people like the idea of thorough check-ups (indeed they pay private firms good money to carry them out), I am not one of them.[doi.org]
Insomnia
  • […] used to establish the electronic database of this research and SPSS v20.0 (SPSS Inc, Chicago, IL) was used for performing statistical analyses.The patients' common main symptoms of overt proteinuria DKD were weak breath and fatigue, numbness of limbs, insomnia[ncbi.nlm.nih.gov]
Bilateral Flank Pain
  • A 55-year-old man of Indian descent, presented to the emergency department with a 2-year history of passing 'milky' white urine, associated with dysuria, urinary retention, bilateral flank pain and 15 kg weight loss.[ncbi.nlm.nih.gov]

Workup

  • Her admission blood pressure was 193/108 mmHg, she had 8 g proteinuria, normal creatinine, and negative immunological and infectious workup.[ncbi.nlm.nih.gov]
  • This approach, however, is dependent on individual experience and not suitable for the routine workup of a large number of patients.[clinchem.aaccjnls.org]
  • Office workup of proteinuria: Am. J. Med. Sci. 320 : 188, 2000.[web.archive.org]
  • This may be done as part of a routine physical, a pregnancy workup, when a urinary tract infection is suspected, as part of a hospital admission, or whenever a healthcare practitioner wants to evaluate kidney function.[labtestsonline.org]
Left Ventricular Hypertrophy
  • Forty-nine patients with hypertension and left ventricular hypertrophy without established proteinuria were examined for microalbuminuria; 41% demonstrated microalbuminuria.[web.archive.org]

Treatment

  • All patients received conventional and symptomatic treatment. In addition, patients in the treatment and control groups were given YQSR (200 mL, twice per day, orally) and losartan (50 mg/d orally), respectively for 6 months.[ncbi.nlm.nih.gov]
  • After 5.5 years of fairly good tolerance of the treatment, proteinuria and painful crural ulcerations appeared.[ncbi.nlm.nih.gov]
  • OBJECTIVE: To study the response of lupus nephritis (LN) patients with persistent proteinuria ( 1 g/day after 6 months corticosteroid and single immunosuppressant treatment, or 3 g/day after 3 months of corticosteroid and single immunosuppressant treatment[ncbi.nlm.nih.gov]
  • We aimed to test the hypothesis that treatment with enalapril and folic acid is more effective in preventing new-onset proteinuria than enalapril alone among hypertensive patients.[ncbi.nlm.nih.gov]
  • Thus, this combination might be the initial treatment of patients with FS.[ncbi.nlm.nih.gov]

Prognosis

  • Moreover, the presence of proteinuria after liver transplantation can assist in the early prediction of poor short-term prognosis for patients receiving liver transplantation. KEYWORDS: Liver transplantation; Mortality; Prognosis; Proteinuria; SOFA[ncbi.nlm.nih.gov]
  • For diabetic patients, distinguishing nondiabetic renal disease (NDRD) from diabetic nephropathy (DN) is important in choosing treatment modalities and determining renal prognosis.[ncbi.nlm.nih.gov]
  • RATIONALE: Mitochondrial nephropathy has a poor prognosis and often progresses to the end-stage renal disease. Renal pathology often is focal segmental glomerulosclerosis (FSGS) and does not respond to steroid therapy or immunosuppressive therapy.[ncbi.nlm.nih.gov]
  • While biomarkers of kidney damage increase during paraquat-induced acute kidney injury (AKI), significant concurrent proteinuria may alter diagnostic thresholds for diagnosis and prognosis to an unknown extent.[ncbi.nlm.nih.gov]
  • Lower baseline proteinuria and better renal function were associated with a higher probability of complete remission, while crescent formation was associated with a worse prognosis.[ncbi.nlm.nih.gov]

Etiology

  • The aim of this study was to evaluate prevalence, etiology, and outcome of proteinuria during the follow-up of children with renal transplantation.[ncbi.nlm.nih.gov]
  • Protein losses of over 2000mg/24 hours in adults and over 40 mg/24 hours in children usually indicates a glomerular etiology. Preeclampsia (toxemia of pregnancy) causes massive loss of protein in the urine.[rnceus.com]
  • Practically all categories in the chapter could be designated 'not otherwise specified', 'unknown etiology' or 'transient'.[icd10data.com]
  • Etiology Causes can be categorized by mechanism. The most common causes of proteinuria are glomerular disorders, typically manifesting as nephrotic syndrome (see Table: Causes of Proteinuria ).[merckmanuals.com]

Epidemiology

  • Author information 1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. 2 Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China. 3 Beijing Municipal[ncbi.nlm.nih.gov]
  • GFR was estimated with the Chronic Kidney Disease Epidemiology Collaboration equation based on serum creatinine, and RHF was defined as GFR 95th percentile adjusted for sex, age, body size, and diabetes and/or hypertension medication.[ncbi.nlm.nih.gov]
  • The volume will cover the epidemiological studies which show that albuminuria is a strong and independent marker of kidney disease progression and cardiovascular events, the molecular details of albumin handling in the kidney at the level of the glomerulus[books.google.ro]
  • KEYWORDS: CKD; epidemiology; multiple behaviour intervention; obesity; proteinuria[ncbi.nlm.nih.gov]
  • Risk factors for CVD were hypertension, diabetes mellitus, dyslipidaemia and the metabolic syndrome. eGFR was evaluated using the Chronic Kidney Disease Epidemiology Collaboration equation.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • This volume provides a comprehensive overview of the renal handling of albumin – from basic mechanisms to the pathophysiology of proteinuric diseases.[books.google.ro]
  • However, the pathophysiology of these associations is debated. In chronic kidney disease (CKD), phosphate retention participates in cardiovascular events and increased cardiovascular mortality.[ncbi.nlm.nih.gov]
  • Future studies are needed to better understand the pathophysiologic mechanisms underlying these associations. Copyright 2017 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.[ncbi.nlm.nih.gov]
  • Author information 1 1Post Graduation Program in Medical Science,Rio de Janeiro State University,Rio de Janeiro 20550-170,Brazil. 2 3Post Graduation Program in Clinical and Experimental Pathophysiology,Rio de Janeiro State University,Rio de Janeiro 20550[ncbi.nlm.nih.gov]
  • There are three different pathophysiological mechanisms that may lead to proteinuria: damage to the glomeruli (glomerular), damage to the tubules (tubular), or overproduction of low-molecular-weight proteins (overflow).[amboss.com]

Prevention

  • All-cause mortality, a prespecified endpoint of the China Stroke Primary Prevention Trial, was the main outcome in this analysis.[ncbi.nlm.nih.gov]
  • This is a post hoc analysis of the renal substudy of the CSPPT (China Stroke Primary Prevention Trial).[ncbi.nlm.nih.gov]
  • Preventing and improving proteinuria may reduce psychological distress in patients with T2DM.[ncbi.nlm.nih.gov]
  • LESSONS: Based on the cases we reported and from the literature, recognition of ADCK4 mutation through early and accurate genetic screening could be helpful in avoiding unnecessary toxicities and in preventing complications arising in mitochondrial nephropathy[ncbi.nlm.nih.gov]
  • CONCLUSION: CKD is prevalent in the southern Taiwanese population aged over 40 years, and we believe that controlling related risk factors could be an important method by which to prevent progression of CKD.[ncbi.nlm.nih.gov]

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