CASE PRESENTATION: A 1-year-old girl was presented to a hospital in the northeastern part of Ghana with a 1-week history of pustular rashes on her scalp and neck, which occasionally ruptured, along with discharge of yellowish purulent fluid. [ncbi.nlm.nih.gov]

Pseudomonas infection of the umbilical stump in the neonate present as a spreading erythema associated with the typical green fruity-smelling discharge. Pseudochromhidrosis due to Pseudomonas aeruginosa presents as green-black sweat. [dermnetnz.org]

• Sepsis

  This case report describes the isolation of a rare Pseudomonas bacterium in a patient presenting with sepsis and skin infection. [ncbi.nlm.nih.gov]

  Therapy was administered upon signs of sepsis in group B; A served as control. Survival was recorded; monocytes were isolated for determination of ex vivo TNFα secretion. Quantitative cultures of organs were performed after death. [tandfonline.com]

  They may trigger catheter-associated urinary tract infection, infection of the lower respiratory tract, wound infection, or sepsis. Pseudomonas spp. frequently cause nosocomial infections. [bode-science-center.com]

  In hospitalized patients, the first sign may be overwhelming gram-negative sepsis Sepsis and Septic Shock Sepsis is a clinical syndrome of life-threatening organ dysfunction caused by a dysregulated response to infection. [msdmanuals.com]

• Inflammation

  Due to the host usually having pre-existing conditions, the inflammation and potential sepsis caused by infection can be fatal. [microbiologysociety.org]

  Clinical Features Symptoms may include: Decreased vision Photophobia Pain Red eye Conjunctiva and/ or lid edema Mucopurulent discharge Signs: Rapidly progressive ulceration with underlying dense suppurative stromal inflammation Diffuse surrounding corneal [vagelos.columbia.edu]

  The limited life-expectancy in cystic fibrosis relates to devastating lung disease: early/recurrent bacterial infections, inflammation and irreversible fibrosis lead to respiratory failure. [cysticfibrosis.org.uk]

  Human leukocytes challenged with Staphylococcus epidermidis have been reported to produce HCN in vitro 20– 22 and it is possible that the airway inflammation caused by P. aeruginosa infection results in cyanide production by leukocytes. [erj.ersjournals.com]

  The research will take place within the Department of Infection, Immunity and Inflammation, at the University of Leicester. [action.org.uk]

• Collapse

  Nevertheless, passage of E80 in casein broth led to the evolution of protease-deficient freeloaders in ∼1 to 2 wk, producing a tragedy of the commons and collapse of the entire population. [pnas.org]

  Surfactant scores are equal to the reciprocal of the greatest dilution at which there was surfactant activity (a collapsed drop). [nature.com]

• Candidiasis

  […] and adalimumab) has significantly advanced the treatment of autoimmune inflammatory disorders such as rheumatoid arthritis.1 However, they seem to impair host resistance to granulomatous infections, such as tuberculosis, histoplasmosis, listeriosis, candidiasis [journals.lww.com]

  Reactions The most common adverse reactions occurring in (>2%) of patients receiving FETROJA compared to imipenem/cilastatin in clinical trials were: diarrhea (4% vs 6%), infusion site reactions (4% vs 5%), constipation (3% vs 4%), rash (3% vs <1%), candidiasis [shionogi.com]

• Congestive Heart Failure

  The enantiomer thus formed is the precursor of captopril, which is an essential drug in the management of congestive heart failure and hypertension. [microbenotes.com]

  Patients who are susceptible to Pseudomonas pneumonia include those with malignant neoplasms, diabetes mellitus, bronchiectasis, emphysema, and congestive heart failure. [jamanetwork.com]

• Pneumonia

  Pneumonia due to Pseudomonas aeruginosa can occurs as several distinct syndromes 3 : community acquired pneumonia - usually in patients with chronic lung disease hospital-acquired pneumonia - usually occurring in the ICU setting - ventilator associated [radiopaedia.org]

  The earliest description of P. aeruginosa pneumonia dates back to 1917 [1]. [bmcinfectdis.biomedcentral.com]

  Primary pneumonia due to Pseudomonas aeruginosa in healthy individuals is rare. [gpnotebook.co.uk]

  Two effector proteins, ExoU and ExoS, are particularly virulent in animal models of acute pneumonia (7). [atsjournals.org]

  Bacterial biofilm formed on the ETTs in intubated patients is a significant risk factor associated with ventilator-associated pneumonia. [microbiologyresearch.org]

• Chest Pain

  If you or someone in your care has chest pains, difficulty breathing, or severe bleeding, it could be a life-threatening emergency. Call 9-1-1 or the local emergency number immediately. [healthlinkbc.ca]

  Initial fever, cough, shortness of breath and chest pain can progress worryingly quickly until the patient is at substantial risk of generalised organ failure. [action.org.uk]

  Chest pain can also occur. 2: Entering the body via a wound or burn to the skin Any kind of damage to the skin, such as a cut or burn, can supply an entry point for Pseudomonas aeruginosa to use. [legionellacontrol.com]

  […] breath, chest pain, productive cough (with white, yellow, or greenish mucus), and congestion Urinary tract: Painful urination, unpleasant or sweet-smelling urine, urgency, cloudy urine Rare Symptoms Shortness of breath, fast heart rate, weak pulse, confusion [verywellhealth.com]

• Ulcer

  Two months later, she developed a central corneal ulceration. Scraping of the corneal lesion revealed Gram-negative bacilli. [ncbi.nlm.nih.gov]

  Ecthyma gangrenosum typically develops in neutropenic patients as erythematous, ulcerated, purple or black skin lesions in the axillary, inguinal, or anogenital areas. [dermnetnz.org]

  On subgroup analysis on patients from the steroids for corneal ulcers trial (SCUT), showed that pseudomonas ulcers had no overall benefit with the addition of corticosteroids[5]. [eyewiki.aao.org]

  Small corneal ulcers are treated with ciprofloxacin 0.3% or levofloxacin 0.5%. Fortified (higher than stock concentration) antibiotic drops, such as tobramycin 15 mg/mL, are used for more significant ulcers. [pharmotech.ch]

  Fortified antibiotics around the clock for sight threatening ulcers. Consider subconjunctival antibiotics. Systemic antibiotics for threatened perforation or scleral involvement. Anticollagenase therapy (i.e. tetracycline family) [vagelos.columbia.edu]

• Skin Rash

  These include ear infections and skin rashes, especially after exposure to water. Pseudomonas bacteria cause well-known conditions such as hot tub rash, a red and itchy skin rash resulting from contaminated water, and swimmer’s ear. [medicalnewstoday.com]

• Dermatitis

  What are the symptoms of Pseudomonas dermatitis? In the non-hospital setting the most common problems are ear infections and skin eruptions (rash). [doh.sd.gov]

  Pseudomonas aeruginosa causes urinary tract infections, respiratory system infections, dermatitis, soft tissue infections, bacteremia, bone and joint infections, gastrointestinal infections and a variety of systemic infections, particularly in patients [ehagroup.com]

  Pseudomonas aeruginosa alone is associated with sepsis, pneumonia, dermatitis, urinary tract infections, and infections in cystic fibrosis patients and the otherwise immunocompromised. [zmescience.com]

  It causes urinary tract infections, respiratory system infections, dermatitis, soft tissue infections, bacteremia, bone and joint infections, gastrointestinal infections and a variety of systemic infections, particularly in patients with severe burns [textbookofbacteriology.net]

• Eruptions

  In the non-hospital setting the most common problems are ear infections and skin eruptions (rash). The rash appears as red raised blotches, and/or, pus filled pimples around a hair follicle; often accompanied by itching. [doh.sd.gov]

  Article Figures/Media 17 References 52 Citing Articles Abstract Background Between March and May 1998, there was an outbreak of a clinically distinct skin eruption on the soles of the feet of children who used a community wading pool. [nejm.org]

• Suggestibility

  Most importantly, all of these studies suggest that RhlR is playing a central role to mediate in vivo QS. [pnas.org]

  While mortality from the infection varies depending on where the infection is, how soon it is treated and the underlying weakness of the patient, some studies suggest a third of infected patients may die. [bbc.co.uk]

  These results suggested that Chryseomonas, Flavimonas, and Pseudomonas are synonymous, and we concluded that Chryseomonas and Flavimonas are junior subjective synonyms of Pseudomonas. [ncbi.nlm.nih.gov]

  This phenotype is characteristic of exposure to antimicrobial compounds at sub-inhibitory concentrations, suggesting that TS was active against P. aeruginosa. [biorxiv.org]

Extensive diagnostic workup for an infectious focus was performed with no results. Finally, an oscillating mass on the aortic valve was detected by TEE five weeks after the initial positive blood cultures. [bmcinfectdis.biomedcentral.com]

[…] procedures that may be helpful in specific scenarios include the following: Fluorescein staining and slit-lamp examination of the cornea for keratitis Flexible fiberoptic bronchoscopy with bronchoalveolar lavage or bronchial brushing Thoracocentesis See Workup [emedicine.medscape.com]

• Pseudomonas

  Pseudomonas taetrolens Haynes, 1957 Species Pseudomonas taiwanensis Wang et al., 2010 Species Pseudomonas thermotolerans Manaia and Moore, 2002 Species Pseudomonas thivervalensis Achouak et al., 2000 Species Pseudomonas tolaasii Paine, 1919 Species Pseudomonas [itis.gov]

  Pseudomonas beteli, Pseudomonas boreopolis, 'Pseudomonas butanovora', Pseudomonas carboxydohydrogena, Pseudomonas cissicola, Pseudomonas doudoroffii, Pseudomonas echinoides, Pseudomonas elongata, Pseudomonas flectens, Pseudomonas geniculata, Pseudomonas [ncbi.nlm.nih.gov]

  […] halophila, Pseudomonas hibiscicola, Pseudomonas huttiensis, Pseudomonas iners, Pseudomonas lanceolata, Pseudomonas lemoignei, Pseudomonas mephitica, Pseudomonas pictorum, Pseudomonas saccharophila, Pseudomonas spinosa, Pseudomonas stanier, Pseudomonas [doi.org]

  Taxon Concept Full Name Pseudomonas atrofaciens (McCulloch 1920) F. [nzor.org.nz]

• Staphylococcus Aureus

  Synergistic interactions of Pseudomonas aeruginosa and Staphylococcus aureus in an in vitro wound model. Infect Immun. 2014;82(11):4718–28. 11. Kumar A, Ting YP. [bmcgenomics.biomedcentral.com]

  P. aeruginosa and Staphylococcus aureus are two major pathogens commonly isolated from CF-affected airways and sputum. [nature.com]

  ABSTRACT In this month's Journal of Bacteriology, Price et al. show that the Pseudomonas aeruginosa produced exopolysaccharide alginate, protects Staphylococcus aureus by dampening the expression of P. aeruginosa virulence products that usually inhibit [jb.asm.org]

  The ESKAPE pathogens include Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp. [drugtargetreview.com]

• Candida

  This suggested that none of the PKs in this study was implicated in Candida-Pseudomonas signaling. [cora.ucc.ie]

  (pyocyanin and 1-hydroxyphenazine are also antifungal agents active against Candida albicans and Aspergillus fumigatus; Kerr J R et al., 1999). [microbiologyinpictures.com]

  Aspergillus Bacillus cereus Bacillus subtilis molecular biology Microbial Biodegradation, Bioremediation and Biotransformation Biofilms Bioinformatics in Microbiology Book reviews Burkholderia Campylobacter Comparative Genomics and Functional Genomics of Candida [horizonpress.com]

  As for antibiotics, horizontal transfer of phage resistance can be acquired by plasmid acquisition.[8] Antifungal resistance[edit] Yeasts such as Candida species can become resistant under long term treatment with azole preparations, requiring treatment [en.wikipedia.org]

  Pseudomonas aeruginosa - Candida albicans interactions: localization and fungal toxicity of a phenazine derivative. Appl Environ Microbiol. 2009; 75 :504–513. [ PMC free article ] [ PubMed ] [ Google Scholar ] 39. [ncbi.nlm.nih.gov]

Adoption of the treatment guideline leads to a reasonable complete cure rate of Pseudomonas peritonitis. Treatment with three antibiotics is not superior than the conventional two antibiotics regimen. [ncbi.nlm.nih.gov]

Nebulized colistin is also a potential treatment for this infection. [bronchiectasisnewstoday.com]

Three of the trials compared active treatment with placebo or no treatment. [cochrane.org]

Treatment combinations including nebulised colistimethate sodium were more effective (n=31/54, 57%) than those with systemic antibiotics alone (n=2/10, 20%) (t-test, p=0.04). [erj.ersjournals.com]

Importantly, treatment by S100A8/A9 provides local infection control. Implications for a role as adjunctive treatment in healing of chronic biofilm-infected wounds are discussed. [isim.ku.dk]

Compared to pneumonia caused by other pathogens, P. aeruginosa CAP exhibits rapid progression, high severity and poor prognosis. [bmcinfectdis.biomedcentral.com]

The importance of this research is illustrated by the high numbers of infected people, the treatment burden posed and the resultant poor prognosis. So far... [cysticfibrosis.org.uk]

It is known to be particularly virulent, with pseudomonas keratitis being more difficult to treat and have worse prognosis than other forms of bacterial keratitis. [eyewiki.aao.org]

Prognosis Prognosis depends on the site of infection and the underlying health of the individual patient. Acute fulminant infections (eg, bacteraemic pneumonia, septicaemia, burn sepsis and meningitis) are associated with significant mortality. [patient.info]

Pseudomonas causes a wide spectrum of diseases; therefore, prognosis is varied. [emedicine.medscape.com]

The purpose of this study is to compare the adhesion capabilities of the most important etiologic agents of microbial ocular infection to the recently available silicone– hydrogel lenses with those to a conventional hydrogel lens. Methods. [repositorium.sdum.uminho.pt]

The other medically important members of this genus are B. pseudomallei and B. mallei, the etiologic agents of melioidosis and glanders, respectively. [accessmedicine.mhmedical.com]

Smolianskaya ADmitrieva NSokolova EKhvatova Not AvailableKulaga E Etiology of infectious complications in cancer patients. [jamanetwork.com]

Infectious etiology of acute exacerbations in severe COPD patients. J. Infect. 67, 516–523 (2013). 3. Yang, L. et al. Evolutionary dynamics of bacteria in a human host environment. Proc. Natl. Acad. Sci. USA 108, 7481–7486 (2011). 4. [nature.com]

Refining our knowledge on the ecology and epidemiology of these bacterial groups, as well as deciphering their evolutionary dynamics are keys for understanding their contrasting lifestyles and consequently improving plant disease control. [frontiersin.org]

ABSTRACT Ribotyping, a method of genotyping bacterial isolates for epidemiologic study, uses rRNA as a probe to detect chromosomal restriction fragment length polymorphisms. [jcm.asm.org]

Epidemiology of Pseudomonas aeruginosa Pseudomonas aeruginosa is primarily a nosocomial pathogen. [ehagroup.com]

RESULTS Table 1⇓ presents the epidemiological and sampling data of the patients included. [erj.ersjournals.com]

Dhalla (eds), Pathophysiological Aspects of Proteases, Springer, Switzerland. doi:10.1007/978-981-10-6141-7_16 DOI https://doi.org/10.1007/978-981-10-6141-7_16 DOWNLOADS Since August 30, 2018 COinS [arrow.tudublin.ie]

Pseudomonas acquisition in young patients with cystic fibrosis: pathophysiology, diagnosis, and management. Curr Opin Pulm Med. 2003 Nov;9(6):492-7. 6- Konstan MW, Morgan WJ, Butler SM, Pasta DJ, Craib ML, Silva SJ. [imj.ie]

[…] include erythema nodosum, a septal panniculitis that often involves the legs but rarely the soles. 15 Traumatic-pressure urticaria is characterized by tender plantar macules and papules resulting from mechanical stress such as running and dancing; its pathophysiology [nejm.org]

[…] a finding which was largely absent from ventilated patients without VAP and healthy controls.[7] The Mycoplasma species most commonly identified, Mycoplasma salivarium, was able to impair the antibacterial functions of monocytes and macrophages.[7] Pathophysiology [en.wikipedia.org]

Pathophysiology P aeruginosa is an opportunistic pathogen. It rarely causes disease in healthy persons. [emedicine.medscape.com]

Author information 1 Department of Infection Control and Prevention, Nippon Medical School Hospital, Japan. [ncbi.nlm.nih.gov]

Andrew Shorr, MD: More importantly, focusing on prevention. [contagionlive.com]

We also identified novel ETT-specific TCSs that could serve as targets to prevent biofilm formation on indwelling devices frequently used in clinical settings. [microbiologyresearch.org]

Infection Prevention and Control. U.S. Centers for Disease Control and Prevention. US-CDC. Travel Notices: Drug-Resistant Infections in Mexico, Alert – Level 2, Practice Enhanced Precautions. Updated 28 January 2019. PHAC. [who.int]