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Proteus


Presentation

  • This case involves an atypical presentation caused by an untreated infected hematoma, emphasizing the need for a high index of suspicion.[ncbi.nlm.nih.gov]
Wound Infection
  • Abstract Bacteria of the genus Proteus of the family Enterobacteriaceae are facultative human pathogens responsible mainly for urinary tract and wound infections, bacteremia and the development of rheumatoid arthritis (RA).[ncbi.nlm.nih.gov]
  • These infections are commonly caused by infected medical equipment including catheters, nebulizers (responsible for inhalation), and examination gloves (responsible for wound infections).[web.uconn.edu]
  • Proteus species can also cause wound infections, sepsis, and pneumonia, mostly in hospitalized patients. [2] Treatment [ edit ] P. mirabilis is generally susceptible to most antibiotics apart from tetracycline and nitrofurantoin, [3] but 10–20% of P.[en.wikipedia.org]
Intravenous Drugs
  • We report a case of a 42-year-old intravenous drug user who presented feeling generally unwell, with lethargy, rigours, confusion and a painful swollen right leg.[ncbi.nlm.nih.gov]
Gangrene
  • CASE PRESENTATION: We report the case of a 52-year-old black man who was referred to our centre for the management of cellulitis and suppurating ulcers of the right leg which had progressed to a wet gangrene.[ncbi.nlm.nih.gov]
Recurrent Urinary Tract Infection
  • Recurrent urinary tract infections with a urease-producing organism (mostly Proteus species) results in formation of staghorn calculi in the kidney.[microbeonline.com]
Sputum
  • PmTAN59 was isolated from a sputum swab from a pneumonia patient in Tanta University Teaching Hospital. PmKAF126 was isolated from a patient with a diabetic foot infection in a hospital in the city of Kafr El-Sheikh.[ncbi.nlm.nih.gov]
Snoring
  • Hauled stark over the gunwale he breathes upward the stench of his green grave, his leprous nosehole snoring to the sun. A seachange this, brown eyes saltblue. Seadeath, mildest of all deaths known to man. Old Father Ocean.[readprint.com]
Toothache
  • Hunger toothache. Encore deux minutes. Look clock. Must get. Fermé. Hired dog! Shoot him to bloody bits with a bang shotgun, bits man spattered walls all brass buttons. Bits all khrrrrklak in place clack back. Not hurt? O, that's all right.[readprint.com]
Red Nose
  • You prayed to the Blessed Virgin that you might not have a red nose. You prayed to the devil in Serpentine avenue that the fubsy widow in front might lift her clothes still more from the wet street. O si, certo![readprint.com]
Lethargy
  • We report a case of a 42-year-old intravenous drug user who presented feeling generally unwell, with lethargy, rigours, confusion and a painful swollen right leg.[ncbi.nlm.nih.gov]
Paresthesia
  • The probability of compartment syndrome in the patient presenting with pain, paresthesias, paresis, and pain with passive stretch, all of which were positive findings in this patient, has been reported to be 98%.[ncbi.nlm.nih.gov]

Workup

  • This approach, however, is dependent on individual experience and not suitable for the routine workup of a large number of patients.[clinchem.aaccjnls.org]
  • It is associated with good long-term prognosis. [3, 4, 5] Accompanying findings in patients with glomerular damage may include the following (see Workup ): Active urine sediment - Dysmorphic red blood cells and red cell casts Hypoalbuminemia Lipiduria[emedicine.medscape.com]

Treatment

  • We reviewed prior cases and treatment regimens, and devised effective treatment, which was guided by in vitro sensitivity and synergy testing on the pathogen. Our patient survived without complications or the need for a surgical intervention.[ncbi.nlm.nih.gov]

Prognosis

  • Prognosis Prognosis varies depending on the severity of complications. The documents contained in this web site are presented for information purposes only.[orpha.net]
  • All patients with poor prognosis (ESKD or CRI) were in group 3 or 4 during follow-up period, whereas no patients in group 1 or 2 during the same period had poor prognosis.[journals.plos.org]
  • Decrease in protein excretion to less than 2 g per day, either in response to therapy or spontaneously, is associated with improved long-term prognosis.[mdcalc.com]
  • Prognosis Prognosis depends on the underlying cause. Prevention It is estimated that 20% of the patients who develop end-stage kidney disease in the UK have glomerulonephritis.[patient.info]
  • Prognosis The vast majority of proteus infections are associated with the urinary tract. Most of the infections are sensitive to the currently available antibiotics and the outcomes are good in immunocompetent patients.[ncbi.nlm.nih.gov]

Etiology

  • Compartment syndrome is an orthopedic emergency with a multitude of etiologies. Although it is most commonly associated with trauma to the extremity, hematoma and infection are 2 rare etiologies of insidious compartment syndrome.[ncbi.nlm.nih.gov]
  • Culture: The choice of the culture media used for the isolation of the etiological agents depend on the nature of the specimen and suspected pathogens. For pus & urine sample, Blood Agar and MacConkey agar are commonly used.[microbeonline.com]
  • Etiology Causal mutations of PS have been reported in two components of the phosphatidylinositol 3-kinase (PI3K)-AKT signaling pathway: PTEN, which make PS a part of the PTEN Hamartoma Tumor Syndrome (PTHS; see this term) and AKT1.[orpha.net]
  • Proteus (trilobite) Medicine [ edit ] Proteus syndrome , a very rare congenital disorder known mostly for its most famous sufferer Joseph Merrick (the Elephant Man) Proteus-like syndrome , a condition similar to Proteus syndrome, but with an uncertain etiology[en.wikipedia.org]

Epidemiology

  • For epidemiological purposes, various molecular typing methods have been developed for this pathogen. However, these methods are labor intensive and time consuming. We evaluated a new method of differentiation between strains.[ncbi.nlm.nih.gov]
  • Although other organisms can trigger a similar response, it is useful to consider gram-negative bacteremia as a distinct entity because of its characteristic epidemiology, pathogenesis, pathophysiology, and treatment.[emedicine.medscape.com]
Sex distribution
Age distribution

Pathophysiology

  • Although other organisms can trigger a similar response, it is useful to consider gram-negative bacteremia as a distinct entity because of its characteristic epidemiology, pathogenesis, pathophysiology, and treatment.[emedicine.medscape.com]
  • Pathophysiology The interaction between P. mirabilis and the host defense (immune) system determines the resultant infection.[ncbi.nlm.nih.gov]
  • The pathophysiologic mechanisms of proteinuria can be classified as glomerular, tubular or overflow ( Table 2 7 ).[aafp.org]
  • There are three different pathophysiological mechanisms that may lead to proteinuria: damage to the glomeruli (glomerular), damage to the tubules (tubular), or overproduction of low-molecular-weight proteins (overflow).[amboss.com]

Prevention

  • This study evaluated the potential for bacteriophage therapy to control P. mirabilis infection and prevent catheter blockage.[ncbi.nlm.nih.gov]

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