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Pseudomonas Aeruginosa


Presentation

  • As for the occurrence of the genes, 100% of the isolates presented the lasR, rhlI and rhlR genes, and 97.5%, presented the lasI gene. In this study nine isolates were not biofilm producers. However, all presented the QS genes.[ncbi.nlm.nih.gov]
  • The present case concerns a 23 year old woman who presented at the General Hospital of Nova Iguaçu with complaints of pain in the right side of the face and was diagnosed with acute sinusitis.[ncbi.nlm.nih.gov]
  • Recently, changes have been observed in the occurrence and clinical presentation of pseudomonal endocarditis, with increasing incidence of nosocomial infections and involvement of the aortic and mitral valves.[ncbi.nlm.nih.gov]
  • The present case might be representative of less common bacterial infections than Neisseria spp. among patients treated with eculizumab.[ncbi.nlm.nih.gov]
  • Blood culture results from the day of hospital presentation grew Pseudomonas aeruginosa Sputum sample and pleural fluid grew P. aeruginosa and were negative for acid-fast bacilli.[ncbi.nlm.nih.gov]
Fever
  • Outcome of pseudomonas enteric fever is unpredictable as multiple systemic lethal complications occur abruptly.[ncbi.nlm.nih.gov]
  • Children with elbow pain and/or swelling with fever should be carefully examined for septic arthritis. Pseudomonas aeruginosa should always be kept in mind in such cases to avoid any delay in effective treatment.[ncbi.nlm.nih.gov]
  • Investigations revealed fever, a gangrenous ulcer on the right cheek, submandibular lymphadenopathy, and thyroid gland enlargement. Her white blood cell count, immunoglobulins, and lymphocyte subsets were unremarkable.[ncbi.nlm.nih.gov]
  • Five months after left ventricular assist device (LVAD) implantation, a 49-year old man developed fever and blood culture was positive for MDR P. aeruginosa, susceptible only to aminoglycosides, ciprofloxacin and colistin.[ncbi.nlm.nih.gov]
  • Patients had inflammatory nodules on a lower limb (n   6) that were unilateral (n   6) and had no fever (n   5). Blood cultures were negative (n   5).[ncbi.nlm.nih.gov]
Chills
  • Bloodstream infections can cause various symptoms, including: Fever and chills Body aches Light-headedness Rapid pulse and breathing Nausea and vomiting Diarrhea Decreased urination Pneumonia can cause: Fever and chills Difficulty breathing Cough, sometimes[everydayhealth.com]
  • Symptoms include: chills fever cough with or without sputum production difficulty breathing Skin When this bacterium infects the skin, it most often affects the hair follicles. This is called folliculitis .[healthline.com]
High Fever
  • A 66-year-old man with diabetes mellitus and a recent history of intermittent urethral self-catheterization was admitted due to a high fever.[ncbi.nlm.nih.gov]
Intravenous Drugs
  • Historically, most cases of P. aeruginosa endocarditis have occurred in the right side of the heart and in outpatients with a history of intravenous drug abuse.[ncbi.nlm.nih.gov]
Fulminant Sepsis
  • This is the case of a previous healthy toddler and his sibling, who both died of fulminant sepsis due to Pseudomonas aeruginosa. Subsequent genetic analysis demonstrated IRAK-4 deficiency with compound heterozygous splice mutations.[ncbi.nlm.nih.gov]
Saddle Nose
  • We present a case of a 65-year-old Caucasian man with a history of rheumatoid arthritis, off immunosuppression for 18 months, who presented with 2 years of chronic headaches, severe fatigue, saddle nose deformity and 20-kilogram unintentional weight loss[ncbi.nlm.nih.gov]
Regurgitation
  • Repeated blood cultures identified Pseudomonas aeruginosa, and transesophageal echocardiography uncovered a new-onset severe aortic regurgitation along with a vegetative valvular structure.[ncbi.nlm.nih.gov]
Left Ventricular Dysfunction
  • A case of a high-risk patient with coronary artery disease and left-ventricular dysfunction, successfully treated for pseudomonal mitral valve endocarditis complicated by splenic abscess formation, is presented here.[ncbi.nlm.nih.gov]
Ptosis
  • Other examination findings were ptosis, restriction of eye movements, periorbital erythema, and chemosis. Radiologic studies showed a large, homogenous mass with a thick capsule in the lateral retrobulbar orbit.[ncbi.nlm.nih.gov]
Cutaneous Manifestation
  • Ecthyma gangrenosum is a known cutaneous manifestation due mainly to Pseudomonas infection with or without septicemia. We describe clinical, biological, and therapeutic data.[ncbi.nlm.nih.gov]
Purpura
  • A healthy 3-year-old girl admitted to the Pediatric Emergency Department presented a sepsis-associated purpura with neurological and respiratory distress. An empiric antibiotherapy (anti-meningococcal) was prescribed.[ncbi.nlm.nih.gov]
Elbow Pain
  • Children with elbow pain and/or swelling with fever should be carefully examined for septic arthritis. Pseudomonas aeruginosa should always be kept in mind in such cases to avoid any delay in effective treatment.[ncbi.nlm.nih.gov]

Workup

  • In further workup, this child was diagnosed as a case of X-linked agammaglobulinaemia. The child was treated successfully with antipseudomonal antibiotics for 6 weeks and intravenous immunoglobulin.[ncbi.nlm.nih.gov]
Polyps
  • Physician assessed erythema/inflammation, ulceration/granulation/polyps, discharge quantity, discharge type and odour using a Visual Analogue Scale (VAS). Patients reported discomfort, itchiness, wetness and smell also using a VAS.[ncbi.nlm.nih.gov]

Treatment

  • A patient with carbapenem-resistant Klebsiella pneumoniae infection is described, and treatment options are discussed.[ncbi.nlm.nih.gov]
  • At this time, clinical data on the role of TOL/TAZ treatment outside of FDA-approved indications is limited.[ncbi.nlm.nih.gov]
  • Surgical necrectomy and application of negative pressure wound therapy (NPWT) was started together with intensive care treatment for sepsis.[ncbi.nlm.nih.gov]
  • These strains are increasingly disseminated worldwide, progressively complicating the treatment of P. aeruginosa infections.[ncbi.nlm.nih.gov]
  • The evolution was favorable under broad-spectrum antibiotic treatment and surgical excision.[ncbi.nlm.nih.gov]

Prognosis

  • Pseudomonas aeruginosa is an unusual pathogen in community-acquired pneumonia, especially in previously healthy adults, but often indicates poor prognosis.[ncbi.nlm.nih.gov]
  • Folliculitis is an important manifestation of intrauterine P. aeruginosa infection, and prompt, effective treatment is crucial to ensuring a good prognosis.[ncbi.nlm.nih.gov]
  • Abstract Previously, endocarditis caused by Pseudomonas aeruginosa mostly involved right-sided valvular infection and generally carried a good prognosis.[ncbi.nlm.nih.gov]
  • […] another study , this bacterial phenotype, known as the mucoid phenotype, is associated with considerable difficulty in eradicating the pathogen, leading to a strong inflammatory response and resulting in an accelerated loss of lung function and a poorer prognosis[cysticfibrosisnewstoday.com]
  • Pathogen detection from respiratory tract specimens is a significant indicator of disease prognosis.[bmjopen.bmj.com]

Etiology

  • There have been rare case reports in previously healthy children and rarer are the cases with double etiology.[ncbi.nlm.nih.gov]
  • Such treatment would include the excision of the etiological factor, drainage and adjuvant antibiotic therapy.[ncbi.nlm.nih.gov]
  • IPAs following kidney transplantation are most often mycotic in etiology, but have been sporadically reported to result from Pseudomonas aeruginosa infection.[ncbi.nlm.nih.gov]
  • Abstract Pseudomonas aeruginosa is an important etiological agent of opportunistic infections. Injectable colistin is available as a last-line treatment option for multidrug-resistant P. aeruginosa infections.[ncbi.nlm.nih.gov]

Epidemiology

  • The epidemiology of P. aeruginosa was studied through analysis of phenotypic markers, including antimicrobial sensitivity profiles. The infection control audit revealed multiple breaches of infection control procedures.[ncbi.nlm.nih.gov]
  • In this article, we review the molecular epidemiology of CRPA in an endemic area, compared to global data.[ncbi.nlm.nih.gov]
  • Epidemiology, predisposing factors, clinical characteristics, antibiotic susceptibilities, and treatment outcomes were compared between the PA and PP groups.[ncbi.nlm.nih.gov]
  • When allied to epidemiological information, WGS can be used to understand outbreak situations rapidly and with certainty. Implementation of WGS in real-time would be a major advance in day-to-day practice.[ncbi.nlm.nih.gov]
  • Here, 20 epidemiologically unrelated strains isolated from patients in a general hospital over a time period of two decades were analyzed using whole genome sequencing.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • Crossref, Medline, CAS, Google Scholar 26 Westh JB: Pulmonary Physiology and Pathophysiology. Lippincott Williams & Wilkins, PA, USA ( 2001 ).[doi.org]
  • Expression profiling in the muscular dystrophies: identification of novel aspects of molecular pathophysiology. J. Cell Biol. 151 : 1321-1336. [ PMC free article ] [ PubMed ] [ Google Scholar ] 9. Clark, D. J., and O. Maaløe. 1967.[ncbi.nlm.nih.gov]
  • The pathophysiology of infections caused by P. aeruginosa is complex as shown by the clinical diversity of diseases associated with this organism and the multiplicity of virulence factors it produces.[doi.org]

Prevention

  • […] and healthy behaviors to prevent antibiotic resistance.[cdc.gov]
  • A single dose of pegfilgrastim or the daily administration of colony-stimulating factors can be used to prevent febrile neutropenia. This may delay the detection of rapidly progressive infections among cancer patients undergoing chemotherapy.[ncbi.nlm.nih.gov]
  • Thus, infection control measures are required for preventing future spread and outbreaks.[ncbi.nlm.nih.gov]
  • According to the Centers for Disease Control and Prevention (CDC), approximately 51 000 healthcare-associated infections caused by Pseudomonas aeruginosa occur annually in the USA, more than 6000 of which (13%) are caused by multidrug resistant (MDR)[ncbi.nlm.nih.gov]

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